Abstract
In this study the hepatic lipoprotein lipase (LPL), activity was evaluated in adult female mice acclimatized at 5-C and submitted to carbon tetrachloride (CCI) or ethionine, in order to determine the possible role of this enzuyme in the fatty liver. The results were compared with those obtained in mice kept at room temperature (27-C) that the same hepatoesteatosis inducing agent. In contrast to animals kept at room temperature, in cold aclimatized mice neither the enhancement of the LPL-liver activity by the action of CCI or ethionine occurred nor the development of fatty infiltration in the liver was observed. We conclude that the low temperature induced a protective effect against CCI or ethionine-induced fatty liver that was correlated with the no-increase of the hepatic LPL activity.
cold acclimatization; hepatic lipoprotein lipase; fatty liver; carbon tetrachloride; ethionine
On the mechanism of protective action of cold acclimatization against carbon tetrachloride - and ethionine-induced fatty liver
Aura Lopez de O.1
C. A. Carmona de G.
H. Moussatche2
Universidad Centro Occidental Lisandro Alvarado, Escuela de Ciencias Veterinárias, Unidade de Investigación en Ciencias Funcionales, Barquisimeto, Venezuela
Instituto Oswaldo Cruz, Departamento de Fisiologia e Farmacodinamica, Rio de Janeiro, Brasil
In this study the hepatic lipoprotein lipase (LPL), activity was evaluated in adult female mice acclimatized at 5-C and submitted to carbon tetrachloride (CCI) or ethionine, in order to determine the possible role of this enzuyme in the fatty liver. The results were compared with those obtained in mice kept at room temperature (27-C) that the same hepatoesteatosis inducing agent. In contrast to animals kept at room temperature, in cold aclimatized mice neither the enhancement of the LPL-liver activity by the action of CCI or ethionine occurred nor the development of fatty infiltration in the liver was observed. We conclude that the low temperature induced a protective effect against CCI or ethionine-induced fatty liver that was correlated with the no-increase of the hepatic LPL activity.
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Publication Dates
-
Publication in this collection
02 June 2009 -
Date of issue
June 1993
