STRUCTURAL ASPECTS OF LIVER AND THYMUS FOLLOWING SYSTEMIC USE OF GANGLIOSIDES
MONTERO EFS,
VON KOSSEL K,
CASTRO LC,
MARINHO LC,
FERREIRA R,
NIGRO AJT
ABSTRACT: Objective: to examine the effect of Gangliosides on morphologic aspects liver and thymus. Methods: Twenty-four Female EPM 1 Wistar rats were immunized with sheep erythrocytes and treated with different doses of Gang (3 and 9mg.kg-1.day-1), and one group (Sham) was treated with vehicle, by intramuscular injection, for up to 7 days. Samples were collected, on days 4 and 7, from liver and thymus which were submitted to light microscopy examination. Results: There was no morphological changes in any group on days 4 and 7 for both studied organs (thymus and liver). The structural organization of the liver into parenchymal, interstitial, vascular, and ductal elements were preserved ( hepatic lobule and efferent central vein with cords of hepatocytes radiating to several peripheral portal tracts). Despite of slight reduction on thymic medulla at 9mg group, just on day 7, the basic structural unit of the thymus, the lobule, was preserved with two morphologically distinctive compartment, cortex and medulla. Conclusion: Based on our data, we can conclude that gangliosides have not induced morphological changes in all groups analyzed, excepted at 9mg group, on day 7, in which maybe, gangliosides could present some influence on T lymphocytes maturation. Further studies would be necessary to elucidate the role of gangliosides on thymic medulla, maybe using higher doses or long-term use.
Publication Dates
-
Publication in this collection
14 Mar 2001 -
Date of issue
2000
