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Brazilian Journal of Nephrology

Print version ISSN 0101-2800

J. Bras. Nefrol. vol.33 no.3 São Paulo July/Sept. 2011

http://dx.doi.org/10.1590/S0101-28002011000300015 

LETTERS

 

Low response to intradermal hepatitis B vaccination in incident hemodialysis patients

 

Baixa resposta da vacinação intradérmica contra hepatite B em pacientes incidentes em hemodiálise

 

 

Carlos Abaeté de los Santos; Regina H Medeiros; Ana Elizabeth PL Figueiredo; Carlos Eduardo Polide-Figueiredo; Domingos Otávio d'Avila; Jaqueline Antonio Pacheco; Carlos Abaeté de los Santos

Faculdade de Medicina da Pontifícia Universidade Católica do Rio Grande do Sul (PUC/RS)

Correspondence to

 

 


ABSTRACT

Keywords: Renal insufficiency, chronic. Renal dialysis. Vaccination. Hepatitis B. virus.


RESUMO

Palavras-chave: Insuficiência renal crônica. Diálise renal. Vacinação. Vírus da Hepate B.


 

 

DEAR EDITOR,

We thank Prof. Alavian for his interest in our paper. The preferential route for hepatitis B (HB) vaccine administration remains controversial in hemodialysis (HD) patients. Our study aiming to compare intramuscular (IM) or intradermal (ID) inoculations was discontinued six months after starting, due to a Safety Monitoring Committee recommendation, since IM vaccination converted 62.3% of the patients, whereas the ID only 13.3%. These results would not allow ethically crossing the groups as proposed. Besides, the aim was to include only naïve patients. However, of those eight patients who did not respond to ID vaccine, seven were submitted to IM injections: three achieved adequate anti-HB levels and four did not. As emphasized in the text, one of the possible causes to the unresponsiveness was the presence of associated inflammation.1 The vaccine dose applied (in micrograms!) may also have been one of the reasons.

 

REFERENCES

1. Medeiros RH, Figueiredo AE, Poli-de-Figueiredo CE, dAvila DO, de los Santos CA. Low response to intradermal hepatitis B vaccination in incident hemodialysis patients. J Bras Nefrol 2011;33:45-:49.         [ Links ]

 

 

Correspondence to:
Carlos Abaeté de los Santos
Faculdade de Medicina da Pontifícia Universidade Católica do Rio Grande do Sul
Av. Ipiranga, 6.690, Porto Alegre (RS) – Brasil, CEP: 90610-000
E-mail: abaete@pucrs.br

Submitted on: 29/07/2011
Accepted on: 02/08/2011

The authors report no conflict of interest.

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