Services on Demand
- Cited by SciELO
- Access statistics
- Cited by Google
- Similars in SciELO
- Similars in Google
Print version ISSN 0103-5053
J. Braz. Chem. Soc. vol.21 no.5 São Paulo 2010
1,3-thiazolium-5-thiolates mesoionic compounds: semiempirical evaluation of their first static hyperpolarizabilities and synthesis of new examples
IDepartamento de Química, Universidade Federal da Paraíba, 58059-900 João Pessoa-PB, Brazil
IILaboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, CP 5009, 58051-970 João Pessoa-PB, Brazil
IIIDepartamento de Química Fundamental, Universidade Federal de Pernambuco, 50670-901 Recife-PE, Brazil
IVDepartamento de Química, Universidade Federal de Santa Maria, 97105-900 Santa Maria-RS, Brazil
Semiempirical AM1-TDHF calculations of the static first hyperpolarizabilities, β(0), of 1,3-thiazolium-5-thiolate mesoionic derivatives were performed. Guided by these results, two new mesoionic compounds - 2-(4-nitrophenyl)-3-methyl-4-(methylphenyl)-1,3-thiazolium-5-thiolate and 2-(4-nitrophenyl)-3-methyl-4-(methoxyphenyl)-1,3-thiazolium-5-thiolate - were synthesized and characterized by analytical and spectroscopic means.
Keywords: mesoionic compounds, 1,3-thiazolium-5-thiolate, nonlinear optical properties, semiempirical calculations, photonic devices
Cálculos semi-empíricos do tipo AM1-TDHF para a primeira hiperpolarizabilidade estática, β(0), de dezesseis compostos mesoiônicos do sistema 1,3-tiazólio-5-tiolato foram realizados. Com base nos resultados obtidos, dois novos compostos mesoiônicos, 2-(4-nitrofenil)-3-metil-4-(metilfenil)-1,3-tiazólio-5-tiolato e 2-(4-nitrofenil)-3-metil-4-(metoxifenil)-1,3-tiazólio-5-tiolato, foram sintetizados e caracterizados por métodos espectroscópicos e analíticos.
During the last few years mesoionic compounds (MIC) have attracted the attention of chemists because of the bonding aspects associated with their unusual structure which can be understood as mesomeric heterocyclic betaines, strongly stabilized by π-electron delocalization and with large dipole moments.1 Such structures can be regarded as equivalents of push-pull organic compounds of the type electron-acceptor (A) - polyenic bridge - electron-donor (D) commonly employed in nonlinear optics.2 But, unlike these symmetric polyenic bridges, the mesoionic rings act as asymmetric bridges and the relative positions of the donor/acceptor groups linked to the ring are very important.3 It has been computationally demonstrated that molecules containing mesoionic rings as asymmetric bridges have a performance for second order nonlinear optical effects equivalent to symmetric polyenic bridges containing more than seven conjugated double bonds.2
In a previous article3 we showed that, by employing the Time-Dependent Hartree-Fock (TDHF) method with the semiempirical AM1 Hamiltonian,4 one can obtain values for the first static hyperpolarizability, β(0), that correlate well with the experimentally observed values for this property. And we have also described, the synthesis and experimental measurements of the nonlinear absorption of 1,3-thiazolium-5-thiolate mesoionic compounds (Figure 1) using nanosecond laser pulses with wavelengths of 570, 605 and 618 nm; led to the observation of nonlinear absorption cross-sections σ2 as large as 10-45 cm4 s per photon.5 These compounds are seemingly very promising for photonic applications. Guided by our AM1-TDHF calculations, we have been further designing and synthesizing mesoionic compounds in our laboratories for photonic applications.6,7
Accordingly, we synthesized new examples of 1,3-thiazolium-5-thiolate mesoionic compounds, especially those with large AM1-TDHF calculated values for β(0).
Figure 1 shows that the mesoionic ring possesses two charged regions separated by what are essentially single bonds.8 It is this charge separation (asymmetry) that is responsible for the large values of β(0) obtained for this class of compounds. Recently, it was proposed by Kuzyk and co-workers9,10 that conjugated bridges with sites of reduced conjugation may be excellent prototypes for increasing the values of β(0). It is worthwhile to mention that the mesoionic compounds that we have been studying for nonlinear optics applications since 1996,3 can be considered as an early example of this paradigm.
Figure 1 shows two groups, RA and RD, linked to the para positions of two phenyl groups. The group containing RD is bound to the anionic region of the mesoionic ring and the group containing RA is bound to the cationic region. In order to enhance the donating properties of the anionic region of the mesoionic ring, we are studying compounds where RD is an electron-donor group. Similarly, we are using electron-acceptor groups in RA in order to enhance the accepting properties of the cationic region of the ring.3
Initially, consider the semiempirical AM1-TDHF calculations of β(0) for a set of sixteen mesoionic molecules (MIC-1 to MIC-16) containing the 1,3-thiazolium-5-thiolate ring (Figure 1).
The ground state geometries of the molecules were optimized using the AM1 semiempirical method implemented in MOPAC module of the Scigress Explorer 7.7 package.11 The MOPAC keywords used during geometry optimization were: GNORM=0.01 (to guarantee an energy minimum), SCFCRT=1.D-8 (to increase the SCF convergence criteria) and XYZ (to describe the optimized geometry in Cartesian coordinates). The nonlinear optical properties were calculated analytically using the TDHF methodology, implemented in the MOPAC module, using the following keywords to predict first static hyperpolarizability: POLAR(E=(0.0), BETA=1, IWFLB=0, TOL=1.D-9, BTOL=1.D-9). We used E=(0.0) to specify the energy of the incident radiation as zero electron volts, BETA=1 and IWFLB=0 for the iterative calculation of the first static hyperpolarizability, TOL and BTOL are, respectively, the cutoff tolerance for the calculation of the polarizability and first hyperpolarizability. The calculated β(0) values are given in Table 1.
Results and Discussion
The dependence of β(0) on the electronic character of the aromatic substituents directly attached to the mesoionic ring is given in Figure 2. The left part of Figure 2 gives β(0) as a function of the Hammett σp electronic parameters of the RD groups on the aromatic substituents (p-C6H4RD, RD= H, Me, i-Pr, OMe ) attached to carbon four of the mesoionic ring;12 the graph clearly shows that the larger the electron donating ability of the RD group, the larger is the first static hyperpolarizabily β(0) with an almost linear trend for each p-C6H4RA group attached to carbon two of the mesoionic ring. Correlation of β(0) with the positive σp parameter of RA (right) shows that, the larger the electron withdrawing ability of RA is, the larger is β(0), but, this time, the increase follows a quadratic function.
Figure 2 shows that the calculated hyperpolarizabilities are much more susceptible to substitutions in RA than to substitutions in RD, i.e., varying the group RA for a fixed RD results in much larger variations in the calculated hyperpolarizabilities than when we vary RD for a fixed RA. This result is not unexpected considering that the exocyclic group of the mesoionic ring already acts as a strong electron-donor group, while the cationic region of the ring does not have a well defined electron-accepting atom and needs a group in RA to direct the electron-accepting properties of the region.
Mesoionic compounds are conveniently described by a two molecular orbital (MO) model3; one MO is associated with the delocalized negative p-charge (HOMO) and linked to the C6H4RD group and the second MO is associated with the delocalized positive π-charge (LUMO) linked to the C6H4RA aryl group. An electron-withdrawing group attached to the LUMO (cationic region) decreases the energy of this MO, while the electron-donating group of the C6H4RD group tends to destabilize the HOMO (anionic region).
In Figure 3 we have a drawing of the HOMO and LUMO of a representative molecule (MIC-1). We can clearly see that these orbitals are asymmetrically localized in the molecule. The most important electronic excitation in mesoionic compounds is a charge transfer transition from the HOMO to the LUMO involving a large dipole moment change.3 Both the decrease of the excitation energy and the increase of the magnitude of dipole moment change upon excitation determine the magnitude of β(0), which in turn determines the nonlinear optical properties of the compound.
In Table 1 we also have some experimental values for the nonlinear absorption cross-sections σ2 of some of the molecules, measured using nanosecond laser pulses with a wavelength of 570 nm.5 We can see that, as the calculated values of β(0) increase, the experimentally observed values of σ2 also increase and that the best σ2 value (345×10-45 cm4 s per photon) was produced for the 2-(4-nitrophenyl)-3-methyl-4-(4-isopropylphenyl)-1,3-thiazolium-5-thiolate (MIC-15, b(0) = 57.22 × 10-30 esu).
Our calculations indicate that 2-(4-nitrophenyl)-3-methyl-4-(methoxyphenyl)-1,3-thiazolium-5-thiolate (MIC-16) has an even larger first static hyperpolarizability (β(0) of 61.49 × 10-30 esu) than MIC-15. Therefore, aiming at producing this improved material for photonic applications, we set up to establish a synthetic protocol leading to it; and, through this route, we also synthesized MIC-14 [2-(4-nitrophenyl)-3-methyl-4-(methylphenyl)-1,3-thiazolium-5-thiolate] which displayed an appreciable β(0) value.
The synthetic route leading to these new mesoionics was essentially the same used previously and involves the in situ 1,3-dipolar cycloaddition/cycloreversion with CS2 of the corresponding 1,3-oxazolinium-5-olates prepared by N-aroylation of C-aryl-methylglicines (Figure 4).13
Compounds MIC-14 and MIC-16 are air stable solids, which had their molecular formulae established by elemental microanalysis and confirmed by mass spectrometry. Other spectroscopic data (1H, 13C NMR and infra red) are in complete agreement with the proposed structures. All these details are in the Experimental section.
Studies of 1H NMR of mesoionic compounds are not very informative when there are not any hydrogen in the heterocyclic ring, however are important in the detection of hydrogens in the substituent groups. In contrast, the 13C NMR spectroscopy is an important tool to characterize the structure of mesoionic compounds due to the large difference in electronic densities between the two regions of the betainic ring (HOMO and LUMO). This difference in electronic density manifests itself in shielding or deshielding effects of the carbons of the heterocyclic ring and of the carbons of aromatic or aliphatic groups linked to the mesoionic ring. The three peaks at ca 160, 150, and 140 ppm are attributed to C5, C2, and C4 respectively (see Figures 5a and 5b). The reason that C4 is at high field compared with C5; although both are in the negative region of the mesoionic ring can be related to the significant partial double bond character of the carbon-thiolate bond (C5S5). The methylic carbon linked to N3 is characterized by a peak at 40 ppm and the methylic protons have chemical shifts around the 3.60 ppm, there is a down-field shift as a result of the positive charge on N3. The carbon atoms with chemical shift at low field, 148 and 160.4 ppm, are affected by deshielding effects caused, respectively, by the existence of the nitro and methoxy groups.
The 13C NMR (APT, 50 MHz, DMSO-d6) study of the compound MIC-14 showed thirteen chemical shifts. Of these, seven were assigned to the quaternary carbons, two to the primary aliphatic carbons and four to the aromatic tertiary carbons. The carbons of the mesoionic ring of MIC-14 have chemical shifts in 152.1; 141.4 and 161.9 ppm assigned, respectively, to C2, C4 e C5 (see Figure 5a). The carbons C10 and C15 have chemical shifts of 40.6 and 21.4 ppm, while the aromatic carbons have chemical shifts of 132.7 (C6); 129.4 (C7, 7'); 123.8 (C8, 8'); 148.5(C9); 129.6 (C11); 129.8 (C12, 12'); 128.2 (C13, 13') and 139.1 (C14).
The 1H NMR (200 MHz, DMSO-d6) spectrum of MIC-14 shows six hydrogen signals. Of these, two intense singlets were observed in the aliphatic region with an integral of 6H for the hydrogens H10 and H15 of the methyl groups, respectively in 3.64 and 2.38 ppm. There was also a signal between 8.27 and 7.23 assigned to the eight aromatic hydrogens.
For compound MIC-16 we observed a similar chemical behavior. The 13C NMR (APT, 50 MHz, DMSO-d6) spectrum showed thirteen signals. The carbons of the mesoionic ring showed chemical shifts of 148.7; 142.5 and 162.5 for C2, C4 and C5, respectively (see Figure 5b). Carbons C10 and C15 show values of chemical shifts that are compatible with the N-methyl group in 40.8 and the methoxy group in 55.2. The aromatic carbons have chemical shifts of 132.6 (C6); 130.4 (C7, 7'); 124.6 (C8, 8'); 148.5 (C9); 121.3 (C11); 132.6 (C12, 12'); 114.3 (C13, 13') and 160.4 (C14).
The 1H NMR (200 MHz, DMSO-d6) spectrum of MIC-16 has six hydrogen signals. Of these, two intense singlets were observed in the aliphatic region with an integral of six hydrogens, three hydrogens were assigned to the N-methyl group of the heterocyclic ring in 3.69 ppm and three were assigned to the methoxy group in 3.90 ppm. In the region between 8.34 and 7.07 ppm we observed corresponding signals the eight aromatic hydrogens.
The results above are in agreement with the results observed by Athayde-Filho et al.14
In this short report we performed theoretical calculations of the static first hyperpolarizability of sixteen mesoionic compounds of the 1,3-thiazolium-5-thiolate system. Based on our calculations, we synthesized and characterized two novel mesoionic compounds that showed large values for this property. Our next step will be the experimental measurement of the nonlinear optical properties of the two synthesized compounds in order to test our theoretical predictions.
All reagents and solvents were obtained from commercial sources and used as supplied. Mass spectra were obtained on a Finnigan GCQ Mat type quadrupole-ion trap spectrometer. IR spectra (KBr) were obtained on a Bruker IFS66 spectrometer. 1H and 13C NMR spectra (DMSO-d6 with internal TMS) were recorded on a Varian Unity Plus 300 MHz spectrometer. Elemental Analysis was carried out on a Perkin Elmer Elemental Microanalyser. Melting points were determined on a Kofler hot-plate apparatus combined with a Carl-Zeiss microscope and are uncorrected.
Preparation of N-methyl-C-arylglycines - general procedure
KCN (12.50 g, 250 mmol) and methylammonium chloride were dissolved in distilled H2O (100 mL). An equimolar amount of the aromatic aldehyde dissolved in MeOH (100 mL) was added, in portions, with vigorous stirring. The mixture was kept under stirring for 2 h. H2O (250 mL) was added, followed by addition of toluene (250 mL). The toluene phase was separated and extracted with HCl(aq) 6 mol L-1 (3 × 100 mL). The combined acid extract was refluxed for 8 h giving the products as white crystals formed on cooling. These were filtered off, washed with CHCl3 and dried under the air.
28.30 g (0.16 mol), IR (KBr) ν max/cm-1: 3250, 2510, 3032, 2955, 2795, 2722, 1737; 1H NMR (300 MHz, DMSO-d6): δ 2.27 (s, 3H), 2.37 (s, 3H), 4.96 (s, 1H), 7.24 (d, J 8.1 Hz, 2H), 7.36 (d, J 8.1 Hz, 2H), 9.64 (s, 2H); 13C NMR (75 MHz, DMSO-d6) δ 169.5, 139.9, 130.1, 129.0, 128.2, 63.1, 31.0, 21.1; MS (EI, 70eV): m/z (%) = 135 (10.16), 134 (100), 120 (4.94), 119 (1.66), 91 (14.83), 77 (2.73), 51 (3.30), 42 (34.69); Anal. Calc. (%) for C10H14ClNO2 = C, 55.69; H, 6.54; N, 6.49. Found: C, 56.07; H, 6.85; N 6.27; yield 65%; mp 214-216 ºC (recryst. EtOH:H2O (1:1, v/v)).
32.00 g, (0.16 mol), IR (KBr) ν max/cm-1: 3188, 2501, 3006, 2960, 2839, 2776, 2782, 1735; 1H NMR (300 MHz, DMSO-d6): δ 2.35 (s, 3H), 3.75 (s, 3H), 4.98 (s, 1H), 7.01 (d, J 8.8 Hz, 2H), 7.43 (d, J 8.8 Hz, 2H), 9.81 (s, 2H); 13C NMR (75 MHz, DMSO-d6) δ 169.4, 160.2, 130.5, 122.9. 114.6, 62.4. 55.5, 30.5; MS (EI, 70eV): m/z (%) = 196 [M - Cl]+ (11.59), 195 (1.28), 165 (6.43), 150 (100), 135 (2.64), 107 (4.85), 77 (2.79), 51 (1.37), 42 (25.70); Anal. Calc. (%) for C10H14ClNO3 = C, 51.84; H, 6.09; N, 6.05. Found: C, 52.12; H, 5.95; N, 5.93; yield 66%; mp 257-258 ºC (recryst. EtOH:H2O (1:1, v/v)).
Preparation of N-amidoacids - general procedure
N-Methyl-C-arylglycines (114,16) (0.30 mol) were dissolved in the minimum amount of NaOH(aq) (10%) with continuous stirring kept for 2 h. Equimolar amounts of 4-nitro-benzoyl chloride were added dropwise and the reaction stirred for 2 h. During this time, the crude product precipitated. The mixture was neutralized with HCl(aq) (10%). The white crystalline products were filtered, washed with H2O, air-dried, and used without further purification:
5.37 g, (0.16 mol), IR (KBr) ν max/cm-1: 3168, 3114, 3082, 2985, 2859, 2861, 1702, 1632; 1H NMR (300 MHz, CDCl3): δ 2.35 (s, 3H), 2.69 (s, 3H), 6.38 (s, 1H). 7.20 (d, J 8.2 Hz, 2H), 7.25 (d, J 8.2 Hz, 2H), 7.61 (d, J 8.4 Hz, 2H), 8.24 (d, J 8.4 Hz, 2H), 7.90 (s, 1H); 13C NMR (75 MHz, CDCl3): δ 173.9, 170.6, 148.5, 141.4, 139.1, 129.7, 129.6, 129.4, 128.1, 123.8, 60.8, 34.6, 21,1; MS (EI, 70 eV): m/z (%) = 327 (1.74), 283 [M-CO2H]+ (15.02), 178 (100), 150 (27.48), 133 (13.91), 132 (73.93), 122 (2.19), 117 (2.55), 91 (9.44); Anal. Calc. for C17H16N2O5: C, 62.19; H, 4,91; N, 8,53. Found: C, 61.88; H, 4.93; N, 8.67; yield 53%, mp 169-171 ºC.
4.72 g, (0.13 mol); IR (KBr) ν max/cm-1: 3001, 2956, 2839, 1699, 1631, 1537, 1349; 1H NMR (300 MHz, CDCl3): δ 2.67 (s, 3H), 3.77 (s, 3H), 6.32 (s, 1H), 6.88 (d, J 8.3 Hz, 2H), 7.24 (d, J 8.3 Hz, 2H), 7.58 (d, J 8.2 Hz, 2H), 8.21 (d, J 8.2 Hz, 2H), 8.67 (s, 1H); 13C NMR (75 MHz, CDCl3): δ 173.8, 170.6, 160.0, 148.4, 141.3, 130.9, 128.1, 124.4, 123.8, 114.4, 60.6, 55.3, 34.6; MS (EI, 70 eV): m/z (%) = 344 [M] (1.01), 300 (55.6), 299 (38.35), 194 (100), 150 (37.31), 149 (70.32), 148 (95.21), 133 (11.36), 122 (9.56), 107 (2.32); Anal. Calc. for C17H16N2O6: C, 59.30; H, 4.68; N, 8.14. Found: C, 60.02; H, 4.61; N, 8.03; yield 44.60%, mp 181-183 ºC.
Preparation of mesoionics compounds - general procedure
The N-aroyl-N-methyl-C-arylglycine (214 or 216) (1.4 mmol) was dissolved in Ac2O (20 mL) and heated, with stirring, at 55 °C for 15 min. After cooling to ambient temperature, CS2 (20 mL) was added and the reaction mixture allowed to stand for 48 h. MeOH/H2O (1:1) was then added until the mixture became cloudy. After standing for 24 h, the desired products precipitated as orange-red crystals, which were recrystallized from MeOH.
0.19 g, (0.51 mmol); IR (KBr) ν max/cm-1: 3117, 3062, 2994, 1607, 1542, 1495, 1429, 1351, 1294; 1H NMR (300 MHz, CDCl3): δ 2.38 (s, 3H), 3.64 (s, 3H), 7.23 (d, J 8.2 Hz, 2H), 7.28 (d, J 8.2 Hz, 2H), 7.64 (d, J 8.8 Hz, 2H), 8.27 (d, J 8.8 Hz, 2H); 13C NMR (75 MHz, CDCl3): δ 161.9, 152.1, 141.4. 139.1, 148.5, 132.7, 129.8, 129.6, 129.4, 128.2, 123.8, 40.6, 21.4; MS (EI, 70 eV): m/z (%) = 343 [M+1] (17.74), 342 [M] (100), 327 (8.07), 296 (19.94), 281 (15.43), 179 (20.14), 166 (2.99), 135 (9.43), 119 (4.41), 91 (4.23), 75 (2.08); Anal. Calc. for C17H14N2O2S2: C, 59.63; H, 4.12; N, 8.18; S, 18.73. Found: C, 60.04; H, 4.71; N, 8.27; S, 19.03; yield 37%, mp 183-185 °C (recryst. EtOH:H2O (1:1, v/v)).
0.29 g, (0.78 mmol); IR (KBr) ν max/cm-1: 3009, 2967, 2897,1590, 1489, 1513, 1426, 1334, 1282; 1H NMR (300 MHz, CDCl3): δ 3.90 (s, 3H), 3.69 (s; 3H), 7.07 (d, J 8.8 Hz, 2H), 7.48 (d, J 8.8 Hz, 2H), 7.88 (d, J 8.4 Hz, 2H), 8.34 (d, J 8.4 Hz, 2H); 13C NMR (75 MHz, CDCl3): δ 162.5, 160.4, 148.7, 148.5, 142.5, 132.6, 130.4, 124.6, 121.3, 114.3, 55.2, 40.8; MS (EI, 70 eV): m/z (%) = 359 [M+1]+ (17), 358 [M] (94.62), 343 (9.58), 312 (47.77), 297 (32.37), 282 (11.51), 210 (9.95), 195 (100), 166 (6.64), 163 (18.62), 151 (29.44), 135 (40.27), 63 (17.59); Anal. Calc. for C17H14N2O3S2, C, 56.96; H, 3.94; N, 7.82; S 17.89. Found: C, 57.13; H, 3.87; N, 8.03; S, 18.03; 56%, mp 215-217 °C (recryst. EtOH:H2O (1:1, v/v)).
Supplementary data are available free of charge at http://jbcs.sbq.org.br, as PDF file.
The authors would like to thank CNPq (Brazil) for research grants and for scholarships.
1. de Athayde, P. F.; Miller, J.; Simas, A. M.; Synthesis 2000, 11, 1565. [ Links ]
2. Silva, A. M. S.; da Rocha, G. B.; Menezes, P. H.; Miller, J.; Simas, A. M.; J. Braz. Chem. Soc. 2005, 16, 583. [ Links ]
3. Moura, G. L. C.; Simas, A. M.; Miller, J.; Chem. Phys. Lett. 1996, 257, 639. [ Links ]
4. Dewar, M. J. S.; Zoebisch, E. G.; Healy, E. F.; Stewart, J. J. P.; J. Am. Chem. Soc. 1985, 107, 3902. [ Links ]
5. Pilla, V.; de Araújo, C. B.; Lira, B. F.; Simas, A. M.; Miller, J., Athayde-Filho, P.F.; Opt. Commun. 2006, 264, 225. [ Links ]
6. Rakov, N.; de Araújo, C. B.; da Rocha, G. B.; Simas, A. M.; Athayde-Filho, P. A. F.; Miller J.; Chem. Phys. Lett. 2000, 332, 13. [ Links ]
7. Bezerra Jr, A. G.; Gomes, A. S. L.; Athayde-Filho, P. F; da Rocha G. B.; Miller, J.; Simas A. M.; Chem.Phys. Lett. 1999, 309, 421. [ Links ]
8. de Oliveira, M. B.; Miller, J.; Pereira, A. B.; Galembeck, S. E.; de Moura, G. L. C.; Simas, A. M.; Phosphorus, Sulfur Silicon Relat. Elem. 1996, 108, 75. [ Links ]
9. Zhou, J. F.; Kuzyk, M. G.; Watkins, D. S.; Opt. Lett. 2006, 31, 2891. [ Links ]
10. Perez-Moreno, J.; Zhao, Y.; Clays, K.; Kuzyk, M. G.; Opt. Lett. 2007, 32, 59. [ Links ]
11. Scigress Explorer version 7.7; Fujitsu: Tokyo, Japan, 2008. [ Links ]
12. Hansch, C.; Leo, A.; Taft, R.W.; Chem. Rev. 1991, 91, 165. [ Links ]
13. Lira, B. F.; de Athayde, P. F.; Miller, J.; Simas, A. M.; Dias, A. D.; Vieira, M. J.; Molecules 2002, 7, 791. [ Links ]
14. Athayde-Filho P. F.; Miller J.; Simas A. M.; Lira B. F.; Luis, J. A. S.; Zuckerman-Schpector, J.; Synthesis 2003, 5, 685. [ Links ]
Received: May 15, 2009
Web Release Date: February 4, 2010