Cutaneous malakoplakia: case report and review^*

Malacoplaquia cutânea: relato de caso com revisão da literatura

Abstracts

Malakoplakia is a rare acquired disease that can affect many systems but is more common in the urogenital tract. Cutaneous malakoplakia is even rarer. It is far more frequent in immunodeficient patients. We report a case of cutaneous malakoplakia in a kidney transplant patient who had recently stopped receiving immunosuppressive therapy to illustrate a review of the relevant recent literature.

Kidney Transplantation; Malacoplakia; Review; Skin

Malacoplaquia é uma doença adquirida rara que pode afetar diversos órgãos e sistemas, mas é mais comum no trato urogenital. O acometimento cutâneo é ainda menos frequente. Atinge principalmente imunodeficientes. Relatamos caso de malacoplaquia cutânea em um paciente transplantado renal que havia recentemente deixado de receber a terapia imunossupressora, a fim de ilustrar uma revisão da literatura recente relevante.

Malacoplasia; Pele; Revisão; Transplante de Rim

INTRODUCTION

Malakoplakia is a term derived from the Greek, meaning "soft plaque".^{1 , 2} The disease was first described in 1902 by Michaelis and Gutman.³ It describes a granulomatous process of infectious etiol ogy triggered by bacteria that occurs preferentially in subjects affected by primary or secondary immunodeficiency.^{4 , 5} The pathogenesis of malakoplakia remains poorly understood, and it is thought to represent an acquired bactericidal defect of macrophages associat ed with infection, immunosuppression, and/or immunosuppressive agentes.^{4 . 6 , 7}

The most common site of occurrence is the urogenital tract, although the condition has also been found to affect the gastrointestinal and respiratory tracts, retroperitoneum, thyroid gland, lymph nodes, bones/joints, middle ear, eyes and brain.^{4 - 9} The condition has been considered rare, and cutaneous malako plakia is even rarer; the first case was reported by Leclerc and Bernier in 1972.¹⁰

We report a case of cutaneous malakoplakia in a kidney transplant recipient and proceed with a review of the topic.

CASE REPORT

A 51-year-old white man from Brazil, suffering from idiopathic chronic renal failure, presented with a immunosuppressive agentes.^{4 . 6 , 7} 2-year history of asymptomatic cutaneous lesion on the left groin, noticed by his nephrologist during hospitalization due to sepsis caused by catheter infection.

The patient was frequently catheterized at this site since an unsuccessful kidney transplantation 2 years before.

The lesion was a yellow-erythematous-purple plaque measuring around 1 cm in diameter, on the left groin, near a femoral vein catheter (Figure 1).

FIGURE 1
Malakoplakia: Picture of the yellow-erythematous- purple plaque measuring little more than 1 cm in diameter on the left groin of the patient near a femoral vein cateter

The lesion was sampled for histopathologic and culture studies. The culture results revealed the growth of Providentia spp and Candida albicans. Histopathologic analysis revealed a chronic inflammatory process characterized by sheets of closely packed macrophages containing PAS-positive inclusions (von Hansemann cells) and calcospherites known as Michaelis-Gutmann bodies, as demonstrated by Von Kossa stain, which shows the homogeneous bodies in black (Figures 2A, 2B e 2C). Prussian blue staining demonstrated the presence of hemosiderin inside macrophages, which may explain the purple color of the lesion (Figure 2D).

FIGURE 2
Malakoplakia: A-hematoxylin-eosin (400 X) stain showing the sheets of macrophages. B-von Hansemann cells in PAS stain (400 X)(black arrow). C-Michaelis- Gutmann bodies, shown in black after Von Kossa staining (400 X)(black arrow). D-Prussian blue demonstrates hemosiderin inside macrophages (400 X)

The patient was treated with surgical excision in association with sulfametoxazol-trimetoprin antibiotic therapy. No evidence of recurrence was detected on 3-year follow-up, as shown in figure 3.

FIGURE 3
Malakoplakia: Left groin picture of the same patient after treatment and 3-year follow-up

DISCUSSION

Malakoplakia is a rare granulomatous disease in which a defect of the killing capacity of macrophages after endocytosis is considered to be the central event. Disturbed phagosome-lysosome fusion was suggested, but it is still not clear how and why this disorder happens, and the hypothesis is not fully accepted.^{11 - 13} We reviewed published articles in indexed periodicals that appeared in a PubMed search performed using the term "cutaneous malakoplakia". Based on Kohl et al. 2008, we added cases of cutaneous malakoplakia published from January 2006 until January 2012, as demonstrated in chart 1.¹⁴

CHART 1

Reported cases of cutaneous Malakoplakia

Reported Cases of Cutaneous Malakoplakia in the Literature*
Case No.	Reference No.	Age/Sex	Location	Gross	Medical History
1	5	51 y/M	Perianal, inguinal, scrotum	Nodules and ulcerations	Kidney Tx
2	5	67 y/M	Right temple	Nodule	Kidney Tx
3	33	69 y/F	Right axilla	Ulceration and mass	RA, breast carcinoma
4	34	40 y/F	Inguinal, broad ligament	Ulceration	N/A
5	10	64 y/M	Perianal	Indurated mass	RA
6	35	35 y/M	Left eyelid	Nodule	Kidney Tx
7	1	64 y/M	Perianal	Ulceration	Lymphoma
8	36	75 y/F	Vulva	Ulceration	RA
9	37	50 y/F	Abdominal wound	Polypoid mass	N/A
10	38	31 y/M	Right axilla	Mass	HIV
11	9	32 y/M	Abdomen	Abdomen Abscess	Kidney Tx
12	9	44 y/M	Perianal and left lung	Abscess	Kidney Tx
13	9	42 y/M	Right axilla	Chronic abscess	SLE
14	39	70 y/M	Buttock	Nodule	Chronic hepatitis C
15	40	75 y/M	Right hand and wrist	Abscess	N/A
16	41	41 y/M	Peritoneal, supraclavicular	Cystic mass and firm nodule	DM
17	42	74 y/M	Perianal	Nonhealing lesion	MPD
18	43	55 y/M	Gluteal cleft	Ulcers	HIV
19	44	67 y/M	Left neck	Mass	No significant PMH
20	45	81 y/F	Frontal mass	Irregular plaque	DM
21	46	56 y/M	Internal canthus of eye	Nodule	Sarcoidosis
22	32	44 y/F	Buttock	Nodule	Kidney Tx
23	47	60 y/F	Nasolabial sulcus	Ulceration	N/A
24	14	2 mo/M	Colorectal and perianal	Polypoid masses	Immunodeficiency
25	2	68 y/M	Left inguinal region	Papules	N/A
26	2	66 y/M	Right axilla	Nodule	RA, DM
27	48	53 y/F	Perineum	Papules	Kidney Tx
28	49	42 y/M	Inguinal region	Mass with ulceration	Lymphoma
29	50	41 y/M	Frontal scalp, right lung	Abscess, pulmonary lesions	HIV, Hepatitis B
30	51	64 y/F	Left neck mass	Mass with cavitation	Thyroidectomy
31	52	60 y/M	Gluteal fold	Cutaneous fistula	DM
32	53	62 y/M	Chest	Ulceration	N/A
33	54	65 y/M	Ureterocutaneous fistula	Abdominal fistula	N/A
34	19	51 y/M	Perianal	Nodule	Heart Tx
35	55	69 y/M	Left arm and flank	Ulceration, mass	Escherichia coli sepsis
36	56	55 y/F	Abdominal wall	Papules	N/A
37	57	22 y/F	Arm	Fluctuating mass	N/A
38	58	52 y/F	Inferior abdomen	Fistula with abscess	Kidney Tx
39	59	30 y/M	Perianal	Abscesses	Dermatomyositis
40	60	51 y/M	Left thigh	Mass with draining abscess	HIV, DM
41	16	60 y/F	Abdominal fold	Pink-yellow plaques	Healthy
42	17	23 y/M	Perianal	Pink nodules	Healthy
43	18	14 Y/M	Gluteal fold	Papule	Healthy
44	20	55 y/F	Right Labia	"Boil" (nodule + abscess)	Heart Tx
45	27	58 y/M	Perianal	Erosive plaque	Psoriasis
46	61	63 y/F	Abdominal wall	Fistula	Pulmonary sarcoidosis
47	62	83 y/F	Neck	Goma (nodule + fistula)	SLE, RA, Sjogren
48	63	45 y/F	Perigenital	Papules, nodules and sinuses	HIV
49	64	24 y/M	Abdominal wall	Fistula	Psoas abscess (Tuberculosis?)
50	65	87 y/M	Buttock	Scaly plaques and polypoid nodules	No significant PMH
51	66	66 y/M	Lower abdomen	Abscesses, nodules and fistula	Poor overall health
52	current article case	51 y/M	Left groin	Plaque	Kidney Tx

While the majority of subjects are immunodeficient patients, including HIV-infected patients, patients with neoplasia, transplanted patients and others, more recently cases involving previously healthy patients have been reported.^{15 - 17} Almost all transplanted patient cases refer to kidney recipients, as the one in this article, but two were reported in heart transplant recipients.^{18 , 19} There are few reports in which prevalence among women is higher (2:1).^{20 , 21} The age peak occurs between the sixth and seventh decades, being even rarer in children.^{17 , 22}

Approximately 90% of patients have coliform bacteria detected in urine, blood, or tissue, suggesting an infectious cause.⁴ The most commonly found bacterium is Escherichia coli, but Klebsiella, Proteus, Pseudomonas, Mycobacterium avium, Mycobacterium tuberculosis, Shigella, Staphylococcus aureus and Enterococcus spp were also found.^{23 , 24} Rhodococcus equi is the most commonly implicated microbe in HIV-infected patients.²⁵ In 75% of cases, the disease affects the genitourinary tract, but other systems have been implicated, including the skin.²⁶

No typical clinical presentation is described, skin presentation varies from papules, plaques, nodules, abscesses with or without fluctuation, and fistula to ulcers, cystic and polypoid masses.¹⁴ Therefore, the diagnosis is predominantly confirmed by anatomopathologic and culture studies. Vanbrabant et al.2004 recently described the possibility of using 18fluoro-deoxyglucose positron emission tomography for diagnosis and follow-up.²⁷

Histopathologically, the pathognomonic finding of Michaelis-Gutmann bodies, which represent partially degraded bacterial organisms, can establish the diagnosis. Michaelis-Gutmann bodies are intracytoplasmic, round-ovoid, basophilic, concentric laminated inclusions in macrophages that are typically enlarged and display foamy cytoplasm and eccentric, hyperchromatic, round nuclei, denoted as Hansemann cells.

Differential diagnosis is possible with other infectious diseases or neoplastic and reactive/reparative processes. Infections to consider include tuberculosis, Whipple's disease, lepromatous leprosy, fungus (Cryptococcus), and parasites (leishmaniasis). Special stains for microorganisms and tissue culture are necessary. Reactive and neoplastic processes include Langerhans cell histiocytosis, fibrous histiocytoma, lymphoma, granular cell tumor, xanthoma, foreign-body granuloma, hemophagocytic syndromes, and sarcoidosis.¹⁴ Although generally presenting benign self-limited evolution, a fatal outcome is possible, but none was described in cutaneous malakoplakia.²⁸ Pseudomalakoplakia was once described as a proliferation of histiocytes at a previous surgical site, but only as an abstract. No other publications on this theme are found.²⁹

Our observation that the disease developed on a site of recognized trauma and contamination, in accordance with other related cases, highlights the importance of direct inoculation of bacteria in the pathophysiology, since the presence of immunosuppression is necessary, but not sufficient for its development.

There are no prospective comparative studies, probably due to the limited incidence, so approaches to management vary from surgical excision, with or without antibiotics, to the use of antibiotics alone.⁸ Van der Voort et al. 1996 compared treatments and concluded that surgical excision achieved the higher cure rate (90%), and that, when comparing antibiotics, quinolones seemed to be superior.⁷ The discontinuation of immunosuppressives and treatment of HIV could also be helpful.^{7 , 9} Sulfamethoxazole-trimethoprim is also cited as effective.³⁰ It was selected by us due to considerations such as cost, access and drug interaction.

We illustrated this article reporting a case of cutaneous malakoplakia synchronous to previous immunosuppressive therapy, in a subject with no current immunosuppressive treatment. The option for surgical plus antibiotic treatment resulted in cure with no recurrence to date. We also reviewed the literature and counted the reported cases of cutaneous malakoplakia described on chart 1 (including this one).^{31 - 66}

REFERENCES

• ¹
  Almagro UA, Choi H, Caya JG, Norback DH. Cutaneous malakoplakia: report of a case and review of the literature. Am J Dermatopathol. 1981;3:295-301.
• ²
  2. Mehregan DR, Mehregan AH, Mehregan DA. Cutaneous malakoplakia: areport of two cases with the use of anti-BCG for the detection for micro-organisms. J Am Acad Dermatol. 2000;43:351-4.
• ³
  Michaelis L, Gutman C. Uber Einschlusse in Blasentumoren. ZKlin Med 1902;47:208-15.
• ⁴
  Stanton MJ, Maxted W. Malacoplakia: a study of the literature and currentconcepts of pathogenesis, diagnosis and treatment. J Urol. 1981;125:139-46.
• ⁵
  Biggar WD, Keating A, Brear RA. Malakoplakia: evidence for an acquired disease secondary to immunosuppression. Transplantation. 1981;31:109-12.
• ⁶
  Rémond B, Dompmartin A, Moreau A, Esnault P, Thomas A, Mandard JC, et al. Cutaneous malacoplakia. Int J Dermatol. 1994;33:538-542.
• ⁷
  van der Voort HJ, ten Velden JA,Wassenaar RP, Silberbusch J. Malacoplakia: two case reports and a comparison of treatment modalities based on a literature review. Arch Intern Med. 1996;156:577-83.
• ⁸
  Lowitt MH, Kariniemi AL, Niemi KM, Kao GF. Cutaneous malacoplakia: a report of two cases and review of the literature. J Am Acad Dermatol. 1996;34:325-32.
• ⁹
  Biggar WD, Crawford L, Cardella C, Bear RA, Gladman D, Reynolds WJ. Malakoplakia and immunosuppressive therapy: reversal of clinical and leukocyte abnormalities after withdrawal of prednisone and azathioprine. Am J Pathol. 1985;199:5-11.
• ¹⁰
  Leclerc JC, Bernier L. Malacoplasie cutanee. Union Med Can. 1972;101:471-3.
• ¹¹
  Abdou NI, NaPombejara C, Sagawa A, Ragland C, Stechschulte DJ, Nilsson U, et al. Malakoplakia: evidence for monocyte lysosomal abnormality correctable by cholinergic agonist in vitro and in vivo. NEJM. 1977;297:1413-9.
• ¹²
  Lou TY, Teplitz C. Malakoplakia: pathogenesis and ultrastructural morphogenesis. A problem of altered macrophage (phagolysosomal) response. Hum Pathol. 1974;5:191-207.
• ¹³
  van Crevel R, Curfs J, van der Ven AJ, Assmann K, Meis JF, van der Meer JW. Functional and morphological monocyte abnormalities in a patient with malakoplakia. Am J Med. 1998;105:74-7.
• ¹⁴
  Kohl SK, Hans CP. Cutaneous malakoplakia. Arch Pathol Lab Med. 2008;132:113-7.
• ¹⁵
  Flann S, Norton J, Pembroke AC Cutaneous malakoplakia in an abdominal skin fold. J Am Acad Dermatol. 2010;62:896-7.
• ¹⁶
  Shawaf AZ, Boushi LA, Douri TH. Perianal cutaneous malakoplakia in an immunocompetent patient. Dermatol Online J. 2010;16:10.
• ¹⁷
  Patrizi A, Giacomini F, Bianchi F, Misciali C, Neri I. Recurrent calcified cutaneous nodule of the perianal region. Arch Dermatol. 2007;143:1441-6.
• ¹⁸
  Rémond B, Dompmartin A, De Pontville M, Moreau A, Mandard JC, Leroy D. Cutaneous malacoplakia in heart transplanted patient. Ann Dermatol Venereol. 1993;120:805-8.
• ¹⁹
  Teeters JC, Betts R, Ryan C, Huether J, Elias K, Hartmann D, et al. Rectal and cutaneous malakoplakia in an orthotopic cardiac transplant recipient. J Heart Lung Transplant. 2007;26:411-3.
• ²⁰
  Long JP Jr, Althausen AF. Malacoplakia: a 25-year experience with a review of the literature. J Urol. 1989;141:1328-31.
• ²¹
  Ben Amna M, Hajri M, Oumaya C, Anis J, Bacha K, Ben Hassine L, et al. Genito-urinary malakoplakia. Report of 10 cases and review of the literature. Ann Urol (Paris). 2002;36:388-91.
• ²²
  Debie B, Cosyns JP, Feyaerts A, Opsomer RJ, Tombal B, Van Cangh PJ, et al. Malacoplakia in children. Prog Urol. 2005;15:511-3.
• ²³
  Rull R, Grande L, García-Valdecasas JC, Bombi JA, Alós LL, Fuster J, et al. Malakoplakia in the gastrointestinal tract of a liver transplant recipient. Transplantation. 1995;59:1492-4.
• ²⁴
  Minor L, Lindgren BW. Malakoplakia of the bladder in a 16-year-old girl. J Urol. 2003;170:568-9.
• ²⁵
  Yuoh G, Hove MG, Wen J, Haque AK. Pulmonary malakoplakia in acquired immunodeficiency syndrome: an ultrastructural study of morphogenesis of Michaelis-Gutmann bodies. Mod Pathol. 1996;9:476-83.
• ²⁶
  McClure J. Malakoplakia. J Pathol. 1983;140:275-330.
• ²⁷
  Vanbrabant P, Drieskens O, Blockmans D. 18-fluoro-deoxyglucose positron emission tomography may contribute to the diagnosis and follow-up of malakoplakia. Acta Clin Belg. 2004;59:138-42
• ²⁸
  Dervan PA, Teeling M, Dempsey J, Drury IM, O'Malley E, O'Connell D. Lymphadenopathy due to fatal histiocytic proliferative disorder containing Michaelis Gutmann bodies. Cancer 1986;57:1337-40.
• ²⁹
  Sina B, Kauffman L. Pseudomalakoplakia [abstract]. J Cutan Pathol 1998;25:513.
• ³⁰
  Herrero C, Torras H, Palou J, Mascaro JM. Successful treatment of a patient with cutaneous malacoplakia with clofazimine and trimethoprim-sulfamethoxazole. J Am Acad Dermatol. 1990;23:947-8.
• ³¹
  Von Hansemann D. Uber Malakoplakie der Hernblase.Virchows Arch. 1903;173:302-8.
• ³²
  Schaller J, Metz K, Schmidt U, Kunze J. Cutaneous malacoplakia in a patient with psoriasis vulgaris. Hautarzt. 1996;47:763-6.
• ³³
  Moore WM, Stokes TL, Cabanas VY. Malakoplakia of the skin: report of a case. Am J Clin Pathol. 1973;60:218-21.
• ³⁴
  Rao NR. Malacoplakia of broad ligament, inguinal region, and endometrium. Arch Pathol. 1969;88:85-8.
• ³⁵
  Addison DJ. Malakoplakia of the eyelid. Ophthalmology. 1986;93:1064-7.
• ³⁶
  Arul KJ, Emmerson RW. Malacoplakia of the skin. Clin Exp Dermatol. 1977;2:131-5.
• ³⁷
  Baez-Giangreco A, Afzal M, Chattopadhyay SK. Malacoplakia: extensive female genital tract and skin involvement. Int J Gynecol Obstet. 1994;45:159-60.
• ³⁸
  Barnard M, Chalvardjian A. Cutaneous malakoplakia in a patient with acquired immunodeficiency syndrome (AIDS). Am J Dermatopathol. 1998;20:185-8.
• ³⁹
  Bodokh I, Lacour JP, Perrin C, Rainero C, Lebreton E, Grosshan E, et al. Malacoplakie cutanee associee a une hepatite chronique due au virus de l'hepatite C. Ann Dermatol Venereol. 1993;120:808-10.
• ⁴⁰
  Carloz B, Bioulac-Sage P, Domercq B, Royer P, Beylot C. Malacoplasie cutanee: a propos d'un cas. Rev Eur Dermatol Mst. 1991;3:259-63.
• ⁴¹
  Chaudhry AP, Satchidanand SK, Anthone R, Baumler RA, Gaeta JF. An unusual case of supraclavicular and colonic malakoplakia-a light and ultrastructural study. J Pathol. 1980;131:193-208.
• ⁴²
  Colby TV. Malakoplakia: two unusual cases which presented diagnostic problems. Am J Surg Pathol. 1978;2:377-82.
• ⁴³
  Davis D, Bigler L, Shimazu C, Omura E. Cutaneous malakoplakia. J Cutan Pathol. 1997;24:93.
• ⁴⁴
  Douglas-Jones AG, Rodd C, James EM, Mills RG. Prediagnostic malakoplakia presenting as a chronic inflammatory mass in the soft tissues of the neck. J Laryngol Otol. 1992;106:173-7.
• ⁴⁵
  Feldmann R, Breier F, Duschet P, Low-Weiser H, Gschnait F. Cutaneous malakoplakia on the forehead. Dermatology. 1997;194:358-60.
• ⁴⁶
  Font RL, Bersani TA, Eagle RC Jr. Malakoplakia of the eyelid: clinical, histopathologic, and ultrastructural characteristics. Ophthalmology. 1988;95:61-8.
• ⁴⁷
  Kumar PV, Tabei SZ. Cutaneous malacoplakia diagnosed by scraping cytology. Acta Cytol. 1988;32:125-7.
• ⁴⁸
  Neiland ML, Silverman AR, Borochovitz D, Saferstein HL. Cutaneous malakoplakia. Am J Dermatopathol. 1981;3:287-94.
• ⁴⁹
  Palazzo JP, Ellison DJ, Garcia IE, Langer C, Scher RM, Hoffman JP, et al. Cutaneous malakoplakia simulating relapsing malignant lymphoma. J Cutan Pathol. 1990;17:171-5.
• ⁵⁰
  Toubes-Klingler E, Prabhu VC, Bernal K, Poage D, Swindells S. Malacoplakia of the cranium and cerebrum in a human immunodeficiency virus-infected man: case report. J Neurosurg. 2006;104:432-5.
• ⁵¹
  Pang LC. Malacoplakia manifesting as a chronic inflammatory mass at the site of a nonhealing surgical wound. Ear Nose Throat J. 2003;82:876-80.
• ⁵²
  Porrazzi LC, De Gregorio A, Ferraraccio F, Maiello FM, Onufrio A. A case of fistulizated pelvic malacoplakia: cytohistologic, immunohistochemical and electron-microscopic study. Appl Pathol. 1989;7:249-55.
• ⁵³
  Price HM, Hanrahan JB, Florida RG. Morphogenesis of calcium laden cytoplasmic bodies in malakoplakia of the skin: an electron microscopic study. Hum Pathol. 1973;4:381-94.
• ⁵⁴
  Reiner RJ, Conway GF, Goodman PA. Retroperitoneal malakoplakia. Urology. 1977;X:276-277.
• ⁵⁵
  Sarkell B, Dannenberg M, Blaylock WK, Patterson JW. Cutaneous malacoplakia. J Am Acad Dermatol. 1994;30:834-6.
• ⁵⁶
  Scullin DR, Hardy R. Malacoplakia of the urinary tract with spread to the abdominal wall. J Urol. 1972;107:908-10.
• ⁵⁷
  Sencer O, Sencer H, Uluoğlu O, Torunoğlu M, Tatlicioğlu E. Malakoplakia of the skin. Ultrastructure and quantitative x-ray microanalysis of Michaelis-Gutmann bodies. Arch Pathol Lab Med. 1979;103:446-50.
• ⁵⁸
  Sian CS, McCabe RE, Lattes CG. Malacoplakia of skin and subcutaneous tissue in a renal transplant recipient. Arch Dermatol. 1981;117:654-5.
• ⁵⁹
  Singh M, Kaur S, Vajpayee BK, Banerjee AK. Cutaneous malakoplakia with dermatomyositis. Int J Dermatol. 1987;26:190-1.
• ⁶⁰
  Wittenberg GP, Douglass MC, Azam M, Lee MW, al-Ujayli B, Lowe L. Cutaneous malacoplakia in a patient with the acquired immunodeficiency syndrome. Arch Dermatol. 1998;134:244-5.
• ⁶¹
  Knausz J, Lipták J, Andrásovszky Z, Baranyay F. Vesico-cutaneous fistula revealing abdominal wall malakoplakia accompanied by Boeck's sarcoidosis. Orv Hetil. 2010;151:220-3.
• ⁶²
  Garg M, Eley KA, Bond SE, Shah KA, Browning L, Watt-Smith SR. Malakoplakia presenting as an enlarging neck mass: Case presentation and review of the literature. Head Neck. 2010;32:1269-72.
• ⁶³
  Savant SR, Amladi ST, Kangle SD, Wadhwa SL, Nayak CS. Cutaneous malakoplakia in an HIV-positive patient. Int J STD AIDS. 2007;18:435-6.
• ⁶⁴
  Sinha SK, Sethy PK, Kaman L, Vaiphei K, Nagi B, Dutta U, et al. Multiple spontaneous enterocutaneous fistulae in malakoplakia. Indian J Gastroenterol. 2003;22:234-5.
• ⁶⁵
  Verma SB. Cutaneous malakoplakia: a rare diagnosis of chronic nodules over the buttocks. Int J Dermatol. 2011;50:184-6.
• ⁶⁶
  Sormes M, Siemann-Harms U, Brandner JM, Moll I. Cutaneous malakoplakia. J Dtsch Dermatol Ges. 2011;9:914-5.

• *
  Syudy carried out at the Dermatology Department of Paulista Medical School (Departamento de Dermatologia da Escola Paulista de Medicina - UNIFESP) - São Paulo (SP) Brazil.

Publication Dates

• Publication in this collection
  June 2013

History

• Received
  02 Apr 2012
• Accepted
  27 June 2012