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Memórias do Instituto Oswaldo Cruz

Print version ISSN 0074-0276

Mem. Inst. Oswaldo Cruz vol.89 no.2 Rio de Janeiro Apr./Jun. 1994

http://dx.doi.org/10.1590/S0074-02761994000200017 

Reversibility of muscle and heart lesions in chronic Trypanosoma cruzi infected mice after late trypanomicidal treatmentSeguraM. A.RaspiE. Molina deBasombrioM. A. Universidad Nacional de Salta, Facultad de Ciencias Naturales Salta Argentina Universidad Nacional de Salta, Facultad de Ciencias de la Salud, Laboratorio de Patologia Experimental Salta Argentina 061994892213216The effect of trypanomicidal treatment upon established histopathological Trypanosoma cruzi induced lesions was studied in Swiss mice. The animals were inoculated with 50 trypomastigotes and infection was allowed to progress without treatment for 99 days. After this period, the animals were divided in three groups, treated for 30 days with either placebo, benznidazole (200 mg/kg/day) or nifurtimox (100 mg/kg/day). These treatments induced 94 and 100 (per cent) cure rates respectively as detected by xenodiagnosis and reduction of antibody levels. Autopsies and histopathological studies of heart, urinary bladderand skeletal muscle performed on day 312 after infection showed almost complete healing without residual lesions. As long periods were allowed between infection, treatment and autopsy, the results indicate that tissue lesions depend, up to advances stages, on the continuous presence of the parasite.Trypanosoma cruzichronic infectionchemotherapyhistopathologyFull text available only in PDF format.Texto completo disponível apenas em PDF.