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Acta Paulista de Enfermagem

Print version ISSN 0103-2100On-line version ISSN 1982-0194

Acta paul. enferm. vol.31 no.3 São Paulo May/June 2018

http://dx.doi.org/10.1590/1982-0194201800042 

Original Article

Factors associated with non-compliance with antiretrovirals in HIV/AIDS patients

Elielza Guerreiro Menezes1 
http://orcid.org/0000-0003-1804-6384

Simone Rodrigues Fernandes dos Santos1 

Giane Zupellari dos Santos Melo1 

Gisele Torrente1 

Arlene dos Santos Pinto2 

Yara Nayá Lopes de Andrade Goiabeira3 

1Universidade do Estado do Amazonas, Manaus, AM, Brazil.

2Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, AM, Brazil.

3Universidade Federal do Maranhão, São Luís, MA, Brazil.

Abstract

Objective

To identify the factors associated to non-compliance with antiretroviral treatment in HIV / AIDS patients at a reference hospital in Manaus.

Methods

Hospital-based, quantitative, cross-sectional study developed with 100 participants with HIV / AIDS in outpatient follow-up. For the data collection, the self-administered “Questionnaire for the evaluation of compliance with antiretroviral treatment in people with HIV / AIDS” (CEAT-VIH) was used. Descriptive analysis was performed using the Pearson chi-square to obtain the p-value.

Results

Male participants were predominant (57%), age between 40 and 59 years (34%), secondary education (49%), without employment bond (84%), monthly income of one to three minimum wages (54% ), unmarried (47%), heterosexual (76%), with sexual partner (56%), without active sexual life (61%), time since diagnosis between six months and five years (59%), no hospitalization (%). The predominant level of compliance was medium compliance (85%). The sociodemographic variables that revealed a statistically significant association with ARVT were sexual orientation (p = 0.010) and time since diagnosis (p = 0.035).

Conclusion

The study showed that people living with HIV comply with ARVT, but with medium compliance. The main factors associated with this result were sexual orientation and time since diagnosis.

Key words: Antiviral therapy; HIV; Acquired immunodeficiency syndrome; Medication adherence; Patient compliance

Introduction

First described in 1981, the Human Immunodeficiency Syndrome went through several demographic and epidemiological changes.(1)

With the discovery of new drugs in recent years, advances have been achieved in the fight against HIV. This fact had an impact on the prognosis and epidemiology of the disease, causing a significant decrease in morbidity and mortality in people living with the virus in Brazil and around the world, but these drugs present new challenges to understand and cope with this disease.(2,3)

Despite these changes in the HIV / AIDS profile, the number of HIV-positive people is still high. According to UNAIDS - Joint United Nations Program on HIV / AIDS, controlling the disease will only be possible when all those infected are being treated. Therefore, the goal “90-90-90” was established, which aims to ensure that all infected people are treated by 2020, that 90% of people living with HIV know they have the virus, 90% receive ARVT - Antiretroviral Therapy and 90% of these have viral suppression.(4)

Treatment compliance being one of the greatest challenges in care for people living with HIV, it is one of the key pieces to reduce future complications and to improve and prolong the quality of life of individuals affected by the virus. The correct use of the antiretrovirals generates a reduction of costs with future hospitalizations due to complications of the infection, as well as of the necessity to exchange the drug for other more complex and expensive medicines.(5)

In order to achieve good rehabilitation and stability of the patient affected by HIV / AIDS, good treatment compliance is fundamental. In this sense, a universal treatment access policy is put in practice with studies on the identification of factors that lead to the interruption of drug therapy, being highly relevant for a better understanding of the problem and for the appropriate performance of health professionals, favoring a higher quality and life expectancy for these people.(6)

In this context, the objective of this study was to identify factors associated to non-compliance with antiretroviral treatment in HIV / AIDS patients at a reference hospital in Manaus.

Methods

This is a quantitative, cross-sectional, hospital-based study conducted at the Outpatient Clinic of the Foundation for Tropical Medicine Dr. Heitor Vieira Dourado. Data collection took place from October 2017 to January 2018. Participants were included in the study during the routine outpatient visit. The interviews were conducted inside the doctor’s office, permitting the secrecy and confidentiality of the information obtained.

The sample was consecutive and non-probabilistic, in accordance with the inclusion criteria: male and female patients, aged 18 years or older; patients diagnosed with HIV for more than six months; being registered in the institution’s UDM-Medication Dispensation Unit; being on antiretroviral therapy for at least six months in the I Doctor system. According to these criteria, 100 participants were included in the study.

The self-administered “Questionnaire for the evaluation of compliance with antiretroviral treatment in people with HIV / AIDS” (CEAT/VIH) was used to collect the data, which was validated for the Brazilian version by Remor, Milner-Moskovics and Preussler.(7) This questionnaire was used to assess the compliance level to antiretroviral treatment. It is multidimensional, covering the main factors that can modulate the treatment compliance behavior.(7) Consisting of 20 questions, CEAT-VIH evaluates the patients’ compliance level to ARVT at three levels: low (d” 52 points or <50%); medium (53 to 78 points or 50 to 84%); and high (e” 79 points or> 85%). The minimum score is 17 and the maximum is 89. The higher the score, the higher the treatment compliance level.(7)

The sociodemographic data related to the patients were obtained through the application of a semistructured questionnaire, prepared by the researcher.

The collected data were organized and systemized in an Excel® spreadsheet and analyzed in Statistical Package for Social Sciences (SPSS), version 2.0.

Descriptive statistics were used for sociodemographic characterization and descriptions of the domain scores. The variables were expressed in absolute and relative frequencies, independent of the measuring level. For the analysis, chi-square tests were performed, inferential analyses with p <0.05 being considered statistically significant.

The development of the study met Brazilian standards of ethics for research involving human subjects and obtained approval from the research ethics committee under CAEE 74054217.4.0000.5016.

Results

In this study, 100 participants answered the questionnaire regarding the sociodemographic data and compliance with ARVT. First, the variables related to the sociodemographic aspects were analyzed, in which the male sex predominated (57%). The predominant age group was between 40 and 59 years old (34%), with secondary education (49%). With regard to employment status, 84% reported being unemployed, with monthly income of one to three minimum wages (54%). The majority of them reported being self-employed, single (47%). The predominant sexual orientation was heterosexual (76%), with a sexual partner (56%), no active sex life (61%), time since diagnosis between six months and five years (59%). The predominant hospitalization was none (59%) during the antiretroviral treatment of HIV patients attended during the study (Table 1).

Table 1 Distribution of sociodemographic data of the 100 participants in the study population 

Variables n(%)
Sex
Male 57(57.0)
Female 43(43.0)
Age Range
18 to 29 years 10(10.0)
30 to 39 years 28(28.0)
40 to 59 years 34(34.0)
50 to 59 years 14(14.0)
>60 years 14(14.0)
Education
Illiterate 2(2.0)
Primary 35(35.0)
Secondary 49(49.0)
Higher 14(14.0)
Employment
Yes 16(16.0)
No 84(84.0)
Monthly income
< 1 minimum wage 42(42.0)
1 to 3 minimum wages 54(54.0)
3 to 5 minimum wages 3(3.0)
> 5 minimum wages 1(1.0)
Marital Status
Single 47(47.0)
Married 11(11.0)
Living with Fixed Partner 33(33.0)
Separated 4(4.0)
Divorced 1(1.0)
Widowed 4(4.0)
Sexual orientation
Homosexual 18(18.0)
Bisexual 6(6.0)
Heterosexual 76(76.0)
Has a sexual partner
Yes 56(56.0)
No 44(44.0)
Active sexual life
Yes 39(39.0)
No 61(61.0)
Time since diagnosis
6 months to 5 years 59(59.0)
6 years to 10 years 28(28.0)
11 to 15 years 7(7.0)
16 to 20 years 6(6.0)
Hospitalization antecedents
None 59(59.0)
1 to 3 times 35(35.0)
3 to 5 times 2(2.0)
> 5 times 4(4.0)

Among the 100 interviewees, 85% were classified as medium compliance, 13% as high and only 2% as low compliance according to their answers and the total CEAT/HIV score. The minimum score in the study was 47 and the maximum 82, with an average score of 70.63 and a standard deviation of 7.67 (Table 2).

Table 2 Classification of antiretroviral treatment compliance data 

Compliance levels* n(%)
Low 2(2.0)
Medium 85(85.0)
High 13(13.0)

*Levels defined according to classification of compliance with antiretroviral therapy of the version of the “cuestionario para la Evaluación de la Adhesión al tratamiento antirretroviral – CEAT/HIV” validated for Brazilian Portuguese

A statistically significant association was observed between two sociodemographic variables and the compliance levels with ARVT: sexual orientation (p=0.010) and time since diagnosis (p=0.035).

When the variables sex, age range, education, employment, monthly income, sexual partner, active sexual life and hospitalization antecedents were considered, no statistically significant association was observed (Table 3).

Table 3 Distribution of sociodemographic data and Compliance Level with Antiretroviral Therapy 

Variables High compliance n(%) Medium compliance n(%) Low compliance n(%) Total n(%) p-value*
Sex
Male 9(16) 46(80) 2(4) 57(100) 0.274
Female 4(9) 39(91) 0(0) 43(100)
Age Range
18 to 29 years 1(10) 9(90) 0(0) 10(100) 0.438
30 to 39 years 3(11) 23(82) 2(7) 28(100)
40 to 59 years 7(20) 27(80) 0(0) 34(100)
50 to 59 years 1(7) 13(93) 0(0) 14(100)
>60 years 1(7) 13(93) 0(0) 14(100)
Education
Illiterate 0(0) 2(100) 0(0) 2(100) 0.622
Primary 3(9) 31(88) 1(3) 35(100)
Secondary 8(16) 41(84) 0(0) 49(100)
Higher 2(14) 11(79) 1(7) 14(100)
Employment
Yes 2(12) 14(88) 0(0) 16(100) 0.819
No 11(13) 71(85) 2(2) 84(100)
Monthly income
< 1 minimum wage 2(5) 39(93) 1(2) 42(100) 0.443
1 to 3 minimum wages 11(20) 42(78) 1(2) 54(100)
3 to 5 minimum wages 0(0) 3(100) 0(0) 3(100)
> 5 minimum wages 0(0) 1(100) 0(0) 1(100)
Marital Status
Single 7(15) 39(83) 1(2) 47(100) 0.735
Married 1(9) 10(11.8) 0(0) 11(100)
Living with Fixed Partner 3(9) 29(88) 1(3) 33(100)
Separated 0(0) 4(100) 0(0) 4(100)
Divorced 0(0) 1(100) 0(00 1(100)
Widowed 2(50) 2(50) 0(0) 4(100)
Sexual orientation
Homosexual 6(33) 11(61) 1(6) 18(100) 0.010
Bisexual 2(33) 4(67) 0(0) 6(100)
Heterosexual 5(6) 70(92) 1(2) 76(100)
Has a sexual partner
Yes 6(46.2) 49(57.6) 1(50.0) 56(100) 0.728
No 7(53.8) 36(42.4) 1(50.0) 44(100)
Active sexual life
Yes 6(15) 32(82) 1(3) 39(100) 0.800
No 7(11) 53(87) 1(2) 61(100)
Time since diagnosis
6 months to 5 years 6(10) 52(88) 1(2) 59(100) 0.035
6 years to 10 years 3(11) 25(89) 0(0) 28(100)
11 to 15 years 3(43) 4(57) 0(0) 7(100)
16 to 20 years 1(17) 4(66) 1(17) 6(100)
Hospitalization antecedents
None 6(10) 52(88) 1(2) 59(100) 0.781
1 to 3 times 7(20) 27(77) 1(3) 35(100)
3 to 5 times 0(0) 2(100) 0(0) 2(100)
> 5 times 0(0) 4(100) 0(0) 4(100)

*p-values calculated by means of Pearson’s chi-square test, comparing the compliance level with each variable

Discussion

The precariousness of research on this topic in the North of Brazil is noted, where the mortality due to AIDS showed the highest growth rate in the past 10 years.(8)

The participants’ sociodemographic characteristics confirm the profile of seropositive individuals in Brazil, with a predominance of males, between 40 and 59 years of age, secondary education level (high school), monthly income between one and three minimum wages, single and heterosexual, with sexual partner, but without active sex life.

Studies conducted in other regions indicated that 60% of infected individuals were male and 58.7% were between 40 and 59 years old.(9) Studies conducted outside Brazil found that female individuals were predominant though.(10)

In another study, results similar to the present study were found, with a predominance of secondary education and monthly income between 1 and 3 minimum wages.(11)

Studies show that, the higher the level of education, the better the people’s perception, as well as the access to information about HIV / AIDS.(3) In this sense, the expected result regarding the education level was lower than that obtained, as in some studies where low education prevailed.(1) As noticed, the result of this study proves how the HIV profile in Brazil has been changing over time.

The results of this study corroborate those of other authors, where single individuals prevailed.(12) Studies have shown that single people have a lower chance of using condoms than married couples.(4) This may influence the increase of infection and transmission risks. They are more promiscuous and less careful about their health because they have to take care of themselves alone.(14)

In 2016, HIV / AIDS infection was predominant among heterosexuals in almost all regions of Brazil, except for the Southeast, where the infection was predominant among homosexuals.(15) These data further affirm the change in the profile of HIV / AIDS, which in the early phase of the disease prevailed among homosexuals.(12)

With regard to the employment bond, we can note some studies with results different from those found in this study, with a prevalence of people living with the virus and being formally employed.(9)

It is observed that most had sexual partners but did not have an active sexual life. Some participants reported having lost sexual pleasure after discovering the virus. In a study conducted in another region, people living with HIV reported restricting or suppressing their sexual practices because they had to reveal their HIV-positive status and were afraid of transmitting the disease, but they kept their sex life active,(16) which did not occur with the participants of this study, as sexual inactivity prevailed.

Regarding the time since diagnosis from six months to five years, our results differed from studies conducted in other regions, where the patients had been living with HIV ≥ 10 years.(9) Few studies are related to the time since diagnosis though, as most of them study the treatment time.

Regarding the hospitalization history, the results showed that no hospitalization prevailed in the study participants. No studies were found in the literature regarding this variable.

There were limitations in this study due to the short time of data collection. Because the data collection was performed in only one clinic and in a state with a high number of seropositives, the study population is considered small.

This study offers an important contribution in presenting the factors associated with non-compliance to ARVT and in measuring the level of compliance of seropositive individuals, making it possible to outline strategies to decrease these factors and to improve compliance with drug therapy.

Concerning the level of compliance with ARVT in the participants with a prevalence of medium compliance, similar results were also found using the same CEAT-HIV assessment tool, which is considered the most specific to assess the compliance level, despite its limitations.(17)

This result is worrisome as virologic failure can occur, making the viral load detectable during the treatment, representing a barrier to the success of the therapy, which can entail risks of disease progression, viral resistance and, consequently, the reduction of future therapies.(11)

For the sake of effective therapy, the patient needs to consume at least 95% of the prescribed medications, in order to keep the viral load undetectable and be able to reasonably reduce the possibility of virus transmission. Thus, the effectiveness of the ARVT depends on the compliance.(8)

On the other hand, other studies carried out in other parts of Brazil showed quite different results, where high compliance levels prevailed. This can be explained by lifestyle variation, access to quality treatment and early diagnosis.(9)

Because AIDS is classified as a chronic disease, we cannot judge this level of compliance as definitive because it can vary at any time during therapy. Therefore, it is important for health professionals to encourage compliance.(11)

Among the variables studied, those associated with ARVT compliance are sexual orientation, where studies with similar results were found in which sexual orientation was statistically significant.(18)

The other variable that presented statistical significance was the time since diagnosis. Some studies argue that, the longer the diagnosis, the better the compliance,(9) but the result of this study did not prove this, in view of variations in the results.

Conclusion

The study showed that people with HIV complied with antiretroviral therapy, but with medium compliance, and the main factors associated with this result were sexual orientation and time since diagnosis. This result is worrying, which may be related to the increase in the transmissibility of the disease and the increase in the number of HIV cases in the state of Amazonas. In this sense, it suggests the follow-up of ARVT compliance in people living with the virus. Assuming that compliance is a continuous process involving not only the seropositive individuals, but also the family and health professionals, the active search of people who dropped out of the treatment is of utmost importance because they did not even enter the research as they were not monitored at the place of study.

Acknowledgements

Acknowledgements to the Foundation for Tropical Medicine; to the State University of Amazonas; and to Mr. Raimundo Jefferson Soares dos Santos.

REFERENCES

1. Medeiros ARC, Lima RLFC, Medeiros LB, Moraes RM, Vianna RPT. Análise de sobrevida de pessoas vivendo com HIV/AIDS. Rev Enferm UFPE Online, 2017; 11(1):47-56. [ Links ]

2. Sousa AI, Pinto VL. Carga viral comunitária do HIV no Brasil, 2007 - 2011: potencial impacto da terapia antirretroviral (HAART) na redução de novas infecções. Rev Bras Epidemiol. 2016;19(3):582–93. [ Links ]

3. Galvão MT, Soares LL, Pedrosa SC, Fiuza ML, Lemos LA. Fiuza ML, et al. Qualidade de vida e adesão à medicação antirretroviral em pessoas com HIV. Acta Paul Enferm. 2015;28(1):48–53. [ Links ]

4. Silva RA, Castro RR, Pereira IR, Oliveira SS. Questionário para avaliação das ações de controle do HIV/Aids na Atenção Básica. Acta Paul Enferm. 2017;30(3):271–9. [ Links ]

5. Bandeira D, Weiller TH, Damaceno AN, Cancian NR, Santos GS, Beck ST. Adesão ao tratamento antirretroviral: uma intervenção multiprofissional. Rev Enferm Centro Oeste Min. 2016;6(3):2446–53. [ Links ]

6. Silva RA, Nelson AR, Duarte FH, Prado NC, Holanda JR, Costa DA. Avaliação da adesão à terapia antirretroviral em pacientes com Aids. Rev Fund Care Online. 2017;9(1):15–20. [ Links ]

7. Remor E, Milner-Moskovics J, Preussler G. Adaptação brasileira do “Cuestionario para la Evaluación de la Adhesión al Tratamiento Antiretroviral”. Rev Saude Publica. 2007;41(5):685–94. [ Links ]

8. Garbin CA, Gatto RC, Garbin AJ. Adesão à Terapia antirretroviral em pacientes HIV soropositivos no Brasil: uma revisão de literatura. Arch Health Invest. 2017;6(2):65–70. [ Links ]

9. Foresto JS, Melo ES, Costa CR, Antonini M, Gir E, Reis RK. Adesão à terapêutica antirretroviral de pessoas vivendo com HIV/aids em um município do interior paulista. Rev Gaúcha Enferm. 2017;38(1):e63158. [ Links ]

10. Remor KV, Ogliari LC, Sakae TM, Galato D. Adesão aos antirretrovirais em pessoas com HIV na grande Florianópolis. Arq Catarin Med. 2017;46(2):53–64. [ Links ]

11. Jacques IJ, Santana JM, Moraes DC, Souza AF, Abrão FM, Oliveira RC. Avaliação da adesão a terapia antirretroviral entre pacientes em atendimento ambulatorial. Rev Bras Ciênc Saúde. 2015; 18(4):303-8. [ Links ]

12. Moura JP, Faria MR. Caracterização e perfil epidemiológico das pessoas que vivem com HIV. Rev Enferm UFPE Online, 2017; 11(12): 5214-20. [ Links ]

13. Silva WS, Oliveira FJ, Serra MA, Rosa CR, Ferreira AG. Fatores associados ao uso de preservativo em pessoas vivendo com HIV/AIDS. Acta Paul Enferm. 2015;28(6):587–92. [ Links ]

14. Ferreira TC, Souza AP, Júnior RS. Perfil clínico e epidemiológico dos portadores do HIV/AIDS com coinfecção de uma unidade de referência especializada em doenças infecciosas parasitárias especiais. Rev Univ Vale Rio Verde. 2015;13(1):419–31. [ Links ]

15. Brasil. Ministério da Saúde (MS). Secretaria de Vigilância em Saúde. Boletim Epidemiológico de HIV/AIDS. 2017; vol. 20. [ Links ]

16. Carvalho PM, Anchiêta LS, Queiroz MM, Aragão AO, Nichiata LY. Sexualidade de pessoas vivendo com HIV/Aids. Rev Interdisciplinar. 2013;6(3):81–8. [ Links ]

17. Moraes DC, Oliveira RC, Costa SF. Adesão de homens vivendo com HIV/Aids ao tratamento antiretroviral. Esc Anna Nery. 2014;18(4):676–81. [ Links ]

18. Lemos LA, Fiuza ML, Reis RK, Ferrer AC, Gir E, Galvão MT. Adesão aos antirretrovirais em pessoas com coinfecção pelo virus da imunodeficiência humana e tuberculose. Rev Lat Am Enfermagem. 2016;24:e2691. [ Links ]

Received: April 6, 2018; Accepted: May 28, 2018

Corresponding author. Elielza Guerreiro Menezes. http://orcid.org/0000-0003-1804-6384. E-mail: egmenezes@uea.edu.br

Conflicts of interest: none to declare

Collaborations

Menezes EG contributed to the project design and to the analysis and interpretation of the data. Santos SRF contributed to the project design and to the analysis and interpretation of the data. Melo GZS contributed to the relevant critical review of the intellectual content. Torrente G collaborated with the relevant critical review of the intellectual content. Pinto AS collaborated with the data collection and execution of the research. Andrade YNL cooperated with the writing of the article and with the relevant critical review of the intellectual content. Both approved the final version for publication.

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