Abstract
Achillea millefolium L. (Compositeae) is used in folk medicine to treat gastric disturbances. Doses of 125, 1500 and 2000 mg/kg protected rats against ulcers induced by ethanol and restraint-in-cold-stress, but not against indomethacininduced ulcers. Injected into the duodenal lumen the extract inhibited the basal acid secretion. Data from studies indicate that the antiulcer activity of A. millefolium must been related to a inhibition of gastric secretion or to a increase of protective factors in gastric mucosa as mucus, bicarbonate and blood flow. In conclusion, this extract effectively protected the gastric mucosa and inhibited gastric acid secretion. Further studies should also be provided for the stimulation of receptors in the parietal cell to elucidate the route whereby the extract produce this action.
Action of crude aqueous extract of leaves of Achillea millefolium L. (Compositae) on gastrointestinal tract
Cristiane Hatsuko Baggio; Cristina Setim Freitas; Paulo Fernando Nhaducue; Lia Rieck; Maria Consuelo Andrade Marques* * mconsu@bio.ufpr.br
Department of Pharmacology, Sector of Biological Sciences, Universidade Federal do Paraná, Centro Politécnico, 81531-990, Curitiba, PR, Brazil
ABSTRACT
Achillea millefolium L. (Compositeae) is used in folk medicine to treat gastric disturbances. Doses of 125, 1500 and 2000 mg/kg protected rats against ulcers induced by ethanol and restraint-in-cold-stress, but not against indomethacininduced ulcers. Injected into the duodenal lumen the extract inhibited the basal acid secretion. Data from studies indicate that the antiulcer activity of A. millefolium must been related to a inhibition of gastric secretion or to a increase of protective factors in gastric mucosa as mucus, bicarbonate and blood flow. In conclusion, this extract effectively protected the gastric mucosa and inhibited gastric acid secretion. Further studies should also be provided for the stimulation of receptors in the parietal cell to elucidate the route whereby the extract produce this action.
Full text available only in PDF format.
Texto completo disponível apenas em PDF.
References
1 Oka, C. Herbário de plantas medicinais. Estufa de mudas em Caucaia do Alto-Cotia, 1998; São Paulo
2 Negri, G. Descrizione e propietá delle piante medicinali e velenose della flora italiana. Erbario Figurato, 1979; 5. ed, Úrico Hoepi Milano
3 Robert, A.; Nezamis, J. E.; Lancaster, C. & Hauchar, A. J. Cytoprotection by prosta-glandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl and thermal injury. Gastroenterology 1979; 77: 433-443
4 Djahanguiri, B. The production of acute gastric ulceration by indomethacin in the rat. Scand. J. Gastroenterol. 1969; 4: 265. 5 Senay, S. E. & Levine, R. J. Synergism between cold restrait for rapid production of stress ulcer in rats. Proc. Soc. Exp. Biol. Med. 1967; 124: 1221-1223
6 Shay, H.; Komarov, S. A.; Fels, S. E.; Meraze, D.; Gruentein, M. & Siplet, H. A simple method for uniform production of gastric ulceration in rat. Gastroenterology 1945; 5: 43-61
7 Domer, F. R. Animal experiments in pharmacological analysis. Charles T. Thomas Publisher, 1971; 669p
8 Anson, M. L. The estimation of pepsin, trypsin, papain and catepsin with hemoglobin. J. Gen. Physiol. 1938; 22: 78-89
9 Szabo, S. Mechanisms of gastric mucosal injury and protection. J. Clin. Gastroenterol. 1991; 13: 21S-34S
10 Glavin, G. B.; Gary, B.; Sansor, S. Experimental gastric mucosal injury: laboratory models reveal mechanisms of pathogenics and new therapeutic strategies. Faseb J. 1992; 6: 825-831
11 Pare, W.; Glavin, G. Animal models of stress in pharmacology. In: Methods in Behavioral Pharmacology, Elsevier Amsterdam. In press, 1992
12 Pachaly, J. R.; Werner, P. R.; Schimanski, J. C.; Ciffoni, E. M. G. Estresse por captura e contensão em animais selvagens. A Hora Veterinária 1993; 74: 47-52
13 Hersey, S. J.; Sachs, G. Gastric acid secretion. Physiological Reviews. USA 1995; 75 (1): 155-189
14 Brodie, D.; Marshall, R. W.; Moreno, O. M. Effect of restrain on gastric acidity in rat. Am. J. Physiol. 1962; 202: 812-814
15 Murakami, M.; Larm, S. K.; Inada, M.; Miyake, M. Pathophysiology and pathogenesis of acute gastric mucosal lesions after hypothermic restraint stress in rats. Gastroenterology 1985; 88: 660-665
16 Al-Yahaia, M. A.; Rafatullah, S.; Mossa, J. S.; Ageel, A. M.; Al-Said, M. S.; Tariq, M. Gastric antisecretory, antiulcer and cytoprotective properties of ethanolic extract of Alpinia galanga in rats. Phytotherapy Research 1990; 4 (3): 112-114
17 Katz, J. Acid secretion and supression. Medical Clinics of North America 1991; 75 (4): 877-887
- 1 Oka, C. Herbário de plantas medicinais. Estufa de mudas em Caucaia do Alto-Cotia, 1998; Săo Paulo
- 2 Negri, G. Descrizione e propietá delle piante medicinali e velenose della flora italiana. Erbario Figurato, 1979; 5. ed, Úrico Hoepi Milano
- 3 Robert, A.; Nezamis, J. E.; Lancaster, C. & Hauchar, A. J. Cytoprotection by prosta-glandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl and thermal injury. Gastroenterology 1979; 77: 433-443
- 4 Djahanguiri, B. The production of acute gastric ulceration by indomethacin in the rat. Scand. J. Gastroenterol. 1969; 4: 265.
- 5 Senay, S. E. & Levine, R. J. Synergism between cold restrait for rapid production of stress ulcer in rats. Proc. Soc. Exp. Biol. Med. 1967; 124: 1221-1223
- 6 Shay, H.; Komarov, S. A.; Fels, S. E.; Meraze, D.; Gruentein, M. & Siplet, H. A simple method for uniform production of gastric ulceration in rat. Gastroenterology 1945; 5: 43-61
- 7 Domer, F. R. Animal experiments in pharmacological analysis. Charles T. Thomas Publisher, 1971; 669p
- 8 Anson, M. L. The estimation of pepsin, trypsin, papain and catepsin with hemoglobin. J. Gen. Physiol. 1938; 22: 78-89
- 9 Szabo, S. Mechanisms of gastric mucosal injury and protection. J. Clin. Gastroenterol. 1991; 13: 21S-34S
- 10 Glavin, G. B.; Gary, B.; Sansor, S. Experimental gastric mucosal injury: laboratory models reveal mechanisms of pathogenics and new therapeutic strategies. Faseb J. 1992; 6: 825-831
- 11 Pare, W.; Glavin, G. Animal models of stress in pharmacology. In: Methods in Behavioral Pharmacology, Elsevier Amsterdam. In press, 1992
- 12 Pachaly, J. R.; Werner, P. R.; Schimanski, J. C.; Ciffoni, E. M. G. Estresse por captura e contensăo em animais selvagens. A Hora Veterinária 1993; 74: 47-52
- 13 Hersey, S. J.; Sachs, G. Gastric acid secretion. Physiological Reviews. USA 1995; 75 (1): 155-189
- 14 Brodie, D.; Marshall, R. W.; Moreno, O. M. Effect of restrain on gastric acidity in rat. Am. J. Physiol. 1962; 202: 812-814
- 15 Murakami, M.; Larm, S. K.; Inada, M.; Miyake, M. Pathophysiology and pathogenesis of acute gastric mucosal lesions after hypothermic restraint stress in rats. Gastroenterology 1985; 88: 660-665
- 16 Al-Yahaia, M. A.; Rafatullah, S.; Mossa, J. S.; Ageel, A. M.; Al-Said, M. S.; Tariq, M. Gastric antisecretory, antiulcer and cytoprotective properties of ethanolic extract of Alpinia galanga in rats. Phytotherapy Research 1990; 4 (3): 112-114
- 17 Katz, J. Acid secretion and supression. Medical Clinics of North America 1991; 75 (4): 877-887
Publication Dates
-
Publication in this collection
05 Oct 2009 -
Date of issue
2002
