Efeito do EGB761 (Extrato de Ginkgo biloba) sobre a qualidade de vida em pacientes asmáticos moderados submetidos a tratamento de manutenção

Hillebrand, M. D.; Oliveira, W. F.

doi:10.1590/S0102-695X2004000300010

Resumos

A busca de tratamentos alternativos e eficazes para o controle da asma brônquica é fator importante na melhora da qualidade de vida dos portadores da doença. O efeito do extrato de Ginkgo biloba (Ginkgo biloba L.), na resposta asmática ao tratamento de manutenção para asma brônquica moderada persistente, foi estudado em um ensaio clínico randomizado, cego, placebo controlado.

The search for efficient and alternative therapies for the asthma control is an important factor to the improvement of life quality in asthmatic patients. The effects of Ginkgo biloba extract (Ginkgo biloba L.) in the response of asthmatics to the maintenance treatment for persistent moderate asthma were studied in a blind, randomized, placebo-controlled clinical trial.

Efeito do EGB₇₆₁ (Extrato de Ginkgo biloba) sobre a qualidade de vida em pacientes asmáticos moderados submetidos a tratamento de manutenção

Hillebrand M. D.^I; Oliveira W. F.^II

^IMédica, Cardiologista, Mestre em Saúde Coletiva, Universidade Luterana do Brasil, Canoas, RS, Brasil

^IIPh.D., Médico, Mestre em Saúde Coletiva, Professor, Departamento de Saúde Coletiva e Diretor, Serviço de Saúde Pública, Hospital Universitário, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brasil

RESUMO

A busca de tratamentos alternativos e eficazes para o controle da asma brônquica é fator importante na melhora da qualidade de vida dos portadores da doença. O efeito do extrato de Ginkgo biloba (Ginkgo biloba L.), na resposta asmática ao tratamento de manutenção para asma brônquica moderada persistente, foi estudado em um ensaio clínico randomizado, cego, placebo controlado.

ABSTRACT

The search for efficient and alternative therapies for the asthma control is an important factor to the improvement of life quality in asthmatic patients. The effects of Ginkgo biloba extract (Ginkgo biloba L.) in the response of asthmatics to the maintenance treatment for persistent moderate asthma were studied in a blind, randomized, placebo-controlled clinical trial.

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Autora para correspondência

Dra. Marinez Domeneghini Hillebrand

Av. Cristóvão Colombo, 2427, sala 501

CEP 90550-005, Porto Alegre, RS

e-mail: mhillebrand@pop.com.br

1 Czygan F: The role of medicinal plants as an important part in modern medicine. In XXIII International Horticultural Congress, Firenze, Italy, 1990.
2 Salvador RL: Herbal medicine: ginkgo. Can Pharm J 1995, 128 (jul-aug): 39-41.
3 Caeser W: Ginkgo biloba: tree which has conquered time. Deutshe Apotheker Zeitung 1989, 29 (nov 9): 2430-2431.
4 DeFeudis FV: Toxicology of EGB 761 in experimental animals and humans: safety of GB 761 containing products (XVII). In Ginkgo biloba extract (EGB 761). From chemistry to the clinic. Edited by Ulstien Medica 1998: 197-201.
5 Houghon P: Ginkgo. Pharm Journal 1994, 253 (jul 23): 122-123
6 Sociedade Brasileira de Pneumologia e Tisiologia: III Consenso Brasileiro no Manejo de Asma. J. Pneumol 2002, 28(1): Jun.
7 Braquet P: Ginkgolides: potent platelet activating factor antagonists from Ginkgo biloba L: chemestry, pharmacology and clinical applications. Drugs Future 1987, 12(jul): 643-699.
8 Mahmoud F: In vitro effects of ginkgolide B on lymphocyte activation, in atopic asthma: comparison with cyclosporine. Jpn J Pharmacol 2001, 85(3): 241-245.
9 Sociedade Brasileira de Pneumologia e Tisiologia: I Consenso Brasileiro sobre espirometria J. Pneumol 1996, 22(3): mai-jun .
10 Juniper EF, Guyatt GH, Epstein RS, Ferrie PJ, Jaeschke R, Hiller TK: Evaluation of impairment of health related quality of life in asthma: development of a questionnaire for use in clinical trials. Thorax 1992, 47:76-83.
11 Juniper EF, Guyatt GH, Ferie PJ, Griffiyh LE: Measuring quality of life in asthma. Am Rev Respir Dis 1993, 147: 832 838.
12 Juniper EF, Guyatt GH, Willan A, Griffith LE: Determining a minimal important change in a disease-specific quality of life questionnaire. J Clin Epidemiol 1994, 47(1): 81-87.
13 Juniper EF, Buist AS, Cox FM, Ferrie PJ, King DR: Validation of a standardized version of the asthma quality of life questionnaire. Chest 1999, 115: 1265 1270.

Datas de Publicação

Publicação nesta coleção
16 Set 2008
Data do Fascículo
2004

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

[1] 1 Czygan F: The role of medicinal plants as an important part in modern medicine. In XXIII International Horticultural Congress, Firenze, Italy, 1990.

[2] 2 Salvador RL: Herbal medicine: ginkgo. Can Pharm J 1995, 128 (jul-aug): 39-41.

[3] 3 Caeser W: Ginkgo biloba: tree which has conquered time. Deutshe Apotheker Zeitung 1989, 29 (nov 9): 2430-2431.

[4] 4 DeFeudis FV: Toxicology of EGB 761 in experimental animals and humans: safety of GB 761 containing products (XVII). In Ginkgo biloba extract (EGB 761). From chemistry to the clinic. Edited by Ulstien Medica 1998: 197-201.

[5] 5 Houghon P: Ginkgo. Pharm Journal 1994, 253 (jul 23): 122-123

[6] 6 Sociedade Brasileira de Pneumologia e Tisiologia: III Consenso Brasileiro no Manejo de Asma. J. Pneumol 2002, 28(1): Jun.

[7] 7 Braquet P: Ginkgolides: potent platelet activating factor antagonists from Ginkgo biloba L: chemestry, pharmacology and clinical applications. Drugs Future 1987, 12(jul): 643-699.

[8] 8 Mahmoud F: In vitro effects of ginkgolide B on lymphocyte activation, in atopic asthma: comparison with cyclosporine. Jpn J Pharmacol 2001, 85(3): 241-245.

[9] 9 Sociedade Brasileira de Pneumologia e Tisiologia: I Consenso Brasileiro sobre espirometria J. Pneumol 1996, 22(3): mai-jun .

[10] 10 Juniper EF, Guyatt GH, Epstein RS, Ferrie PJ, Jaeschke R, Hiller TK: Evaluation of impairment of health related quality of life in asthma: development of a questionnaire for use in clinical trials. Thorax 1992, 47:76-83.

[11] 11 Juniper EF, Guyatt GH, Ferie PJ, Griffiyh LE: Measuring quality of life in asthma. Am Rev Respir Dis 1993, 147: 832 838.

[12] 12 Juniper EF, Guyatt GH, Willan A, Griffith LE: Determining a minimal important change in a disease-specific quality of life questionnaire. J Clin Epidemiol 1994, 47(1): 81-87.

[13] 13 Juniper EF, Buist AS, Cox FM, Ferrie PJ, King DR: Validation of a standardized version of the asthma quality of life questionnaire. Chest 1999, 115: 1265 1270.