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Print version ISSN 0365-0596On-line version ISSN 1806-4841
An. Bras. Dermatol. vol.86 no.4 supl.1 Rio de Janeiro July/Aug. 2011
Proliferating trichilemmal tumor - case report*
Luíza Helena dos Santos CavaleiroI; Fernanda de Oliveira VianaI; Clivia Maria Moraes de Oliveira CarneiroII; Mario Fernando Ribeiro de MirandaIII
IMD, Resident in the Dermatology Department, Federal University of Pará (UFPA), Belém, Brazil
IIMA in Tropical Diseases awarded by the Federal University of Pará, Associate Professor of Dermatology at Federal University of Pará (UFPA), Belém, Brazil
IIISpecialist in Dermatology, certified by the Brazilian Society of Dermatolgy (SBD). Specialist in Dermatopathology, certified by the International Committee for Dermatopathology (ICDP) and the Union Européenne des Médecins Specialists (UEMS), Associate Professor of Dermatology at the Federal University of Pará (UFPA). Responsible for the dermatopathology laboratory of the Dermatology Department, Federal University of Pará (UFPA), Belém, Brazil
Proliferating trichilemmal tumor (PTT) is an uncommon neoplasm arising from the follicular isthmus. Its histological characteristic is the presence of trichilemmal keratinization. PTT usually presents as a solitary nodule on the scalp of elderly women. We describe a case of a PTT on the gluteal region (buttocks) of a 16-year-old female, presenting as a solitary nodule.
Keywords: Cysts; Histology; Buttocks
Proliferating trichilemmal tumor (PTT) is an uncommon neoplasm, first described in 1966 by Wilson and Jones 1 as a "proliferating epidermoid cyst." Most lesions occur on the scalp of elderly women as a solitary nodular lesion. 2-4 We report an unusual case, rarely reported in the international literature, of a TTP which presented as a nodular tumor located on the buttock of a young female patient.
16-year-old female patient reported the appearance five months ago of a pruritic papule on the gluteal region, which gradually evolved as a tumor, with episodes of bleeding at the site. Dermatological examination showed a pedunculated, cracked, bleeding and ulcerated tumoral lesion measuring about 2.5cm located on the patient's left buttock (Figure 1). We performed complete excision of the lesion. Histological examination revealed an intradermal proliferation with lobular architecture formed by clusters of pleomorphic epithelioid cells with eosinophilic cytoplasm and nuclear atypia, surrounded by a fibrous pseudocapsule (Figure 2). The tumor presented foci of acantholysis and areas consisting of a set of clear cells with keratinized centers, representing trichilemmal differentiation (Figures 3 and 4). The stroma exhibited numerous vessels and granulation tissue on epidermal hyperplasia. The correlation of clinical findings with histopathology confirmed the diagnosis of PTT.
TTP is an uncommon adnexal neoplasm differentiating towards the follicular outer root sheath epithelium. It is believed that it is caused by a trichilemmal cyst (TC). TTP and CT possess trichilemmal keratinization as a histological marker (abrupt transition from epithelial nucleated cells to anucleate, keratinized cells, without the formation of granular layer). 2 The TTP are generally larger and more atypical when compared with CT and in some cases may simulate squamous cell carcinoma. 3, 4 About 90% of cases involve scalp lesions, described clinically as slow growth solitary nodular lesions. 3,4,5 Other less common locations include the neck, trunk, armpits, groin, vulva, lower and upper limbs, upper lip and buttocks. 2,6,8 Reports exist of multiple lesions, ulceration and bleeding 2,5. Women are more affected than men, with age at onset of over 60, although cases have been reported in young people. 3,5,6,9 The tumor is characterized histologically by the proliferation of basaloid and squamous cells with abrupt trichilemmal keratinization and varying degrees of cytologic atypia. 5 Some cells may appear clear or vacuolated and the periphery of the epithelial cells displays PAS-positive eosinophilic membrane. 5 In the majority of reports it is characterized as a benign lesion. 4,10 Reports exist of clinical and histological malignant forms with local or lymph node spread but these are rarely hematogenous.5,10 to 12 The higher risk of metastasis is present when the lesion occurs in areas other than the scalp, when it is fast-growing and infiltrative, is over five centimeters in diameter and/or presents cytological atypia and mitotic activity. 10 The treatment of choice is surgical resection with a safety margin of one centimeter. 4,9 Due to the high local recurrence rate, Mohs micrographic surgery would appear to be a therapeutic option. 13
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12. Lopez-Rios F, Rodriguez-Peralto JL, Aguilar A, Hernandez L, Gallego M. Proliferating trichilemmal cyst with focal invasion: report of a case and a review of the literature. Am J Dermatopathol. 2000;22:183-7. [ Links ]
13. Tierney E, Ochoa M, Rudkin G, Soriano TT. Mohs' micrographic surgery of a proliferating trichilemmal tumor in a young man. Dermatol Surg 2005;31:359-63. [ Links ]
Mailing address: Received on 30.12.2010. * Study undertaken at the Dermatology Department, Federal University of Pará (UFPA), Belém, Brazil.
Fernanda de Oliveira Viana
Rua Tibúrcio Cavalcante, 2777 - Apartamento 702 Dionísio Torres
60125-101 Fortaleza (CE) - Brazil
Approved by the Advisory Board and accepted for publication on 19.02.11.
Conflict of interest: None
Financial funding: None
Received on 30.12.2010.
* Study undertaken at the Dermatology Department, Federal University of Pará (UFPA), Belém, Brazil.