Formulation and conservation of a pharmaceutical form with leaf extracts from Acacia aroma Gill. ex Hook et Arn

^ICátedra de Farmacotecnia II . Facultad de Bioquimica, Quimica y Farmacia

^IICátedra de Fitoquimica. Facultad de Bioquimica, Quimica y Farmacia. Ayacucho 471. San Miguel de Tucumán. CP 4000. Tucumán. Argentina

ABSTRACT

Leaf fluid extracts of Acacia aroma GILL. ex Hook et Arn showed antibacterial activity against antibiotic multiresistant bacteria isolated from clinical samples, antioxidant and ant-inflammatory activities. Toxicological studies carried out on Artemia salina and Allium cepa attested none toxicity potential. The aim of this work was to elaborate a formulation of topical antibacterial hydrogel with Carbopol acrylic acid polymer containing an A. aroma fluid extract in order to compare with a hydrogel containing commercial antibiotic. The optimal extract concentration in this formulation was determined according to the values of minimal inhibitory concentration and minimal bactericidal concentration for Staphylococcus aureus, methicillin-resistant (F7) and Pseudomonas aeruginosa (F352). Physical, chemical, rheological and microbiological stability was observed at least during one year. The hydrogel containing Acacia leaves fluid extract shows remarkable antibacterial effect with a broadspectrum efficacy against Gram positive and Gram negative bacteria at low concentration.

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Acknowledgements

This research was partially supported by the Consejo de Investigación de la Universidad Nacional de Tucumán, Argentina, and by the Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina.

Corresponding author

Dra. María Inés Isla

Cátedra de Fitoquímica. Instituto de Estudios Vegetales.

Facultad de Bioquímica, Química y Farmacia.

Universidad Nacional de Tucumán.

Ayacucho 471

4000 - San Miguel de Tucumán. Argentina

Fax: [phone]

e-mail: [e-mail]

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Formulation and conservation of a pharmaceutical form with leaf extracts from Acacia aroma Gill. ex Hook et Arn.

Arias M. E^I; Gomez J. D.^I; Vatuone M.^II; Isla M. I.^II,*

Publication Dates

• Publication in this collection
  16 Sept 2008
• Date of issue
  2004