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Revista Brasileira de Farmacognosia

Print version ISSN 0102-695X

Rev. bras. farmacogn. vol.12  supl.1 Maringá  2002 

Effect of Plantago australis leaves on different gastric ulcer models



M.E. Bürger*; P.C. Ghedini; B. Baldisserotto; N.M.S. Palmeiro; C.E. Almeida; C.F. Lenzi; A.C. Silva; C.Q. Oliveira

Departamento de Fisiologia, Universidade Federal de Santa Maria, 97105-900, Santa Maria, RS, Brazil




The anti-ulcerogenic effect of the crude ethanolic extract (CEE) of Plantago australis leaves was tested against ethanol-, indomethacin-, and cold restrain-induced stress ulcers. The CEE (500 and 1000 mg/kg) reduced the lesion index (LI) and the ulcer index in ethanol-induced ulcers, and the dose of 1000 mg/kg increased the amount of mucous. The highest dose of the CEE reduced the LI of cold restraint-induced stress ulcers when compared to the control group. The indomethacin-induced ulcers were not affected by this extract.



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