A male patient, mason, 33-years-old, reported the presence of papulonodular lesions on his face and dorsum over the past 30 days (Figure 1). His symptoms progressed with the development of headache, dizziness, malaise, and fever. Complete blood count and kidney and liver function tests were normal. HIV, HTLV, viral hepatitis and VDRL serological tests were also normal. Histopathological examination of the skin lesion revealed mucus and numerous Cryptococci on the dermis (Figure 2). Direct mycological examination and culture showed yeast suggestive of Cryptococcus ssp (Figure 3). Specific biochemical tests indicated Cryptococcus gattii growth. Spinal cord fluid showed lymphocytic pleocytosis and increased protein and reduced glucose levels. Direct assay and culture were positive for C. gattii. Computed tomography of the chest and bronchoscopy showed a lesion in the lower lobe of his left lung (Figure 4). An assay of Cryptococcus ssp. in the bronchial lavage fluid was positive. We prescribed amphotericin B deoxycholate (50mg/day) and fluconazole (450 mg every 12 hours for four weeks and maintenance dose of 300mg/week for eight weeks). The patient showed improvement of skin lesions and neurological and pulmonary symptoms.

Figure 1 Papulonodular lesions, some showing hematic crusts and umbilicated center, on the face and upper dorsum 

Figure 2 Presence of rounded structures compatible with Cryptococcus ssp.(Mucicarmine stain, 400x) 

Figure 3 Milky colony growth, similar to dripping candle wax, in Sabouraud agar, suggestive of Cryptococcus ssp. 

Figure 4 Bronchoscopy showing a tumor lesion located in the lower lobe of the left lung.