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Revista Brasileira de Reumatologia

Print version ISSN 0482-5004

Rev. Bras. Reumatol. vol.52 no.6 São Paulo Nov./Dec. 2012

http://dx.doi.org/10.1590/S0482-50042012000600001 

EDITORIAL

 

Antinucleosome and anti-C1q antibodies in juvenile systemic lupus erythematosus

 

 

In adults with systemic lupus erythematosus (SLE), antinucleosome antibodies have already been described as markers of disease activity and lupus nephritis.1-4 In addition, anti-C1q and antinucleosome antibodies have an amplifying effect on the etiopathogenesis of lupus nephritis in adults.5 In this issue of the Brazilian Journal of Rheumaotlogy, Jesus et al.6 have clearly shown the association of those antibodies with lupus nephritis, indicating that they could be a potential biomarker of renal lesion in juvenile SLE. In a previous study, that same group of researchers had already demonstrated the association of antinucleosome antibodies with disease activity, but not with lupus nephritis.7 One of the major concerns of rheumatologists is to identify a test that can be used in the follow-up of patients with SLE, both adult and juvenile, especially for establishing disease activity and its correct diagnosis. Thus, the study by Jesus et al.6 has shown that anti-C1q and antinucleosome antibodies have high specificity and elevated positive predictive value (over 97%) to diagnose lupus, being considered reliable instruments for clinical practice. Finally, those authors have also suggested that anti-C1q and antinucleosome antibodies should be measured in the investigation of lupus, especially in patients with juvenile SLE, who test negative for anti-dsDNA antibodies.

 

Paulo Louzada-Junior
Max Victor Carioca Freitas

Editors-in-chief, Brazilian Journal of Rheumatology

 

REFERENCES

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7. Jesus AA, Silva CA, Carneiro-Sampaio M, Sheinberg M, Mangueira CL, Marie SK et al. Anti-C1q antibodies in juvenile-onset systemic lupus erythematosus. Ann N Y Acad Sci 2009;1173:235-8.         [ Links ]