versão impressa ISSN 0100-3984
Radiol Bras vol.45 no.4 São Paulo jul./ago. 2012
ARTIGO ORIGINAL ORIGINAL ARTICLE
Magnetic resonance imaging findings of disc-related epidural cysts in nonsurgical and postoperative microdiscectomy patients*
Achados de ressonância magnética em cistos epidurais de origem discal em pacientes não operados e após microdiscectomia
Marcelo Novelino SimãoI; Clyde A. HelmsII; William J. RichardsonIII
IPhD, MD, Physician at Central de Diagnóstico Ribeirão Preto (Cedirp), Ribeirão Preto, SP, Brazil
IIMD, Professor of Radiology, Chairman of Musculoskeletal Section, Duke University Medical Center, Durham, NC, USA
IIIMD, Professor of Orthopedic Surgery, Chief of Spine Surgery Section, Duke University Medical Center, Durham, NC, USA
OBJECTIVE: To demonstrate five discal cysts with detailed magnetic resonance imaging findings in nonsurgical and following postoperative microdiscectomy.
MATERIALS AND METHODS: Five discal cysts in four patients who underwent magnetic resonance imaging were found through a search in our database and referral from a single orthopedic spine surgeon. Computed tomography in two cases and computed tomography discography in one case were also performed.
RESULTS: Five discal cysts were present in four patients. Three patients had no history of previous lumbar surgery and the other patient presented with two discal cysts and recurrent symptoms after partial laminectomy and microdiscectomy. All were oval shaped and seated in the anterior epidural space. Four were ventrolateral, and the other one was centrally positioned in the anterior spinal canal. One showed continuity with the central disc following discography. Three were surgically removed.
CONCLUSION: Magnetic resonance imaging can easily depict an epidural cyst and the diagnosis of a discal cyst should be raised when an homogeneous ventrolateral epidural cyst contiguous to a mild degenerated disc is identified.
Keywords: Magnetic resonance imaging; Lumbar spine; Discal cyst; Extradural cyst.
OBJETIVO: Demonstrar os achados de imagem em cinco casos de cisto discal em pacientes sem cirurgia prévia e após microdiscectomia.
MATERIAIS E MÉTODOS: Cinco cistos discais em quatro pacientes submetidos a exames de ressonância magnética foram identificados após procura em nossos sistemas de dados e por referência de um cirurgião ortopédico especialista em coluna. Exames de tomografia computadorizada também estavam disponíveis em dois casos e discografia por tomografia computadorizada em um caso.
RESULTADOS: Três pacientes não tinham história prévia de cirurgia lombar e o outro paciente, que tinha dois cistos discais, apresentava recorrência dos sintomas após laminectomia parcial e microdiscectomia. Todos os cistos mostravam aspecto ovalado e estavam localizados no espaço epidural anterior, sendo quatro ventrolaterais, e o outro estava posicionado na região central do espaço epidural anterior. A discografia por tomografia computadorizada, disponível em um caso, demonstrou continuidade do cisto com o disco. Três foram submetidos a ressecção cirúrgica.
CONCLUSÃO: A ressonância magnética pode facilmente identificar um cisto epidural e o diagnóstico de cisto discal deve ser considerado quando uma imagem cística homogênea, localizada no espaço epidural anterior, ventrolateral, e em contato com um disco parcialmente degenerado for identificada.
Unitermos: Ressonância magnética; Coluna lombar; Cisto discal; Cisto epidural.
Lumbar radiculopathy is a very common condition usually related to degenerative disease of the spine and herniated discs. Several other conditions have been associated with radiculopathy, among them epidural cysts(1,2). The most common locations are the facet joint and the ligamentum flavum(3). A case of a ganglion cyst of the lumbar spine annulus fibrosus compressing a nerve root was reported by Kornberg in 1995(4). A cyst that communicates with the intervertebral disc is called a "discal cyst" and is very rarely found, being first described by Kono et al. in 1999(5). A more complete description was made by Chiba et al. in 2001(6). The pathogenesis of discal cysts is unclear, with several suggested hypotheses including a mechanism similar to that of meniscal cyst of the knee and synovial cyst of the facet(5); hematoma resorption(6) or that such cysts are ganglion cysts that derive from the annulus fibrosus(7) or the posterior longitudinal ligament; findings of residual disc tissue in the cyst wall(1) and discal cyst followed by a herniated disc(8) supporting the theory of focal degeneration. Cyst-like fluid collections communicating with the annulus fibrosus have also been described as a rare complication of microdiscectomy in patients with recurrence of radicular pain(9,10).
The authors' purpose is to demonstrate five discal cysts with detailed magnetic resonance imaging (MRI) findings, including two cases of cysts which appeared following microdiscectomy.
MATERIALS AND METHODS
The subjects of our study consisted of five discal cysts found at MRI in four patients identified after a search in the authors' institution database and referral from a single orthopedic spine surgeon. All images were obtained with a 1.5 T scanner (Signa Excite or HDx; GE Healthcare, Milwaukee, WI, USA) and the protocol included sagittal T1-weighted sequences (TR 550/TE 14) and T2-weighted sequences (TR 4000/TE 60), 26 × 26 cm field of view, 4.0 mm slice thickness with 1.0 mm section gap, matrix 256 × 256 and axial T2-weighted sequences (TR 4000/TE 7090), 16 × 16 cm field of view and 4.0 mm slice thickness with 0.41.0 mm section gap continuous or angulated in discal spaces and matrix 256 × 256. Also, computed tomography (CT) was performed in two cases and CT discography (CTD) in one case. A two-year imaging follow-up was available for one patient with clinical follow-up. Surgical report was available for three of the cases.
A summary of clinical and imaging findings is shown on Table 1.
The present study includes data regarding five discal cysts in four patients (three men and one woman, mean age 29.7 years, age range 2136 years). Three patients had no previous history of lumbar surgery at the level of the discal cyst and presented with clinical symptoms of lumbar pain and radiculopathy. The other patient presented with two discal cysts and recurrent symptoms after partial laminectomy and microdiscectomy performed at both levels twelve weeks before symptoms recurrence.
There were three cysts at L4-L5 level and two at L5-S1 level. All cysts presented homogeneous, low-to-moderate signal intensity on T1-weighted images and high signal intensity on T2-weighted images, and were oval shaped, being seated in the anterior epidural space. Four cysts were ventrolaterally located, one to the right, two to the left, and one with bilateral extension. The other one was centrally positioned in the anterior spinal canal. No MRI sign of intracystic hemorrhage or bone erosion was observed. The adjacent disc presented mild signs of degeneration in all cases.
A communication with the annulus fibrosus was suggested in all cases based on the MRI T2-weighted images (Figure 1) and in one case was confirmed by CT discography (Figure 2). In two cases, CT images were also available and showed epidural tissue slightly hypodense to the disc (Figure 3).
One patient (case 1) had no available follow-up data. Case 3 was conservatively treated and had unchanged cyst findings at one-year MRI follow-up, and two years of unchanged tissue with epidural mass effect since the first CT examination.
Surgery was performed in patient 2 and findings included a discal cyst in the extradural space with a distinct fibrous capsule and containing slightly bloody serous fluid (Figure 3).
Patient 4 had previously undergone lumbar microdiscectomy at L4-L5 and L5-S1 levels, and 12 weeks later presented recurrent lumbar pain related to postsurgical pseudocysts at both levels (Figure 4), and was surgically treated in another institution.
Lumbar pain and radiculopathy are very common clinical conditions and MRI is performed to rule out the presence of a herniated disc which is probably the most common reason for lumbar spine investigations. Epidural cysts may be clinically indistinguishable from a herniated disc, but constitute a less common cause of radiculopathy(6). Differential diagnoses include discal cysts, perineural cysts, facet synovial cysts, ganglion cysts of the posterior longitudinal ligament or ligamentum flavum, cystic nerve sheath tumors, extradural arachnoid cysts, enteric or dermoid cysts or other cyst-like conditions such as epidural varices and premembranous hematomas(57). In a review of uncommon presentations of degenerative disc disease at MRI in eight patients, Eerens et al.(11) have found one case of discal cyst.
The ventrolateral epidural space could also be occupied by an extruded disc fragment, just like a discal cyst. Usually, a disc fragment is easily differentiated from a discal cyst at MRI due to signal characteristics and enhancement pattern. A disc fragment has low signal intensity on T1- and T2‑weighted images, and a cystic mass is homogeneous and isointense to cerebrospinal fluid, although it may have some heterogeneous components due to protein contents. A discal fragment rarely presents myxoid degeneration of disc material with diffuse apoptotic change and may cause troubles in the diagnosis due to the high signal intensity on T2-weighted images(12). Although not essential and not available in any case of our series, post-contrast images features include a nonenhancing disc fragment surrounded by thick granulation tissue in extruded hernia(13), while contrast-enhanced MRI delineates a thin rim enhancement in discal cyst(5), which contributes to elucidate the differential diagnosis..
The diagnosis of discal cyst may be achieved with basis on MRI findings of a ventrolateral homogeneous epidural cyst hypointense on T1- and hyperintense on T2-weighted images. Occasionally, in the presence of intracystic hemorrhage, cysts appear as hyperintense images on T1- and T2-weighted sequences(13). The finding of continuity to the annulus fibrosus in a cyst contiguous to the disc may not be seen at MRI. In this case, discography or CTD may be useful to identify such communication(1,5,6,8,12,14,15). Marhsam et al.(7) suggest that the finding of a communication at discography could be predominantly iatrogenic, the result of a tear in the annulus fibrosus opened by forced injection. In cases of minimal apparent disruption of the annulus fibrosus during probing at surgery in young individuals, discal cyst may have a more optimistic long-term prognosis, as opposed to an intervertebral disc herniation(16).
A direct continuity between the cyst and the disc on sagittal T2-weighted images could be defined in all of the present nonoperative cases, likewise previously reported in the literature(17). Atypical presentations also include osteolytic change of the vertebral body adjacent to the cyst(5,18) and gas-containing cysts(19). The identification of communication of epidural gas collection implicated as a possible cause of radicular symptoms and the disc tissue may also be made by CTD. The vacuum phenomenon has been proposed as the cause of the gas formation(20).
Histological findings of discal cysts include a capsule consisting of dense fibrous connective tissue with no disc material inside(57). This finding in association with lack of definitive communication between cyst and disc on MRI T2-weighted sequences is indicative that discal cyst is probably synonymous with ganglion cysts of either posterior longitudinal ligament or annulus fibrosus, and may represent a developmental or degenerative anomaly, with no particular advantage in distinguishing them(21,22). On the other hand, the identification of residual herniated tissue in the cyst wall(1), disc material with myxoid degeneration and apoptosis of chondrocytes in the herniated disc material(12), and discal cyst followed by intervertebral disc herniation(8) could be associated with the pathogenesis of the discal cyst, suggesting the hypothesis of focal degeneration.
Postsurgical pseudocysts have been described after laminectomy and lumbar discectomy, and suggested causes include arachnoid hernia through a fissure in the dura mater induced by surgical trauma and persistent spinal fluid or blood leakage leading to the development of pseudomeningocele. A ventral pseudocyst may ossify but usually it contains serous-hemosiderin fluid(2). Postoperative annular pseudocyst is a rare complication of microdiscectomy. Its pathogenesis is probably related to the granulation tissue "pseudocapsule" surrounding the herniated disc that was not disrupted during surgery, creating a potential space where fluid might accumulate by diffusion through the disrupted annulus fibrosus. The increased disc pressure caused by repetitive loading and enlargement of this pseudocyst could cause symptoms(10). The first description of a postsurgical intervertebral disc cyst was made by Grabel et al. in 1988(9) in a patient with clinical symptoms of failed microdiscectomy. It was interpreted as most likely representing blood breakdown products resulting from surgery. The blood was prevented from escaping into the epidural space probably because the L5 nerve root had tamponated the incised segment of the posterior longitudinal ligament. To the authors' knowledge, cases of double postsurgical annular pseudocysts have never been reported.
Several treatments have been proposed for discal cysts, including surgical resection(5,6), fluoroscopy- or CT-guided percutaneous steroid injection(23,24), CT-guided percutaneous aspiration(25) or by percutaneous endoscopic transforaminal approach(26). A case of spontaneous regression of a discal cyst was reported by Chou et al.(27), although the patient has received epidural injection and S1 selective nerve block, both injections containing anesthetic and steroid agents. The authors have felt that is was not clear whether the drugs contributed to the cyst regression, but the steroids could certainly have diffused toward the cyst and caused regression.
Based on the above described cases and on the literature review, it is clear that MRI can easily depict an epidural cyst and that the diagnosis of a discal cyst should be considered in cases where homogeneous ventrolateral epidural cyst contiguous to a partially degenerated disc is identified even if a definitive connection with the annulus fibrosus is not possible in nonsurgical patients or as microdiscectomy complication.
The authors thank Dr. Xavier M. G. R. G. Stump, São Paulo, Brazil, for providing some images for the present study.
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Dr. Marcelo N. Simão.
Rua Manoel Achê, 921, ap. 172, Jardim Irajá.
Ribeirão Preto, SP, Brazil, 14020-590.
Received January 13, 2012.
Accepted after revision June 15, 2012.
* Study developed at Central de Diagnóstico Ribeirão Preto (Cedirp), Ribeirão Preto, SP, Brazil, and Duke University Medical Center, Durham, NC, USA.