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Memórias do Instituto Oswaldo Cruz

Print version ISSN 0074-0276On-line version ISSN 1678-8060

Mem. Inst. Oswaldo Cruz vol.89 no.4 Rio de Janeiro Oct./Dec. 1994 

Studies on the replication of Mayaro virus grown in interferon treated cells

M. C. S. Rebello1 

M. E. F. Fonseca2 

J. O. Marinho1 

M. A. Rebello1 

Universidade Federal do Rio de Janeiro, Centro de Ciências de Saúde, Instituto de Biofísica Carlos Chagas Filho, Rio de Janeiro, Brasil

Universidade Federal do Rio de Janeiro, Centro de Ciéncias de Saúde, Instituto de Microbiologia, Rio de Janeiro, Brasil


Mayaro virus grown in interferon treated infected cells has been characterized with regard to its ability to replicate in vertebrate (TC7) and invertebrate (Aedes albopictus) cells. Virus purified from interferon treated TC7 cells adsorbs and penetrates to the same extent as the control virus. During infection, these virus particles caused inhibition of host protein synthesis and synthesized the same spectrum of viral proteins as normal virus. This population however, was apparently more sensitive to interferon treatment. Electron microscopy of TC7 cells showed the presence of numerous aberrant virus particles budding from the plasma membrane.

Key words: interferon; Mayaro virus replication


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