THESIS: F. A. Reis submitted this dissertation for her Master of Sciences degree in Anatomy publicly examined at the Institute of Biosciences UNESP - Botucatu, São Paulo, Brazil, in July 1999.
Advisor: Prof. Dr. Antonio de Castro Rodrigues
ABSTRACT. Peripheral nerve repair was accomplished using the two different techniques of suture and fibrin glue coaptation derived from snake venom. The results were compared based on morphological criteria. The possibility was studied of regenerating axons from an intact nerve (n. vagus) to grow into a nerve graft (n. fibularis). The grafts were harvested after 8 and 12 weeks post-surgery and then processed for light and electron microscopy. The diameters and thicknessof the regenerating nerve fibers were measured. A high rate of success (number of animals) was obtained in the suture group. The rate of regenerated nerve fibers was higher in the fibrin glue group. The histological and ultrastructural analyses confirmed the presence of regenerated nerve fibers in both grafts (suture and fibrin glue). The diameter and thickness of the regenerated axons in the grafts were smaller if compared to the donor nerve (n. vagus). It was concluded that the spinal nerve graft (n. fibularis) was efficient in the regeneration of nerve fibers from the intact cranial nerve (n. vagus).
CORRESPONDENCE TO: F. A. REIS Centro de Ciências Biológicas e da Saúde, UNIVALE, Caixa Postal 295, Governador Valadares, CEP 35030-390, MG, Brasil.
E-mail: fabiolar@net.em.com.br
A.C. Rodrigues Departamento de Anatomia, Instituto de Biociências, UNESP, CEP 18618-000, Botucatu, SP, Brasil.
E-mail: acastro@ibb.unesp.br
Publication Dates
-
Publication in this collection
25 Feb 2000 -
Date of issue
2000
