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On-line version ISSN 1678-4391
Braz J Infect Dis vol.6 no.1 Salvador Feb. 2002
Bilateral peripheral facial palsy secondary to lymphoma in a patient with HIV/AIDS: a case report and literature review
Maria das Graças Sasaki; Patrícia G. B. Leite; Andréa G. B. Leite and Sérgio Monteiro de Almeida
Federal University of Paraná, Clinical Hospital of Curitiba, PR, Brazil
Neurological complications represent one of the most important causes of morbidity and mortality in patients with HIV/AIDS. However, peripheral neuropathy comprises only 5% to 20% of the total neurological complications and facial nerve palsy, especially when it is bilateral, is a less common manifestation. Peripheral facial palsy has been considered as a possible neurological complication of the early stage of HIV infection but the number of reported cases in the literature is limited. Histological findings of nervous tissue in peripheral facial palsy at an early stage of HIV infection include a degenerative and not suppurative inflammatory process, but its etiology remains obscure. Peripheral facial palsy in the late stage of HIV infection is characterized by an advanced immunological deficit and generally it is secondary to an opportunistic infection of the CNS, such as neurotoxoplasmosis and lymphoma. However, this peripheral attack of the facial nerve is not very common at this late stage of HIV infection. Bilateral peripheral facial palsy as a complication of non-Hodgkin's lymphoma is considered an extremely rare entity. There are no published reports of bilateral peripheral facial palsy secondary to lymphomas or other neoplasms of the CNS in immunosupressed patients. Non-Hodgkin's lymphoma (NHL) has been considered a late and relatively common manifestation of HIV infection, but an exact cause for the higher incidence of this malignant neoplasm in HIV/AIDS patients is still uncertain.
Key Words: HIV, facial palsy, lymphoma.
Neurological complications are among the most important causes of morbidity and mortality in patients with HIV/AIDS . However, peripheral neuropathy comprises only 5% to 20% of the total neurological complications [2,3], and facial nerve palsy, especially bilateral, is quite uncommon [1,4].
Though there have been some reports of facial palsy as a late complication of HIV infection , this neuropathy occurs mainly at early stages of virus infection . However, in the specificcase of bilateral facial palsy, there is no report of this type of complication late in the course of HIV infection, as found in our patient, who had bilateral facial palsy as a primary manifestation of a non-Hodgkin's lymphoma.
Non-Hodgkin's lymphoma has been considered a late manifestation of HIV infection [6,7], being frequently present in extranodal sites and particularly in the central nervous system (CNS) . We report a case of bilateral facial palsy as a primary manifestation of non-Hodgkin's lymphoma in an HIV/AIDS patient.
A 39-year-old homosexual male patient was admitted with a complaint of generalized myalgia, periorbit pain, headache and blotched vision with diplopia. Physical examination demonstrated a bilateral peripheral facial palsy predominantly on the right side (Figure 1).
He had a 10 year-old positive ELISA test for HIV, which had been performed when the patient had a recurrent herpes simplex virus infection. At this time, the patient began the use of zidovudine, stavudine, indinavir and prophylaxis with trimethoprim-sulfamethoxazole. There was a history of marihuana use, but he denied intravenous drug abuse. The CD4 and CD8 counts were 175 cells/ml (17.5%) and 573 cells/ml (57.3%) respectively.
Cerebrospinal fluid (CSF) analysis revealed a total cellularity of 175 cells/mm3, with 75% blasts and 25% lymphocytes. The CSF total protein level was 430 mg/dl and the glucose level was 13 mg/dl. The CSF immunophenotype showed 70% B-lymphocytes and 30% T-lymphocytes (23% CD3+ and 7% CD4+), with a positive light Kappa chain and a negative light Lambda chain. No organisms were seen on Gram's stain, and cultures were negative for bacterial, fungal, viral, and mycobacterial organisms. The CSF specimen was tested for cytomegalovirus antibodies and herpes simplex virus antigen; both were negative. A computer tomography (CT) scan of the brain was normal. An abdominal ultrasound made after the lumbar puncture revealed retro-peritoneal lymphadenopathy, which was confirmed by a CT of the abdomen. The latter also showed a hepatic steatosis, intestinal wall thickening and a lymphadenopathy of the hepatic hilum.
Because of the hypothesis of non-Hodgkin lymphoma, a weekly cycle of CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) was begun, with a partial improvement of the symptoms, including the bilateral facial palsy. However, during the period of clinical observation, the patient worsened and died.
Acute peripheral facial palsy can occur at any stage of HIV infection, even preceding the appearance of HIV antibodies, but it seems more common in a healthy HIV carrier than in a patient with AIDS. Thus, peripheral paralysis can be divided into two types according to it's etiology: one related with early stages and another related with late stages of HIV infection.
Early stage of HIV infection. Peripheral facial palsy has been considered as a possible neurological complication of the early stages of HIV infection , but there have been few reported cases, especially when we consider peripheral facial palsy related to AIDS, as in our patient.
Histological findings of nervous tissue in the peripheral facial palsy at early stages of HIV infection include a degenerative and non suppurative inflammatory process, but its etiology remains obscure . Recent investigations suggest an infectious origin to this HIV related facial palsy, including principally, herpes simplex virus, adenovirus, mumps virus, rubella virus and, more recently, HIV . Because of the great number of microorganisms involved, some authors support the idea of a common pathogenic mechanism, in which an immunological reaction associated with an infectious event could determinate a generalized cranial neuropathy that involves a compressive and degenerative process of the VII cranial nerve . However, although this physiopathological hypothesis is a result of a long study, and though the predictive value of HIV in peripheral facial palsy reaches 73.63% in African reports , there is disagreement about the possibility of this neuropathy being caused by an immunological reaction against HIV or other pathogen. The relation between Bell's palsy and HIV infection may be only a coincidence, especially in the countries where the prevalence of HIV is high. We cannot attribute a direct role of HIV in facial palsy, especially since viral proteins have never been found in biopsies of peripheral nerves acutely compromised in the early stages of retrovirus infections [12,13].On the other hand, the lack of virus at nerve biopsy in acute cases does not preclude its participation in the neuropathological inflammatory process; this could occur by immunocomplex development, especially because the acute stage of HIV infection is not always accompanied by immunosuppression .
We found only three reported cases of bilateral facial palsy in the early stage of HIV infection [4,15,16]and there was no primary pathology that would justify a bilateral attack of cranial nerve VII. Thus, the physiopathological mechanism is probably the same as in a unilateral pathology.
Late stage. Peripheral facial palsy at a late stage of HIV infection is characterized by an advanced immunological deficit and generally it is secondary to an opportunistic infection of the CNS, such as neurotoxoplasmosis and lymphoma. On the other hand, as we have already commented, this peripheral attack of the facial nerve is not very common at this late stage of HIV infection.
It is already known that in the immunocompetent patient, bilateral peripheral facial palsy is frequently associated with a complex of systemic pathology symptoms . Thus, a detailed investigation of any patient with this diagnosis is fundamental.
In non-HIV patients some etiologies of bilateral facial palsy are already well described and they include polyarteritis nodosa, sarcoidosis, Lyme disease, acute or chronic otitis media, bulbar palsy, infectious mononucleosis, syphilis, tetanus, malaria, tuberculosis, leprosy, Melkersson-Rosenthal's syndrome, Guillan-Barre's syndrome, after rabies, poliomyelitis or influenza immunization and other malignant causes, especially acute leukemia [13,17-19]. Bilateral peripheral facial palsy as a complication of non-Hodgkin's lymphoma is considered an extremely rare entity. Ozmenoglu et al.  reported a bilateral disorder in the facial nerve associated with a non-Hodgkin's lymphoma in a non-HIV patient. There are no reports of bilateral peripheral facial palsy secondary to lymphoma or other neoplasms of the CNS in immunosuppressed patients.
Non-Hodgkin's lymphoma (NHL) has been considered a late and relatively common manifestation of HIV infection [6,20], but an exact cause for the higher incidence of this malignant neoplasm in HIV/AIDS patient is still uncertain. There are some theories that involve an ongoing infection by Epstein-Barr virus and a release of B-cell proliferation inducing cytokines by T-cells infected by HIV [8,21]. So, NHL associated with AIDS has different clinical and pathological characteristics from that found in the non AIDS-infected individuals. Histologically, many cases are B cell lymphomas, with an intermediate or high degree of malignance [6,8,22,23], while clinically they are characterized by their predominance at extranodal sites [22,24]particularly in the gastrointestinal tract and the CNS .
In the specific case of primary NHL of the CNS, the most common symptoms are dizziness, focal neurological dysfunction, headache and/or cranial nerve palsy [26,27].
Diagnose of brain NHL is based on cytological confirmation by biopsy or cytology of CSF . Radiological evaluation generally demonstrates one or two homogeneous or heterogeneous lesions in parenchyma, and can have an enhanced contrast on CT scan. Otherwise, NHL shows a brain toxoplasmosis-like lesion, which does not permit a definitive diagnosis of this neoplasm using only imaging methods [29,30].
The sensibility of detection methods for finding malignant cells in CSF varies with the neoplasm type, with meningeal involvement and with the extension of this involvement [31-34]. The percentage of primary brain tumor detection in CSF varies from 7.3% to 69.2%, with gliomas and medulloblastomas being more frequently detected [31,35]. In primary lymphomas of the CNS, malignant cells were detected in CSF in about 20% to 30% of the patients , as in our patient.
Some factors can help to increase the probability of finding neoplasmic cells in CSF, such as: multiple lumbar punctures, withdrawal of at least 10 ml of CSF, immediate processing of the sample and care at the collection site [36-38]. More sensible and specific methods than cellular morphology are also necessary for adequate identification of malignant cells in CSF. Immunocytochemistry and immunophenotype methods, and tumor biochemistry markers can help in this diagnosis [39-42]. In primary brain lymphoma, the level of soluble CD27 is increased in CSF [43,44], and Epstein-Barr virus (EBV) investigation by PCR also has diagnostic value [40,45].
Peripheral facial palsy, including bilateral cases, must always be an alert signal in the HIV-infected patient, considering that this palsy may be an initial manifestation of an NHL, which consequently will compromise the prognosis of HIV/AIDS patients.
1. Mastroianni A., Coronado O., Manfredi R., Chiodo F. Paralisi di Bell in corso di infezione da HIV. Minerva Med 1994;85:117-9. [ Links ]
2. Parry G.J. Peripheral Neuropathies Associated with Human Immunodeficiency Virus Infection. Ann Neur 1988;23:S49-S53. [ Links ]
3. Uldry P.A., Regli F. Isolated and recurrent peripheral facial paralysis in human infection with human immunodeficiency virus. Schweiz Med Wochenschr. 1988;118(27-28):1029-31. [ Links ]
4. Krasner C.G., Cohen S.H. Bilateral Bell's palsy and aseptic meningitis in a patient with acute immunodeficiency virus seroconversion. WJM 1993;159(5):604-5. [ Links ]
5. Belec L., Georges A.J., Vuillecard E. Peripheral facial nerve palsy indicating HIV infection. Lancet 1989;i:1421. [ Links ]
6. Levine A.M., Halley J.S., Pike M.C., et al. Human immunodeficiency virus-related lymphoma. Prognostic factors predictive of survival. Cancer 1991;68:2466-72. [ Links ]
7. Knowles D.M., Chamulak G.A., Subar M., et al. Lymphoid Neoplasia Associated with the Acquired Immunodeficiency Syndrome (AIDS). Ann Intern Med 1988;108:744-53. [ Links ]
8. Tulpule A., Levine A. AIDS-Related Lymphoma. Blood Reviews 1999;13:147-50. [ Links ]
9. Özmenglu M., Arseven O., Candan S., Siviloglu C. Bilateral facial paralysis secondary to lymphoma. ORL 1993;55:117-9. [ Links ]
10. Morgan M., Nathwani D. Facial palsy and infection: the unfolding story. Clin Inf Dis 1992;14:263. [ Links ]
11. Ajoua R.P., Kouassi B. Seropositivité aux tests de syndrome d'immnuno déficience acquise affection ORL à evolution chronique (à propos de 30 cas colligés dans lês services ORL d'Abidjan, Cote d'Ivoire). Publ Méd Afr 1989;100:109-15. [ Links ]
12. Bergstrom L., Baker B.B. Syndromes associated with congenital facial paralysis. Otolaryngol Head Neck Surg 1981;89:336-42. [ Links ]
13. Brown M.M., Thompson A., Goh B.T., et al. Bell's palsy and HIV infection. J Neurol Neurosurg Psychiatry 1988;51:425-6. [ Links ]
14. Dalakas M., Wichman A., Sever J. AIDS and the nervous system. J Am Med Ass 1991;16:2396. [ Links ]
15. Toma E., Poisson M., Claessens M.R., et al. Herpes simplex type 2 pericarditis and bilateral facial palsy in a patient with AIDS. J Inf Dis 1989;160(3):553-4. [ Links ]
16. Wechsler A.F., Ho D.D. Bilateral Bell's palsy at the time of HIV seroconversion. Neurology 1989;39:747-8. [ Links ]
17. Stahl N., Ferit T. Recurrent bilateral peripheral facial palsy. J Laringol Otol 1989;103:117-9. [ Links ]
18. May M., Klein S.R. Differential Diagnosis of Facial Nerve Palsy. Otolaryngologic Clinics of North America 1991;24(3):613-41. [ Links ]
19. Gorlin R.J., Sedaba H. Meldersson-Rosental syndrome. Modern Medicine 1970;10:148-9. [ Links ]
20. Chand V., Sweeney C., Agger W.A. Mental neuropathy in patients with AIDS-associated malignant lymphoma. Clin Inf Dis 1997;24:521-2. [ Links ]
21. Massod R., Zhang Y., Bond M.W., et al. Interleukin 10 is an autocrine growth factor for AIDS-related B-cell lymphoma. Blood 1995;85:3423-30. [ Links ]
22. Kaplan L.D., Abrams D.I., Feigal E., et al. AIDS-associated non-Hodgkin's lymphoma in San Francisco. JAMA 1989;261:719-24. [ Links ]
23. Pluda J.M., Yarchoan R., Jaffe E.S., et al. Development of Non-Hodgkin lymphoma in a cohort of patients with sever human immunodeficiency virus (HIV) infection on long-term antiretroviral therapy. Ann Int Med 1990;113(4):276-82. [ Links ]
24. Levine A.M., Gill P.S., Meyer P.R. Retrovirus and malignant lymphoma in homosexual men. JAMA 1985;254(14):1921-6. [ Links ]
25. Kalter S.P., Riggs S.A., Cabanillas F., et al. Aggressive non-Hodgkin's lymphomas in immunocompromised homosexual males. Blood 1985;66(3):655-9. [ Links ]
26. Gill P.S., Graham R.A., Broswell, et al. A comparison of imaging, clinical and pathologic aspects of space occupying lesions within the brain in patients with acquired immunodeficiency syndrome. Am J Physiol Imag 1986;1:134-41. [ Links ]
27. So Y.T., Beckstead J.H., Davis R.L. Primary central nervous system lymphoma in acquired immune deficiency syndrome: a clinical and pathological study. Ann Neurol 1986;20:566-72. [ Links ]
28. Balm M., Hammack J. Leptomeningeal carcinomatosis: presenting features and prognostic factors. Arch Neurol 1996;53:626-32. [ Links ]
29. De Reuck J., Vanderdonckt P., de Bleecker J., et al. Mitotic activity in cerebrospinal fluid cells. Clin Neurol Neurosurg 1988;90:117-9. [ Links ]
29. Glass J.P., Melamed M., Chernik N.L., Posner J.B. Malignant cells in cerebrospinal fluid (CSF): the meaning of a positive CSF cytology. Neurology 1979;29:1369-75. [ Links ]
30. Kjeldsber C.R., Knight J.A. Body fluids. American Society of Clinical Pathologists. Chigaco. 1993; p. 65-157. [ Links ]
31. Van Oostenbrugge R.J., Twijnstra A. Presenting features and value of diagnostic procedures in leptomeningeal metastasis. Neurology 1999;53:382-5. [ Links ]
32. Prayson R.A., Fischler D.F. Cerebrospinal fluid cytology: an 11 year experience with 5951 specimens. Arch Pathol Lab Med 1998;122:47-51. [ Links ]
33. Freilich R.J., Krol G., De Angelis L.M. Neuroimaging and cerebrospinal fluid cytology in the diagnosis of leptomeningeal metastasis. Ann Neurol 1995;38:51-7. [ Links ]
34. Glantz M.J., Cole B.F., Glantz L.K., et al. Cerebrospinal fluid cytology in patients with cancer: minimizing false-negative results. Cancer 1998;82:733-9. [ Links ]
35. Rogers L.R., Duchesneau P.M., Nunez C., et al. Comparison of cisternal and lumbar CSF examination in leptomeningeal metastasis. Neurology 1992;42:1239-41. [ Links ]
36. Cibas E.S., Maldin M.G., Posner J.B., Melamed M.R. Detection of DNA abnormalities by flow cytometry in cells from cerebrospinal fluid. Am J Clin Pathol 1987;88: 570-7. [ Links ]
37. De Luca A., Antinori A., Congolani A., et al. Evaluations of cerebrospinal fluid EBV-DNA and IL-10 as markers for in vivo diagnosis of AIDS-related primary central nervous system lymphoma. Br J Hematol 1995; 90:844-9. [ Links ]
38. Edwards M.S.B., Davis R.L., Laurent J.P. Tumor markers and cytologic features of cerebrospinal fluid. Cancer 1985;56:1773-7. [ Links ]
39. Finlay L.J., Coins S.C. Brains tumors in children: advances in diagnosis. Am J Ped Hematol/Oncol 1987;9:246-55. [ Links ]
40. Kersten M.J., Evers L.M., Dellemijn P.L.I., et al. Elevation of cerebrospinal fluid soluble CD27 levels in patients with meningeal localization of lymphoid malignancies. Blood 1996;87:1985-9. [ Links ]
41. Murare S., Saio M., Takenaka K. Increased levels of CSF soluble CD27 in patients with primary central nervous system lymphoma. Cancer 1998;132:181-6. [ Links ]
42. Sadler M., Brink N.S., Gaszzard B.G. Management of intracerebral lesions in patients with HIV: a retrospective study with discussion of diagnostic problems. Q J Med 1998;91:205-17. [ Links ]
Address to correspondence
Dr. Patrícia Gurgel Batista Leite
Rua Bruno Filgueira, 2001/71 Champagnat
Zip code: 80730-380 - Curitiba Paraná Brazil
Phone: (41) 336-1265. Fax : (41) 336-8363
Received on 21 May 2001
Revised 15 February 2002