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Extrahepatic biliary cystadenocarcinoma mimicking Klatskin tumor

LETTER TO THE EDITOR

Extrahepatic biliary cystadenocarcinoma mimicking Klatskin tumor

Sergio Renato Pais-Costa; Sandro Jose Martins; Sergio Luiz Melo Araujo; Olímpia Alves Teixeira Lima; Marcio Almeida Paes; Marcio Lobo Guimaraes

Hospital Santa Lucia, Brasília, DF, Brazil

Correspondence

INTRODUCTION

Biliary cystadenocarcinoma (BCAC) is a very rare malignant cystic neoplasm. Some authors think this particular neoplasm was conversion of biliary cystadenoma over several years of evolution. In the majority of the cases, it habitually occurs in the liver parenchyma (intrahepatic cystadenocarcinoma); sometimes can be observed extrahepatic biliary origin3,4,6,7,8,10,11 extrahepatic biliary cystadenocarcinoma, (EBCAC), which generally leads jaundice associated with palpable mass1,2,5,6,9. In the past, the diagnosis was done by means of endoscopic retrograde cholangiopancreatography. However, actually the computed tomography or even nuclear magnetic resonance are preferred due non-invasive approaches1,2,3,4,5,6,7,8,9,10.

Sometimes, EBCAC has difficulties on differential diagnosis with cholangiocarcinoma, mainly when occurs in the hepatic hilum6. The surgical treatment provides good prognosis; however, en-bloc biliary tract resection with hepatectomy may be necessary to get free margins3,6,10. To date, was not found any case reported in Brazil, nor successful operation using a en-bloc biliary resection with hepatectomy to treat it.

CASE REPORT

A 54 year-old caucasian man presented with painless obstructive jaundice and hepatic palpable mass which began one month before. Liver functions tests showed elevated bilirubin levels of 14,8 ng/dl, alkaline phosphatase of 1067 U/l, gamma-glutamyl transferase of 550 U/l, AST of 175 U/l, and ALT 143 U/l. The alpha-fetoprotein was normal while Ca19,9 was high about 345 U/l. The patient underwent a computed tomography that showed a cystic lesion with irregularity and thickened wall in conjunction with dilated intrahepatic bile ducts mainly left side with atrophy of left lobe. Subsequently, he was submitted a cholangioresonance that showed dilatation of intrahepatic biliary tree more significant at the left side biliary duct with irregularity and thickened wall close to hepatic confluence (Figure 1). The patient underwent radiological examination without signals of systemic dissemination. Therefore, main diagnosis was hilar cholangiocarcinoma or extrahepatic biliary cystadenoma or cystadenocarcinoma. Surgical treatment was indicated, and resection of the suprapancreatic biliary tree including hilar confluence and en-bloc extended left hepatectomy with caudate lobectomy was performed. A formal hilar lymphadenectomy was also realized during surgical resection (Figure 2). One self limited biliary leakage was observed, and treated by conservative management. The patient was discharged at 15th postoperative day. Definitive histological examination showed cystadenocarcinoma of left hepatic duct with free margins (Figure 3). Immunohistochemical studies showed positive reactions for carcinoembryonic antigen (CEA), cytokeratin 19 and CA 19.9. No postoperative adjuvant treatment was performed. To date, one year of follow-up, the patient is alive without tumor recurrence.




DISCUSSION

BCAC is a rare malignant epithelial neoplasm of bile ducts. Takayasu et al.9 reported an incidence of 0,41 % among all hepatic malignant epithelial tumors. Almost all of these tumors are intrahepatic while the minority arise in the major bile ducts or even gallbladder (extrahepatic origin). EBCAC arise more frequently hepatic confluence or even sectorial duct (left or right) than gallbladder1,3,6,7,8,10. There are few reports on literature about these uncommon neoplasms1,2,3,4,5,6,7,8,9,10. Especially in Brazil, no case was reported. Azambuja et al.1 reported a single case but this tumor was an intrahepatic BCAC1. This tumor is more frequently observed in middle-aged people and may occur in both gender having a less favorable prognosis in man3. In accordance to Devaney et al.4 there are at least two well-defined types of hepatobiliary cystadenocarcinoma. One developing exclusively in female patients, usually accompanied by an "ovarian-like" stroma, which follows an indolent course and the other, lacking the distinct cellular stroma, seen in males, follows an aggressive biological behavior that may result in the patient's death from tumor10.

While intra-hepatic BCAC leads abdominal mass or pain, EBCAC leads generally obstructive jaundice that may eventually be accompanied by symptoms. More lately, it may lead weight loss and ascites that denotes advanced disease1,3,6,7,8,10.

Despite its rarity, EBCAC should remind as differential diagnosis with hilar cholangiocarcinoma in patients who present high obstructive jaundice as the present case10. Like this tumor present more loco-regional dissemination than distant metastasis1,10.

Histological, BCAC are characterized by papillary projections with a multilayered cell lining with foci of dysplasia and moderate mitotic activity10. In BCAC most tumor cells were positive on immunohistochemical staining for cytoqueratin, epithelial membrane antigen, CA 19.9 and carcinoembryonic antigen4.

Although the diagnosis is histological and may be confirmed by immunohistochemistry, image examinations may contribute for suspect diagnosis. Computed tomography and more recently magnetic cholangioresonance may reveal multilocular cystic lesion with internal septations or nodularities. More rarely, as the case described, an unilocular lesion may be observed6. Some authors have suggested that presence of nodules or coarse calcifications along the wall or septa favor the BCAC2,6. However, as reported Tseng et al.10, EBCAC may be confounded with hilar cholangiocarcinoma because may lead dilatation of the intrahepatic biliary ducts and atrophy of the affected lobe such as observed in present case. Different from Tseng et al.10, the present authors observed no hepatolithiasis in this case. The real cause of atrophy of the left hepatic lobe was unknown.

Tseng et al.10 suggested that the tumor would lead compression of the left trunk of the portal vein that could deviate hepatic flow for right lobe. As this case of the EBCAC, it presents a difficult differential diagnosis with common hilar cholangiocarcinoma because on image examinations EBCAC may be confounded due intense dilatation of intra-hepatic biliary tree. Independently of the diagnosis as EBCAC as hilar cholangiocarcinoma, the treatment has been total resection of the lesion with free margins, because partial resection has been associated a high levels of recurrence and dismal prognosis1,2,3,4,5,6,7,8,9. Generally, surgical resection may be associated with hepatectomy, due proximity of the hepatic parenchyma3,10. Radical resection is the only curative treatment and may be associated either cure or long-term survival1,2,3,4,5,6,7,8,9. The overall prognosis may be good since a radical resection is performed, as in the present case.

REFERENCES

  • 1. Azambuja E, Batista RG, Waetcher FL, Sampaio JA, Alvares-da-Silva MR, Fleck JF. Biliary cystoadenocarcinoma. Revista AMRIGS 2004; 48(3): 186-9.
  • 2. Buetow PC, Buck JL, Pantograg-Brown L. Biliary cystadenoma and cystadenocarcinoma: clinical-imaging-pathologic correlations with emphasis on the importance of ovarian stroma. Radiology 1995; 196: 805-10.
  • 3. Davies W, Chow M, Nagorney D. Extrahepatic Biliary Cystadenomas and Cystadenocarcinoma. Report of Seven Cases and Review of the Literature. Ann Surg 1995; 222(5), 619-25.
  • 4. Devaney K, Goodman ZD, Ishak KG. Hepatobiliary Cystadenoma and Cystadenocarcinoma: A Light Microscopic and Immunohistochemical Study of 70 patients. Am J Surg Pathol 1994; 18 (11): 1078-91.
  • 5. Erdogan D, Busch ORC, Van Delden OM, Gouma DJ, Van Gulik T. World J Gastroenterol 2006; 12 (35): 5735-8.
  • 6. Korobkin M, Stephens DH, Lee JK. Biliary cystadenoma and cystadenocarcinoma: CT and sonographic findings. A J R 1989; 153: 507-11.
  • 7. Lauffer JM, Baer HU, Maurer CA, Stoupis CH, Buchler MW. Biliary cystadenocarcinoma of the liver: the need for complete resection. Eur J Cancer 1998; 34 (12): 1845-51.
  • 8. Owono P, Scoazec JY, Valete PJ, Dumortier J, Gouysse G, Berger F, Boulez J, Partensky C. Cystadénomes et cystadénocarcinomes hépatobiliaires. Etude clinique, radiologique et anatomopathologique de 7 cas. Gastroenterol Clin Biol 2001; 25: 414-21.
  • 9. Takayasu K, Muramatsu Y, Moriyama N. Imaging diagnosis of bile duct cystadenocarcinoma. Cancer 1988; 61: 941-6.
  • 10. Tseng C, Pan YS, Chen CY, Liu CS, Wu DC, Wang WM et al. Biliary cystadenocracinoma associated with atrophy of the left hepatic lobe and hepatolithiasis mimicking intrahepatic cholangiocarcinoma: A case report. Kaohsiung J Med Sci 2004; 20(4): 198-202.
  • 11. Yu Q, Chen T, wan YL, Min J, Guo H. Intrahepatic biliary cystadenocarcinoma: clinical analysis of 4 cases. Hepatobiliary Pancreat Dis Int 2009; 8 (1): 71-4.
  • Correspondência:

    Sergio Renato Pais Costa,
    e-mail
  • Publication Dates

    • Publication in this collection
      16 May 2013
    • Date of issue
      Mar 2013
    Colégio Brasileiro de Cirurgia Digestiva Av. Brigadeiro Luiz Antonio, 278 - 6° - Salas 10 e 11, 01318-901 São Paulo/SP Brasil, Tel.: (11) 3288-8174/3289-0741 - São Paulo - SP - Brazil
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