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Memórias do Instituto Oswaldo Cruz

Print version ISSN 0074-0276On-line version ISSN 1678-8060

Mem. Inst. Oswaldo Cruz vol.89 no.1 Rio de Janeiro Jan./Mar. 1994

http://dx.doi.org/10.1590/S0074-02761994000100013 

Sialoglycoconjugates in Trypanosoma cruzi-host cell interaction: possible biological model - a review

Alane Beatriz Vermelho

Maria Nazareth Leal Meirelles1 

Instituto Oswaldo Cruz, Departamento de Ultra-estrutura e Biologia Celular, Rio de Janeiro, Brasil

ABSTRACT

A number of glycoconjugates, including glycolipids and glycoproteins, participate in the process of host-cell invasion by Trypanosoma cruzi and one of the most important carbohydrates involved on this interaction is sialic acid. It is known that parasite trans-sialidase participates with sialic acid in a coordinated fashion in the initial stages of invasion. Given the importance of these sialogycoconjugates, this review sets out various possible biological models for the interaction between the parasite and mammalian cells that possess a sialylated receptor/ligand system.

Key words: sialoglycoconjugates; Trypanosoma cruzi-host cell; sialic acid; neuraminidase, trans-sialidase; biologicals models

 

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