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Association between depression and work stress in nursing professionals with technical education level 1 1 Supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Brazil, process # 12/24761-8.

Abstract

Objective:

to analize the relationship between depression and work stress in nursing professionals with technical education level of a teaching hospital in a city of the state of São Paulo.

Methods:

a cross-sectional study was carried out with 310 nursing technicians and nursing assistants, randomly selected. The outcome analyzed was the report of depression and its relationship with high levels of work stress, measured using the Job Stress Scale. Descriptive statistics and logistic regression were performed.

Results:

the prevalence of depression in this study was 20%, and it was more expressive in females, aged over 40 years, living without a partner and in smokers. The chance of depression was twice as high among professionals showing high levels of work stress, even after multiple regression adjusting.

Conclusion:

depressive symptoms were strongly associated with high stress levels among nursing assistants and nursing technicians, evidencing a problem to be considered along with the planning of specific intervention programs for this population, as well as the need for better cases management by the supervisors.

Descriptors
Depression; Stress Psychological; Cross Sectional Studies; Nursing

Resumo

Objetivo:

analisar a relação entre depressão e estresse laboral em profissionais de enfermagem de nível médio, de um hospital escola no interior paulista.

Método:

foi realizado um estudo transversal com 310 técnicos e auxiliares de enfermagem, selecionados aleatoriamente. O desfecho analisado foi o relato de depressão e sua relação com alto nível de estresse laboral, mensurado pela Job Stress Scale. Foi realizada estatística descritiva e regressão logística.

Resultados:

a prevalência de depressão neste estudo foi de 20%, mais expressiva em pessoas do sexo feminino, com idade superior a 40 anos, que vivem sem companheiro e entre fumantes. A chance de depressão foi duas vezes maior entre os profissionais que apresentaram alto nível de estresse laboral, mesmo após o controle na regressão múltipla.

Conclusão:

sintomas depressivos estiveram fortemente associados ao alto nível de estresse entre auxiliares e técnicos de enfermagem, evidenciando uma problemática a ser considerada junto ao planejamento de programas específicos de intervenção para esta população, bem como a necessidade de melhor gerenciamento dos casos por parte dos supervisores.

Descritores:
Depressão; Estresse Psicológico; Estudos Transversais; Enfermagem

Resumen

Objetivo:

analizar la relación entre depresión y estrés laboral en profesionales de enfermería de nivel medio, en un hospital universitario en el interior de São Paulo.

Método:

se ha llevado a cabo un estudio transversal con 310 técnicos y auxiliares de enfermería, seleccionados al azar. El desenlace analizado ha sido la historia de depresión y su relación con los altos niveles de estrés laboral, medidos por la Job Stress Scale. Se han realizado estadística descriptiva y regresión logística.

Resultados:

la prevalencia de depresión en este estudio fue del 20%, más expresiva en las mujeres, de edad superior de 40 años, que viven sin pareja y en los fumadores. La posibilidad de padecer depresión ha sido dos veces más grande entre los profesionales que mostraron un alto nivel de estrés en el trabajo, incluso después del control en la regresión múltiple.

Conclusión:

los síntomas depresivos se han asociado fuertemente con altos niveles de estrés entre los auxiliares y técnicos de enfermería, evidenciando un problema a tener en cuenta por los programas de planificación específicos de intervención para esta población, así como la necesidad de una mejor gestión de los casos por los supervisores.

Descriptores:
Depressión; Estrés Psicológico; Estudios Transversales; Enfermería

Introduction

Depression is a mental disorder characterized by sadness, lack of confidence, adynamy, decreased energy, loss of confidence and self-esteem, sense of guilt, suicidal ideation, decreased concentration and inadequate pattern of sleep and appetite. It can be understood as a continuation of negative feelings and can lead to dysfunction of the individual(1-2).

On the world stage, depression can be considered as a public health problem due to its high prevalence and to the functional disability that it causes 3. World Health Organization. Revised global burden of disease (GBD) 2002 estimates. Genebra: World Health Organization; 2005..

The distribution of the prevalence of depressive disorders occurs in an unequal manner in the population, being more significant in women 4. Van de Velde S, Bracke P, Levecque K. Gender differences in depression in 23 European countries. Cross-national variation in the gender gap in depression. Soc Sci Med. 2010;71(2):305-13., less favored economic classes 5. Everson SA, Maty SC, Lynch JW, Kaplan GA. Epidemiologic evidence for the relation between socioeconomic status and depression, obesity, and diabetes. J Psychosom Res. 2002 Oct;53(4):891-5., young individuals 6. Barros MBdA, César CLG, Carandina L, Torre GD. Social inequalities in the prevalence of chronic diseases in Brazil, PNAD-2003. Ciênc Saúde Coletiva. 2006;11:911-26.and in individuals with chronic diseases 7. Boing AF, Melo GR, Boing AC, Moretti-Pires RO, Peres KG, Peres MA. Association between depression and chronic diseases: results from a population-based study. Rev Saúde Publica. 2012 Aug;46(4):617-23.. The prevalence of depression may vary among populations. In the United States, for example, 12% of women suffer from depression yearly, whereas the disease reaches 7% of the male population 8. Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005 Jun;62(6):617-27.. In Brazil, it is estimated that about 6% of the general population had depression in 2003 6. Barros MBdA, César CLG, Carandina L, Torre GD. Social inequalities in the prevalence of chronic diseases in Brazil, PNAD-2003. Ciênc Saúde Coletiva. 2006;11:911-26..

The damage to the population is not associated only to the deleterious consequences on the biopsychosocial spheres of individuals, interfering actively also in the labor sphere. Depression affects the quality of life of individuals and productivity in the workplace, which may result in financial loss arising from absenteeism 1. Manetti ML, Marziale MHP. Aspects associated to work-related depression on nursing staff. Estudos Psicol. (Natal). 2007;12:79-85..

The professionals who interact most part of the time with individuals in need of support are the most

susceptible to mental illness(1,9). Among them, it is highlighted the nursing professionals who work directly with the intimacy, pain and fears that are part of the human suffering. Relationship problems in the work environment, difficulties of relocating, strenuous working days, system of shifts, as well as exposure to physical, chemical and biological agents equally constitute predisposing factors for the onset of depression(1,10).

The relationship between depression and the worker is directly modulated by stressors in the work environment. Work stress, defined as a result of the imbalance between the demands of professional practice and worker's coping ability, is associated with professional strain, negatively affecting the mental health of workers 1111 . Kirchhof ALC, Magnago TSBdS, Camponogara S, Griep RH, Tavares JP, Prestes FC, et al. Working conditions and social-demographic characteristics related to the presence of minor psychic disorders in nursing workers. Texto Contexto Enferm. 2009;18:215-23.. The prevalence rates of depression or depressive symptoms among nursing professionals are higher than 20%(2,12), considered high when compared with the general population.

This study aims to analyze the relationship between depression and work stress among nursing professionals with technical education level of a teaching hospital in a city of the state of São Paulo.

Methods

In this study, resources of the quantitative, crosssectional and descriptive-exploratory approach were used. It was developed in a large hospital in a city of the state of São Paulo.

The research population covers all nursing technicians and nursing assistants working in that hospital. It was decided to carry out the study in this population (nursing technicians and assistants), considering that these professionals perform high demand workloads and have little control on the work performed, due to their type of training and constant supervision by the professional nurse.

According to information of the Human Resources sector, at the beginning of data collection, the hospital employed 987 nursing assistants and 148 nursing technicians, totaling 1135 employees. The initial study sample consisted of 338 participants. The sample size was calculated to detect an expected prevalence of 50%, with 95% confidence interval and maximum error of 5%. Randomization was carried out using the SPSS software and data collection occurred from July to January 2013.

The professionals who performed their professional activities, at least for a year and of both genders were included in the sample. The professionals who were away from work or on vacation during the data collection period were excluded from the research.

Considering the ethical aspects of research involving human subjects (Resolution 196/96), this study received authorization of the facility for its achievement and was subject to evaluation by the Ethics and Research Committee of the School of Nursing of Ribeirão Preto, University of São Paulo (EERP/USP) and approved under Opinion number 23.433/2011, with CAAE protocol number 01658912.0000.5393. The Ethics and Research Committee of the Clinical Hospital of the Faculty of Medicine of Ribeirão Preto, University of São Paulo (HCFMRP/USP), also approved it.

Data were collected by postgraduate students, trained individually and in their own work environment. For data collection, it was used a questionnaire on sociodemographic, working and health conditions, as well as the Childhood Traume Questionnaire- CTQ 1313 . Bernstein DP, Stein JA, Newcomb MD, Walker E, Pogge D, Ahluvalia T, et al. Development and validation of a brief screening version of the Childhood Trauma Questionnaire. Child Abuse Negl. 2003 Feb;27(2):169-90.scale and the Job Stress Scale (JSS) 1414 . Karasek RA, Theorell T, Schwartz JE, Schnall PL, Pieper CF, Michela JL. Job characteristics in relation to the prevalence of myocardial infarction in the US Health Examination Survey (HES) and the Health and Nutrition Examination Survey (HANES). Am J Public Health. 1988 Aug;78(8):910-8..

The dependent variable was the reporting of depression at some point in life. The question used was applied in the health supplements of the National Survey by Household Sample from 2003 to 2008: "Has any doctor or health professional ever said that you have depression?". This type of variable has been used in studies that evaluate reports of depression, respiratory diseases and other health conditions(7,15). The High Level of Work Stress Exposure was the main independent variable, collected using the Work Stress Scale (JSS).

For control, the variables used were: gender (male and female), age (collected as quantitative variable and categorized as about 40 years), religious practice (yes or no), marital status (with or without partner), work complexity level (medium or high, according to the work unit), time of employment in the institution (about 15 years), work leave in a year (yes or no), tobacco use (yes or no), reporting of chronic diseases (yes or no) and early stress (yes or no).

High Level of Work Stress Exposure was the independent variable of interest and it was measured using the Working Stress Scale (Job Stress Scale). In the model proposed by Karasek, this scale was originally developed in Sweden, for evaluation of occupational stress 1414 . Karasek RA, Theorell T, Schwartz JE, Schnall PL, Pieper CF, Michela JL. Job characteristics in relation to the prevalence of myocardial infarction in the US Health Examination Survey (HES) and the Health and Nutrition Examination Survey (HANES). Am J Public Health. 1988 Aug;78(8):910-8., which was summarized and validated for Portuguese by Alves 1616 . Alves MGM, Chor D, Faerstein E, Lopes CS, Werneck GL. Versão resumida da "job stress scale": adaptação para o português. Rev Saúde Publica. 2004;38(2):164-71.. This scale addresses three categories equivalent to the dimensions: psychological (demand), work (control) and social support. It consists of 17 questions, with five to evaluate the demand, six to evaluate the control and six for social support. To calculate the level of work stress exposure, it was carried out a combination involving only the demand and control dimensions, resulting in the low, intermediate and high categories. For the demand and control dimensions, the response options are presented in a Likert-type scale, ranging from "frequently" (4) and "never/almost never" (1). For the dimensions of interest of the present study, it was used the dichotomizing with the cutoff point on the average, after confirming normal distribution, according to the recommendations of the Job Content Questionnaire User's Guide 1717 . Karasek RA, Theorell T. Healthy work-stress, productivity, and the reconstruction of working life. New York (US): Basic Books; 1990., yielding low control (≤17), high control (≥18), low demand (≤13) and high demand (≥14).

To determine the type of job, the answers were distributed in four categories of the Job Strain Modelproposed by Karasek 1717 . Karasek RA, Theorell T. Healthy work-stress, productivity, and the reconstruction of working life. New York (US): Basic Books; 1990.: low strain job (low demand and high control), passive job (low demand and low control), active job (high demand and high control) and high strain job (high demand and low control). Finally, the four types of job were re-grouped to provide the Level of Occupational Stress Exposure, according to its three categories: High (high demand, independent variable), Intermediate (active and passive jobs) and Low (low demand). In this study, it was considered only professionals presenting high levels.

The early stress independent variable was evaluated by the Childhood Trauma Questionnaire (CTQ) 1313 . Bernstein DP, Stein JA, Newcomb MD, Walker E, Pogge D, Ahluvalia T, et al. Development and validation of a brief screening version of the Childhood Trauma Questionnaire. Child Abuse Negl. 2003 Feb;27(2):169-90.scale. The brief version of the CTQ, used in this study and consisting of 28 items, has been modified and validated, keeping the same properties of the original version, however, with faster application. The items of the CTQ are answered in a Likert-type scale, which ranges from 1 (never) to 5 (always), with inverted scoring in the items 5, 7, 10, 13, 15, 16, 19, 21, 22, 26 and 28.

This questionnaire was translated and adapted to Portuguese in 2006, by Grassi-Oliveira 1717 . Karasek RA, Theorell T. Healthy work-stress, productivity, and the reconstruction of working life. New York (US): Basic Books; 1990.. In the validation study 1818 . Grassi-Oliveira R, Stein LM, Pezzi JC. Translation and content validation of the Childhood Trauma Questionnaire into Portuguese language. Rev Saúde Publica. 2006 Apr;40(2):249-55., it was performed exploratory and confirmatory factor analyzes regarding the construct validity, pointing out the following subtypes of early stress, whose score ranges from 5 to 25: Emotional Abuse (statements 3, 8, 14, 18 and 25), Physical Abuse (statements 9, 11, 12, 15 and 17) and Sexual Abuse (statements 20, 21, 23, 24 and 27); Physical Negligence (statements 1, 2, 4, 6 and 26) and Emotional Negligence (statements 5, 7, 13, 19 and 28). The statements 10, 16 and 22 correspond to the scale of control of minimization/ denial of abuse experience 1313 . Bernstein DP, Stein JA, Newcomb MD, Walker E, Pogge D, Ahluvalia T, et al. Development and validation of a brief screening version of the Childhood Trauma Questionnaire. Child Abuse Negl. 2003 Feb;27(2):169-90..

The scoring of the CTQ is achieved by the sum of points related to each statement of each dimension, totaling five scores in the end. For the individual be rated with early stress in childhood, it is necessary to score in the ratings of moderate-severeor severeextreme. The ratings of the CTQ are described in

Figure 11313 . Bernstein DP, Stein JA, Newcomb MD, Walker E, Pogge D, Ahluvalia T, et al. Development and validation of a brief screening version of the Childhood Trauma Questionnaire. Child Abuse Negl. 2003 Feb;27(2):169-90..

A pilot study was carried out with the first 20 participants. After data analysis, there was no need for changes in the original proposal for the approach of participants or data collection and consequently, the results of this pilot study were included in the study, continuing the collection.

Descriptive analysis of the dependent and independent variables was performed, using the Chisquare test, to assess the relationship among the variables. In this study, the Cronbach's alpha value for internal reliability of the CTQ scale was 0.85 and 0.74 for the JSS.

Multiple regression analysis using Stata 9 and crude analysis of the outcome (depression) with each of the independent variables were performed. Those presenting p < 0.20 were included in the multivariate model according to the Stepwise Forwardmethod, when the association between depression and high level of work stress was adjusted for all independent variables. It was maintained in the analysis, those with p < 0.20 or that fitted to the measurements obtained from another dimension.

Figure 1
Ratings of the subtypes of Early Stress according to severity (Adapted from Bernstein et al., 2003) 1313 . Bernstein DP, Stein JA, Newcomb MD, Walker E, Pogge D, Ahluvalia T, et al. Development and validation of a brief screening version of the Childhood Trauma Questionnaire. Child Abuse Negl. 2003 Feb;27(2):169-90.

Results

It was interviewed 310 nursing technicians and nursing assistants, from July to January 2013, totaling a response rate of 91.7%. The participants were mostly women (76.1%), aged over 40 years, with religious practice (92.5%) and with a partner (58.1%). In relation to working conditions, most of the interviewees work in sectors considered of high complexity (77.9%) and for less than 15 years in the institution.

About 50% were out of work due to illness in the past year. Most respondents reported having at least one chronic disease (76.1%) and 11.3% use tobacco. About a third (37.3%) reported early stress in childhood and 17.4% work under high stress level.

Medical diagnosis of depression was reported by 20%, which was higher among: women (24.5%), aged over 40 years (24.4%), people who do not live with a partner (28.5%), work for more than 15 years in the institution (26.9%), had work leave in the last year (28.4%), have a high level of work stress (35.2%), smokers (37.1%), have at least one chronic disease (26.6%) and have experienced early stress (37.1%). Further details about these data is shown in Table 1.

In the crude analysis, it was investigated the chances of occurrence of depression according to the variables of interest. There was statistical significance among all conditions, except for religious practice (p= 0.212) and work complexity level (p= 0.237). It is highlighted the relationship between depression and work leave, chronic disease, high level of work stress and early stress (p<0.001). The values observed for the other variables under study are shown in Table 2.

Nursing technicians and nursing assistants with high levels of work stress had prevalence of depression 2.69 times higher when compared to those without work stress in the crude model ( Table 3). In the subsequent models, with adjustments for demographic, socioeconomic, work and health conditions, magnitude of the Odds Ratio (OR) decreased. However, prevalence was 2.03 times higher in the group exposed to high levels of work stress (p = 0.048).

Table 1
Sample characteristics and prevalence of depression, according to sociodemographic variables, working conditions and health conditions, among nursing technicians and nursing assistants. Ribeirão Preto, SP, Brazil, 2013

Table 2
Logistic regression analysis of depression, according to sociodemographic variables, working conditions and health conditions, among nursing technicians and nursing assistants. Ribeirão Preto, SP, Brazil, 2013

Table 3
Multiple regression analysis between depression (yes/no) and high level of work stress (yes/no), among nursing technicians and nursing assistants. Ribeirão Preto, SP, Brazil, 2013

Discussion

Nursing technicians and nursing assistants who work with high levels of work stress had higher prevalence of depression, even after adjustment of the demographic, socioeconomic and health conditions. The literature points out that, the work performed with high stress levels is harmful to both mental health and physical health of individuals and is associated with several signs and symptoms of illness

at work(18-19).

The prevalence of depression, mentioned in this study was 20%, and more expressive in females, aged over 40 years, living without a partner and among smokers, similar to other studies in similar populations(1-2). High level of work stress was present in 17.4% of nursing professionals with technical education level and strongly related to depression.

These findings are consistent with the national and international literature. In a study performed in 2013, with nursing workers in the South of Brazil, the prevalence of high demand job was 21.8% and the prevalence of common mental disorders was 20.6% 2020 . Urbanetto Jde S, Magalhaes MC, Maciel VO, Sant'anna VM, Gustavo Ada S, Poli-de-Figueiredo CE, et al. Work-related stress according to the demand-control model and minor psychic disorders in nursing workers. Rev Esc Enferm USP. 2013 Oct;47(5):1180-6.. In a literature review on the occurrence of depression in nursing workers, the average prevalence was 28.8% 1. Manetti ML, Marziale MHP. Aspects associated to work-related depression on nursing staff. Estudos Psicol. (Natal). 2007;12:79-85.. Still regarding to jobs with high stress level, another study with nursing professionals in Brazil, the prevalence was 21.2% 1111 . Kirchhof ALC, Magnago TSBdS, Camponogara S, Griep RH, Tavares JP, Prestes FC, et al. Working conditions and social-demographic characteristics related to the presence of minor psychic disorders in nursing workers. Texto Contexto Enferm. 2009;18:215-23..

Work stress can be defined as individual reactions to the characteristics of the work environment, perceived by the worker, rising from an imbalance between individual technical skills and work requirements 2121 . Paris L, Omar A. Predictores de satisfacción laboral en médicos y enfermeros. Estudos Psicol. (Natal). 2008;13:233-44.. This imbalance can lead to psychological and physical suffering for the worker, causing physical disease and mental disorders.

The relationship between depression and work stress is significantly related to working conditions in nursing professionals with technical education level 1. Manetti ML, Marziale MHP. Aspects associated to work-related depression on nursing staff. Estudos Psicol. (Natal). 2007;12:79-85.. The work performed by these professionals is characterized by the low control of the activities performed, work overload, repetitive tasks, high level of competitiveness and low pay 1010 . Mark G, Smith AP. Occupational stress, job characteristics, coping, and the mental health of nurses. Br J Health Psychol. 2012 Sep;17(3):505-21.. These factors can lead to stress development and, if not solved, they can lead to deterioration of mental health, manifested by depression or other mental disorders(22-23).

The main factors related to depression in nursing workers can be subdivided into internal and external to the work environment. The organization of work is pointed out as the major factor by a literature review carried out in 2007, followed by the social relations at work and working conditions. Socio-demographic characteristics, female gender, age over 59 years and low family income are among the main factors external to the work environment. In addition, individual characteristics, such as skills of problem coping and family support, are also critical in the development of stress and depression 1. Manetti ML, Marziale MHP. Aspects associated to work-related depression on nursing staff. Estudos Psicol. (Natal). 2007;12:79-85..

A study performed with nursing professionals of Portugal, pointed out that the main stressful situations are related to decision-making, in which the errors can lead to serious consequences, inflexibility of the hierarchical superiors, work of preparing technical reports, difficulty in dealing with failures and professional problems 2424 . Gomes AR, Cruz JF, Cabanelas S. Occupational stress in health professionals: a study with Portuguese nurses. Psicol Teoria Pesqui. 2009;25:307-18..

As consequence of depression related to work stress, it is mentioned the tension and dissatisfaction at work, factors that can act in a bidirectional fashion, as the stress load on the worker and his co-workers increases. The stress-related depression at work also harms the physical and mental health, absenteeism, quality of care, which could increase the employee turnover in the sectors 1. Manetti ML, Marziale MHP. Aspects associated to work-related depression on nursing staff. Estudos Psicol. (Natal). 2007;12:79-85..

The relationship between high levels of work stress and occurrence of depression can be considered bidirectional, as it has consequences such as deterioration of the quality of life, work satisfaction and relationships with co-workers and may cause more stress and worsening of depressive disorders 2424 . Gomes AR, Cruz JF, Cabanelas S. Occupational stress in health professionals: a study with Portuguese nurses. Psicol Teoria Pesqui. 2009;25:307-18..

In addition to factors triggering depression, related to high level of work stress, factors that protect workers from these situations could be mentioned. A study carried out in 2011 pointed out that having support from supervisors, regular meals, physical exercises, better possibilities of use of the skills and greater job satisfaction may decrease the occurrence of work-related stress and depression 2. Gao YQ, Pan BC, Sun W, Wu H, Wang JN, Wang L. Depressive symptoms among Chinese nurses: prevalence and the associated factors. J Adv Nurs. 2012 May;68(5):1166-75.. In addition, more free weekends and less emotional stress also contribute to the improvement of work by decreasing the level of stress and depression 2525 . Ruggiero JS. Health, work variables, and job satisfaction among nurses. J Nurs Adm. 2005 May;35(5):254-63..

As limitations of this study, it is pointed out that transversal data collection may prevent the establishment of causal and chronological relationship among the events of interest. Longitudinal studies can be developed in further investigations, to establish the cause and effect relationship among the phenomena studied.

It is also worth mentioning the limitations caused by diagnostic and memory biases. In many situations, people may believe to have depression, by presenting similar symptoms to that disclosed by the media, even without a more accurate medical diagnosis. The memory biases are established, once the outcome was measured retrospectively, which can also lead to underestimation of the magnitude of depression.

Despite the limitations presented, the study achieved a high response rate and distribution of the sample similar to other hospital units, with different complexity profiles. The magnitude of the association studied was also very expressive, showing strong inter-relationship between depression and high levels of work stress.

Conclusion

In the light of the epidemiological situation observed in the studied sample, with strong association between depression and high level of work stress among nursing workers with technical education level, the design of strategies for prevention and treatment of this population group becomes essential. These issues should be considered when planning specific intervention programs, as well as the need for a better management of cases by the supervisors.

The focus of preventive action should be related to restructuring actions of the working conditions, allowing more free time for leisure activities, expansion of managerial support, greater incentive to the use of the professional skills, better division of workload and greater professional recognition. In addition, the development of specific programs of treatment for healthcare professionals should be encouraged in health institutions, such as better management of the existing cases by the supervisors and favorable working environments.

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    Gomes AR, Cruz JF, Cabanelas S. Occupational stress in health professionals: a study with Portuguese nurses. Psicol Teoria Pesqui. 2009;25:307-18.
  • 25
    Ruggiero JS. Health, work variables, and job satisfaction among nurses. J Nurs Adm. 2005 May;35(5):254-63.
  • 1
    Supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Brazil, process # 12/24761-8.

Publication Dates

  • Publication in this collection
    July-Aug 2015

History

  • Received
    17 Mar 2014
  • Accepted
    21 Feb 2015
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