Print version ISSN 0104-4230
Rev. Assoc. Med. Bras. vol.55 no.4 São Paulo 2009
ARTIGO DE REVISÃO
Testes neuropsicológicos e direção na demência: uma revisão da literatura recente
Marcia Thereza SilvaI, *; Jerson LaksII; Eliasz EngelhardtIII
IMédica Psiquiatra. Mestrado pela Universidade Federal do Rio de Janeiro UFRJ, Rio de Janeiro, RJ
IIDoutorado em Medicina e Psiquiatria pela Universidade Federal do Rio de Janeiro -UFRJ, Professor Adjunto da Faculdade de Ciências Médicas da Universidade Estadual do Rio de Janeiro -UERJ, Coordenador do Centro para Doença de ALzheimer e outros Transtornos Mentais na Velhice do Instituto de Psiquiatria da UFRJ, Rio de Janeiro, RJ
IIIProfessor Titular-Instituto de Neurologia Deolindo Couto e Coordenador do Setor de Neurologia Cognitiva e do Comportamento do Instituto de Neurologia da Universidade Federal do Rio de Janeiro UFRJ, Rio de Janeiro, RJ
INTRODUCTION: Neuropsychological tests measure several aspects of cognition and are useful to evaluate elderly drivers with cognitive impairment. However, there is no consensus on a standard battery of tests that could accurately predict safe driving.
OBJECTIVE: The aim of this study is to review specific neuropsychological measures that may be useful to predict driving competence of demented individuals.
METHOD: To address neuropsychologicaltests used for dementia and the ability to drive, the authors searched for the keywords dementia, Alzheimer's, drive, driver, drivers, driving, tests, neuropsychological, and assessment, in Medline, PubMed, ISI and SciELO databases seeking articles from 2000 to 2008.
RESUTLS: From 131 articles, 27 met the inclusion criteria. Porteus Maze, Clock drawing, Trail B, UFOV and NAB Tests were found to be the most relevant neuropsychological measures for the evaluation of fitness to drive.
CONCLUSION: Porteus Maze, Clock Drawing, Trail B, UFOV and NAB tests highlight visuospatial attention demands and/ or executive function. Those and other visuospatial and executive measures may be useful to predict driving competence of demented individuals.
Key words: Dementia. Alzheimer. Driving. Neuropsychology. Aged.
INTRODUÇÃO: Testes neuropsicológicos aferem diversos aspectos de cognição e são úteis para avaliar motoristas idosos que apresentam déficits cognitivos. Entretanto, ainda não existe consenso sobre uma bateria de testes capaz de apurar com eficiência os riscos de dirigir. Objetivo. O objetivo deste estudo foi revisar medidas neuropsicológicas específicas, capazes de prognosticar competência para dirigir em indivíduos com demência.
MÉTODOS: Para identificar testes neuropsicológicos que predizem habilidade para dirigir, os autores intersectaram as palavras-chave: demência, Alzheimer, dirigir, condutor, condutores, direção, testes, neuropsicológicos e avaliação nas bases Medline, Pubmed, ISI e Scielo, buscando artigos entre os anos 2000 e 2008.
RESULTADOS: Dos 131 artigos encontrados, 27 deles apresentaram critérios de inclusão. Os testes: Labirinto de Porteus, Desenho do Relógio, Trilhas -parte B, 'UFOV' (Campo de Visão Útil) e 'NAB' (Bateria de Avaliação Neuropsicológica) demonstraram-se como as mais relevantes medidas neuropsicológicas que avaliam aptidão para dirigir.
CONCLUSÃO: Os testes: Labirinto de Porteus, Desenho do Relógio, Trilhas -parte B, UFOV e NAB demandam atenção vísuo-espacial e/ ou função executiva. Estas e outras medidas de desempenho executivo e função vísuo-espacial possivelmente exercem importante papelna predição de competência para dirigir emidosos com demência.
Unitermos: Demência. Alzheimer. Direção. Neuropsicologia. Idosos.
Preserved motor, perceptual, and cognitive functions are necessary for driving competence. Impairment in such areas affects the ability to drive and may cause accidents and fatal crashes. The risk of motor vehicle crashes for individuals with cognitive decline was first reported in 19671. Dementia is a well recognized risk factor for unsafe driving2, although some early-demented individuals retain driving capacity during the initial stages of disease 3,4. In general, subjects with dementia are poorer drivers than cognitively normal people, and increasing attention has been given to driving capacity and cognitive impairment. Crash risk is proportional to the severity of dementia5. The problem, however, consists in estimating fitness to drive in persons with mild dementia. Physicians are constantly faced by situations in which they are asked to decide on whether the elderly should give up driving. This is a key issue in clinical practice with the elderly, since it affects the freedom to circulate and also some aspects of self-esteem of people who have always been independent.
A growing body of literature supports the utility of neuropsychological assessment to predict driving competence of elderly with early-stage cognitive decline6. Neuropsychological testing provides a useful instrument for diagnosis and prognosis in geriatric assessment7. Because of the increasing number of elderly at risk for driving impairment, the consensus on objective tests for driving assessment is critical. Relevance of neuropsychological measures in the evaluation of fitness to drive has not yet been established2, nor is a 'Test Stand Battery' predictive of safe driving capacity available. Also, there is no consensus by investigators and professionals on whether old people with mild dementia should be prohibited to drive. The aim of this study is to review the evidence of specific neuropsychological measures that may be useful to predict driving competence of demented individuals.
The authors conducted a review of the literature on neuropsychological measures and drivers with Dementia by searching Medline, SciELO, PubMed and ISI databases for articles from 2000 to 2008. Keywords used in combination were (neuropsychological and drive), (tests and driving), (driving and dementia), (driver and dementia), (Alzheimer and driver), (neuropsychological and driving), (assessment and driver), (driving and Alzheimer), (drive and dementia) and (dementia and drivers). Studies published in peer-reviewed journals that correlated driving performance with neuropsychological tests in demented drivers were included in this review. Studies with subjects aged 60 years or more presenting questionable dementia and/ or well defined cognitive loss were also included. Reports were excluded if they did not emphasize dementia with neuropsychological measures and ability to drive, if criteria of dementia were not described. Case studies, letters, comments, case reports and unpublished studies were not included.
Search of literature yielded 27 studies that met criteria for inclusion out of 131 articles (26 studies were not about dementia; 49 studies did not emphasize neuropsychological measures; 22 articles were neither on dementia nor on neuropsychological measures; 3 studies were letters and 4 articles were not on driving competence). Studies disclosed conflicting results on cognitive factors and tests related to driving impairment among aged drivers with early dementia. Papers from 2000 to 2008, excluding review articles, are shown in table 1.
A number of prospective and review studies have examined scores on the MMSE in relation to driving competence8-15 . Literature has yielded variable results. Some papers showed correlation between MMSE and driving competence11-15 , while other results showed MMSE scores that did not reflect ability to drive8-13 .
Specific tests with visuospatial and executive/ attention tests demands demonstrate correlation with driving competence2,12,16-19. Porteus Maze appears as a predictor of driving ability2,20. Ott et al.2 evaluated the ability to drive in subjects with possible dementia and mild dementia with standard neuropsychological tests: Porteus Maze, Controlled Oral Word Association, Clock Drawing, and Trail Making Test (TMT) -Part B21. Results showed that Porteus Maze performance and Trail B time were correlated with driving scores, but Porteus Maze was the only significant test to evaluate driving capacity. However, performance on the TMT has been significantly associated with ability to drive8,14,19-26, especially Trail B, which evaluates executive function. In particular, Frankston et al. 6 studied 29 individuals (13 with mild dementia) comparing TMT and a variant of it, the Color Trails Test 27 (CTT). Results showed that both tools are useful and provide similar information regarding road test outcome. A study by Brown et al. 18 showed the correlation between road test performance and scores on Driving Scenes Test of the new Neuropsychological Assessment Battery28 (NAB). Participants included 31 individuals with diagnosis of very mild dementia and 24 healthy elderly. NAB tests appeared to have ecological validity for on-road driving ability in very mildly demented individuals. Whelihan et al.22 also found a strong relationship between visual attention and executive tests and on-road test performance, but not with other neuropsychological measures. They examined 46 older persons with mild cognitive decline using several measures, including general (e.g. MMSE), visuospatial (e.g. Visual Form Discrimination Test29), executive/attention (e.g. Useful Field of View30, 31 (UFOV), TMT and Porteus Maze), language (e.g. Generative Naming32), and learning/memory measures (Brief Visual Memory Test33). Results showed consistent correlation between road test performance and executive and visual attention demands. Other studies found a strong correlation between UFOV and ability to drive14,17,18,34. Correlation between Clock Drawing Test and fitness to drive was demonstrated in some studies23,35,36 and they all mentioned the Clock Drawing as an efficient instrument. Grace et al. 20compared driving performance in Alzheimer's and Parkinson's patients using Rey-Osterrieth Complex Figure37 (ROCF), Trail B, Hopkins Verbal List Learning Test38 (HVLT) and specific motor symptoms. According to the authors, a major finding of this study was that driving impairment for both patient groups was related to performance on ROCF and Trail B measures, which are involved with executive and visuospatial functions. However, ROCF may not predict ability to drive26.
Some reviews investigated the role of neuropsychological measures and driving ability in mildly demented drivers8,39,40-42. They evaluated studies over the last 30 years, alerting about inconsistent results involving neuropsychological measures and driving competence. However, there is evidence that performance of executive and visual attention tasks was related to on-road tests of driving capacity2,6,8,13,16-19,43-45.
The British Psychological Society has stated, "no one test, or sets of tests, can as yet be recommended for off-road assess-ment"46 and the American Academy of Neurology (AAN) recommends that elderly with possible Alzheimer's disease, who have a total CDR score of 0.5 must be submitted to a driving evaluation39.
The purpose of this review was to examine the effectiveness of neuropsychological evaluations to test driving competence. The period studied comprised the eight years of this decade. We decided to review only the most recent studies and describe some that showed direct correlation between specific neuropsychological measures and ability to drive of demented elderly, since there were already a number of systematic reviews of previous studies on the issue.
Studies investigating the relationship between driving and neuropsychological tests among the elderly and mildly demented populations have yielded contradictory results. The Mini-Mental State Examination (MMSE) is one of the most frequently administered cognitive screening tools to investigate impairment of elderly and their ability to drive47 . In general, most articles agree that MMSE may fail to predict competence to drive in elderly with early cognitive decline39, probably because MMSE focuses mainly on orientation, language, and memory omitting the other domains of cognitive functioning important for driving competence. As such the, MMSE did not predict future crashes or traffic violations9,10,43.
Visual attention/ perception and executive demands are related to driving impairment8,13,16-19,44,45. Porteus Maze is a brief, nonverbal test that yields information to assess the ability to plan and change problem solving approaches25, and appears to be a predictor of driving ability2,20. NAB tests incorporate several aspects of visual attention including working memory, visual scanning, selective attention and attention to detail. Correlation was found between road-test performance and scores on Driving Scenes Test of the new NAB28 . UFOV, an executive/ attention test covers the ability to focus and the speed of visual attention. Some studies found a strong correlation between UFOV and ability to drive13,17,18,34. In particular, UFOV is a now commercially available resource that seems to be promising as a predictor of driving ability.
The American Medical Association's (AMA) document, Physician's Guide to Assessing and Counseling Older Drivers48 recommends the Clock Drawing Test and Trail Making Test-Part B as tools for the evaluation of drivers, rather than exclusively for the evaluation of dementia severity. The validity of the Clock Drawing Test was demonstrated in some studies23,35,36 . However, a recent systematic review disclosed that this is not sufficiently justified41 , although all Clock Drawing Test scoring methods appear as an efficient instrument to evaluate fitness to drive36 .
Our review found that no single test is sensitive enough to predict ability to drive. Performance of tests on visuospatial demands may identify fitness to drive in early dementia. Tasks that assess executive processing, particularly those that also have visuomotor demands may be useful to identify at-risk drivers with early dementia. Other cognitive measures, including memory scores, did not adequately predict driving performance in demented persons.
Porteus Maze, Clock Drawing, Trail B, UFOV and NAB tests correlate significantly with on-road driving performance. In contrast, MMSEis a rather limited instrument to estimate driving competence. MMSE scores do not include perception, and motor evaluations which are domains of cognitive functioning important for driving competence. Tasks that assess visuospatial attention and executive demands such as computer-administered tests should be the focus of future simulator studies49. Such assessments may have good ecological validity to evaluate driving performance.
Our study includes a small number of articles, which may have limited our findings.
Driving competence is a key feature in daily clinical practice with elderly patients, regardless of the physician's specialization. Usually, the physician has to decide whether the patient is still able to drive and is also asked by the family which measures should be taken in this regard. Among other results, this review shows that the MMSE score is not reliable for making this decision, and that specific visuospatial and executive tests should be performed.
Conflict of interest: none
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Artigo recebido: 16/06/08
Aceito para publicação: 04/11/08
Trabalho realizado pelo Centro para Alzheimer e outros Transtornos Mentais na Velhice -Instituto de Psiquiatria do Rio de Janeiro IPUB/ Universidade Federal do Rio de Janeiro UFRJ, Rio de Janeiro, RJ
* Correspondência: Rua Fernando Osório, nº 35 - apto. 802 Flamengo, Rio de Janeiro RJ, CEP: 22230-040, firstname.lastname@example.org