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Revista da Associação Médica Brasileira

Print version ISSN 0104-4230On-line version ISSN 1806-9282

Rev. Assoc. Med. Bras. vol.62 no.3 São Paulo May/June 2016

http://dx.doi.org/10.1590/1806-9282.62.03.207 

Original Articles

Cancer patients, emergencies service and provision of palliative care

Pacientes oncológicos, serviço de urgência e oferta de cuidados paliativos

Bruno Miranda1 

Suely Arruda Vidal2  * 

Maria Júlia Gonçalves de Mello3 

Jurema Telles de Oliveira Lima4 

Judith Correia Rêgo5 

Milena Cândido Pantaleão5 

Viviane Gomes Carneiro Leão5 

Fernando Antônio Ribeiro de Gusmão Filho6 

José Iran da Costa Júnior7 

1MSc in Palliative Care – Physician and Instructor of the Medical Oncology Residency Program at Instituto de Medicina Integral Prof. Fernando Figueira (Imip), Recife, PE, Brazil

2PhD in Maternal and Child Health – Lecturer of the Graduate Program; Researcher of the Study Group on Management and Evaluation of Health, Imip, Recife, PE, Brazil

3PhD in Tropical Medicine from Centro de Ciências da Saúde, Universidade Federal de Pernambuco. Operations Coordinator, Dinter Inca/Imip. Lecturer of the Undergraduate Program at Faculdade Pernambucana de Saúde, and of the Graduate Program at Imip, Recife, PE, Brazil

4MSc in Health Sciences from Universidade de Pernambuco. Oncology PhD Student at Dinter Inca/Imip. Vice-coordinator of the Professional Master of Palliative Care Program linked to the Medical Residency in Health, Imip. Lecturer of the Medical Undergraduate Program, Faculdade Pernambucana de Saúde, Recife, PE, Brazil

5Medical Student, Faculdade Pernambucana de Saúde, Recife, PE, Brazil

6PhD in Public Health from Centro de Pesquisas Aggeu Magalhães, Pernambuco, PE. Director of Human Resource Management, Health Department of Recife, PE, and Researcher of the Study Group on Management and Evaluation of Health, Imip, Recife, PE, Brazil

7Oncology PhD Student at Dinter Inca/Imip. Director of Hospital de Câncer de Pernambuco, Recife, PE, Brazil


SUMMARY

Objective:

To describe the clinical and sociodemographic profile of cancer patients admitted to the Emergency Center for High Complexity Oncologic Assistance, observing the coverage of palliative and home care.

Method:

Cross sectional study including adult cancer patients admitted to the emergency service (September-December/2011) with a minimum length of hospital stay of two hours. Student’s t-test and Pearson chi-square test were used to compare the means.

Results:

191 patients were enrolled, 47.6% elderly, 64.4% women, 75.4% from the city of Recife and greater area. The symptom prevalent at admission was pain (46.6%). 4.2% of patients were linked to palliative care and 2.1% to home care. The most prevalent cancers: cervix (18.3%), breast (13.6%) and prostate (10.5%); 70.7% were in advanced stages (IV, 47.1%); 39.4% without any cancer therapy.

Conclusion:

Patients sought the emergency service on account of pain, probably due to the incipient coverage of palliative and home care. These actions should be included to oncologic therapy as soon as possible to minimize the suffering of the patient/family and integrate the skills of oncologists and emergency professionals.

Keywords neoplasms; palliative care; home care; emergency medical services

RESUMO

Objetivo:

descrever o perfil clínico e sociodemográfico de pacientes oncológicos atendidos na emergência de um Centro de Alta Complexidade em Oncologia, observando a cobertura dos cuidados paliativos e assistência domiciliar.

Método:

estudo de corte transversal com adultos oncológicos atendidos na emergência (setembro a dezembro de 2011) e tempo de permanência superior a 2 horas. Usaram-se teste t-Student de comparação de médias e qui-quadrado.

Resultados:

participaram 191 pacientes, 47,6% idosos, 64,4% mulheres e 75,4% procedentes de Recife e região metropolitana. Dor (46,6%) foi o sintoma prevalente à admissão. Os pacientes sob cuidados paliativos eram 4,2% e sob atenção domiciliar, 2,1%. Os cânceres mais frequentes foram colo uterino (18,3%), mama (13,6%) e próstata (10,5%), sendo 70,7% em estadios avançados (IV, 47,1%) e 40% sem terapia oncológica.

Conclusão:

a procura da emergência por causa de dor deveu-se, provavelmente, à baixa cobertura de cuidados paliativos e atenção domiciliar, os quais precisam ser associados precocemente à terapia oncológica para minimização do sofrimento dos pacientes/familiares e integrar as competências de oncologistas e profissionais de emergências.

Palavras-chave neoplasias; cuidados paliativos; serviços de assistência domiciliar; serviços médicos de emergência

INTRODUCTION

Cancer is currently the second cause of death in the world1 and in Brazil,2 causing greater impact in poor and developing countries.3 This fact is associated with the increasing aging of the world population; the adoption of unhealthy habits such as smoking, sedentary lifestyle and poor diet; sexually transmitted infections; and lack of access to health services for early detection and treatment.4

In Brazil, factors such as changes in the demographic profile with more people aged 50 years or older and an epidemiological polarization caused by growth in chronic-degenerative diseases, increase the likelihood of cancer.2

This change in the Brazilian profile led to the need for restructuring the health system, especially in relation to the care of chronic diseases such as cancer.5 The Ministry of Health (MH) launched by Ordinance Nº 2,439/GM on December 8, 2005, its National Policy for Oncologic Care with actions related to promotion, prevention, diagnosis, treatment, rehabilitation and palliative care.6 The policy was later revised, updated and extended by Ordinance Nº 874/GM on May 16, 2013, which established the National Policy for Cancer Control and Prevention in the Health Care Network of Patients with Chronic Diseases under the Brazilian Unified Health System (SUS).7

This policy calls for the implementation of a line of care at all levels, in a hierarchical network, establishing the obligation of integrated care, with primary and emergency services. The latter should be provided by tertiary units, called Units for High Complexity Care in Oncology (Unacon) and Centers for High Complexity Care in Oncology (Cacon). These recommendations are continually updated and integrated with other policies and strategic actions for confronting chronic noncommunicable diseases (CNCD)7 and with home care services (HCS).8

Oncologic patients, especially those with advanced disease, due to the natural history of their disease, anticancer therapy and/or lack of control of symptoms, may present complications or significant deterioration in their clinical condition requiring emergency care. Therefore, this action is a key part of a comprehensive care aiming to improve quality of life and relief of suffering.9

In relation to urgent and emergency services, cancer patients face difficulties and challenges, although the policy states that the Cacon must operate 24 hours a day.8

Urgent and emergency services should comply with the health care model in force in Brazil, which today often functions as access to health care. This is due to the low effectiveness of primary care and the difficulty of access to high complexity services and hospitalization.10 Nevertheless, the logic of emergency care escapes the basic principles of palliative treatment for patients at the end of life, and can lead to increased and unnecessary suffering.10,11

Considering the lack of local studies on this, our study aims to analyze the clinical and sociodemographic profile of cancer patients seen in the emergency service of a Cacon, considering the availability of palliative care (PC) and home care (HC).

METHOD

This is a descriptive, cross-sectional study with an analytical component carried out at the emergency room (ER) of the Instituto de Medicina Integral Prof. Fernando Figueira (Imip), a teaching and research hospital that belongs to the oncology care network of the state of Pernambuco as a Cacon center.

The study population consisted of patients with cancer treated at oncological service and attended at ER for oncologic monitored from September 2011 to December 2011, with length of stay >2 hours, aged 18 years or older. The instrument used for data collection consisted of a structured questionnaire with items on sociodemographic profile, and other specific questions on reason for seeking emergency care, medical condition, diagnosis, staging, cancer treatment and monitoring in the PC outpatient clinic and HCS. We conducted a pilot study to test the instrument in early September 2011. After necessary adjustments, data collection was held from September 20th to December 21st 2011, every day (including weekends and holidays), three times.

The database was built with double entry in the SQL Server software and Frame Work application. Frequency distribution tables, charts in Excel spreadsheet version 8.0, and statistical tests (Student’s-t test for mean comparison and chi-square test) were prepared using Epi Info 3.5.3.

This project was approved by the Ethics Committee on Human Research of the Imip, no. 2426-11 and CAAE no. 0085.0.099.000-11.

RESULTS

191 medical reviews were performed including those of 20 patients who sought the ER service two times or more. The maximum number of ER entries by a single patient was 6, and 64.4% of the patients were female. Clinical and sociodemographic variables are shown in Table 1.

TABLE 1 Characteristics of cancer patients seen in the emergency service of the Imip, and their progression. Recife, 2011. 

Variables n %
Gender
Female 123 64.4
Male 68 35.6
Age (years)
≥ 60 91 47.1
40-59 69 35.7
18-39 30 17.2
Origin
Recife 71 37.2
GRA 73 38.2
Others 47 24.6
Type of treatment
None 78 39.5
Chemotherapy 60 30.3
Radiotherapy 19 9.6
Hormone replacement 16 8.1
Chemo and radiotherapy 11 5.5
Surgery 3 1.5
Others 11 5.5
Progression
Hospital discharge 86 45.0
Admission 97 50.8
Transfer 4 2.1
Death 4 2.1

GRA: great Recife area.

Most patients came from Recife and greater area (75.4%). They were aged between 19 and 91 years, mean 57 years, and 47.6% were older than 60. Among the identified clinical conditions, only 4.2% were characterized as oncologic emergencies, and 19.9% as infection. The most frequent symptom was pain (46.6%) and there was no statistically significant difference in any particular subgroup in that respect. As for tumor topography, cervical (18.3%), breast (13.6%) and prostate (10.5%) cancers were predominant. Advanced disease characterized as stages III and IV represented 70.7% of patients, with 47.1% at stage IV. In 14.7% of the reviews, patients were still at staging phase.

Regarding oncological therapeutic modalities being offered at the time of admission (Table 2), 39.4% had no specific treatment, 30.3% were undergoing chemotherapy, 9.6% were undergoing radiotherapy, and 5.6% chemotherapy combined with radiotherapy.

TABLE 2 Clinical characteristics of cancer patients seen in the emergency service of the Imip, and treated by home care and/or palliative care. Recife, 2011. 

Clinical Total=191 HCS/PC p
characteristics n (%) Yes: 10 No: 181
n (%) n (%)
Symptoms
Pain 100 (46.6) 6 (60) 83 (45.9) 0.29
General, non-specific 61 (21.2) - -
GI¥ 50 (10.9) - -
Respiratory 30 (11.5) - -
Other 35 (19.9) - -
Clinical diagnosis
Infection 37 (19.4) - -
Disease progression 29 (15.2) - -
Treatment toxicity 15 (7.9) - -
Oncologic 8 (4.2) - -
emergency
Undiagnosed 58 (30.4) - -
Others 44 (23.0) - -
Oncologic diagnosis
Cervix 35 (18.3) 3 (30) 32 (17.6) 0.44
Breast 26 (13.6) 2 (20) 24 (13.2)
Prostate 20 (10.5) 2 (20) 18 (9.9)
Lung 18 (9.4) 1 (10) 17 (9.3)
Other sites 92 (48.2) 2 (20) 90 (47.1)
Staging
I and II 28 (14.6) 1 (10) 27 (14.9) 0.51
III 45 (23.6) 1 (10) 44 (24.3)
IV 90 (47.2) 7 (70) 83 (45.8)
Not staged 28 (14.6) 1 (10) 27 (14.9)

¥Gastrointestinal tract; HCS: home care services; PC: palliative care.

4.2% of patients were being monitored in the PC outpatient clinic and 2.1% in HCS. No statistically significant differences were observed between the groups of patients in PC and HC in relation to complaints of pain (Table 3).

TABLE 3 Clinical status of cancer patients seen in the emergency service of the Imip and reason for dismissal. Recife, 2011. 

Clinical
status
Hospital
discharge
n (%)
Admission
n (%)
Death
n
Transfer
n
Total
n (%)
Infection 8 (9.4) 28 (28.9) 1 - 37 (19.4)
Disease progression 2 (2.4) 27 (27.8) - - 29 (15.2)
Treatment toxicity 9 (10.6) 6(6.2) - - 15 (7.9)
Oncologic emergency 1 (1.2) 6(6.2) - 1 8(4.2)
Unknown 47 (55.3) 8 (8.2) 1 2 58 (30.4)
Other 19 (22.1) 22 (22.7) 2 1 44 (23.0)
Total 86 97 4 4 191

DISCUSSION

This study used the emergency care as a proxy for the quality of care provided to cancer patients and the effectiveness of pain control programs, under PC and HCS.

Emergency care is an important part of the comprehensive care of cancer patients.7 However, there were few cases characterized as oncologic emergencies reviewed at the ER/Imip, unlike other countries.11-15 In this study, most of the demands were medical situations that could be assessed and classified according to risk, and assisted by a general practitioner in their places of residence; many were related to deficient care network.

The reorganization of the hierarchical and regionalized network would prevent one in five patients to be displaced from rural areas in the state for case review in a reference hospital, as noted here. The trip can aggravate the clinical status due to transport difficulties, increase the suffering of the patient and family, and generate family financial expenditure and system overload in the higher complexity service.

The high prevalence of breast and cervical cancer in patients who sought emergency care at the Imip (about 1/3 of all cancers) may portray late diagnosis, poor access to diagnostic screening with cytology, low quality examination and also difficult access to specialized services, which is mostly supported by the prevalence of diagnosis being made with advanced disease (stage III and IV).

It is estimated that 30 to 90% of cancer patients are affected by moderate to severe pain in the course of their disease and that 80% of patients in the terminal phase are affected.9,11,13-15 In this study, the main complaint in the emergency room was pain, similar to that reported in a 2007 systematic review.16 However, even with the recommendation of the World Health Organization (WHO)17 and the Brazilian MH,7 as well as a high probability of success in pain control, this symptom is still neglected worldwide.18

Knowledge and skills development for adequate pain management should be a priority for health professionals. Also, public health managers should be sensitized to this possibility in order to provide the units with standard resources for effective control of pain in 95% of cancer patients,19,20-22 and thus promote patient welliness.7,12

There are several hypotheses for the inadequate control of pain: from difficulty of the medical staff to properly measure the complaint, to the arrogance-ignorance paradox in the medical profession;22 in addition, there is also insufficient medical knowledge about opioids and pain treatment, and lack of pain medication or difficulty to obtain opioids, combined with the legal difficulties to prescribe such drugs.12,18,20,21

A result that draws attention is that approximately half of patients do not receive any specific cancer therapy. This suggests that the emergency service allows the start of treatment for new situations resulting from the disease, or not directly related to cancer. The situation finds no support in the Policy,7 which broadens access when it expands the assistance to all levels of complexity, and gives the idea that the patients already have disease at such an advanced stage that they would no longer benefit from these therapies.

Several cultural and social barriers, and others associated with the training of human resources, restructuring of logic supply of care and integration of knowledge and practices that need to be overcome,18,23,24 are reported in the implementation of PC services in Brazil and worldwide.

The WHO21 and the Brazilian MH7 propose the offering of PC services as soon as possible whenever diseases considered severe, progressive, incurable, threatening the continuity of life, are diagnosed. These services can be provided even at a primary level. At first, such care does not exclude specific antineoplastic therapies.24,25 However, we see that the referral of patients to PC services has occurred repeatedly in the late stages of the disease, representing a major barrier to access in many parts of the world.26,27

The finding that few cancer patients treated at the ER were in PC or HC promoted a discussion among professionals of the institution in order to create expansion strategies. This is because the evidence shows that the implementation of these instances of care improves symptom control and the quality of life of cancer patients, reducing the demand for emergency care.24,28,29

Cases that should be reviewed in other levels of care (outpatient, home, basic unit), hinder patient monitoring when treated in emergency services. This is due both to the absence of records produced in emergency settings, and the lack of an integrated system with outpatient information. Service levels should operate together, under the same regulation, with reference and counter-reference that provides monitoring sites before and after the emergency care.12,17

Conclusion

The results of this study proved challenging for service providers and for policymakers. The main types of cancer identified in the emergency could be prevented, diagnosed early, treated and cured. And even in cases with advanced stages, the pain could have been reduced and the family assisted in order to cope with the disease.

However, incipient levels of PC and HCS coverage were found, indicating that these services need to be expanded and integrated into early cancer therapy aimed at relieving the suffering of both the patients and their families. Palliative care should be part of the skills required not only from oncologists, but from all health professionals who work in emergency services.

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Received: August 11, 2014; Accepted: May 04, 2015

*Address: Rua Francisco da Cunha, 1910/102-B, Boa Viagem, Recife, PE – Brazil, Postal code: 51020-041, Phone: +55 81 2122-4122 (Imip). suely@imip.org.br

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