SciELO - Scientific Electronic Library Online

 
vol.57 número4Frequency of anti-Leptospira interrogans agglutinins in bovine serum samples in Minas Gerais, Brazil, 1980 to 2002Cranial cruciate ligament reconstruction in dogs associated or not to chondroitin sulfate índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Articulo

Indicadores

Links relacionados

Compartir


Arquivo Brasileiro de Medicina Veterinária e Zootecnia

versión impresa ISSN 0102-0935

Arq. Bras. Med. Vet. Zootec. v.57 n.4 Belo Horizonte ago. 2005

http://dx.doi.org/10.1590/S0102-09352005000400003 

VETERINARY MEDICINE

 

Chronic valvular disease: correlation between clinical, electrocardiographic, radiographic and echocardiographic aspects in dogs

 

Doença valvar crônica: correlação entre aspectos clínicos, eletrocardiográficos, radiográficos e ecocardiográficos em cães

 

 

E.C. Soares; M.H.M.A. Larsson*; R.J. Yamato

Faculdade de Medicina Veterinária e Zootecnia – Universidade de São Paulo Avenida Ceci, 543 - Planalto Paulista 04065-000 - São Paulo, SP

 

 


ABSTRACT

Echocardiographic aspects of chronic mitral valvular disease were studied and compared to physical, radiographic and electrocardiographic aspects. Seventy dogs were used, and clinical examination, thoracic radiography, electrocardiogram and echocardiogram were performed. Correlations between regurgitation severity with cardiac failure functional class and murmur intensity were observed. The electrocardiogram showed a low sensibility in detecting cardiac chamber enlargement, caused by mitral regurgitation. All the dogs with severe mitral regurgitation showed cardiomegaly according to thoracic radiographies.

Keywords: dog, heart, cardiac failure, echocardiography, cardiac valve


RESUMO

Avaliaram-se os aspectos ecocardiográficos da doença valvar crônica, comparando-os com os aspectos clínicos, radiográficos e eletrocardiográficos em cães. Estudaram-se 70 animais, realizando-se exames físicos, radiografias torácicas, eletrocardiograma e ecocardiograma. Observaram-se correlações entre a gravidade da regurgitação, a classe funcional da insuficiência cardíaca e a intensidade de sopro. O eletrocardiograma mostrou baixa sensibilidade para detectar aumento de câmaras cardíacas causadas por regurgitação mitral. Todos os cães com regurgitação mitral grave apresentaram cardiomegalia nas radiografias torácicas

Palavras-chave: cão, coração, insuficiência cardíaca, ecocardiografia, valva cardíaca


 

 

INTRODUCTION

The echocardiography is considered a new diagnostic method in veterinary medicine but definitely it is the most useful subsidiary exam in mitral chronic valvular disease (CVD). It provides information about the valvular lesion, regurgitation severity, and cardiac chambers size.

In CVD, the valvular lesion often is seen as leaflets thickening, and sometimes chordae tendinae rupture can occur. Also, left atrial and ventricular enlargement, free wall and septum hypertrophy, and/or increased shortening fraction can be observed (Boon, 1998).

The hemodynamic consequences of mitral insufficiency can be roughly evaluated by left atrial and ventricular chamber enlargement. When medium and large regurgitant jets occur, these chambers appear enlarged, secondary to volumetric overload. However, the enlargement of left chamber can be a good indication of the regurgitation severity just when atrial fibrilation or acute insufficiency do not occur (Morcerf, 1996).

According to Amberger et al. (1995), the aortic root to left atrial ratio, which has been used to evaluate atrial size, decreases as mitral regurgitation increases, but authors did not consider such cases as atrial fibrilation or acute insufficiency.

Pedersen (2000) considers the left atrium and ventricle size as a good indicator of mitral insufficiency, but he remarked that these measures have a large variation, even in dogs of similar body weight. Moreover, it was observed that an animal which presented mitral insufficiency for a period of five years, as example, showed the left atrium larger than the other that presented mitral regurgitation for a shorter period of time.

Despite the controversies, the Doppler echo is the best method in order to evaluate the regurgitation severity of mitral insufficiency. The pulsed wave (PW) Doppler allows classifying the regurgitation severity into mild, moderate or severe, in accordance to flow characteristics, as well as the area of left atrium the jet occupies. However, this method is quite old and it was replaced by color flow in the 80s. The color flow or color Doppler is much more efficient and practical. Several studies have been done in order to find a correlation between regurgitation degree and New York Heart Association/International Small Animal Cardiac Health Council (NYHA/ISACHC) heart failure functional class, murmur intensity and electrocardiographic and radiographic findings and different results have been achieved (Häggström et al., 1995; Pedersen et al., 1999).

The goal of this study was to compare the severity of regurgitation on echo to clinical aspects, as ISACHC heart failure functional class and murmur intensity, as well as to electrocardiographic and radiographic findings.

 

MATERIALS AND METHODS

Seventy mongrels and purebred, male and female dogs, at different ages, were presented to a cardiology service, showing signs related to cardiac failure or just murmurs at cardiac auscultation.

Questions concerning about cardiac failure symptoms were made and the obtained data were joined to the findings of clinical examination and subsidiary exams in order to pool the animals into groups according to the ISACHC cardiac failure classification.

Cardiac auscultation was performed and that allowed classifying the murmurs according to the 1 to 6 scale (Darke et al., 1996).

The radiographic examination of thorax was performed by radiodiagnosis device, CGR, 300 mA, 125 kV, CH 3000 model. The radiographic evaluation was made by the vertebral heart size method described by Buchanan and Bücheler (1995).

Electrocardiographic exams of the animals were performed in right lateral recumbence, recording the bipolar standard leads, I, II and III, the augmented unipolar limb leads, aVR, aVL, aVF, and unipolar precordial chest leads, CV5RL (rV2), CV6LU (V2), CV6LL (V4) and V10 (Edwards, 1991; Tilley, 1992).

The echocardiographic exams were performed by a Hitachi echocardiography device, model EUB-515A, provided with pulsed-wave, continuous-wave, and color-flow Doppler, and a 3.5 or 5.0 MHZ transducer. The dogs were positioned over a proper table, on lateral recumbence, according to Pipers et al. (1991). The technique and interpretation of the exams agreed to Thomas (1984), Morcerf (1996) and Boon (1998).

M mode measurements included: aorta diameter (Ao) measured in the beginning of the systole, left atrium diameter (LA) measured in the end of the systole, left ventricle diameter in diastole (LVDd), left ventricle diameter in systole (LVDs) and fractional shortening (FS) .

Doppler (PW and color flow) was usedto evaluate the regurgitation degree semiquantitatively. The method was that which compares the area of the regurgitant jet to the total area of the left atrium (Boon, 1998). So, when the jet occupied less the 20% of the left atrium, a discrete mitral insufficiency was considered. If it ranged from 20 to 50%, it would be classified as moderate and if it reached more than 50% of the left atrium area, important mitral insufficiency would be considered.

 

RESULTS

The Tables 1, 2, 3, 4 and 5 show M mode measurements and mitral regurgitation intensity of dogs classified as IA, IB, II, IIIA and IIIB, respectively.

 

 

 

 

 

 

 

 

 

 

The comparisons among clinical, electrocardiographic, radiographic and echocardiographic findings are showed in Tables 6, 7, 8 and 9.

 

 

 

 

 

 

Data on Table 6 compare echocardiographic findings to cardiac failure functional class. They reveal that five (62.5%) out of eight animals included in IA functional class (asymptomatic patient; heart disease detectable by cardiac murmur, arrhythmia or cardiac enlargement, detected by radiography or echocardiography, but without overload volume or pressure ventricular hypertrophy), showed mild regurgitation on echocardiography and the other three dogs showed moderate insufficiency. Among dogs included in IB functional class (asymptomatic patient, with signs of cardiac disease and overload volume or pressure hypertrophy), 37.5% showed mild regurgitation, while the same percentage had moderate, and 25.0% had severe mitral regurgitation.

By taking FCIII dogs into account it was observed that among those included in IIIA functional class, six (75.0%) revealed severe and two (25.0%) moderate insufficiency, while dogs in CFIIIB showed severe mitral regurgitation.

Dogs classified as FCII revealed mild (38.1%) and moderate (40.4%) mitral regurgitation in most cases. Only 21.5% showed severe insufficiency.

Data on Table 7 compare echocardiographic findings to murmur intensity and show that most dogs which had low intensity murmurs revealed mild mitral regurgitation on echocardiographic exam. Most dogs with grade 4 murmur intensity showed moderate insufficiency, and those with grade 5 or 6 murmur intensity showed mainly severe regurgitation.

Data on Table 8 compare echocardiographic and electrocardiographic findings, demonstrating that most dogs which showed mild regurgitation on echo (83.3%) did not reveal electrocardiographic abnormalities. Out of those which revealed severe mitral regurgitation, 38.0% did not have electrocardiographic abnormalities that could suggest cardiac chambers enlargement.

Data on Table 9, comparing echocardiographic to radiographic findings, reveal that most dogs with mild mitral regurgitation did not have radiographic abnormalities on cardiac silhouette. On the other hand, dogs with moderate or severe mitral regurgitation showed 60.0% or 85.7% of cardiomegaly on thoracic radiographies.

Some rhythm disturbances were detected, as supraventricular premature complexes in four dogs (5.7%), ventricular premature complexes in four dogs (5.7%), sinoatrial blockade in four dogs (5.7%), atrioventricular blockade in two dogs (2.9%) and right bundle blockade in two dogs (2.9%).

 

DISCUSSION

By comparing the heart failure classification with the regurgitation severity, it was observed that the degree of regurgitation correlates very well with the severity of heart failure.

Amberger et al. (1995) compared echocardiographic findings with cardiac failure classification. According to this study, 100% of dogs included in class IV (NYHA), or advanced cardiac failure, showed LA/Ao ratio > 1, which means that all animals had left atrium enlargement.

Boon (1998) referred that stages 3 and 4 of the NYHA criteria for dogs' atrial size were significantly larger than the stage 2, while stage 2 failure were significantly larger than the atrial of dogs with no heart failure or stage 1 heart failure. Uehara and Takahashi (1996), by measuring the mitral regurgitation by the ratio of color flow mapping area of mitral regurgitant jet/aortic forward flow mapping area, demonstrated that this ratio increases as cardiac failure worse.

By comparing murmur intensity to mitral regurgitation severity (Table 7), it was observed that the regurgitation severity also correlates with the murmur intensity. Opposite to these findings, Amberger et al. (1995) claimed that the murmur intensity is not a good indication of regurgitation hemodynamic severity. Yet, Sisson and Ettinger (1999) referred that high intensity murmurs originate in narrow orifices, with small regurgitant jets. As the disease advances, murmur intensity declines, because pressure difference between ventricle and atrium decreases. Braunwald (1997) also described a negative correlation between these characteristics. Tribouilloy et al. (1986) referred that auscultation has a sensibility of just 74.5% to detect regurgitant flows. On the other hand, Häggström et al. (1995) studied Cavalier King Charles Spaniels and observed that dogs which had high intensity murmurs revealed left ventricle diastolic diameter and LA/Ao ratio higher than dogs which presented moderate intensity murmurs, and these had chambers size higher than those which had low intensity murmurs. Pedersen (2000) and Pedersen et al. (1999) stated that murmur intensity increases with regurgitation severity, evaluated by color flow Doppler.

The Table 8 shows that the electrocardiographic exam is not a reliable diagnostic method to evaluate CVD hemodynamic consequences, mainly due to its low sensibility. However, it can be observed that all cases that the electrocardiographic recordings pointed to left atrial enlargement revealed left atrium dilation on echo, and this meant a good predictive value, similarly to the electrocardiogram low sensibility observed by Lombard and Spencer (1985).

Finally, data on Table 4 show a good association between regurgitation severity and radiographic findings; cardiomegaly was observed mainly in cases of severe valve insufficiency. The same was found by Lombard and Spencer (1985). The false positives cases can be due to the subjective radiographic criteria for left atrial enlargement, which may overestimate the size of cardiac chambers.

 

REFERENCES

AMBERGER, C.; GLARDON, O.; LOMBARD, C.W. Validité des examens complementaires dans l'evaluation de l'insuffisance cardiaque par endocardiose mitrale. Étude a partir de 106 cas. Pratiq. Med. Chirurg. Anim. Comp., v.30, p.659-670, 1995.        [ Links ]

BOON, J.A. Acquired heart disease. In: MANUAL of veterinary echocardiography. Baltimore: Williams & Wilkins, 1998. cap. 4, p.261-382.        [ Links ]

BRAUNWALD, E. Valvulopatias. In: BRAUNWALD, E. Tratado de medicina cardiovascular. 5.ed. São Paulo: Roca, 1997. p.1075-1148.        [ Links ]

BUCHANAN, J.W.; BÜCHELER, J. Vertebral scale system to measure canine heart size im radiographs. J. Am. Vet. Med. Assoc., v.206, p.194-199, 1995.        [ Links ]

DARKE, P.G.G.; BONAGURA, J.D; KELLY, D.F. Color atlas of veterinary cardiology. London: Mosby-Wolfe, 1996. 186p.        [ Links ]

EDWARDS, N. J. Bolton's handbook of canine and feline electrocardiography. 2.ed. Philadelphia: W.B. Saunders, 1991. 381p.        [ Links ]

HÄGGSTRÖM, J.; KVART, C.; HANSSON, K. Heart sounds and murmurs: changes related to severity of chronic valvular disease in the Cavalier King Charles Spaniel. J. Vet. Int. Med., v.9, p.75-85, 1995.        [ Links ]

LOMBARD, C.W.; SPENCER, C.P. Correlation of radiographic, echocardiographic and electrocardiographic signs of left heart enlargemente in dogs with mitral regurgitation. Vet. Radiol., v.26, p.89-97, 1985.        [ Links ]

MORCERF, F.A. Ecocardiografia. 2.ed. Rio de Janeiro:Revinter, 1996. 671p.        [ Links ]

PEDERSEN, H.D. Diagnóstico de la enfermedad de la válvula mitral mixomatosa canina. Waltham Focus, v.10, p.3-9, 2000.        [ Links ]

PEDERSEN, H.D.; HÄGGSTRÖM, J.; FALK, T. et al. Auscultation in mild regurgitation in dogs: observer variation, effects o physical maneuvers, and agreement with color Doppler echocardiography and phonocardiography. J. Vet. Int. Med., v.13, p.56-64, 1999.        [ Links ]

PIPERS, F.S.; BONAGURA, J.D.; HAMLIN, R.L. et al. Echocardiographic abnormalities of the mitral valve associated with left-side heart diseases in the dog. J. Am. Vet. Med. Assoc., v.179, p.580-586, 1991.        [ Links ]

SISSON, D.; ETTINGER, S.J. The physical examination. In: FOX, P.R.; SISSON, D.; MOISE, N.S. Textbook of canine and feline cardiology. 2.ed. Philadelphia: W.B Saunders, 1999. cap.2, p.46-64.        [ Links ]

THOMAS, W.P. Two-dimensional, real time echocardiography in the dog: technique and anatomic validation. Vet. Radiol., v.25, p.50-64, 1984.        [ Links ]

TILLEY, P.T. Essentials of canine and feline electrocardiography. 3.ed. Philadelphia: Lea & Febiger, 1992. 470p.        [ Links ]

TRIBOUILLOY, C.; CASIER, B.; VOVAN, A. et al. Apport du Doppler pulsé et continu au qualitatif et quantitatif d'insuffisance mitrale. Arch. Mal. Coeur, v.76, p.473-481, 1986        [ Links ]

UEHARA, Y.; TAKAHASHI, M. Quantitative evaluation of the severity of mitral insufficiency in dogs by the color Doppler method. J. Vet. Med. Sci., v.58, p.249-253, 1996.        [ Links ]

 

 

Recebido para publicação em 14 de abril de 2004
Recebido para publicação, após modificações, em 11 de fevereiro de 2005
Apoio financeiro: FAPESP

 

 

* Autor para correspondência (corresponding author)
E-mail: akaolar@usp.br