SciELO - Scientific Electronic Library Online

 
vol.22 issue6Evaluation of Q angle in differents static posturesEffects of exercise on pain of musculoskeletal disorders: a systematic review author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Acta Ortopédica Brasileira

Print version ISSN 1413-7852

Acta ortop. bras. vol.22 no.6 São Paulo Nov./Dec. 2014

https://doi.org/10.1590/1413-78522014220601009 

Review Article

Outcomes in orthopedics and traumatology: translating research into practice

Vinícius Ynoe de Moraes 1  

Paula Martins de Oliveira Ferrari 1  

Guilherme Conforto Gracitelli 1  

Flávio Faloppa 1  

João Carlos Belloti 1  

1.Department of Orthopedics - Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil


ABSTRACT

Clinical research is focused in generating evidence that is feasible to be applicable to practitioners. However, translating research-focused evidence into practice may be challenging and often misleading. This article aims is to pinpoint these challenges and suggest some methodological safeguards, taking platelet-rich plasma therapies and knee osteochondral injuries as examples. Studies and systematic reviews involving the following concepts will be investigated: clinically relevant outcomes, systematic errors on sample calculation, internal and external validity. Relevant studies on platelet-rich plasma for muscle-tendon lesions and updates on osteochondral lesions treatment were included in this analysis. Authors and clinicians should consider these concepts for the implementation and application of dissemination of the best evidence. Research results should be challenged by a weighted analysis of its methodological soundness and applicability. Level of Evidence V, Therapeutic Studies - Investigating the Results of Treatment.

Key words: Orthopedics; Knee joint; Platelet-rich plasma; Evidence-based medicine; Outcomes research

INTRODUCTION

Outcome is defined as the final event of an intervention (of an experimental study) or of an observation (of an observational study).1 Currently, relevant outcome is understood as that effect is important to the patient, such as function and/or quality of life.2 , 3

It is known that these are the best parameters to translate treatment effectiveness, because they consider the evaluation - subjective and reported by the patient - as the most relevant to health care.2 On orthopedics research, it is a surgeon task to decide which outcome is relevant for the studied clinical condition, despite this decision is often a challenge.

The defiance about the choice of the best measure for outcome - that results in an applicable evidence on daily practice (external validity)4 is grounding extensive surgical clinical research. Numerous publications devoted to "research on research", example of metalanguage applied to medical science, are dedicated to solving the translational gap between ideal environment research (effective results) and clinical practice (actual results).5 - 7

However, systematic reviews and evidence-based guidelines are redundant to show that part of the current research does not address the relevant outcomes to clinical practice, resulting in waste of human and economic.8 - 10 In this context, the ethical implications of conducting research without relevance or optimization of objectives may not be forgotten.11 - 13

Since the 90's, orthopedic-researchers aim at a paradigm shift from the "surgeon centered" to the "patient-centered" research.14 - 17 To make it possible, prolific efforts sedimented methodologies (e.g. randomization and blinding methods, intention to treat analysis) and tools (e.g. questionnaires and scales) which are sine qua non conditions for enthusiasts of based on evidences orthopedics.14 , 17 - 19

In the 2010's, making a research following these above concepts is to ratify the position sedimented by those pioneer researchers. Although the concept is well accepted in the scientific community, there are obstacles and pitfalls regarding methodology and its interpretation.18

This review aims to expose concepts, applied to the orthopedic traumatology reality, of clinical research centered in relevant results, with the patient as the main informant of his condition.

Paradigm shift: prioritizing patient-centered assessment

It is a consensus that clinical outcomes, such as range of motion, strength and bone healing do not reflect entirely the post intervention status and often led the orthopedic community to misguided conclusions.2 The more complete concept takes into account the specific functional dimension (clinical condition or region) and / or overall quality of life (physical, mental and social aspects).5 , 20

Subjectively, let the patient judge his own condition leads us to avoid two major pitfalls: the interventor bias, evaluating their own interventions and their subsequent judgment of success or failure.

As additional condition for the choice of a good outcome, attention should be given to the establishment of a robust method (internal validity) of hypothesis verification, what could increase the results applicability (external validity). One should opt for conducting the study so that it can be the most reliable conditions of daily life, so that its effectiveness is proven. Some randomized clinical trials are often targets of criticism when conducted "very controlled" because their results can translate more efficiency than effectiveness. (Table 1)

Table 1 Concepts for methodological assessment. 

Concept3,5 Definition
Internal validity Ability of a study to reduce the chance of systematic errors (bias) through the optimization of the research methods
 External validity It is the ability of the result to generate reliable generalizations to its target population (applicability)
Effectiveness Ability of an specific intervention to produce the expected results - used under normal circumstances (medical practice, for example)
Efficiency Ability of an specific intervention to produce the expected results - when used under ideal circumstances (laboratory studies, clinical studies with very restricted methodology)

How to measure these results? Sample calculation and clinical tools

For the evaluation of patient focused outcomes, a large number of general and specific clinical tools are available and validated for our population. (Table 2)

Table 2 Necessary characteristics to a questionnaire as a research tool. 

Characteristics2,5 Description
Reproducibility (test-retest reliability) Ability of different measurements to generate the same result under steady and constant conditions
Validity Ability of a test to measure what it proposes.
 It is subdivided into validity of:
1. Contents: Subjective evaluation of whether the components of the test include content / size to be measured;
2. Criterion: comparative evaluation against established "gold" standard;
3. Constructive: Assessment if the components of the test are comparable to clinical parameters and / or laboratory parameters relevant to clinical condition, in the absence of a gold standard.
Responsiveness Ability of a test to demonstrate relevant differences to researchers, surgeons and patients
Specificity Ability to demonstrate plausible differentials to the studied condition

The clinical tools allow considering the patient in the trial of clinical interventions and strengthen the actions of the researcher in evaluating what treatment method is the best. As a principle, it is recommended the use of specific tools (organ/member/specific disease) instead of the general ones.5

As a complement, the practical use of these concepts, arises the concept of minimally significant clinical difference (MSCD), defined in 1989.21 The initial argument of its practical plausibility is the finding that frequently identified statistic differences do not reflect relevant clinical differences.2 , 21 The definition of MSCD is set up as:22 "the smallest difference in a punctuation / score in the domain of interest in which patients perceive the presence of benefit and would require a shift in treatment paradigm, in the absence of adverse side effects and excessive costs."

Translation of the outcomes: clinically relevant differences

Clinical trials may include one single group or more than one group. When there is a comparison, there is a possibility of generating assertions regarding the effectiveness of an A intervention versus a B intervention. To allow this it is necessary to be sure that both groups are comparable, often randomly allocated.23

Randomization, in itself does not guarantee that the comparison between the groups is valid.24 Statistically, it is necessary that the groups present sufficient sample number, ideally calculated a priori. The challenges of this step are described in Table 3.

Table 3 Sample number determination - difficulties and challenges. 

Research scenario Characters
Insufficient sample number, difference detected between groups The difference between the groups may have occurred at random, unreliable results. Frequent in unplanned subgroup analyzes *. TYPE I ERROR.
Insufficient sample size, no difference detected between the groups The difference between groups was not detected because there are few individuals in the comparison groups. Increasing the sample size will detect these differences. Frequent scenario in surgery studies. TYPE II ERROR.
Sufficient sample size, calculation performed previously Results are possibly extrapolated to clinical practice. Steps of evidence-based medicine should be applied to ensure the reliability of the final product. (1. Clinical question; 2. Searching the best evidence; 3. Critical analysis; 4. Application) There is the possibility to detect statistical differences without clinical relevance (see next topic).

Researchers often opt for subgroups analysis. The data obtained should be considered with caution.

Applied clinical research: platelet-rich plasma

Until present times, studies involving platelet rich plasma failed to demonstrate the effectiveness of this treatment modality for orthopedic conditions such as rotator cuff tears, lateral epicondylitis and knee ligament injuries.25 These studies - due to their recentness - are already focused on self-reported functional outcomes, under the presented research protocol. Many of these, despite being presented with sophisticated research designs are research products with low sample number, which may lead the reader to reach erroneous conclusions. Furthermore, the concept of minimally significant clinical difference must be taken into account.

Meta-analysis involving patients who underwent application of platelet rich plasma demonstrated a statistical difference for the pain outcome (measured by analogue scale) for arthroscopic rotator cuff repair, lateral epicondylitis, tendinopathy and rupture of the Achilles tendon. In this result - evaluated for up to three months, it was identified that the difference between the averages for allocation groups was - 0.95 with a confidence interval (95% CI) going from the minimum to maximum of -1.41 -0.48.

Surgeons and researchers should reflect if a maximum difference, in the most favorable scenario to Platelet-Rich Plasma of 1.41 brings benefit to justify the application of Platelet-Rich Plasma. In this meta-analysis, the authors indicate that this difference is marginal and that possibly does not translate into relevant clinical benefit.25 In this research spectrum, studies show that differences above 3 points are those that result in relevant clinical differences.2 , 26

Applied clinical research: osteochondral knee lesions

The incidence of osteochondral lesions (OCL) of the knee are estimated at 900,000 per year in the United States of America27 and affect the population in different age groups with 36% greater prevalence in the population of athlets.28 The low capacity for regeneration of cartilage tissue, associated with frequent progression to osteoarthritis make these lesions widely studied and of great clinical interest issue currently.

When studying OCL in clinical trials, we must have in mind some confounding variables included in several clinical trials that are usually associated to patients with OCL, but should not be considered all together. An example that is frequently reported is the analysis on the anterior cruciate ligament (ACL) intervention associated with OCL,29 , 30 in which the treatment with ACL reconstruction can directly influence the results of cartilage repair and vice versa.

Osteochondritis dissecans (OCD) is another greatly mentioned theme in clinical trials for treatment of cartilage injuries.31 Given the different behavior of this disease compared to isolated cartilage lesion, this patient population should be assessed separately in the studies.

What if we do not get a significant sample to study the isolated desired population? In these cases the ideal is to create subgroups in the same analysis in order to isolate the effect of each population. An example of a clinical trial is: Micro-fracture versus mosaicoplasty in isolated chondral injury and OCD. When assaying these patients, analysis of groups for isolated chondral injury and OCD should be separated.

The main or primary outcomes in LOC clinical studies should be the patient's function, quality of life and treatment complications. Functional outcomes are assessed by functional scores - among which the most used are the Western Ontario and McMaster Universities questinnaire-WOMAC,32 the International cartilage repair score-ICRS SCORE, the Knee injury and osteoarthritis outcomes score-KOOS,33 the International knee documentation Committee subjective knee evaluation form - IKDC34 and the Lysholm knee scoring scale-LYSHOLM35 - some presented on Table 4.36 - 41 The quality of life can be assessed by the SF-3642 or World Health Organization (WHOQoL) questionnaires. For treatment complications such as infection and stiffness, revision surgery should also be considered among the most important outcomes.

Table 4 Instruments for functional scores assessment. 

Instrument Description
DASH (Disability of arm, shoulder and hand) Region-specific questionnaire, self-applied. Translated and validated into Brazilian Portuguese, in a population with rheumatoid arthritis. Measures dysfunction of the arm, shoulder and hand. Its evaluation considers activity of both upper limbs, globally. Has additional (optional) modules addressing sports, music and work performance. There is good correlation between full version and summarized version (Quick DASH).
PRWE  (Patient-rated wrist evaluation score) Region-specific questionnaire, self-applied. Translated into Brazilian Portuguese. It still has to be validated. Initially idealized for distal radius fractures, measures dysfunctions of the affected wrist. Approaches pain and function. There are studies demonstrating good psychometric qualities. Adequate correlation with SF-36 and DASH.
CONSTANT – MURLEY (Constant-Murley questionnaire) Region-specific questionnaire, applied by the interviewer. Initially indicated for all shoulder conditions; however, there was the development of disease-specific scores, such as WORC (for the rotator cuff) and ROWE (for instability). It assesses pain, everyday life activities, strength and range of motion. Studies show good reproducibility, despite it lacks specificity for shoulder instability.
MHQ (Michigan hand questionnaire) Region-specific questionnaire, self-applied. Indicated for general assessment of all conditions of the hand. Evaluates pain, function, esthetic and satisfaction. Unlike the DASH questionnaire, it rates separately left and right hands.
BHQ (Boston Carpal Tunnel Questionnaire, Levine-Katz Questionnaire) Disease-specific questionnaire self-applied or applied by the interviewer. Evaluates function and symptoms. There is extensive literature validating this tool, with good correlation with the SF-36 and DASH. Indicated for evaluation of patients with carpal tunnel syndrome..
WORC (Western Ontario Rotator Cuff Index) Disease-specific questionnaire, for rotator cuff evaluation. It is the most used of Western Ontario Shoulder Indexes, which also includes tools for instability (WOSI) and osteoarthritis (WOOS) of the shoulder.
UCLA (University of California at Los Angeles Shoulder Rating Scale ) Region-specific questionnaire, self-reported. Used to assess shoulder function. Evaluates pain, function, range of motion/active flexion, strength/active flexion and satisfaction. The instrument is criticized due to the empirical generation of the questionnaire items, different weighing between the evaluated criteria without a supporting  methodological background.
SST (Simple Shoulder Test) Region-specific questionnaire, self-reported. Used for the evaluation of every shoulder condition of the shoulder. Consists of 12 “yes or no” questions.
WOMAC Region-specific questionnaire, self-applied. Validated for personal, phone, or electronic interview, through computer or cell phone. Translated and validated into Brazilian Portuguese.32,36 Originally developed in 1982 to detect treatment response for osteoarthritis of hip and knee. Currently, it has been used for chondral lesions of the knee and injury of the anterior cruciate ligament (ACL). It is based in three parameters: pain during various movements and positions, severity of joint stiffness and difficulty in performing activities of daily living. The abridged version has been used but is not recommended by the WOMAC web site. The questionnaire is available on the website after request approval (http://www.womac.org).
IKDC (Subjective Knee Evaluation Form) Region-specific questionnaire, self-applied and not validated for interviews. Translated and validated into Portuguese.34,37 Developed for various knee injuries. The IKDC addresses symptoms (pain, stiffness, edema, joint locking and instability) and daily and sports activities, current functions and functions prior to injury (the latter topic is not accounted for the score). Indicated for knee injuries (ACL, anterior cruciate ligament; PCL, posterior cruciate ligament, collateral ligaments, osteochondritis dissecans, knee sprain and meniscal lesion) and corrective interventions  (recosntructions of ACL, PCL, and collateral ligaments, meniscal repair, meniscectomy, chondral injury repair, platelet rich plasma infusion, tibial osteotomy and lateral release. Questionnaire available at http://www.sportsmed.org/tabs/research/ikdc.aspx
Tegner Questionnaire created for interviews, but currently self-applied. Developed in 1985 to assess the level of physical and sports activity of the patients. Originally suggested as a complement to the LYSHOLM score in patients with ACL injury. Based on a range of daily living, recreation and competitive sports activities that are identified to the patient habits. Available on the original publication.38
AOFAS Questionnaire created in 1994 by a committee of the American Orthopedic Foot and Ankle Society (AOFAS). Divides the foot and ankle evaluation based on anatomical scales: hind foot and ankle, mid foot, metatarsal phalangeal (MF) and inter phalangeal (IF) of the hallux, MF and IF the smaller toes, which allows its use in several diseases and interventions of the foot and ankle. Translated in 2008, full text available in the original publication in Portuguese.39
Kujala The Kujala score or scale of the anterior pain of the knee, developed in 1993  is a self-applied questionnaire. It features 13 items evaluated at rest and after specific activities such as walking, running, jumping, squatting, sitting for long periods and climbing stairs. Currently, it is widely used for clinical studies and for monitoring patients with patellofemoral or anterior knee pain. Translated and adapted into Portuguese in 2011.40 It is sensitive for anterior knee pain detection, but poor for differentiate recurrent patellar dislocation and single patellar dislocation.
Lysholm Region-specific questionnaire, self-applied. Validated for personal interview, but frequently used as self-applied. It assesses joint stability after ligament reconstructions. The revised scale has 8 categories: gait, support, joint locking, instability, pain, edema, climbing stairs and squatting. Currently used to assess ligament injuries (ACL, PCL and collateral), meniscal,chondral and knee dislocation. Used to evaluate interventions such as arthroscopy, ligament reconstruction, cartilage repair, tibial osteotomy, infusion of hyaluronic acid and therapeutic exercises. Translated and adapted into Portuguese. Full text publication available.35,41

Many clinical trials on cartilage focus on less important end points for clinical studies, such as imaging studies and postoperative biopsies. There is no question on the validity of these analysis for understanding the disease, but the clinical and radiological or clinical histological correlation are often very weak and do not express the functional outcome of these patients.43

FINAL CONSIDERATIONS

The incorporation of the above outlined concepts are important for a good practice of MBE, both from the perspective of the researcher-orthopedist, as of the consumer of health information. It is an essential condition to conduct research in orthopedics and traumatology surgery.

REFERENCES

1. Bhandari M, Tornetta P 3rd, Guyatt GH. Glossary of evidence-based orthopaedic terminology. Clin Orthop Relat Res. 2003;(413):158-63. [ Links ]

2. Szabo RM. Outcomes assessment in hand surgery: when are they meaningful? J Hand Surg Am. 2001;26(6):993-1002. [ Links ]

3. Higgins JS. Cochrane handbook for systematic reviews of interventions 4.2.4 [updated March 2005]. 2005. [ Links ]

4. Paradis C. Bias in surgical research. Ann Surg. 2008;248(2):180-8. [ Links ]

5. Hoang-Kim A, Pegreffi F, Moroni A, Ladd A. Measuring wrist and hand function: common scales and checklists. Injury. 2011;42(3):253-8. [ Links ]

6. Slobogean GP, Slobogean BL. Measuring shoulder injury function: common scales and checklists. Injury. 2011;42(3):248-52. [ Links ]

7. Moraes VY, Belloti JC, Moraes FY, Galbiatti JA, Palácio EP, Santos JB, et al. Hierarchy of evidence relating to hand surgery in Brazilian orthopedic journals. Sao Paulo Med J. 2011;129(2):94-8. [ Links ]

8. Harris JD, Erickson BJ, Abrams GD, Cvetanovich GL, McCormick FM, Gupta AK, et al. Methodologic quality of knee articular cartilage studies. Arthroscopy. 2013;29(7):1243-1252.e5 . [ Links ]

9. Griffin XL, Wallace D, Parsons N, Costa ML. Platelet rich therapies for long bone healing in adults. Cochrane Database Syst Rev. 2012;7:CD009496. [ Links ]

10. Seida JC, LeBlanc C, Schouten JR, Mousavi SS, Hartling L, Vandermeer B, et al. Systematic review: nonoperative and operative treatments for rotator cuff tears. Ann Intern Med. 2010;153(4):246-55. [ Links ]

11. Altman D. The scandal of poor medical research. BMJ. 1994;308:283 -4. [ Links ]

12. Williamson PR, Gamble C, Altman DG, Hutton JL. Outcome selection bias in meta-analysis. Stat Methods Med Res. 2005;14(5):515-24. [ Links ]

13. Moraes VY, Belloti JC, Faloppa F, Bhandari M. Collaborative multicenter trials in Latin America: challenges and opportunities in orthopedic and trauma surgery. Sao Paulo Med J. 2013;131(3):187-92. [ Links ]

14. van Oldenrijk J, Sierevelt IN, Schafroth MU, Poolman RW. Design considerations in implant-related randomized trials. J Long Term Eff Med Implants. 2007;17(2):153-63. [ Links ]

15. Szabo RM. Show me the evidence. J Hand Surg Am. 2008;33(2):150-6. [ Links ]

16. Vanhoutte EK, Faber CG, Merkies IS. Statistical significance or clinical relevance? Ned Tijdschr Geneeskd. 2010;154:A2516. [ Links ]

17. Thoma A, Farrokhyar F, Bhandari M, Tandan V; Evidence-Based Surgery Working Group. Users' guide to the surgical literature. How to assess a randomized controlled trial in surgery. Can J Surg. 2004;47(3):200-8. [ Links ]

18. Poolman RW, Kerkhoffs GM, Struijs PA, Bhandari M, International Evidence-Based Orthopedic Surgery Working Group. Don't be misled by the orthopedic literature : tips for critical appraisal. Acta Orthop. 2007;78(2):162-71. [ Links ]

19. Poolman RW, Struijs PA, Krips R, Sierevelt IN, Marti RK, Farrokhyar F, et al. Reporting of outcomes in orthopaedic randomized trials: does blinding of outcome assessors matter? J Bone Joint Surg Am. 2007;89(3):550-8. [ Links ]

20. Bryant D, Fernandes N. Measuring patient outcomes: a primer. Injury. 2011;42(3):232-5. [ Links ]

21. Jaeschke R, Singer J, Guyatt GH. Measurement of health status. Ascertaining the minimal clinically important difference. Control Clin Trials. 1989;10(4):407-15. [ Links ]

22. Cook CE. Clinimetrics Corner: The Minimal Clinically Important Change Score (MCID): A Necessary Pretense. J Man Manip Ther. 2008;16(4):E82-3. [ Links ]

23. Vena D, Morrison E, Sprague S, Hanson B, Joensson A, Bhandari M. User's guide to a randomized trial about an orthopedic implant. J Long Term Eff Med Implants 2007; 17:111-20. [ Links ]

24. Altman DG. Better reporting of randomised controlled trials: the CONSORT statement. BMJ. 1996;313(7057):570-1. [ Links ]

25. Moraes VY, Lenza M, Tamaoki MJ, Faloppa F, Belloti JC. Platelet-rich therapies for musculoskeletal soft tissue injuries. Cochrane Database Syst Rev. 2013;12:CD010071. [ Links ]

26. Sorensen AA, Howard D, Tan WH, Ketchersid J, Calfee RP. Minimal clinically important differences of 3 patient-rated outcomes instruments. J Hand Surg Am. 2013;38(4):641-9. [ Links ]

27. Mithoefer K, McAdams T, Williams RJ, Kreuz PC, Mandelbaum BR. Clinical efficacy of the microfracture technique for articular cartilage repair in the knee: an evidence-based systematic analysis. Am J Sports Med. 2009;37(10):2053-63. [ Links ]

28. Flanigan DC, Harris JD, Trinh TQ, Siston RA, Brophy RH. Prevalence of chondral defects in athletes' knees: a systematic review. Med Sci Sports Exerc. 2010;42(10):1795-801. [ Links ]

29. Gudas R, Siupsinskas L. Is that possible to restore pre-injury physical activity level after one-stage articular cartilage and anterior cruciate ligament reconstruction procedure? Br J Sports Med. 2013;47(10):e3. [ Links ]

30. Imade S, Kumahashi N, Kuwata S, Kadowaki M, Tanaka T, Takuwa H, et al. A comparison of patient-reported outcomes and arthroscopic findings between drilling and autologous osteochondral grafting for the treatment of articular cartilage defects combined with anterior cruciate ligament injury. Knee. 2013;20(5):354-9. [ Links ]

31. Gudas R, Kalesinskas RJ, Kimtys V, Stankevicius E, Toliusis V, Bernotavicius G, et al. A prospective randomized clinical study of mosaic osteochondral autologous transplantation versus microfracture for the treatment of osteochondral defects in the knee joint in young athletes. Arthroscopy. 2005;21(9):1066-75. [ Links ]

32. Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol. 1988;15(12):1833-40. [ Links ]

33. Roos EM, Roos HP, Lohmander LS, Ekdahl C, Beynnon BD. Knee Injury and Osteoarthritis Outcome Score (KOOS)--development of a self-administered outcome measure. J Orthop Sports Phys Ther. 1998;28(2):88-96. [ Links ]

34. Irrgang JJ, Anderson AF, Boland AL, Harner CD, Kurosaka M, Neyret P, et al. Development and validation of the international knee documentation committee subjective knee form. Am J Sports Med. 2001;29(5):600-13. [ Links ]

35. Lysholm J, Gillquist J. Evaluation of knee ligament surgery results with special emphasis on use of a scoring scale. Am J Sports Med. 1982;10(3):150-4. [ Links ]

36. Fernandes MI: Tradução e validação do questionário de qualidade de vida específico para osteoartrose WOMAC (Western Ontario McMaster Universities) para a língua portuguesa. São Paulo, 2003. 103p. Tese de Mestrado - Universidade Federal de São Paulo - Escola Paulista de Medicina - Reumatologia. [ Links ]

37. Metsavaht L, Leporace G, Riberto M, Sposito MM, Del Castillo LN, Oliveira LP, et al. Translation and cross-cultural adaptation of the lower extremity functional scale into a Brazilian Portuguese version and validation on patients with knee injuries. J Orthop Sports Phys Ther. 2012;42(11):932-9. [ Links ]

38. Tegner Y, Lysholm J. Rating systems in the evaluation of knee ligament injuries. Clin Orthop Relat Res. 1985;(198):43-9. [ Links ]

39. Rodrigues RC, Masiero D, Mizusaki JM, Imoto AM, Peccin MS, Cohen M, et al. Translation, cultural adaptation and validation of the "American Orthopaedic Foot and Ankle Society´s (AOFAS) Ankle-Hind foot Scale". Acta Ortop Bras. 2008;16(2):107-11. [ Links ]

40. Aquino VS, Falcon SF, Neves LM, Rodrigues RC, Sendin FA. Translation and cross-cultural adaptation of the scoring of patella femoral disorder into portuguese preliminary study. Acta Ortop Bras. 2011;19(5):273-9. [ Links ]

41. Peccin MS, Ciconelli R, Cohen M. Specific questionnaire for knee symptoms- the "Lysholm Knee Socring Scale" - translation and validation into portuguese. Acta Ortop Bras. 2006;14(5):268-72. [ Links ]

42. Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992;30(6):473-83. [ Links ]

43. Krusche-Mandl I, Schmitt B, Zak L, Apprich S, Aldrian S, Juras V, et al. Long-term results 8 years after autologous osteochondral transplantation: 7 T gagCEST and sodium magnetic resonance imaging with morphological and clinical correlation. Osteoarthritis Cartilage. 2012;20(5):357-63. [ Links ]

Work developed at Department of Orthopedics - Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil

Received: August 19, 2014; Accepted: September 01, 2014

Correspondence: Disciplina de Cirurgia da Mão e Membro Superior, Universidade Federal de São Paulo (UNIFESP). Rua Borges Lagoa, 778. São Paulo, SP, Brazil. vymoraes@gmail.com

All the authors declare that there is no potential conflict of interest referring to this article.

Creative Commons License This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.