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Revista Paulista de Pediatria

Print version ISSN 0103-0582

Rev. paul. pediatr. vol.30 no.1 São Paulo  2012

https://doi.org/10.1590/S0103-05822012000100013 

ORIGINAL ARTICLE

 

Blood pressure in children with sickle cell disease

 

Presión arterial en niños portadores de enfermedad falciforme

 

 

Ho Chi HsienI; João Thomas A. CarvalhaesII; Josefina Aparecida P. BragaIII

Instituição: Escola Paulista de Medicina da Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil
IMestre em Pediatria e Ciências Aplicadas à Pediatria pela Escola Paulista de Medicina da Unifesp; Médico Assistente do Setor de Nefrologia Pediátrica do Departamento de Pediatria da Escola Paulista de Medicina da Unifesp, São Paulo, SP, Brasil
IIDoutor em Pediatria pela Escola Paulista de Medicina da Unifesp; Professor Adjunto e Chefe do Setor de Nefrologia Pediátrica do Departamento de Pediatria da Escola Paulista de Medicina da Unifesp, São Paulo, SP, Brasil
IIIDoutora em Pediatria e Ciências Aplicadas à Pediatria pela Escola Paulista de Medicina da Unifesp; Professora Adjunta e Chefe do Setor de Hematologia Pediátrica do Departamento de Pediatria da Escola Paulista de Medicina da Unifesp, São Paulo, SP, Brasil

Endereço para correspondência

 

 


ABSTRACT

OBJECTIVE: To evaluate blood pressure (BP) in children with sickle cell disease (SCD).
METHODS: Observational descriptive study of BP in 70 children with SCD. BP values were classified according to the V Brazilian Guidelines in Arterial Hypertension. Patients were divided into groups according to genotype (HbSS, HbSC) and according to age: group I, three to four years and 11 months; group II, five to eight years and 11 months; and group III, nine to 13 years and 11 months. The Student's t test and ANOVA were used for statistical analyses, and the level of significance was set at p<0.05.
RESULTS: Mean and standard deviation (SD) of systolic BP (SBP) (mmHg) were 95.9±11.45, and of diastolic BP (DBP), 62.6±7.78. Means according to age group were: group I - SBP 91.2±5.78 and DBP 61.5±7.15; group II - SBP 97.3±10.86 and DBP 64.4±7.89; and group III - SBP 100.0±9.88 and DBP 61.5±4.94. Results showed that 5.7% of the patients had hypertension and 8.6%, pre-hypertension. Mean SBP and DBP of HbSC and HbSS patients did not differ.
CONCLUSIONS: Further studies should be conducted to assess BP in patients with SCD and determine possible causes of hypertension in these patients.

Key-words: blood pressure; hypertension; anemia, sickle cell; child.


RESUMEN

OBJETIVO: Evaluar los valores de la presión arterial (PA) en niños portadores de enfermedad falciforme (EF).
MÉTODOS: Estudio observacional unicéntrico descriptivo de PA de 70 niños portadores de EF acompañadas en el ambulatorio de Hematología Pediátrica. Los valores de la PA obtenidos fueron clasificados conforme a las V Directrices Brasileñas de Hipertensión Arterial. Los pacientes fueron  distribuidos según el genotipo en grupo HbSS y HbSC, y  según la franja de edad: grupo I (tres años a cuatro años y 11  meses), grupo II (cinco años a ocho años y 11 meses) y grupo III (nueve años a 13 años y 11 meses).
RESULTADOS: El promedio y la desviación estándar (DE) de las medidas de la PA sistólica (PAS) (mmHg) fueron 95,9±11,45 y de la PA diastólica (PAD) 62,6±7,78. Los promedios de la PA por franja de edad fueron: grupo I, PAS 91,2±5,78 y PAD 61,5±7,15; grupo II, PAS 97,3±10,86 y PAD 64,4±7,89; y grupo III, PAS 100,0±9,88 y PAD 61,5±4,94. Se observó que el 5,7% de los pacientes presentaban hipertensión arterial (HA) y el 8,6% eran pre-hipertensos. El promedio de los valores de la PAS y PAD entre los pacientes HbSS y HbSC no difirió significativamente. En el análisis estadístico, se aplicó la prueba t de Student y ANOVA, siendo significante p<0,05.
CONCLUSIONES: La detección de HA en niños confirma la importancia de verificar la PA en la rutina pediátrica. Nuevos estudios deben realizarse para evaluar la PA en pacientes con EF y detectar las posibles causas de HA en esos pacientes.

Palabras clave: presión arterial; hipertensión; anemia falciforme; niño.


 

 

Introduction

Sickle cell disease (SCD), the most frequent hematological disease in Brazil, affects an important portion of the population in different countries. Brazilian authors estimate 3,500 new cases per year(1,2). The HbS gene may combine with other hereditary hemoglobin anomalies, such as hemoglobin C, hemoglobin D and β-thalassemia, and generate combinations that are also symptomatic, called hemoglobinopathy SC, hemoglobinopathy SD and S/β-thalassemia. All these symptomatic forms of expression of the HbS gene are known as SCD.

The epidemiological features, clinical signs and symptoms and hematological characteristics of SCD vary according to genotype, and the HbSS genotype is the most severe form of the disease. It leads to numerous complications, such as acute vaso-occlusive events and chronic disease, which may affect almost all organs and systems and result in high morbidity and a shorter life expectancy among these patients(2).

Kidney problems, common in SCD, start in childhood. About one third of all adolescents and young adults with SCD have nephropathies and renal abnormalities, such as impaired urinary concentration ability, defects in urinary acidification and potassium excretion, as well as glomerular disorders, such as glomerular hyperfiltration and proteinuria(3-5) Hypertension (HT), although frequent in African ethnicities, has not been frequently diagnosed in patients with SCD(3). Studies with adults with SCD showed that they had a lower incidence of HT and lower blood pressure (BP) values than patients without hemoglobinopathy S, but these findings have not been confirmed in pediatric populations(6-10). Gordeuk et al(11) found that patients with SCD have a higher risk of pulmonary hypertension and renal failure when their blood pressure was elevated.

The evaluation of BP in children and adolescents should be part of the clinical pediatric routine, and normative values for healthy children and adolescents are already available(12). However, few studies have evaluated BP in children with SCD. This study evaluated BP in children and adolescents with SCD followed up in the Pediatric Hematology Department of Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM-Unifesp), São Paulo, Brazil, to investigate whether BP values are similar to those found among children without hemoglobinopathies and whether HT, a risk factor for stroke and pulmonary hypertension among patients with SCD, is also found in this population. Results were compared with BP values used in the literature for pediatric populations and evaluated according to the nutritional status of the patients included in this study.

 

Method

This observational descriptive study was conducted in the Outpatient Pediatric Hematology Service of EPM-Unifesp, São Paulo, Brazil, from March 2006 to July 2007. This study enrolled all patients with SCD (hemoglobinopathy HbSS and HbSC) aged three to 14 years, who were seen in the outpatient service during the study. The patients were distributed into groups according to genotype (HbSS and HbSC) and according to age: group I - three to four years and 11 months; group II - five to eight years and 11 months; and group III - nine years and 13 years and 11 months. Patients were excluded if they had hemoglobinopathy HbS β-thalassemia, were receiving treatment with corticosteroids, anti-inflammatory, anticonvulsant or antihistaminic drugs, bronchodilators, digitalis or BP lowering agents or, at the time of data collection, had a fever or a sickling crisis.

This study was approved by the Ethics in Research Committee of Unifesp under no. 0437/03. Parents or guardians received information about the study and provided written consent for participation.

BP, weight and height were measured by the same author (pediatric nephrologist) in the morning, and a specific form was used to record data. Three BP measurements were made for each patient at three different times, always by the same author, and all care was taken to minimize anxiety and fear of the procedures. Measurements were made using an aneroid sphygmomanometer (Lane, Medsafe Ltd., Cambridge, United Kingdom), acquired from OPAS and regularly calibrated, and the cuffs were size six, eight, 10 or 12 (Welch Allyn, Welch Allyn Inc, Skaneateles Falls, NY). BP measurements followed the V Brazilian Guidelines in Arterial Hypertension(12). BP values for the groups of patients were compared with BP values established in the literature and defined in the V Brazilian Guidelines in Arterial Hypertension(12). Systolic (SBP) and diastolic BP (SBP and DBP) were defined as normal when below the value of the 90th percentile for age, sex and height percentile, as long as below 120/80mmHg. The borderline value was defined as BP equal to or greater than the 90th percentile and below the 95th percentile for age, sex and height percentile; for adolescents, any value equal to or greater than 120/80mmHg was classified as borderline, even if below the 95th percentile for age, sex and height percentile. HT was defined as BP equal to or greater than the 95th percentile for age, sex and height percentile(12).

A digital platform scale (Filizola,, Filizola S.A., São Paulo, Brazil) was used to measure weight, and a wooden vertical stadiometer was used for height; the horizontal rod was adjusted to rest on the top of the head at a right angle with the vertical ruler. Anthropometric measurements were made with the patient barefooted and wearing as little clothing as possible. Anthropometric data and the nutritional status were analyzed using the Epi-Info 6.04b software, Microsoft® Excel, and the WHO Anthro 2006(13) and Anthro Plus 2007(14). The anthropometric indices used to evaluate nutritional status were weight/age (W/A), height/age (H/A) and weight/height (W/H) expressed as Z scores. Nutritional status according to BMI was classified using the growth charts issued by the World Health Organization (WHO).

Quantitative variables were described as central tendency measures and compared using the Student's t test. ANOVA was used to compare the variables between the different age groups. The level of significance was set at 5% (p<0.05) for all tests.

 

Results

This study included 70 patients (35 girls, 50%) aged three years and two months to 14 years (mean[SD] = 7.2±3.2; median = 6.1 years). Genotype was HbSS for 44 (63%) patients and HbSC for 26 (37%).

Mean (mmHg) values and standard deviations for SBP and DBP were 95.9±11.4 and 62.6±7.7. In the groups of patients with genotypes HbSS and HbSC, SBP was 97.7±10.1 and 93.0±8.4 (p=0.060) and DBP was 62.4±7.1 and 62.53±8.7 (p=0.460).

The anthropometric and nutritional status deteriorated significantly with age (Table 1). Protein-energy malnutrition (PEM) was found in five patients (7.14%), two in group I and three in group III. The risk of PEM was found in 12 (17,1%) patients, five in group I and seven in group III.

 

 

SBP, but not DBP, became significantly higher with age (Table 2).

 

 

HT was confirmed in four (5.71%) of the patients, two in group I (one HbSC and one HbSS) and two in group II (both HbSS), but there were no differences between sexes. Borderline BP was found in six (8.6%) patients, one (HbSC) in group I and five in group II (four HbSS and one HbSC); all five patients were boys. The anthropometric profile of the four patients with HT and the six with borderline BP did not differ significantly from the profile of the other patients.

SBP and DBP in the group of patients with malnutrition and risk of malnutrition were not significantly different from BP values in the group of patients with normal weight (Tables 3 and 4).

 

 

 

 

Discussion

BP increases progressively with age: SBP is below 100mmHg in children younger than six years and reaches 120/80mmHg in adulthood. Considered optimal(12), such variation may be understood as a physiological adaptation to physical development. In children, BP changes progressively with age, and studies demonstrated that, for that to occur, there must also be an increase in weight and height(15,16).

Anthropometric results in this study are similar to those found in the literature and describe that patients with SCD may have, starting at two years of age, a body growth delay that affects weight more than height and accentuates progressively up to 18 years of age(17). Mean SBP and DBP in our study are similar to those found in studies with healthy children conducted by Brandão(18), Moura et al(19), and Sarni et al(20).

Martorell et al(21) evaluated BP in children without any hemoglobinopathies and reported that those with PEM had BP lower than normal-weight children, but our study did not confirm it. The number of patients with PEM in our sample was small, which reduces analytical power. Several studies(6-10) with adults found that SCD is associated with lower BP values and lower incidence of HT than among the general population, which may be a beneficial factor, because HT is a risk factor for sickling crises, pulmonary hypertension and strokes(11).

This study found that BP was abnormal (hypertension and pre-hypertension) in 14.3% of the patients, in agreement with findings reported by Becton et al(5) in a study with 90 patients with SCD and ages ranging from two to 18 years. The detection of 5.7% of the patients with HT is also similar to findings reported in studies conducted with adults and children with SCD, as well as the values found in the Brazilian and international literature for healthy children and adolescents(4,17,19,22). In the study conducted by 10 patients (11.1%) had hypertension, and four of them also had microalbuminuria.

The identification of patients with pre-hypertension should be seen as a warning sign because there is greater risk of progressing into HT(23), which occurred in 8.6% of the cases in the sample under evaluation in our study. Becton et al(5) also found a similar percentage (6.2%), and one of their patients had microalbuminuria.

Studies with children have found an association between HT and BMI(23-25). We did not confirm such association, probably because BMI was normal and unaltered in all groups. However, other factors may explain those findings: patients with SCD have changes in plasma renin, endothelin and nitric oxide metabolites because of vaso-occlusion, and those changes affect the balance between vasodilatation and vasoconstriction, which is not seen in undernourished children(26-28).

Findings of HT in children with SCD stress the importance of measuring BP. Patients with BP above mean values are also exposed to greater risks of vaso-occlusive crises and death.

Mean SBP and DBP in our study were similar to those found in studies with healthy children without any hemoglobinopathies. The identification of abnormal BP (hypertension and pre-hypertension) in patients with SCD confirms the importance of routine BP measurements in pediatric routine. Multi-center studies should be conducted to evaluate BP in children and adolescents with SCD and detect possible causes of hypertension among these patients.

 

References

1. Cançado RD, Jesus JA. Sickle cell disease in Brazil. Rev Bras Hematol Hemoter 2007;29:204-6.         [ Links ]

2. Brasil. Agência Nacional de Vigilância Sanitária. Manual de diagnóstico e tratamento de doenças falciformes. Brasília: ANVISA; 2002.         [ Links ]

3. Magalhães IQ. Renal abnormalities in sickle cell disease. Rev Bras Hematol Hemoter 2007;29:279-84.         [ Links ]

4. Gurkan S, Scarponi KJ , Hotchkiss H , Savage B, Drachtman R. Lactate dehydrogenase as a predictor of kidney involvement in patients with sickle cell anemia. Pediatr Nephrol 2010;25:2123-7.         [ Links ]

5. Becton LJ, Kalpatthi RV, Rackoff E, Disco D, Orak JK, Jackson SM et al. Prevalence and clinical correlates of microalbuminuria in children with sickle cell disease. Pediatr Nephrol 2010;25:1505-11.         [ Links ]

6. Johnson CS. Arterial blood pressure and hypervicosity in sickle cell disease. Hematol Oncol Clin North Am 2005;19:827-37.         [ Links ]

7. Johnson CS, Giorgio AJ. Arterial blood pressure in adults with sickle cell disease. Arch Intern Med 1981;141:891-3.         [ Links ]

8. Grell GA, Alleyne GA, Serjeant GR. Blood pressure in adults with homozygous sickle cell disease. Lancet 1981;2:1166.         [ Links ]

9. Pegelow CH, Colangelo L, Steinberg M, Wright EC, Smith J, Phillips G et al. Natural history of blood pressure in sickle cell disease: risks for stroke and death associated with relative hypertension in sickle cell anemia. Am J Med 1997;102:171-7.         [ Links ]

10. Karayaylalí I, Onal M, Yíldízer K, Seyrek N, Paydas S, Akoglu E et al. Low blood pressure, decreased incidence of hypertension, and renal cardiac, and autonomic nervous system functions in patients with sickle cell syndromes. Nephron 2002;91:535-7.         [ Links ]

11. Gordeuk VR, Sachdev V, Taylor JG, Gladwin MT, Kato G, Castro OL. Relative systemic hypertension with sickle cell disease is associated with risk of pulmonary hypertension and renal insufficiency. Am J Hematol 2008;83:15-8.         [ Links ]

12. Sociedade Brasileira de Cardiologia; Sociedade Brasileira de Hipertensão; Sociedade Brasileira de Nefrologia. V Brazilian Guidelines in Arterial Hypertension. Arq Bras Cardiol 2007;89:e24-79.         [ Links ]

13. World Health Organization. WHO child growth standards: methods and development. Length/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age. Geneva: WHO; 2006.         [ Links ]

14. World Health Organization. WHO child growth standards: methods and development. Lenth/height-for-age,weight-for-age,weight-for-length,weight-for-height and body mass index-for-age. Geneva: WHO; 2007. Available from: http://www.who.int/childgrowth/standards/technical_report/en/        [ Links ]

15. Sinaiko AR, Gomez-Marin O, Prineas RJ. "Significant" diastolic hypertension in pre-high school black and white children. The children and adolescents blood pressure program. Am J Hypertens 1988;1:178-80.         [ Links ]

16. De Swiet M. The epidemiology of hypertension in children. Br Med Bull 1986;42:172-5.         [ Links ]

17. Zago MA, Kerbauy J, Souza HM, Figueiredo MS, Costa FF, Cruz SM et al. Growth and sexual maturation of Brazilian patients with sickle cell diseases. Trop Geogr Med 1992;44:317-21.         [ Links ]

18. Brandão AP. The importance of physical development in the behavior of the arterial pressure curve in children from 6 to 9. Arq Bras Cardiol 1987;48:203-9.         [ Links ]

19. Moura AA, Silva MA, Ferraz MR, Rivera IR. Prevalence of high blood pressure in children and adolescents from the city of Maceió, Brazil. J Pediatr ( Rio J) 2004;80:35-40.         [ Links ]

20. Sarni RO, Souza FI, Pitta TS, Fernandez AP, Hix S, Fonseca FA. Low birth weight: influence on blood pressure, body composition and anthropometric indexes. Arq Med ABC 2005;30:76-82.         [ Links ]

21. Martorell R, Yarbrough C, Klein RE, Lechtig A. Malnutrition, body size and skeletal maturation: interrelationships and implications for cath-up growth. Hum Biol 1979;51:371-89.         [ Links ]

22. Monego ET, Jardim PC. Determinants of risk of cardiovascular diseases in schoolchildren. Arq Bras Cardiol 2006;87:37-45.         [ Links ]

23. Chobanian AV. Prehypertension revisited. Hypertension 2006;48:812-4.         [ Links ]

24. Sorof JM, Lai D, Turner J, Poffenbarger T, Portman RJ. Overweight, ethnicity, and the prevalence of hypertension in school-aged children. Pediatrics 2004;113:475-82.         [ Links ]

25. Rosner B, Prineas R, Daniels SR, Loggie J. Blood pressure differences between blacks and whites in relation to body size among US children and adolescents. Am J Epidemiol 2000;151:1007-19.         [ Links ]

26. Hatch FE, Crowe LR, Miles DE, Young JP, Portner ME. Altered vascular reactivity in sickle hemoglobinopathy. A possible protective factor from hypertension. Am J Hypertens 1989;2:2-8.         [ Links ]

27. Hammerman SI, Kourembanas S, Conca TJ, Tucci M, Brauer M, Farber HW. Endothelin-1 production during the acute chest syndrome in sickle cell disease. Am J Respir Crit Care Med 1997;156:280-5.         [ Links ]

28. Reiter CD, Gladwin MT. An emerging role for nitric oxide in sickle cell disease vascular homeostasis and therapy. Curr Opin Hematol 2003;10:99-107.         [ Links ]

 

 

Endereço para correspondência:
Josefina Aparecida P. Braga
Rua Dr. Diogo de Faria, 307
CEP 04037-000 - São Paulo/SP
E-mail: pellegrini.braga@unifesp.br

Recebido em: 3/3/2011
Aprovado em: 20/7/2011
Conflito de interesse: nada a declarar

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