Migration of Schistosoma mansoni sambon (Trematoda, Schistosomatidae) from skin to lungs in immunized NZ rabbits (Lagomorpha, Leporidae) by autoradiographic analysis

Migration of Schistosoma mansoni sambon (Trematoda, Schistosomatidae) from skin to lungs in immunized NZ rabbits (Lagomorpha, Leporidae) by autoradiographic analysis

R. Magalhães Pinto^I; Dely Noronha^I; Marília S. S. Almeida^I; Naftale Katz^II; Miriam Tendler^I

^IDepartamento de Helmintologia, Instituto Oswaldo Cruz (FIOCRUZ), Caixa Postal 926, 21045-900 Rio de Janeiro, Rio de Janeiro, Brasil

^IICentro de Pesquisas René Rachou (FIOCRUZ), 39220-000 Belo Horizonte, Minas Gerais, Brasil

ABSTRACT

Skin to lung migration of Schistosoma mansoni Sambon, 1907 - (⁷⁵ Se) - selenomethionine-labeled cercariae was tracked by tissue autoradiography on days 1, 4, 6, 8 after challenge, in rabbits immunized with a S. mansoni derived saline extract. Either in vaccinated animals or in those of the control unprimed group, the peak of skin schistosomula occurs 24hs after infection. Comparison between peaks of lungs migrating larvae showed that, in control animals, the increase of worm burden in this site, is detected on the 6th day post-infection, differing from immunized rabbits, in which this peak occurs on day 4, when skin and lungs counts are still equivalent, decreasing gradually, showing a different pattern of the S. mansoni migration and suggesting that main parasite attrition occurs during the late skin and early lung phases in the immunized group.

Key words:Schistosoma mansoni, migration, autoradiography, immunization, rabbits

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ACKNOWLEDGEMENTS. To Dr. Nicolau Maués da Serra Freire, Universidade Federal Rural do Rio de Janeiro (UFRRJ), for the graphic transposition of the results.

BIBLIOGRAPHIC REFERENCES

Recebido em 01.II.1994; aceito em 08.VIII.1994.

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Publication Dates

• Publication in this collection
  31 July 2009
• Date of issue
  1994

History

• Accepted
  08 Aug 1994
• Received
  01 Feb 1994