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Brazilian Journal of Genetics

Print version ISSN 0100-8455On-line version ISSN 1678-4502

Braz. J. Genet. vol.19 no.4 Ribeirão Preto  1996 

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A simple model for the estimation of congenital malformation frequency in racially mixed populations



J.S. Lopez-Camelo; P.H. Cabello; M.G. Dutra

Departamento de Genética, Instituto Oswaldo Cruz, Av. Brasil 4365, 21045-900 Rio de Janeiro, Brasil. Phone: 55-21-5984358; Fax: 55-21-5903495. Send correspondence to J.S.L.-C.




A simple model is proposed, using the method of maximum likelihood to estimate malformation frequencies in racial groups based on data obtained from hospital services. This model uses the proportions of racial admixture, and the observed malformation frequency. It was applied to two defects: postaxial polydactyly and cleft lip, the frequencies of which are recognizedly heterogeneous among racial groups. The frequencies estimated in each racial group were those expected for these malformations, which proves the applicability of the method.

Keywords: congenital malformation; racially mixed populations.




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