Abstract
Mayaro virus grown in interferon treated infected cells has been characterized with regard to its ability to replicate in vertebrate (TC7) and invertebrate (Aedes albopictus) cells. Virus purified from interferon treated TC7 cells adsorbs and penetrates to the same extent as the control virus. During infection, these virus particles caused inhibition of host protein synthesis and synthesized the same spectrum of viral proteins as normal virus. This population however, was apparently more sensitive to interferon treatment. Electron microscopy of TC7 cells showed the presence of numerous aberrant virus particles budding from the plasma membrane.
interferon; Mayaro virus replication
Studies on the replication of Mayaro virus grown in interferon treated cells
M. C. S. Rebello1
M. E. F. Fonseca2
J. O. Marinho1
M. A. Rebello1
Universidade Federal do Rio de Janeiro, Centro de Ciências de Saúde, Instituto de Biofísica Carlos Chagas Filho, Rio de Janeiro, Brasil
Universidade Federal do Rio de Janeiro, Centro de Ciéncias de Saúde, Instituto de Microbiologia, Rio de Janeiro, Brasil
Mayaro virus grown in interferon treated infected cells has been characterized with regard to its ability to replicate in vertebrate (TC7) and invertebrate (Aedes albopictus) cells. Virus purified from interferon treated TC7 cells adsorbs and penetrates to the same extent as the control virus. During infection, these virus particles caused inhibition of host protein synthesis and synthesized the same spectrum of viral proteins as normal virus. This population however, was apparently more sensitive to interferon treatment. Electron microscopy of TC7 cells showed the presence of numerous aberrant virus particles budding from the plasma membrane.
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Publication Dates
-
Publication in this collection
01 June 2009 -
Date of issue
Dec 1994
