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On-line version ISSN 1678-4790
J. Braz. Chem. Soc. vol.16 no.6a São Paulo Nov./Dec. 2005
Ana N. F. Mendes; José R. Gregório; Ricardo G. da Rosa*
Instituto de Química, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 9500, 91501-970 Porto Alegre - RS, Brazil
Hydroformylation experiments were performed with technical-grade methyl oleate (MO) and soybean oil (SO) using [RhH(CO)(PPh3)3] and [RhCl3.3H2O] (double bond/Rh = 745) as catalyst precursors modified or not by triphenylphosphine. [RhH(CO)(PPh3)3] shows 100% conversion and 80-91% selectivity to aldehydes in only 4h for both substrates under mild conditions (100 °C, 40 bar, CO/H2 = 2:1, ligand/Rh = 10:1). Despite the rapid isomerisation of the soybean oil, producing trans isomers and conjugated dienes, no effects were observed on its further conversion to aldehydes. The reaction of soybean oil conducted with pure [RhCl3.3H2O] produced only conjugated dienes, and when this precursor was modified with triphenylphosphine (ligand/Rh = 10:1) no reaction was observed at all. Curiously, yellow crystals corresponding to the complex [Rh(Cl)(CO)(PPh3)2] were quantitatively isolated at the end of the reaction .
Keywords: soybean oil, methyl oleate, hydroformylation, rhodium
Reações de hidroformilação foram realizadas com oleato de metila grau técnico e óleo de soja usando [RhH(CO)(PPh3)3] e [RhCl3.3H2O] (ligação dupla/Rh = 745) como precursores catalíticos, modificados ou não por trifenilfosfina. O complexo [RhH(CO)(PPh3)3] levou a 100% de conversão e 80-91% de produtos hidroformilados em 4 h para ambos substratos, sob condições reacionais brandas (100 ºC, 40 bar, CO/H2 = 2:1, ligante/Rh = 10:1). Verificou-se a rápida isomerização do óleo de soja, produzindo isomeros trans e dienos conjugados, porém sem prejuízo à hidroformilação. A reação do óleo de soja com [RhCl3.3H2O] puro, produz somente dienos conjugados, mas quando esse precursor foi modificado com trifenilfosfina (ligante/Rh = 10:1), nenhuma reação foi observada. Curiosamente, cristais amarelos correspondente ao complexo [Rh(Cl)(CO)(PPh3)2] foram quantitativamente isolados ao final da reação.
World demand for ecologically correct and biodegradable products is on the rise. This motivates researchers to accomplish their work using vegetable oils and their derivatives in the synthesis of materials where they had once relied on petrochemical sources.1,2
The hydroformylation reaction, commonly known as the oxo process, is a useful way to chemically modify fatty acid esters and vegetable oils, thereby increasing their economic value. Moreover, the aldehydes produced are excellent raw materials which can be used in the formation of a plethora of compounds with applications in many areas such as lubricants, plasticizers, urethanes, and coatings.3,4 Hydroformylation can also be accomplished in the presence of many other functional groups like esters, amides, nitriles etc. and occurs with 100% atom economy.5,6 In the literature there are several works on the hydroformylation of unsaturated fatty esters and vegetable oils using mainly rhodium catalysts. Frankel7 reported a highly selective rhodium system for the hydroformylation of methyl oleate (MO) into methyl 9(10)-formylstearate, at 95-110 °C with a 1:1 mixture of H2 and CO at 500 to 2000 psi (34.5 to 137.9 bar) with or without solvent. The rhodium catalyst, (5% Rh supported on carbon, CaCO3 or Al2O3) in the presence of triphenylphosphine and under hydroformylation conditions, provided 90-99% conversion to hydroformylated products. The same author reported the hydroformylation of methyl linoleate and methyl linolenate with a rhodium catalyst (5% Rh supported on Al2O3) in the presence of triphenylphosphine. The reactions yielded 1,4-diformyl esters as major products and 1,3-diformyl esters as minor products. Unsaturated and saturated monoformyl esters were also produced from both substrates as well as triformyl esters from methyl linolenate.8
Muilwijk et al.3 reported a series of hydroformylation experiments performed with high-grade and technical-grade MO and a rhodium catalyst modified by the bulky tris(2-tert-butyl-4-methylphenyl)phosphite. Under reaction conditions where MO/Rh = 910, T = 80-100 ºC, P = 20 bar, CO/H2 = 1:1, with toluene as solvent, 95% conversion of pure MO was observed in 3h. The authors also noticed fast isomerization of the substrate to an olefin with a trans configuration that reacts slower than the original cis oleate. The use of technical-grade MO (containing 14% of methyl linoleate, ML) results in lower reaction rates because dienes form stable p-allylic intermediates. More drastic conditions were required to obtain higher rates in the hydroformylation of technical-grade MO (MO/Rh = 910, T = 50-120ºC, P = 50-80 bar, CO/H2 = 1:1-1:6, toluene as solvent). Several ML isomers were also formed during the reaction. The hydroformylation of these isomers resulted in a complex mixture of products, in particular methyl formylstearates, methyl formyloleates and methyl diformylstearates.
In 2002, Kandanarachchi et al. reported the hydroformylation of vegetable oils (soybean, safflower, high oleic safflower and linseed) using [Rh(CO)2(acac)] as catalyst precursor in the presence of PPh3 or P(OPh)3.9 In this work, the authors observed a rhodium p-allyl complex formed from the catalyst and the diene (methyl linoleate), but they did not observe any significant effects of its formation on the reaction rate for vegetable oils.
First synthesized by Vaska in 196310 and used five years later as catalyst in a hydroformylation reaction by Wilkinson,11 the complex [RhH(CO)(PPh3)3] is one of the most active and studied precursors for the conversion of a-olefins into aldehydes.12-15 However, to the best of our knowledge no systematic study on the hydroformylation of internal olefins such as fatty esters has been done before.
As catalytic and stoichiometric transformations of vegetable oils are the main aims of our laboratory,16-18 we decided to investigate the hydroformylation of technical-grade methyl oleate and soybean oil with the complex [RhH(CO)(PPh3)3].
Initially, we describe the [RhH(CO)(PPh3)3] catalyzed hydroformylation of MO as a model for the subsequent hydroformylation of soybean oil (SO). We report on the effects of: reaction time, the presence of PPh3 as a modifier ligand and the CO/H2 ratio. In addition, this Rh(I) preformed complex is compared with those generated in situ from [RhCl3.3H2O] and CO/H2, modified or unmodified by PPh3. Concerning the substrates, both present similar reactivity for hydroformylation. However, [RhH(CO)(PPh3)3] and [RhCl3.3H2O] show a remarkably different catalytic performance.
[RhCl3.3H2O] was purchased from Pressure Chemical and used as received. [RhH(CO)(PPh3)3] was prepared according to a procedure described in the literature.19 Methyl Oleate (ACROS Organics, technical-grade, containing ca. 7.5% of methyl linoleate) and Soybean Oil (Bunge) were used after filtration on neutral alumina to remove impurities, such as peroxides. Triphenylphosphine (PPh3, 99%) was purchased from Alpha and used as received. The gases H2 (AGA, 99.999%) and CO (Air Products, 99%) were used as received.
1H and 13C Nuclear Magnetic Resonance (NMR) spectra were obtained using a Varian VXR-200 200 MHz instrument. Chemical shifts were reported in ppm (d) relative to tetramethylsilane (TMS), using CDCl3 as internal standard. FT-IR measurements were taken from thin films of liquid samples using NaCl windows in a Mattson-3020 FT-IR spectrometer. The appearance of a band at 2694 cm-1 indicates the presence of an aldehydic hydrogen.8
The reactions were carried out in a glass-lined and magnetically stirred stainless-steel mini-reactor (100 mL) without solvent. In a typical reaction a mixture of 0.0218g (0.0238 mmol) of [RhH(CO)(PPh3)3], 4.6768 g (17.7 mmol of double bonds) of technical-grade methyl oleate (or 3.3024 g, 17.7 mmol of double bonds, of soybean oil) and 0.0419 g (0.16 mmol) of PPh3, were charged into the reactor and sealed in. The sealed reactor was purged three times with hydrogen, pressurized with CO and H2 (40 bar, CO/H2 = 2), and then heated in an oil bath with controlled temperature (100 ºC). At the end of the reaction time the mixture was cooled to room temperature and filtered on silica gel using dichloromethane as eluent. The samples were analyzed by 1H NMR, 13C NMR and FT-IR.
The conversion and selectivity of the hydroformylation of soybean oil or methyl oleate samples were determined by 1H NMR. The calculations are presented below using Figures 1-2 as examples.
Determination of double bond number (DBN) for technical-grade methyl oleate
The hydrogen signals were attributed according to the literature.20 This attribution is shown in Figure 1.
We chose the signal corresponding to the methoxy group (d 3.6 ) as the internal standard. So 1/3 of its area was related to one hydrogen area which was taken as a normalization factor (NF) in all further calculations. As A corresponds to the area of the olefinic hydrogens the double bond number is given by equation 1.
Applying this equation, the initial DBN value for the technical-grade MO is 1.12.
Determination of double bond number (DBN) for soybean oil
The hydrogen signals were attributed according to the literature.20 This attribution is shown in Figure 2.
For SO double bond number calculations, the signals corresponding to the terminal hydrogens of glycerol (4.1-4.3 ppm) were taken as the internal standard. Therefore, the area value related to one hydrogen is 1/4 of the area integrated below these signals, which will be taken as a normalization factor (NF) in further calculations. According to Miyake, A refers to the area of the two olefinic hydrogens plus the internal hydrogen of glycerol. This gives us equation 2 for the calculation of the double bond number for SO.
This equation is also applied in the calculation of DBN after the hydroformylation procedure. The initial DBN value calculated for the SO is 4.1.
To calculate the conversion for both substrates it is just necessary to know the relative amount of double bonds that disappeared:
where DBNi is the initial double bond number and DBNf is the final double bond number.
For the calculation of selectivity in hydroformylation we need to correlate the normalized area of the aldehydic hydrogen (J, at d 9.5) with respect to the double bonds consumed as stated by equation (4). In the case of selectivity in isomerisation, evaluated in terms of double bond conjugation and quantified by the integration of the signals M at d 5.5 - 6.4,21 the same equation (4) is applied replacing J by M.
Results and Discussion
Attempting to perform the reactions under mild conditions, we decided to start using 20 bar of total pressure (CO/H2 = 1) for both substrates. However, this resulted in very poor reproductibility that should be related to kinetic and/or diffusion problems. Increasing the total pressure to 40 bar we then had excellent reproductibility considering the typical error of an NMR experiment (ca. 10%). This observation confirms our assumption about the importance of the diffusion effects. The results of the hydroformylation of methyl oleate with [RhH(CO)(PPh3)3] are presented in Table 1. All entries in Table 1 are presented as average values for at least two reactions. In all cases the only products observed were those arisen from hydroformylation and hydrogenation.
Effect of reaction time and addition of triphenylphosphine
Analyzing the results of Table 1, we see that for 24h of reaction time (entry 1) 100% of conversion is attained along with 55% selectivity for hydroformylation. For 6h of reaction time (entry 2) the conversion drops to 69% but the selectivity remains almost the same. Upon addition of an excess of PPh3 (PPh3/Rh = 10, entry 3) the activity of the catalytic system rises 4 times (see TOF numbers) with respect to entry 1 but maintains the same selectivity. This means that phosphine plays an important role in the stabilization of the same active species initially generated from the catalyst precursor.
Effect of CO/H2 ratio
A twofold excess of CO over H2 was used to reduce the hydrogenation. Comparing entry 4 to entry 1, no effect can be observed either on conversion or on selectivity. On the other hand, comparing entry 5 to entry 2 we find a significant change in the conversion rate, but the selectivity is still not affected. The combined effects of an excess of CO and phosphine led to the best results (entries 6 and 7) in terms of conversion and selectivity to hydroformylation.
Those results allow us to define the model conditions for the hydroformylation of MO as 40 bar, CO/H2 = 2, 100 ºC, PPh3/Rh = 10 and t = 6h. The results for the hydroformylation of a real sample of soybean oil applying these conditions are summarized in Table 2. Besides hydroformylated and isomerized soybean oil, the only other product observed was hydrogenated SO.
The optimized conditions for MO, when applied to SO, gave the same quantitative results (entry 1) supporting our assumption that the former would behave well as a model molecule.
In order to check out the catalytic activity, the reaction time was reduced from 6h to 4h and 2h (entries 2 and 3, respectively). With a 4h reaction time same performance as in 6h was attained, although with a 2h reaction time conversion and selectivity of the hydroformylation dropped. It is interesting to note that when conversion was not complete we observed double bond isomerisation, as noticed by Larock,21 confirming that it occurs faster than hydroformylation. The isomerisations, which mean double bond conjugation, could represent a problem for the catalytic activity because conjugated dienes in the presence of transition metal hydrides should form very stable p-allylic complexes.3,9,22 The results presented in Table 2 (entries 1-3) show that this is not the case, since the conjugated products are readily converted to aldehydes. Also, the similar performance shown by the catalytic system in the presence of the monoinsaturated MO and the polyinsaturated SO may be taken as another piece of evidence demonstrating the aptitude of the rhodium allylic intermediates as active species for the hydroformylation. Triphenylphosphine excess had no effect on conversion (entries 2 and 4-6). An attempt to perform the reaction starting from pure [RhCl3.3H2O] as catalyst (entry 7) led to only double bond conjugation and very low conversion. No catalytically active species are formed from [RhCl3.3H2O] in the presence of PPh3 (entry 8), since no reaction was observed. Instead, yellow crystals characterized by FT-IR23 and showing the same spectrum of the complex [Rh(Cl)(CO)(PPh3)2] were quantitatively isolated at the end of reaction time. Entry 9 proves the unexpected inertness of [Rh(Cl)(CO)(PPh3)2] as a catalyst precursor, with very low conversion.24
Entries 10 and 11 were run in order to prove that conjugated SO is also an active substrate for the hydroformylation reaction. We performed the reactions under the same conditions as in reactions 2-3, starting with SO previously conjugated with [RhCl3.3H2O] (entry 7). As expected, considering the NMR error, conjugated SO is as suitable as ordinary SO for hydroformylation, thus proving that the allyl-rhodium intermediates probably formed do not affect the catalytic activity.
[RhH(CO)(PPh3)3] proved to be a suitable catalyst for the hydroformylation of MO and SO. We have been able to achieve very good results in 4h, obtaining almost totally hydroformylated oils. The use of an excess of PPh3 over Rh (10:1) and CO over H2 (2:1) simultaneously proved to increase both conversion and selectivity. However, individually neither PPh3 nor CO in excess has any significant effect on catalysis. [RhCl3.3H2O] does not catalyze hydroformylation although it causes some double bond isomerisation (conjugation). In the presence of CO, H2 and PPh3, [RhCl3.3H2O] quantitatively forms inactive [Rh(Cl)(CO)(PPh3)2] instead of the catalytic active species. Conjugation of the double bonds of SO occurs during the reaction, but does not affect either reaction rate or selectivity.
A. N. F. Mendes thanks CAPES-Brazil for a fellowship.
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Received: November 6, 2004
Published on the web: September 15, 2005