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Cadernos de Saúde Pública

Print version ISSN 0102-311XOn-line version ISSN 1678-4464

Cad. Saúde Pública vol.31  supl.1 Rio de Janeiro Nov. 2015

http://dx.doi.org/10.1590/0102-311X00083814 

BRIEF COMMUNICATION

Hepatitis B and C in household and health services solid waste workers

Hepatite B e C em profissionais que coletam resíduos de serviço de saúde e domiciliares

Hepatitis B y C en los trabajadores responsables de la recolección de residuos sólidos domiciliarios y de servicios de salud

Marcos Paulo Gomes Mol1 

Dirceu Bartolomeu Greco2 

Sandy Cairncross3 

Leo Heller4 

1Centro de Pesquisas e Desenvolvimento, Fundação Ezequiel Dias, Belo Horizonte, Brasil.

2Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.

3London School of Hygiene and Tropical Medicine, London, U.K.

4Escola de Engenharia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.

Abstract

Human contact with solid waste poses biological, chemical, and physical health risks for workers involved in waste collection, transportation, and storage. The potential risk to human health resulting from contact with health services waste or household waste still sparks considerable controversy. The aim of this study was to identify the context of scientific discussions on risk/infection from the hepatitis B and C viruses in workers that collect solid waste from health services or households. The search covered publications up to 2013 in Brazilian and international databases, and 11 articles were selected through a literature review. Of these, six conclude that there is an increased risk of infection in workers that collect household waste when compared to those unexposed to waste, three point to greater risk for workers that collect health services waste as compared to those that collect ordinary waste, and the other two found no difference between exposed and unexposed individuals.

Key words: Solid Waste; Hepatitis B; Hepatitis C; Urban Health

Resumo

O contato humano com os resíduos implica riscos biológicos, químicos e físicos à saúde dos trabalhadores envolvidos com a coleta, o transporte e o armazenamento. O potencial de risco para a saúde humana decorrente do contato com os resíduos de saúde ou domiciliares ainda gera muita polêmica. Sendo assim, a proposta deste trabalho foi de identificar o contexto das discussões científicas sobre risco/infecção pelos vírus das hepatites B e C em trabalhadores que coletam resíduos de serviço de saúde ou domiciliares. As buscas abrangeram publicações até 2013 em bancos de dados nacionais e internacionais, sendo selecionados 11 artigos através de uma revisão da literatura, dos quais seis concluem que há maior risco de infecção nos trabalhadores que coletam resíduos domiciliares se comparados com os não expostos aos resíduos, três estudos apontam haver maiores riscos entre os profissionais que coletam os resíduos de saúde se comparados com aqueles que coletam os resíduos comuns, e outros dois concluem não haver diferenças entre expostos e não expostos.

Palavras-Chave: Resíduos Sólidos; Hepatite B; Hepatite C; Saúde Urbana

Resumen

El contacto humano con los residuos implica riesgos biológicos, químicos y físicos para la salud de los trabajadores que participan en su recogida, transporte y almacenamiento. El riesgo potencial para la salud humana, como resultado del contacto con los desechos médicos o del hogar, sigue generando mucha controversia. Por lo tanto, el propósito de este estudio fue identificar el contexto de las discusiones científicas sobre el riesgo/infección por el virus de la hepatitis B y C en los trabajadores de recolección de residuos de servicios de salud o del hogar. Fueron recogidos artículos publicados hasta 2013 en bancos de datos nacionales e internacionales; se seleccionaron 11 artículos a través de una revisión de la literatura, seis de los cuales concluyen que hay un mayor riesgo de infección entre los trabajadores que recogen la basura doméstica, en comparación con los no expuestos a los residuos, tres estudios sugieren que existe un mayor riesgo entre los profesionales que recogen los residuos médicos, en comparación con los que la recogida de residuos ordinarios, y otras dos concluyen que no había diferencias entre expuestos y no expuestos.

Palabras-clave: Residuos Sólidos; Hepatitis B; Hepatitis C; Salud Urbana

Introduction

The management of urban solid waste in urban centers is growing in complexity and receiving increasing attention from researchers because of the potential impact on the environment and on human health if not well managed 1,2,3,4. Workers involved in management of these wastes are exposed to biological, chemical and physical risks to their health 2,5,6,7,8.

Of the types of solid waste, health care waste are particularly likely to contain biological and chemical agents 9. Only a fraction of urban solid waste are potential sources of disease for those who have inadequate contact with them. A particular risk is that of injury or infection from sharps 10,11.

The risk to human health from health care waste, compared to that from urban solid waste in general, is a subject of debate among researchers and managers. Some have claimed that the handling of health care waste involves additional risks to health, beyond those arising from domestic waste 6,9,12,13,14. Others, however have denied that there is any difference between the two 15,16,17,18.

Two reviews of the literature were found, one of which 12 focused on studies of hepatitis A and B in workers who handled waste, but only one of the papers identified involved an epidemiological study 19; another review 20 selected five cross-sectional studies, of which four correspond with papers in Table 119,21,22,23.

Table 1 Articles selected for inclusion in this review (in order of year of publication). 

Reference Date of study Country Sample size Study groups Outcome measure * Findings
Anagaw, et al. 27 April- June 2011 Ethiopia 200 100 collectors of health care waste (hospital) & 100 cleaning staff (who collect ordinary waste) HBV (HBsAg), HCV (Anti-HCV) HBV (OR: 6.3; p = 0.04); HCV (OR: 7.5; p = 0.02). Prevalence of HBV & HCV significantly higher in workers collecting health care waste
Rachiotis et al. 21 2007-2008 Greece 210 102 collectors of urban solid waste and 108 gardeners HBV (HBsAg, Anti-HBc and Anti-HBs) HBV (OR: 4.05; 95%CI: 1.23-13.33) – progressive increase risk for infection with age. Accidents with sharps (RR: 2.64; 95%CI: 1.01-6.96)
Shiferaw et al. 26 May- July 2010 Ethiopia 252 126 collectors of health care waste (hospital) & 126 who collect normal non-clinical waste in a hospital HBV (HbsAg and Anti-HBcAg) HBsAg (OR: 8; 95%CI: 1.02-63.02); Anti-HBcAg (OR: 1.5; 95%CI: 1.1-2.1). High prevalence of HBV in workers collecting health care waste compared with those who do not
Graudenz 5 September 2007/ February 2008 Brazil 217 64 (landfill), 41 (urban solid waste collection), 35 (sweepers), 45 (drivers) & 32 controls (railway maintenance) HBV (Anti-HBc) No difference in prevalence of hepatitis B between study groups (percentage positive varied between groups from 6.3 to 20, with p = 0.439)
Franka et al. 28 January-December 2004 Libya 600 300 collectors of health care waste (medical center) and 300 who collect only ordinary waste (urban solid waste) HIV, HBV (HBsAg), HCV (Anti-HCV) HBV (OR: 7.14; p < 0.04); HCV (OR: not given; p < 0.005). HIV not detected. Higher prevalence of HBV & HCV in health care waste group than in urban solid waste group
Luksamijarulkul et al. 25 Not stated Thailand 354 169 collectors of urban solid waste & 185 public cleansing workers (not in direct contact with waste) HAV, HBV (HBsAg, Anti-HBs and Anti-HBc) 49.4% seropositive for HBV, 5.9% for HBsAg, 37.3% for anti-HBs, 6.2% only for anti-HBc, & 85% with anti-HAV antibodies (p = 0.0058 most exposed collectors). For HAV no significant difference was found
Squeri et al. 23 March- May 2005 Italy 327 All were workers who collected urban solid waste HBV (HBsAg and Anti-HBc), HCV (Anti-HCV) 183 (55.96%) protected from HBV by the presence of HBsAb (98 by immunization and 85 by previous contact). 120 (36.7%) at risk of infection. 24 (7.34%) infected by HBV and 5 (1.52%) had contact with HBV and HCV
Mariolis et al. 24 Not stated Greece 69 All were workers who collected urban solid waste HAV, HBV (HBsAg, Anti-HBs and Anti-HBc), HCV (Anti-HCV) 37 (53.6%) were HAV positive; 15 (21.7%) had been exposed to HBV. Of the whole study group, 7 (10.1%) had been immunised against HBV. 4.3% were HBV chronically infected. One was found to be HCV positive
Dounias et al. 22 September 1999/ December 2001 Greece 159 71 collectors of urban solid waste & 88 office workers (not in direct contact with waste) HBV (HBsAg, Anti-HBs and Anti-HBc) Prevalence of HBsAg was higher in exposed (11.3%) than in non-exposed (4.5%), but difference was not significant. Prevalence of anti-HBc was 24% among exposed and 8% in non-exposed, also not significant
Ferreira et al. 29 May- July 1996 Brazil 186 31 collectors de health care waste (hospitals) & 155 collectors of domestic urban solid waste HBV (Anti-HBc) HBV (OR: 0.9; 95%CI: 0.24-3.05;). No significant difference in risk found between the groups of workers studied
Corrao et al. 19 Not stated Italy 93 45 sweepers, 21 waste collectors, 19 machine operators, 5 sewer workers and 3 office workers HAV, HBV (HBsAg, Anti-HBs and Anti-Hbc) Positive for HBV in each group were: 9 (20.0%) sweepers, 6 (28.6%) waste collectors, 1 (5.3%) machine operator, 2 (40.0%) sewer workers and 0 (0.0%) among the office workers

* Sensitivities of serology tests for Hepatitis B: Anti-HBc – detects acute, chronic, cure stages; HbsAg – detects incubation, acute, chronic stages; Anti-HBs – vaccinated.

The aim of this review was to identify the context of scientific discussion on hepatitis B and C infection in workers who collect solid waste, whether domestic or from health care facilities, in order to assess the balance of evidence on this subject. The subject has relevant implications for urban health, considering its links with waste production by an increasingly urbanized population, environmental determinants, and the social vulnerability of the population occupationally involved in waste management.

Methodology

The search was carried out between January and December 2013, accessing the world’s major publication databases, including: Web of Science, Web of Knowledge Cross Search, SciELO, and MEDLINE/PubMed.

The following search terms were used: hepatitis, prevalence of hepatitis, health care waste, medical waste, biomedical waste, solid waste, waste, waste workers, municipal solid waste workers, medical waste handlers and health care workers. All studies in which the health outcome was infection with hepatitis B or C virus in workers who collect domestic or health care waste were reviewed. No criterion was set regarding the size or gender of the study population.

Results

Figure 1 shows the process of screening and evaluation. Eleven papers met the requirements for inclusion in this review. Table 1 shows the general characteristics of the included studies.

Figure 1 Flowchart of the process of article selection. 

Six of the studies concluded that workers collecting urban solid waste are exposed to greater risk when compared with those who have no exposure 19,21,22,23,24,25, although one study found no such additional risk 5. With regard to health care waste, three studies indicate higher risk among those collecting than those working with urban solid waste 26,27,28, and a fourth study found none 29.

Four of the papers included consider workers who collect hospital waste 26,27,28,29, comparing with workers dealing with ordinary refuse. The study by Ferreira et al. 29 involved hospital and municipal waste collection workers, compared with others who covered residential areas.

Discussion

All papers used cross-sectional study designs, limiting the possibility of assessing a cause and effect relationship by making it difficult to identify the moment at which infection occurred.

Some studies determined that immunization against HBV and being under treatment for the disease should be exclusion criteria, so as to mitigate any possible selection bias. These studies show the vulnerability of the workers who are exposed to infection without the appropriate immunization 5,21,22,26,29.

Another limitation of some studies is the small number of subjects included (Table 1). This limits the representativeness of the study population. Considering prevalence for exposed and non-exposed subjects, seven studies 5,19,21,22,24,25,29 did not have a sufficient sample size to ensure statistical significance, according to Kelsey et al. 30.

Five studies 5,19,21,22,25 included workers in activities not associated with waste collection as the control group. Other studies 26,27,28,29 included household waste collectors as the control group. Finally, two studies 23,24 had no control groups at all.

Some studies do not describe any method to control for confounding factors, such as sexual behavior, injecting drug use or accidents involving sharps 19,23,24,5,28.

Two papers 26,27 show that accidents with sharps and the use of injectable drugs do not affect the statistical significance of the association between exposure and infection with HBV.

Finally, other studies 21,22 examine several potential confounders, such as age, level of schooling and exposure to waste, and find a significant association.

Conclusion

The small number of papers found in this review suggests that the theme would benefit from research in greater depth. While most studies indicate a possible association between exposure to waste and infection by HBV or HCV, further research is needed to clarify this.

The papers in this review suggest that the handling of health care waste involves a higher risk of infection with HBV and HCV, compared with urban solid waste handlers. The studies providing the main evidence for that conclusion were based in hospitals, and no information is available about the separation of different categories of waste.

It must be emphasized that vaccination against hepatitis B is mandatory to protect workers who are exposed to waste, urban solid waste or health care waste, and it must be a sine qua non part of the admission process for these workers. An immunization evidentiary test is also recommended to ensure the success of vaccination.

Acknowledgments

We acknowledge the research incentives provide by the Fundação Ezequiel Dias (Funed) and the financial support of the Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG).

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Received: May 28, 2014; Revised: July 08, 2015; Accepted: September 09, 2015

Correspondence. M. P. G. Mol Centro de Pesquisas e Desenvolvimento Fundação Ezequiel Dias Rua Conde Pereira Carneiro 80, Belo Horizonte, MG 30510-010, Brasil. marcos_mol@yahoo.com.br

Contributors

M. P. G. Mol and L. Heller conceived the study, analyzed and interpreted the results, and were responsible for precision and integrity in all aspects of the work. D. B. Greco and S. Cairncross were responsible for critical review of the manuscript for its intellectual content and approval of the published version.

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