Cardiovascular effects induced by the aqueous fraction of the ethanol extract of the stem of Solanum stipulaceum in rats

Cardiovascular effects induced by the aqueous fraction of the ethanol extract of the stem of Solanum stipulaceum in rats

E.A.N. Ribeiro^I; M.C.P. Batitucci^II; J.A.T. Lima^I; I.G.A. Araújo^I; H. Mauad^II; I.A. MedeirosI,^*

^ILaboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, CP 5009, 58051-970, João Pessoa, PB

^IIDepartamento de Ciências Fisiológicas, Universidade Federal do Espírito Santo, Vitória, ES, Brazil

ABSTRACT

The cardiovascular effects induced by the aqueous fraction of the ethanol extract of the stem (AFS) of Solanum stipulaceum Roem. & Schult were studied in rats. In non-anesthetized rats, AFS injections produced significant and dosedependent hypotension associated with increase in heart rate. In isolated rat superior mesenteric rings, AFS was able to antagonize the contractions induced by phenylephrine and KCl. The vasorelaxant activity of AFS was not inhibited by either removal of vascular endothelium, L-NAME, atropine or indomethacine. In isolated rat atrial preparations, AFS produced concentration-related negative inotropic and chronotropic responses. These results suggest that the hypotensive effect of AFS is due to a peripheral vasodilation, which can not be attributed to the participation of vascular endothelium. Finally, AFS acts directly on the heart decreasing contractility and heart rate.

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• 1 D'Arcy WG. The solanaceae since 1976 with a review of its biogeography. In: J.G. Hawkes, R.N. Lester, M. ee & N. Estrada-R., editors, Solanaceae III: Taxonomy, Chemistry, Evolution, Royal Botanic Gardens Kew, 1991: 75-137
• 2 Chagnon M. General pharmacologic inventory of medicinal plants of rwanda. Journal of Ethnopharmacology 1984; 12 (3): 239-51
• 3 Dhar ML, Dhar MM, Dhawan BN, Mehrotra BN, Ray C. Screening of indian plants for biological activity: Part I. Indian Journal of Experimental Biology 1968; 6: 232-47
• 4 Adesina SK. Studies on some plants used as anticonvulsants in amerindian and african traditional medicine. Fitoterapia 1982; 53: 147-62
• 5 Ataíde JR. Atividade farmacológica dos extratos da jurubeba roxa Solanum paludosum Moric. In: Dissertaçăo de mestrado do curso de pós-graduaçăo em produtos naturais (farmacologia e química) / UFPB, Joăo Pessoa, 1982
• 6 Oliveira EJ, Medeiros IA, Mukeierjee R. Hypotensive and spasmolytic effects of normacusine B from Strychnos atlantica root. Phytomedicine 1996; 3: 45-49
• 7 Tanaka Y, Mochizuki Y, Tanaka H, Shigenobu K. Significant role of neuronal non-N-type calcium channels in the sympathetic neurogenic contraction of rat mesenteric artery. British Journal of Pharmacology 1999; 128: 1602-8
• 8 Nasa Y, Ichihara K, Yoshida R, Abiko Y. Positive inotropic and negative chronotropic effects of (-)-cis-diltiazem in rat isolated atria. British Journal of Pharmacology 1992; 105 (3): 696-702
• 9 Nelson MT, Patlak JB, Worley JF, Standen NB. Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone. American Journal of Physiology 1990; 259 (1 Pt 1): C3-C18
• 10 Karaki H, Ozaki H, Hori M, Mitsui-Saito M, Amano K, Harada K, Miyamoto S, Nakazawa H, Won KJ, Sato K. Calcium movements, distribution, and functions in smooth muscle. Pharmacological Reviews 1997; 49 (2):157-230
• 11 Gurney AM. Mechanisms of drugs-induced vasodilatation. Journal of Pharmacy and Pharmacology 1994; 46 (4): 242-251
• 12 Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: Physiology, pathophysiology and pharmacology. Pharmacological Reviews 1991; 43: 109-42
• 13 Moncada S, Higgs EA. The L-arginine-nitric oxide pathway. New England Journal of Medicine 1993; 29: 2002-12

Publication Dates

• Publication in this collection
  05 Oct 2009
• Date of issue
  2002