Evolution and projection of knee arthroplasties from 2003 to 2030 in the state of São Paulo

SUMMARY

OBJECTIVE

Analyze data regarding total knee arthroplasty (TKA) carried out by the Public Health System (SUS) in the state of São Paulo from 2003 to 2010 and determine the projections expected for 2030.

METHODS

A cross-sectional study (observational). We analyzed 10,952 patients who underwent primary total knee arthroplasty (PTKA) and revision total knee arthroplasty (RTKA) in the state of São Paulo between 2003 and 2010. The collection of data based on ICD-10 and HAA (Hospital Admission Authorization) were provided by the Tabnet and Sigtap software (Management System for the Table of Procedures, Medications, and OPM by SUS). The following variables were analyzed: gender, number of PTKAs and RTKAs, and their projections. The information collected formed a database developed in Excel® for Windows, and the statistical analysis was performed by the Stata® 11 SE and Minitab 16 software.

RESULTS

There was a significant difference in the prevalence of TKA between genders (p<0.0001); most of the patients were females (7,891; 72%). The projection for 2030 when compared with the first year of the series, 2003, indicates a growth of 428% for PTKA and 1,380% for RTKA, with a greater increase percentage of RTKA in males than in females (1,558% and 1,318%, respectively).

CONCLUSION

The proportions of the RTKA projection are much greater than those of PTKA by 2030, with a greater percentage of increase of RTKA in males than in females.

Osteoarthrosis; Arthroplasty; Knee; Forecasting

RESUMO

OBJETIVO

Analisar os dados referentes às artroplastias totais de joelho (ATJ) realizadas pelo Sistema Público de Saúde (SUS) no estado de São Paulo de 2003 a 2010 e determinar as projeções esperadas para 2030.

MÉTODOS

Estudo transversal (observacional). Foram analisados 10.952 pacientes que realizaram artroplastia total de joelho primária (ATJP) e revisão (ATJR) no estado de São Paulo entre 2003 e 2010. A coleta de dados baseados no CID-10 e AIH (Autorização de Internação Hospitalar) foram fornecidos pelo programa Tabnet e Sigtap (Sistema de Gerenciamento da Tabela de Procedimentos, Medicamentos e OPM do SUS). Foram analisadas as seguintes variáveis: gênero, número de ATJP e número de ATJR, além de suas projeções. As informações coletadas formaram um banco de dados desenvolvido no programa Excel® for Windows e a análise estatística foi realizada pelos softwares Stata® 11 SE e Minitab 16.

RESULTADOS

Houve diferença significativa na prevalência da ATJ entre os gêneros (p<0,0001), sendo a maioria do gênero feminino (7.891; 72%). A projeção para 2030 quando comparado com o primeiro ano da série, 2003, indica um crescimento de 428% para as ATJP e 1.380% nas ATJR, com uma porcentagem de aumento maior nas ATJR no gênero masculino do que no feminino (1.558% e 1.318%, respectivamente).

CONCLUSÃO

As proporções de projeção da ATJR se mostram muito maiores do que nas ATJP até o ano de 2030, percebendo-se uma porcentagem de aumento maior de ATJR no gênero masculino comparado ao feminino.

Osteoartrose; Artroplastia; Joelho; Previsões

INTRODUCTION

Over the past decades, there has been an increase in the longevity and life expectancy of the people in the state of São Paulo¹. In 2000, the state’s population was approximately 37 million inhabitants, of which 8.9% were elderly individuals (over 60 years)¹. In 2014, this percentage increased to 11.89% of the more than 44 million inhabitants of São Paulo¹. For 2030, it is expected that 21% of a total population of 48 million will be elderly individuals¹. Recently, with the absolute number increase of the elderly population, the number of patients with osteoarthritis of the knee (OAK), particularly in the most populous Brazilian state². Among the therapeutic options available for treating symptomatic advanced TKA, there is total knee arthroplasty (TKA)². This surgery represents a technological breakthrough in OAK surgical procedures; it is effective to reduce pain, realign the affected lower limb, restore function, and optimize the decreased articular mobility³. TKA allows a functional improvement in around 90% of the patients, with implants durability at around 95% in 15 years and 91% in 21 years².

The development of instrumental support and particular devices, in addition to the improvement of surgical techniques and anesthetic procedures, broadened the indication criteria for KTA, including the age range over 40 years old, provided the procedure’s eligibility conditions are met by younger and more active OAK patients⁴. The increase of TKA indications in the fifth and sixth decades of life has been reported in other countries, with emphasis on the public health system⁶. The increased number of people in their 80’s and 90’s in clinical conditions to become TKA surgery candidates and the increased prevalence of obesity in the Brazilian population, which is a risk factor for OAK progression, has caused an increasing demand for TKA, and consequently of TKA revision cases (RTKA), thus determining a tendency of increased number of these surgeries in the coming years, especially in reference centers⁴,⁸,⁹. The greater number of indications for these types of arthroplasty will increase the health system’s financial expenditures related to these primary interventions (ATKs) and surgical re-interventions in the coming decades².

Thus, there was an expansion of the number of PTKAs and, consequently, an increase in revisions and the possibility of an even greater rise in numbers over the next 30 years¹⁰. Among the primary etiologies for RTKA, periprosthetic joint infection stands out, presenting an unfavorable impact on the functional clinical outcomes, increased hospital costs, and mortality rates in patients infected¹²,¹⁴. Other etiologies responsible for revisions are the loosening of the implants, instability, joint stiffness, and pain after the TKA¹².

The objective of this study is to analyze data regarding total knee arthroplasty (TKA) carried out by the Public Health System (SUS) in the state of São Paulo from 2003 to 2010 and determine the projections expected for 2030.

METHODS

This study was conducted with the approval of the institution’s ethics committee (CAAE: 48693115.1.0000.5463).

The data available were collected from the Tabnet software (a software developed to allow the technical staff of the Ministry of Health, State and Municipal Health Departments quickly tabulate files in DBF format - dbFast, which constitutes the basic components of the SUS Information Systems in their intranet or on their websites) and Sigtap system (Management System for the Table of Procedures, Medications, and OPM by SUS) concerning the epidemiological assessment of TKAs performed in the state of São Paulo, from 2003 to 2010. This time interval was selected due to the redefinition of the strategy for increased access to elective surgical procedures under the SUS in 2011 and regulated by Decree 1,340, of 29 June 2012, of the Ministry of Health, which encompassed knee arthroplasties. These programs are administered by the Hospital Information System of SUS - SIH/SUS, managed by the Ministry of Health, through the Department of Health Assistance, along with State and Municipal Health Departments, and processed by the Datasus - Department of Informatics of SUS, of the Executive Secretariat of the Ministry of Health. The instruments used to record the patients included in the program were the HAAs (Hospital Admission Authorization) of patients admitted with the underlying disease, according to the International Classification of Diseases (ICD - 10). The ICDs selected were M17 for knee arthrosis and T84 for complications of prosthetic devices.

The hypothesis is that the demand for PTKA and RTKA will increase substantially by the year 2030. To test this hypothesis, we performed statistical projections, by means of linear regression, of the total number of PTKAs and RTKAs between 2011 and 2030 based on the medical records available in the database of the Unified Health System (SUS) for the state of São Paulo, between January 2003 and December 2010.

We analyzed data concerning TKAs (primary and revision) performed by SUS in the state of São Paulo, between January 2003 and December 2010, to determine the expected trends and projections of these arthroplasties by 2030. The variables evaluated in this study were the type of arthroplasty, the date of surgery and gender, which were presented in tables with absolute and relative frequency distribution. The normality of the variables was tested using the Shapiro Wilk test¹⁰, and the proportion comparison of the variables was performed using the Test for the Equality of Two Proportions¹⁶. The trend analysis was performed by polynomial regression models. All analyses were performed with a significance level of 5%; therefore, results were considered statistically significant when p-value < 0.05, always considering two-tailed alternative hypotheses.

The information collected formed a database developed in Excel® for Windows, and the statistical analysis was performed by the Stata® 11 SE and Minitab 16 software.

RESULTS

This study analyzed 10,952 patients who underwent TKA between January 2003 and December 2010. There was a significant difference in prevalence between genders (p<0.0001), with mostly female patients (7,891; 72%), i.e., there were, on average, 2.6 times more procedures of TKA performed in women than in men (Table 1).

TABLE 1
DISTRIBUTION OF TKAS PER GENDER, FROM 2003 TO 2010.

Gender	No.	%	p
Fem	7,891	72%	<0.0001
Male	3,061	28%
Total	10,952	100%

There was a significant increase in PTKA and RTKA surgeries (p<0.0001) in the period analyzed. In 2003, the first year analyzed, 830 TKAs and RTKAs 91 were performed. In the last year analyzed, 2010, 1,839 TKAs and 420 RTKAs were performed, an increase of 122% and 362%, respectively, in the number of surgeries performed between the first and the last year analyzed (Table 2).

TABLE 2
DISTRIBUTION OF TKAS PER GENDER, FROM 2003 TO 2010.

Type of ATK	Year								Growth % (initial year x final year)
	2003	2004	2005	2006	2007	2008	2009	2010
Primary	830	840	917	1001	1105	1187	1552	1839	122%
Revision	91	102	116	133	169	333	317	420	362%
Total	921	942	1033	1134	1274	1520	1869	2259	145%

As for the projections, the results showed that by 2030, the number of TKAs would increase with statistical significance (p<0.0001). When compared with the first year of the series, 2003, the projection indicates a growth of 428% for PTKAs and 1,380% for RTKAs (Table 3 and Figure 1). It should be noted that the proportion ratio between the types of surgery is decreasing: in 2003, the proportion ratio between PTKA and RTKA was 9.1:1, i.e., nine primary surgeries were performed, on average, for each revision surgery. In the projection for 2030, the proportion dropped to 3.3:1, i.e., it indicates that for every three primary surgeries, one revision surgery will be performed.

TABLE 3
ATKS EVOLUTION FROM 2003 TO 2010, AND PROJECTIONS BY 2030.

Type of ATK	Historical series								Projections				Growth % (initial x final)
	2003	2004	2005	2006	2007	2008	2009	2010	2015	2020	2025	2030
Primary	830	840	917	1001	1105	1187	1152	1839	2326	3013	3700	4386	428%
Revision	91	102	116	133	169	333	317	420	621	863	1105	1347	1380%
Primary ratio	9.1:1	8.2:1	7.9:1	7.5:1	6.5:1	3.6:1	4.9:1	4.4:1	3.7:1	3.5:1	3.3:1	3.3:1	-

FIGURE 1
ATKS EVOLUTION FROM 2003 TO 2010 AND PROJECTIONS BY 2030.

The result showed that, for 2030, the number of PTKAs increased with statistical significance (p<0.0001) for the female gender. When compared with the first year of the series, 2003, the projection indicates a growth of 388% for PTKAs and 1,318% for RTKAs, with a 3.2:1 ratio for the projections.

The results showed that, for 2030, the number of TKA increased with statistical significance (p<0.0001) for males. When compared with the first year of the series, 2003, the projection indicates a growth of 552% for PTKAs and 1,558% for RTKAs, with a 3.3:1 ratio for the projections (Figure 2).

FIGURE 2
RATKS EVOLUTION FROM 2003 TO 2010 AND PROJECTIONS BY 2030, PER GENDER

DISCUSSION

The most important finding of this study was that the TKA demand , for both primary and revision, has a growing trend, with a projected increase of 428% for the primary type and 1,380% for revisions, by 2030. Although primary prosthesis are more frequent, the ratio between the proportion of primary prostheses and revisions is decreasing considerably (9.1:1 in 2003 and 3.3:1 in 2030).

Our study showed an increasing trend of TKA, which was also found in studies conducted in other countries. In the United States, a study carried out over a similar period of time found that the demand for PTKA and RTKA is expected to grow 673% and 601%, respectively, between 2005 and 2030¹¹. Data analyses relating to England and Wales suggest that, by 2030, the volume of TKAs and RTKAs will have increased by 117% and 332%, respectively, between 2012 and 2030¹⁸. Another European study presented data that predict a 297% demographic projection for the number of TKAs by 2030 in the Netherlands¹⁹. Another study showed that TKAs would increase by 45% over the next three decades in Italy²⁰.

Another study reports that event young patients (under 65 years) will have an increase in the number of prosthesis and revisions by 2030, and highlights the weight that young patients may represent in the future of the demand for primary and revision surgery²¹. A study conducted in the United States and in Ontario, Canada, demonstrated that the rates of TKA have increased in North America, with the contribution of the increased number of young people undergoing prosthetic replacement of joints, which indicated an expansion of indications²². Another international study corroborates the increased projection, estimating a 183% growth of TKAs by 2026²³. This increase in the demand for TKAs and RTKAs will create a significant socioeconomic burden and require planned and programmed health strategies to ensure the necessary resources are allocated to meet the demand of the population affected by OAK¹⁷.

In the gender analysis, when confronted with other international case series, we found an increase proportionally similar for men and women²³. However, after analyzing the procedures based on type and gender, we saw a greater percentage increase in RTKA in males than in females (1,558% and 1,318%, respectively). This disparity justifies further research to determine the extent to which it reflects changes in the risk of the disease or inequalities in public health services. Women usually seek early medical care due to functional disabilities associated mainly to complaints of pain during walking and daily living activities, while men postpone medical assistance and complain about the deleterious effects of OAK on leisure activities²⁴. Women have a longer life expectancy and have presented increased use of TKA in recent years, but face greater barriers to access to the surgical treatment²,⁵,²⁵. Women are willing to undergo surgery, just like men, but are less likely to receive an indication to a specialist in comparison with men with advanced OAK²⁵.

Additional national epidemiological data, such as the latest updated projections of this study, provide a forecast for surgeons, hospitals, health services and the formulators of public policies to plan for the future demand for ATKs and RTKAs over the next decades². The data relating to projections made in this study identified a proportional increase of RTKA indications in comparison with to TKA over the next decade, allowing for a planned health budget and the development of strategic measures to encompass this increased demand for knee arthroplasty surgeries. Among the possible etiologies responsible for the increased number of RTKAs in the sample analyzed, periprosthetic joint infection (PJI) stands out in several different stages, i.e., early (less than three months), intermediate (between 3 and 24 months) and late (after 24 months), according to the classification proposed by Zimmerli et al.²⁷. The lack of standardization and multi-professional teams specialized in the diagnosis and treatment of PJI made the follow-up of these patients in SUS even more difficult. Two national studies conducted in public hospitals in São Paulo, which included part of the period of time analyzed in our study, corroborated this possibility²⁸. Since then, protocols have been implemented and developed jointly by infectologists, anesthesiologists, and nursing professionals to prevent, diagnose, monitor, and optimize therapeutic strategies to minimize such complication³⁰.

The increase of prosthetic knee joint replacement surgeries is an urgent reality and requires improvements in the management of hospitals, training of medical professionals, and specialized nursing teams, due to the positive association between the experience of the surgeon and the surgical volume of knee arthroplasties performed at referral centers with more favorable outcomes, lower rate of complications, and lower costs²,⁹,¹¹,¹⁴. The projections in this study are limited to an extrapolation of historical data. The trends established may not persist in the future because of the influence of certain factors, such as improvements in the implant technology or new pharmaceutical discoveries that may impact the physiopathology and progression of OAK.

The weaknesses of this study are the lack of standardization of surgical techniques, the absence of data such as patient age and comorbidities, which could identify risk factors for arthroplasties, absence of etiologies and indications for the surgery, complications related to the procedure and the lack of knowledge of materials and implants used for the knee prostheses. These data were not collected due to the diversity of information from medical records and absence of interviews with the patients who underwent surgery.

CONCLUSION

The projected proportions of revision prosthesis are much greater than those of primary prosthesis by 2030. The increasing percentage of RTKAs was greater in males when compared with females.

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Publication Dates

• Publication in this collection
  05 Aug 2019
• Date of issue
  July 2019

History

• Received
  09 Nov 2018
• Accepted
  25 Nov 2018