Physalis angulata L. antineoplasic activity, in vitro, evaluation fromit's stems and fruit capsules

Physalis angulata L. antineoplasic activity, in vitro, evaluation fromit's stems and fruit capsules

I.M. RibeiroI,^*; M.T.G. Silva^I; R.D.A. Soares^III; C.M. Stutz^II; M. Bozza^IV; T.C.B. Tomassini^I

^ILaboratório de Química Produtos Naturais, PN2, Far-Manguinhos/Fiocruz, Rio de Janeiro, RJ

^IILaboratório de Farmacologia Aplicada I, Rua Sizenando Nabuco, 100, 21041-250, Far-Manguinhos/Fiocruz, Rio de Janeiro, RJ

^IIILaboratório de Imunopatologia/DBBM-IOC- Fiocruz, Av. Brasil, 4365, Manguinhos, 21045-900, Rio de Janeiro, RJ

^IVLaboratório de Informação e Imunidade, Cidade Universitária CCS/Ilha do Fundão, 21941-190, Rio de Janeiro, RJ, Brazil

ABSTRACT

Physalis angulata L. (genus Physalis; family Solanaceae) is an herbaceous specimen that grows plentifully at North, Northeast and Middleast Brazilian's regions1. Its fruits are edible, roots and epigeal parts are taken as tea or infusion, all through the world as traditional medicine. Despite of this usefulness not much scientific work has been done on it. This research carried out with plant material (stems and fruit capsules) has the main aim to find out anti-neoplasic activity. The obtained results are described in Table 1. The most significant inhibition values are those for fruit capsules fractions such as 97% mouse lymphoma; 93% Erlich carcinoma strains when was assayed with MGTS-1-2ai and MGTS-1-1ai respectively. In the course on going studies on the biological response and chemical constituents of P. angulata some fractions were obtained from stems and fruit capsules ethanolic and methanolic extracts. The extract prepared from roots of P. angulata is the most clinically used by physicians for treatment of human hepatic disorders, despite the substance responsible for the efficacy still a matter of argument.

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Publication Dates

• Publication in this collection
  05 Oct 2009
• Date of issue
  2002