Abstract
An ethanol extract of aerial parts of Spigelia anthelmia was submitted to vacuum column chromatography being eluted with hexane, chloroform, ethyl acetate and methanol. The four extracts were assayed for anthelmintic activity against Haemonchus contortus, the main nematode in caprines. The ethyl acetate extract showed the strongest anthelmintic activity and the chemical study of this extract revealed as main constituents the alkaloid spiganthine and 3,7-dihydroxy-3',4'- dimethoxyflavone.
Chemical investigation of Spigelia anthelmia Linn. used in Brazilian folk medicine as anthelmintic
Selene Maia de MoraisI, * * selene@uece.br ; Cláudia Maria Leal BeviláquaII; Júlia Aprecida L. de SouzaI; Luciana Moura de AssisII
IDepartamento de Física e Química, Centro de Ciências e Tecnologia, Universidade Estadual do Ceará
IIFaculdade de Veterinária da Universidade Estadual do Ceará, Av. Paranjana, 1700, Campus do Itaperi, Serrinha, 60740-000, Fortaleza, CE, Brazil
ABSTRACT
An ethanol extract of aerial parts of Spigelia anthelmia was submitted to vacuum column chromatography being eluted with hexane, chloroform, ethyl acetate and methanol. The four extracts were assayed for anthelmintic activity against Haemonchus contortus, the main nematode in caprines. The ethyl acetate extract showed the strongest anthelmintic activity and the chemical study of this extract revealed as main constituents the alkaloid spiganthine and 3,7-dihydroxy-3',4'- dimethoxyflavone.
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Publication Dates
-
Publication in this collection
05 Oct 2009 -
Date of issue
2002
