SciELO - Scientific Electronic Library Online

 
vol.27Impact of work aspects on communication, emotional intelligence and empathy in nursingLearning from mistakes: analyzing incidents in a neonatal care unit author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Revista Latino-Americana de Enfermagem

On-line version ISSN 1518-8345

Rev. Latino-Am. Enfermagem vol.27  Ribeirão Preto  2019  Epub Feb 04, 2019

http://dx.doi.org/10.1590/1518-8345.2735.3119 

Original Article

How long before hospital admission do the symptoms of heart failure decompensation arise?

Maraísa Carine Born1 
http://orcid.org/0000-0003-0093-2329

Karina de Oliveira Azzolin2 

Emiliane Nogueira de Souza1 

1Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.

2Universidade Federal do Rio Grande do Sul, Escola de Enfermagem, Porto Alegre, RS, Brazil.

ABSTRACT

Objective:

to identify the signs and symptoms of decompensation of heart failure (HF) and the duration of time to hospital admission.

Method:

this is a cross-sectional study with adult patients hospitalized for decompensated HF in a teaching hospital located in southern Brazil from July to October 2017. Data collection was performed through a structured questionnaire that included sociodemographic, clinical signs and symptoms of HF. In the data analysis, the following tests were applied: t-Student, Mann Whitney U-Test, Chi-Square Tests.

Results:

94 patients, aged between 42 and 98 years old (mean of 71.2 years old) were included. The most prevalent signs and symptoms before emergency admission were dyspnea (79.8%), cough (29.8%), orthopnea (27.7%), edema (23.4%), and fatigue (22.3%). The median time from onset of signs and symptoms to arrival in the emergency room is fatigue and edema 7 days, orthopnea 5 days, cough 4 days and dyspnea 3 days.

Conclusion:

the set of classic signs and symptoms of decompensation of HF occurs around seven days before the emergency search and dyspnea is the worsening that leads the patient to a hospital emergency.

Descriptors: Heart Failure; Intensive Care Units; Nursing; Nursing Care; Signs and Symptoms; Self Care

Introduction

Heart failure (HF) has been a serious and progressive public health problem, leading to an increase in hospital readmissions, a risk of early mortality, a significant impact on the quality of life of patients, and an important source of high costs for the health system, whose elderly population is growing1-2. It is characterized as one of the main causes of hospitalization in adults, the first cause of hospitalization in elderly patients3-4, and the main cause of rehospitalization according to the Brazilian Registry of Acute Heart Failure (BREATHE), study that outlined the scenario of HF in Brazil5. The reasons occur specifically by three factors: population aging; increased incidence of precursor diseases such as systemic arterial hypertension (SAH), obesity, diabetes mellitus (DM); and improved therapeutics in several cardiac disorders such as acute myocardial infarction (AMI) and valvulopathies, which allows an increase in the survival of these patients, who eventually develop HF over the years5.

Although the advances in optimal clinical and therapeutic management have been observed, HF remains a challenge for the health team, resulting in physical and psychological suffering2, caused by the lack of knowledge of non-pharmacological measures, inadequate adherence to medication treatment, and by the inability to identify and interpret the signs and symptoms of disease decompensation4-6.

Patients hospitalized for acutely decompensated HF had until recently a poor prognosis, but better identification of symptoms and therefore more appropriate treatments led to a 40-50% reduction in mortality in a short period of time. Therefore, nursing actions aimed at educating patients and their families for the early recognition of signs and symptoms, indicators of worsening, are important to seek immediate medical attention without the loss of critical time, hours or even before adequate treatment5.

It is known that the late recognition of these clinical manifestations is associated with an increase in rates of hospitalizations and complications, mainly including mortality. About two-thirds of these acute events occur in patients with known HF, and about one third is the first event in individuals without the diagnosis of HF7-8.

Incomplete understanding of the process of identification, interpretation of signs and symptoms of HF, and decision making by patients can be a barrier to the success of professional interventions aimed at effective self-care and prevention of readmission. Although some studies9-11 have already evaluated patients’ experiences, including how signs and symptoms were interpreted and managed before hospitalization, there is a gap in examining the time between the onset of these clinical manifestations and the search for a service emergency room. This study aims to explore the relationship between the duration of signs and symptoms that patients associate with worsening HF, being in their homes, before seeking health care in a hospital environment. The identification of the mean time of onset of the symptoms that lead the patients to seek an emergency service is a relevant data to compose the set of information that professionals must consider to offer interventions directed to the management of HF.

With the results, it is expected to highlight the relevance to the clinical practice of the nurse, instigating to develop learning interventions to the patients, so they can know how to evaluate, recognize and manage their signs and symptoms of decompensated HF antecedents of the moment of hospitalization, seeking early care. Thus, the objective of this study was to identify the signs and symptoms of decompensation of HF and the duration of the period until hospital admission.

Method

This is a cross-sectional study with quantitative approach performed with adult patients with HF diagnosis hospitalized for decompensation in a hospital complex located in southern Brazil. Patients aged ≥ 18 years old, of both genders, with medical diagnosis of decompensated HF, were included. Patients with psychiatric disorders and degenerative neurological diseases, patients with hemodynamic instability at admission, and patients in the recent postoperative period (up to three postoperative months) were not included in the study.

A prevalence of 94% of dyspnea was estimated12, with a precision and significance of 5%, and the minimum number of participants was 87. In the period from July to October 2017, data collection was performed through a structured questionnaire that comprised sociodemographic, clinical data and signs and symptoms of HF. For sociodemographic characterization, age, gender, race, education level, marital status, employment status, and origin were registered. A health plan, intensive care unit admission (ICU) and in-hospital mortality were found to characterize hospital admission. In the clinical profile, the time of illness and hospitalization in the last year for decompensated HF according to the patient’s own report, presence of comorbidities, etiology and functional class of HF according to New York Heart Association (NYHA) criteria were identified13. Also, left ventricular ejection fraction (LVEF) was recorded according to the last echocardiogram, presence, and duration of signs and symptoms of HF experienced before hospital admission according to the patient’s report.

Data collection was performed by the trained researcher who approached the patient to participate in the study. The patients were approached within 48 hours of hospital admission. Those who agreed to participate completed the structured questionnaire in an average time of 15 minutes. After the collection with the patient, some information was checked in the electronic medical records of the hospital, in a reserved place. The data were tabulated in the Excel for Windows worksheet and later exported, processed and analyzed in the Statistical Package for Social Science (SPSS), version 23.0. Descriptive and analytical techniques were adopted for statistical analysis. Continuous variables were expressed as mean and standard deviation or median and percentiles (25-75), and categorical variables, with absolute (n) and relative (%) frequencies. For the normality of the data, the Kolmogorov Smirnov test was applied. The study variables were compared using Student’s t-test and Mann Whitney U Test for independent samples as they followed the normal distribution. The association of sociodemographic and clinical variables was evaluated using the Chi-Square test. The results were considered statistically significant if p <0.05, with 95% confidence interval.

The study was approved by the Research Ethics Committee of the Hospital Irmandade Santa Casa de Misericórdia in Porto Alegre under opinion 2,157,007/2017. The participants received verbal and written information from the research and signed the Informed Consent Term. The ethical precepts of Resolution 466/2012 of the National Health Council14 were respected.

Results

A total of 94 patients, aged between 42 and 98 years old, with a mean age of 71.2±13.4 years old, 53.2% were male, 98.9% were white, and 64.9% had incomplete elementary school. Table 1 shows the sociodemographic characteristics of the sample.

Table 1 Sociodemographic characteristics of patients with heart failure. Porto Alegre, RS, Brazil, 2017 

Variable n(%)
Age (years old) 71.2 ±13.4*
Age group
>60 years old 72(76.6)
<60 years old 22(23.4)
Gender
Male 50(53.2)
Education level
Incomplete Elementary school 61(64.9)
Complete High School 25(26.6)
Race
White 93(98.9)
Marital status
Married 56(59.6)
Widow 27(28.7)
Single 8(8.5)
Separate/divorced 3(3.2)
Job situation
Retired 68(72.3)
Active 21(22.3)
On leave 5(5.3)
Health insurance
Additional Plan 50(53.2)
Unified Health System (SUS) 44(46.8)

* Variable described as mean; ± standard deviation

In the last 12 months, 29.4% of 54.3% patients analyzed readmitted for decompensated HF, were hospitalized at least twice. Of the study participants, 42.6% went to the ICU, with in-hospital mortality of 13.8%.

Regarding clinical characteristics, the prevalence of participants in functional classes II and III (45.7% and 46.8%, respectively) was observed. The most frequent HF etiology was ischemia (38%). The mean of the LVEF in the 83 patients with an echocardiogram report was 48.3±16.1, ranging from 20% to 81%. Table 2 shows the clinical characteristics of the sample.

Table 2 Clinical characteristics of patients with heart failure. Porto Alegre, RS, Brazil, 2017 

Variable n(%)
Disease duration (years) 18.2±15.1*
Last year hospitalization for decompensated CI
Yes 51(54.3)
If so, how many times 2.1±1.4*
No 43(45.7)
Etiology
Ischemic 38(40.4)
Hypertensive 24(25.5)
Valvar 20(21.3)
Idiopathic dilated 11(11.7)
Chagasic 1(1.1)
Functional class (NYHA)
II 43(45.7)
III 44(46.8)
IV 7(7.4)
EF § (%) 48.3±16.1*
Presence of comorbidities
Arterial hypertension 71(75.5)
Ischemic Heart Disease 50(52.3)
Diabetes Mellitus 36(38.3)
Smoking 36(38.3)
Chronic Renal Insufficiency 23(24.5)
Chronic obstructive pulmonary disease 23(24.5)
Dyslipidemia 20(21.3)
Valvopathy 19(20.2)
Alcoholism 12(12.8)
Depression 9(9.6)
Cancer Treatment 6(6.4)

* Variables described as mean; ± standard deviation.CI: cardiac insufficiency; NYHA: New York Heart Association; §EF: ejection fraction: value calculated with a total of 83 patients with an echocardiogram report.

The most prevalent signs and symptoms before hospital admission were dyspnea (79.8%), cough (29.8%), orthopnea (27.7%), edema (23.4%) and fatigue (22.3%). Table 3 shows the relation of signs and symptoms and their duration before hospital admission reported by the patients.

Table 3 Presence of signs and symptoms before hospital admission. Porto Alegre, RS, Brazil, 2017 

Variables Presence n(%) Duration in days md(p25-p75)
Dyspnea 75(79.8) 3(1.0-7.0)
Cough 28(29.8) 4(2.0-7.0)
Orthopnea 26(27.7) 5(1.0-14.0)
Edema in the legs, ankles, and/or feet 22(23.4) 7(3.0-14.0)
Tiredness 21(22.3) 7(2.5-15.0)
Angina 12(12.8) 1(1.0-1.75)
Weakness 8(8.5) 1(1.0-6.25)
Cognitive problems 8(8.5) 2(1.25-5.75)
Dizziness 8(8.5) 1(1.0-1.75)
Nausea and vomiting 7(7.4) 2/(1.0-3.0)
Pallor and sweat 5(5.3) 3/(1.5-4.0)
Ascites 4(4.3) 1/(1.0-5.5)
Palpitation 4(4.3) 1/(1.0-1.75)

The association between the most prevalent signs and symptoms before the admission to the emergency room and the health insurance, before the hospitalization in the last year and the ejection fraction was found to be a significant association between the presence of edema and previous hospitalization (p=0.047). Data is presented in Table 4.

Table 4 Association of signs and symptoms more prevalent with health insurance, hospitalization in the last year for decompensated heart failure and ejection fraction. Porto Alegre, RS, Brazil, 2017 

Variable Health insurance md(p25-p75) Last year hospitalization for decompensated heart failure md(p25-p75) Ejection Fraction md(p25-p75)
SUS* Additional Hospitalized Not hospitalized EF ≤ 45% EF > 45%
Dyspnea 3(1.0-7.0) 3.5(1.0-8.5) 3(1.0-7.0) 4(2.0-7.0) 3.5(1.0-14.0) 4(1.75-7.0)
p-value 0.605 0.385 0.979
Cough § 6.5(1.5-7.75) 3.5(2.0-7.0) 3.5(2.75-8.75) 5(1.75-7.0) 1.5(1.25-7.0) 5.5(3.0-7.0)
p-value 0.224 0.306 0.921
Orthopnea 3.5(1.0-9.5) 7(1.0-60.0) 3(1.0-7.0) 7.5(2.5-26.0) 5(1.0-25.5) 7(3.0-19.0)
p-value 0.347 0.123 0.734
Edema § 7(4.0-14.0) 7(3.0-13.5) 6(3.0-11.5) 10.5(6.5-18.0) 4(2.5-14.0) 7(3.0-13.25)
p-value 0.263 0.047 0.553
Tiredness 9(2.5-45.0) 7(2.0-14.0) 3(1.5-14.5) 14(4.75-30.0) 14(2.5-15) 4(2.0-30.0)
p-value 0.605 0.161 0.705

*SUS: Unified Health System; EF: Ejection Fraction; Test: Mann Whitney U Test; §Teste:t- Student.

Discussion

This study identified the occurrence of signs and symptoms of decompensated HF and the duration of time until the patient sought a hospital emergency service.

Regarding the occurrence of signs and symptoms before the hospital admission, the intensification of dyspnea was the most prevalent. This finding is in agreement with the other studies that proved to be the most important cause of readmission1-3,15-16. Other signs and symptoms were also evidenced in this study: cough, orthopnea, edema, and fatigue. Although these signs and symptoms appear with greater intensity before the search for hospital care, orthopnea is more characteristic for HF, since the others can also be found in other clinical conditions17. Data from the international literature point out the importance of recognizing HF symptoms, characterized as a complex phenomenon since patients present a variety of symptom combinations at different time intervals, charactered as a mixture of acute and chronic symptoms18.

Another study shows that the ability of patients to recognize, interpret and assess worsening symptoms of HF is limited. Suffering and intensification of symptoms such as dyspnoea, edema, and orthopnea are related to the greater delay in care. These delays in seeking care vary from hours to days from onset of symptoms to hospital admission19. The identification, tolerance, and decompensation of signs and symptoms caused these patients to seek hospital care within a period of up to seven days. These data are similar at the time of presenting symptoms before hospital admission12,20-21. The mean duration of early symptoms of decompensated HF was one to nine days, but duration of dyspnea ranges from one to eight, 5 days before searching for service.

It is known that symptoms such as edema, weight gain, and fatigue are tolerated by patients with HF around seven days and dyspnea for three days before seeking a health service9,22. These data is similar to our results because the demand for care was within seven days for the clinical manifestations of worsening HF, and dyspnea in three days. It is inferred that the predominance of these symptoms can vary from 24 hours to two weeks, although most report the presence of the symptom of up to seven days, but there were cases in which the patient took more than 60 days to seek medical attention, the which may have aggravated their clinical condition, with a higher risk of severe complications, including death.

In our study, more than half of the patients hospitalized for decompensated HF were readmitted to the hospital in the last 12 months. This is similar to another study23, which showed that 60% are readmitted in 90 days. In the national registry of HF, a study called BREATHE, approximately half of all patients hospitalized with this diagnosis are readmitted within the first 90 days after hospital discharge, and this hospital readmission is considered a risk factor for death5.

Together with the high rates of readmissions, the high in-hospital mortality rate was 13.8% of patients admitted for HF decompensated in this study, higher than the mortality rate in the BREATHE registry (12.6%)5, and in the DATASUS records, which is 11.0%24. These data are more than twice that found in US and European registries: 4.0% in-hospital mortality in the ADHERE study and 3.8% in the Euro Heart Survey5.

It is observed that most of the causes of hospitalization are associated with multiple other aggravating risk factors5. The presence of multiple comorbidities associated with HF, as shown in the results of this study, may contribute to complications and accelerate decompensation, associated or not with preserved EF (>45%). Consequently, a longer hospital stay may be required to compensate for HF, requiring ICU admission, and a worse prognosis for in-hospital death. Despite efforts by researchers to identify factors associated with frequent hospital readmissions, it is not possible to identify the real reason for clinical decompensation in 30% to 40% of cases5.

In view of these findings, it is possible to infer that patients are slow to recognize or even know the exacerbation and worsening of HF to seek hospital care, since the mortality rate and the worsening were high, with a relatively high percentage of ICU admission.

Therefore, the fact that HF is a chronic and progressive disease should be highlighted, that the patient should be involved in the identification of the signs and symptoms of HF, thus being able to communicate the family/companion and seek hospital care earlier, as delays in seeking medical care worsen the clinical situation.

Therefore, it is necessary to better understand how patients identify and value the occurrence of clinical manifestations of worsening of the disease, considering the presence of comorbidities, such as the identification of signs and symptoms that lead them to seek health care in the environment to be able to draw up strategies that aim to achieve and maintain the clinical stability of these patients through a personalized education for self-care. Effective self-care has been recognized as an important and indispensable component in the recognition of CI decompensation8.

Measures can be instituted in these readmissions, taking advantage of the impact caused by hospitalization and the symptoms of decompensation. Early hospital discharge planning can be performed, including daily visits to assess and reinforce adherence, support patient and family members, and emphasize the early recognition of signs and symptoms of worsening. This approach can be used successfully to decrease or prevent further hospital admissions. It should be emphasized that the data of this study point to the need to highlight, together with patients and family members, the most characteristic signs and symptoms of HF decompensation. According to the results, it is believed that in the presence of at least one of the signs and symptoms that precede resting dyspnea, such as tiredness, edema, orthopnea, and cough, the patient already needs a professional support, which is not necessarily a hospital emergency, but rather in primary care services or CI management programs.

In this context, the nurse performs an important role in planning actions for the social and health challenges related to the aging of the population and the significant increase in the prevalence of non-communicable chronic diseases. Continuous follow-up of patients with HF is a recommendation of Class 18 in the recent guidelines on the clinical management of HF25, and patient engagement is one of the main strategies of the care plan. Thus, nursing interventions to meet the patient’s needs require careful and strategic planning (including an accurate assessment of the needs and support network available), choice of the best approach and an evaluation of the effectiveness of the practice of self-care and its translation into favorable results.

Currently, it is recommended that patients with HF receive multidisciplinary care during their follow-up at different levels of health care. This strategy has greatly reduced hospitalization rates and re-hospitalization due to decompensation and it has had an impact on the quality of life of these patients8. The purpose of multidisciplinary follow-up is to teach, reinforce, improve and constantly evaluate self-care skills, which include weight monitoring, hydrosaline restriction, physical activity, drug compliance, sign, and symptom monitoring and the demand for an early health care.

This study brings contributions referring to the main triggers for the search of a hospital emergency service, elucidating the time that the patients remain with the signs and symptoms of decompensation of the CI at home until the search of care. It is important to mention that decision-making in seeking a health service is related not only to the identification and interpretation of signs and symptoms of worsening HF but also to external factors such as access to health services and professionals, previous experiences in terms of problem-solving in settings other than a hospital emergency, and the support resources patients have to travel to a health facility. The best management of HF is through an adequate understanding of the context of the patient to customize the educational interventions so the patient and the family feel engaged in the therapeutic plan.

As a limitation of this study, there were the behavior of variables not evaluated over time to infer causal relationships between them.

Conclusion

A set of signs and symptoms of HF decompensation, consisting of dyspnea, cough, orthopnea, edema, and fatigue in general, has been present for at least seven days before the search for health care. Among them, dyspnea is the most prevalent and decisive symptom for the patient to seek a hospital emergency service, taking approximately three days.

In this sense, the results can subsidize personalized educational interventions with the aim of helping patients and family members better manage the onset episodes of clinical manifestations of HF decompensation.

References

1 Aliti GB, Linhares JCC, Linch GFC, Ruschel KB, Rabelo ER. Signs and symptoms in patients with decompensated heart failure: priorities nursing diagnoses. Rev Gaúcha Enferm. 2011;32(3):590-5.doi: 10.1590/S1983-14472011000300022. [ Links ]

2 Sousa MM, Oliveira JS, Soares MJGO, Bezerra SMMS, Araújo AA, Oliveira SHS. Asociación de condiciones social y clínicas para calidad de vida del paciente con insuficiencia cardiaca. Rev Gaúcha Enferm. 2017;38(2):e65885. doi: 10.1590/1983- 1447.2017.02.65885. [ Links ]

3 Poffo MR, Assis AV, Fracasso M, Londero Filho OM, Alves SMM, Bald AP et al. Profile of Patients Hospitalized for Heart Failure in Tertiary Care Hospital. Int J Cardiovasc Sci. 2017;30(3):189-198.doi: 10.5935/2359-4802.20170044. [ Links ]

4 Holgín EA. Comportamientos y capacidad de agencia de autocuidado de adultos con insuficiencia cardíaca. Av Enferm. 2010;28(1):21-30.doi: 10.15446/av.enferm. https://revistas.unal.edu.co/index.php/avenferm/article/view/15624/18155. [ Links ]

5 Albuquerque DC, Souza Neto JD, Bacal F, Rohde LEP, Pereira SB, Berwanger O et al. I Brazilian Registry of Heart Failure - Clinical Aspects, Care Quality and Hospitalization Outcomes. Arq Bras Cardiol. 2015;104(6):433-42.doi: 10.5935/abc.20150031. [ Links ]

6 Boisvert S, Belhumeur AP, Gonçalves N, Doré M, Francoeur J, Gallani MC. An integrative literature review on nursing interventions aimed at increasing self-care among heart failure patients. Rev. Latino-Am. Enfermagem. 2015;23(4):753-68. doi: 10.1590/0104-1169.0370.2612. [ Links ]

7 Reis APM, Souza AG, Ferreira GCO, Oliveira JMR, Venancio JC, Fernandes TM, et al. Prevalence of heart failure in brazil: a problem of public health. Rev Educ Saúde. 2016;4(2):24-30.doi: 10.29237/2358-9868.2016v4i2. [ Links ]

8 Bocchi EA, Marcondes-Braga FG, Ayub-Ferreira SM, Rohde LE, Oliveira WA, Almeida DR etal.III Diretriz Brasileira de Insuficiência Cardíaca Crônica. Arq Bras Cardiol. 2009;93(1 suppl 1):3-70.doi: 10.1590/S0066-782X2009002000001. [ Links ]

9 Lee KS, Moser DK, Dracup K. Relationship between self-care and comprehensive understanding of heart failure and its signs and symptoms.Eur J Cardiovasc Nurs. 2018;17(6): 496-504. doi: 10.1177 / 1474515117745056. [ Links ]

10 Giamouzis G, Kalogeropoulos A, Georgiopoulou V, Laskar S, Smith AL, Dunbar S, et al. Hospitalization epidemic in patients with heart failure: risk factors, risk prediction, knowledge gaps, and future directions. J Cardiac Fail. 2011;17: 54-75. doi: 10.1016/j.cardfail.2010.08.010 [ Links ]

11 Reeder KM, Ercole PM, Peek GM, CE. Symptom perceptions and self-care behaviors in patients who self-manage heart failure. J Cardiovasc Nurs. 2015;30(1): E1-E7. doi: 10.1097/JCN.0000000000000117 [ Links ]

12 Lee KS. Symptom assessment and management in patients with heart failure. 2012. 143 f. Theses and Dissertations Nursing - College of Nursing - University of Kentucky, UKnowledge. ReinoUnido; 2012.https://uknowledge.uky.edu/nursing_etds/2Links ]

13 Bocchi EA, Marcondes-Braga FG, Bacal F, Ferraz AS, Albuquerque D, Rodrigues D, et al.Atualização da Diretriz Brasileira de Insuficiência Cardíaca Crônica - 2012. Arq Bras Cardiol. 2012;98(1 Suppl 1):1-33.doi: 10.1590/S0066-782X2012000700001. [ Links ]

14 Conselho Nacional de Saúde (BR). Resolução nº 466, de 12 de dezembro de 2012. Disponível em: &lt;http://conselho.saude.gov.br/resolucoes/2012/Reso466.pdf.&gt; Acesso em: 5 dez 2017. [ Links ]

15 Mangini S, Pires PV, Braga FGM, Bacal F. Decompensated heart failure. Einstein. 2013;11(3):383-91.doi: 10.1590/S1679-45082013000300022. [ Links ]

16 Barretto AC, Del Carlo CH, Cardoso JN, Morgado PC, Munhoz RT, Eid MO et al. Hospital readmissions and death from heart failure - rates still alarming. Arq Bras Cardiol. 2008;91(5):335-41.doi: 10.1590/S0066-782X2008001700009. [ Links ]

17 Wang CS, FitzGerald JM, Schulzer M, Mak E, Ayas NT. Does this dyspneic patient in the emergency department have congestive heart failure? JAMA. 2005;294(15):1944-56.doi: 10.1001/jama.294.15.1944. [ Links ]

18 Altice NF, Madigan EA. Factors associated with delayed care-seeking in hospitalized patients with heart failure. Heart & Lung: J Crit Care. 2012;41(3):244-54. doi: 10.1016/j.hrtlng.2011.09.007. [ Links ]

19 Gravely-Witte S, Jurgens CY, Tamim H, Grace SL. Length of delay in seeking medical care by patients with heart failure symptoms and the role of symptom-related factors: A narrative review. Eur J Heart Failure. 2010;12(10):1122-9.doi: 10.1093/eurjhf/hfq122.0. [ Links ]

20 Jurgens CY, Hoke L, Byrnes J, Riegel B. Why do elders delay responding to heart failure symptoms? Nurs Res. 2009;58(4):274-82.doi: 10.1097/NNR.0b013e3181ac1581. [ Links ]

21 Friedman MM, Quinn JR. Heart failure patients' time, symptoms, and actions before a hospital admission. J Cardiovasc Nurs. 2008;23(6):506-12.doi: 10.1097/01.JCN.0000338928.51093.40. [ Links ]

22 Van der Wal MH, Jaarsma T, van Veldhuisen DJ. Noncompliance in patients with heart failure: how can we manage it? Eur J Heart Fail. 2005;7(1):5-17. doi: 10.1016/j.ejheart.2004.04.007. [ Links ]

23 Roger VL. Epidemiology of heart failure. Circ Res. 2013;113(6):646-59.doi: 10.1161/CIRCRESAHA.113.300268. [ Links ]

24 Ministério da Saúde (BR). Datasus [Internet]. Brasília: Ministério da Saúde. Morbidade hospitalar do SUS por local de internação: notas técnicas no ano de 2016. Lista Morb CID-10: Insuficiência cardíaca. Disponível em: http://tabnet.datasus.gov.br/cgi/tabcgi.exe?sih/cnv/niuf.def Acesso em: 25 nov, 2017. [ Links ]

25 Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Drazner MH, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013;62(16):e147-239.doi: 10.1161/CIR.0b013e31829e8776. [ Links ]

26 Yancy CW, Jessup M, Bozkurt B, et al. ACCF/AHA Guideline for the Management of Heart Failure. J Am Coll Cardiol. 2015;30(1): E1-E7 doi: 201310.1016/j.jacc.2013.05.019 [ Links ]

Received: March 19, 2018; Accepted: October 22, 2018

Corresponding Author: Maraísa Carine Born E-mail: mara.born@hotmail.com

Creative Commons License This is an open-access article distributed under the terms of the Creative Commons Attribution License