SciELO - Scientific Electronic Library Online

vol.128 issue2Incidence trend for breast cancer among young women in Goiânia, BrazilDiagnostic accuracy of sonography for pleural effusion: systematic review author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Sao Paulo Medical Journal

Print version ISSN 1516-3180

Sao Paulo Med. J. vol.128 no.2 São Paulo  2010 



Methodological adequacy of articles published in two open-access Brazilian cardiology periodicals


Adequação metodológica dos artigos publicados em dois periódicos brasileiros de cardiologia disponíveis em open-access



Cristiane Rufino MacedoI; Davi Leite da SilvaII; Maria Eduarda PugaI

IMSc. Research assistant at the Brazilian Cochrane Center and Doctoral Student in the Discipline of Emergency Medicine and Evidence-Based Medicine, Universidade Federal de São Paulo — Escola Paulista de Medicina (Unifesp-EPM), São Paulo, Brazil
IIAssistant at the Brazilian Cochrane Center

Address for correspondence




CONTEXT AND OBJECTIVE: The use of rigorous scientific methods has contributed towards developing scientific articles of excellent methodological quality. This has made it possible to promote their citation and increase the impact factor. Brazilian periodicals have had to adapt to certain quality standards demanded by these indexing organizations, such as the content and the number of original articles published in each issue. This study aimed to evaluate the methodological adequacy of two Brazilian periodicals within the field of cardiology that are indexed in several databases and freely accessible through the Scientific Electronic Library Online (SciELO), and which are now indexed by the Web of Science (Institute for Scientific Information, ISI).
DESIGN AND SETTING: Descriptive study at Brazilian Cochrane Center.
METHODS: All the published articles were evaluated according to merit assessment (content) and form assessment (performance).
RESULTS: Ninety-six percent of the articles analyzed presented study designs that were adequate for answering the objectives.
CONCLUSIONS: These two Brazilian periodicals within the field of cardiology published methodologically adequate articles, since they followed the quality standards. Thus, these periodicals can be considered both for consultation and as vehicles for publishing future articles. For further analyses, it is essential to apply other indicators of scientific activity such as bibliometrics, which evaluates quantitative aspects of the production, dissemination and use of information, and scientometrics, which is also concerned with the development of science policies, within which it is often superimposed on bibliometrics.

Key words: Cardiology; Access to information; Epidemiologic research design; Methods; Publications.


CONTEXTO E OBJETIVO: A utilização de métodos científicos rigorosos tem contribuído para o desenvolvimento de artigos científicos de excelente qualidade metodológica, o que permite a promoção da sua citação, bem como o aumento do fator de impacto. Os periódicos nacionais tiveram que se adequar a alguns padrões de qualidade exigidos pelos indexadores, como por exemplo o conteúdo e o número de artigos originais publicados em cada fascículo. O objetivo foi avaliar a adequação metodológica de dois periódicos brasileiros, na área de cardiologia, indexados em várias bases de dados e disponíveis em livre acesso na Scientific Electronic Library Online (SciELO) e atualmente indexados na Web of Science (Institute for Scientific Information, ISI).
TIPO DE ESTUDO E LOCAL: Estudo descritivo realizado no Centro Cochrane do Brasil.
MÉTODO: Todos os artigos foram avaliados quanto ao mérito (conteúdo) e quanto à forma (desempenho).
RESULTADO: Foi observada uma taxa de 96% de adequação metodológica entre os artigos avaliados, que apresentaram desenho de estudo adequado para responder o objetivo proposto.
CONCLUSÕES: Esses dois periódicos brasileiros na área da cardiologia publicaram artigos metodologicamente adequados, considerando os critérios de qualidade utilizados. Assim, esses periódicos podem ser considerados para consulta e como veículos para a publicação de artigos futuros. Para análises posteriores, é essencial a aplicação de outros indicadores de atividade científica, como a bibliometria, que avalia aspectos quantitativos da produção, disseminação e uso da informação, e a cienciometria, que também considera o desenvolvimento de políticas de ciência, e que muitas vezes se sobrepõe à bibliometria.

Palavras-chave: Cardiologia; Acesso à informação; Projetos de pesquisa epidemiológica; Métodos; Publicações.




Mankind is now living in the age of information and knowledge, in which people who can master the flow of information that is available are the ones who can keep up to date in some manner and have access to best practices.

It has also been seen that the quantity of the information available in the principal communication media, among which the Internet can be highlighted, leaves people with a sense of anxiety. People sense that, day by day, this avalanche of information has been making them insecure because of the feeling that they are missing something, i.e. some important information that should be coming out at this time. Because of the quantity of data and ease of obtaining it, people feel that they are unable to master it.

In the field of healthcare, there are greater quantities of published information and a better structure for organizing it and making it available, compared with other fields of knowledge. Some of the most important virtual databases (some with free access) containing scientific articles within the field of healthcare are the following:1

a) Medline ( –– 5,400 indexed periodicals in 37 languages, containing 16 million references to papers, with free access.

b) The Cochrane Library ( –– with free access in Brazil. This database presents:

- 6,076 full texts of systematic reviews –– Cochrane Database of Systematic Reviews (CDSR; Cochrane Reviews).

- 11,887 summaries of non-Cochrane systematic reviews with quality assessment –– Database of Abstracts of Reviews of Effects (DARE; Other Reviews).

- 608,405 summaries of clinical trials published in Medline, Embase and other sources –– Cochrane Central Register of Controlled Trials (CENTRAL; Clinical Trials).

- 12,778 methodological studies –– Cochrane Methodology Register (CMR; Methods Studies).

- 7,724 health technology assessments –– Health Technology Assessment Database (HTA; Technology Assessments).

- 28,159 economic evaluations –– NHS Economic Evaluation Database (NHSEED; Economic Evaluations)

c) Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde - –– open access to 500,000 bibliographic records of articles published in around 1,500 health science periodicals.

d) Embase ( –– 4,800 indexed periodicals in 30 languages – 12 million article references – access by subscription.

Within the databases cited above, there are some periodicals that form part of a movement known as open access, i.e. provision of open access to the digital medium, in which these periodicals are made available in full text form, free from any onus. The free public availability of these texts on the Internet makes it possible for them to be read, printed and downloaded. In this manner, both the periodical and the paper and its authors will have greater visibility.2 This facility of having the full text available, and the complete collections of many periodicals, gives rise to reflection regarding the quality of these periodicals and published studies.

The Institute for Scientific Information (ISI), based in Philadelphia, United States, has assessed scientific production in many fields. The principal parameter used is the so-called impact factor. This is calculated by dividing the number of citations that a periodical receives over a two-year period by the total number of articles published in that periodical.3 The use of rigorous scientific methods has contributed towards developing scientific articles of excellent methodological quality. This has made it possible to promote their citation and increase the impact factor.

In Brazil, the impact factor has been used as a parameter for assessing the quality of authors' and journals' scientific production, including by government commissions and bodies, such as the Coordination Office for Advancement of University-level Personnel (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Capes), which classifies postgraduate programs and their supervisors according to the papers that are published from students' theses, graded using the impact factors of the journals involved.4

Brazilian periodicals have had to adapt to certain quality standards demanded by these indexing organizations, such as the content and the number of original articles published in each issue of the periodical. However, the assessments of researchers' intellectual production has been limited to the number of citations and the impact factor of the periodicals in which their articles were published, without any specific rigorous critical evaluation of each article. This has led to distortions in science of "publish or perish" nature. There is now a lack of major attention to critical analyses on the general quality of the articles published in each periodical, which would provide a better correlation with the meritocracy of both researchers and periodicals.



To assess the articles that were published in two Brazilian periodicals in the field of cardiology: Arquivos Brasileiros de Cardiologia and Revista Brasileira de Cirurgia Cardiovascular. These journals are indexed in the most important worldwide databases (PubMed, Lilacs and Scopus) and have recently also gained indexation in the Web of Science/ISI. They are also available in the Scientific Electronic Library (SciELO Online) through open access.



We selected two periodicals within the field of cardiology (Arquivos Brasileiros de Cardiologia and Revista Brasileira de Cirurgia Cardiovascular), which are available through open access (SciELO - Scientific Electronic Library Online - and can also be retrieved directly from the databases in which they are indexed (PubMed, Lilacs and Scopus).

The period chosen for analysis was the year 2007, during which the first of these periodicals published two volumes and the second published only one volume.

Two types of evaluation were performed, according to quality standards:5

1. Merit assessment (content), consisting of quantitative analysis on all the articles published and their distribution between sections.

2. Form assessment (performance), consisting of analysis on study designs to evaluate how closely the research design matched the study objective.

For the merit assessment, the division of content was investigated. In other words, all the articles were classified with regard to the particular naming of sections in each periodical. No exclusion criteria were determined for this outcome.

To assess form with regard to performance, each article was classified according to its study design, for example: systematic review of the literature, narrative review of the literature, clinical trial, retrospective cohort, prospective cohort, case-control study, case series, cross-sectional study, analytical cross-sectional study, diagnostic test study, guideline study, study on animals, anatomopathological or in vitro study, or specialists' opinion.6 Articles named in the journal sections as letter to the editor, editorials or in memoriam were excluded from this analysis.

The articles included in the study design analysis were assessed regarding the adequacy of the match between the research design and the study objective. Papers that presented a study design that is recommended for answering the objective were considered to have adequate designs. For example, articles on therapeutics require randomized trials, or systematic reviews or meta-analyses on such trials. Articles on diagnostic tests require accuracy studies, while investigations on the natural history of diseases require cohort studies, and so on.

Two reviewers assessed each article, independently, and the disagreements between them were solved by reaching a consensus.



All the articles published in the year 2007 in the periodicals Arquivos Brasileiros de Cardiologia and Revista Brasileira de Cirurgia Cardiovascular were evaluated. In Arquivos Brasileiros de Cardiologia, 244 published articles distributed in two volumes (88 and 89) consisting of six issues each (numbered 1 to 6) were found. Volume 88 also presented two supplementary issues (supplement 1 and supplement 2). In Revista Brasileira de Cirurgia Cardiovascular, 90 published articles were distributed in a single volume (volume 22) consisting of four issues (numbered 1 to 4).

Each of the periodicals had sections that were named in a particular way to present its articles. The naming of the sections and the distribution of the articles are presented separately for each periodical in Tables 1 and 2.





With regard to study design, it was found that both periodicals presented different types of study: diagnostic test, prospective cohort, retrospective cohort, case report, case series, clinical trial, narrative review of the literature, cross-sectional prevalence study, analytical cross-sectional study, guidelines, specialists' opinions and in vitro anatomopathological studies, both on animals and on humans.

The articles were evaluated regarding their methodological adequacy, i.e. whether the study design was adequate for the study objective. Ninety-six percent of the articles analyzed, in both periodicals, presented study designs that were adequate for answering the objectives.



In this study, the articles were evaluated according to the section names used in each of the periodicals, along with the study design and its methodological adequacy.

In the merit assessment, we found that each periodical had its own criteria for naming the journal sections. Distributing articles into different sections has the aim of organizing them to facilitate understanding among readers. The two periodicals had some sections in common, such as Editorial, Original Articles, Review Articles, Case Reports and Letters to the Editor, but in different proportions: for example, Arquivos Brasileiros de Cardiologia only published one editorial.7 However, there were also some sections that were peculiar to each journal. For example, Arquivos Brasileiros de Cardiologia presented the following sections: Anatomopathological Session (sic), Clinical Radiological Session (sic), Brief Comments, In Memoriam, Point of View, Image, Clinical Update and Guideline.8-11 In Revista Brasileira de Cirurgia Cardiovascular, different sections were found, for example: Special Article, Brief Communication, Clinical Surgical Correlation and Experience of the Service.12-14

Among the articles appearing in sections with different names in Arquivos Brasileiros de Cardiologia, there were two in the Clinical-Radiographic Correlation section that in reality were case reports.8,9 In the Brief Comments, one cohort study was found.11 One of the strong points of the present study was that it made comparisons between recent, simultaneously published journals within the same field, in the same country, without apparent conflicts of interest.

The articles were then classified according to their study design. Cross-sectional studies15-18 and case reports were the types most frequently found, respectively in Arquivos Brasileiros de Cardiologia and Revista Brasileira de Cirurgia Cardiovascular.19,20

The two periodicals together published a total of five guidelines, both in regular issues and in supplements, as can be seen in Arquivos Brasileiros de Cardiologia.10,21-24

Analysis on the articles published according to levels of evidence (Oxford) showed that none of them presented level 1 evidence (systematic reviews), but that there were narrative reviews of the literature. On the other hand, we found studies presenting level 2 evidence, such as clinical trials. Other types of study, such as cohorts, case series, case-control studies, specialists' opinions and studies on animals were also found.11,25-47

A high proportion of the articles in both periodicals (96%) presented methodological adequacy, i.e. a good match between the study objectives and the study design used. This is of great value for increasing the quality of the scientific knowledge produced in the field of cardiology in Brazil. In comparison, in a recent study evaluating papers published on diseases of the larynx, it was found that the study design matched the study objectives in only 3% of them.48



1. Implications for practice

From analysis on these two Brazilian periodicals within the field of cardiology, which are indexed in several databases and are available with open access, we found that both of them were methodologically adequate, since they followed the quality standards. Thus, these periodicals can be recommended both for consultation and as vehicles for publishing future articles.

2. Implications for further research

For future analyses, it is essential to apply other indicators of scientific activity such as bibliometrics, which evaluates quantitative aspects of the production, dissemination and use of information, and scientometrics, which not only evaluates the quantitative aspects of scientific activities but also is concerned with the development of science policies, within which it is often superimposed on bibliometrics.



1. Lefebvre C, Manheimer E, Glanville J. Chapter 6: Searching for studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.0.2 (updated September 2009). The Cochrane Collaboration; 2009. Available from: Accessed in 2010 (Apr 22).         [ Links ]

2. BioMed Central. The Open Access Publisher. BioMed Central open access charter. Available from: Accessed in 2010 (Apr 22).         [ Links ]

3. Galileu D, Rocha FF, Nicolato R, Teixeira AL, Romano-Silva MA, Correa H. Produção brasileira em periódicos psiquiátricos de alto fator de impacto em 2005 [Brazilian production in psychiatric journals with high impact factor in 2005]. J Bras Psiquiatr. 2006;55(2):120-4.         [ Links ]

4. Garfield E. SCI Journal Citation Reports: a bibliometric analysis of science journals in the ISI database. Philadelphia: Institute for Scientific Information; 1995.         [ Links ]

5. Krzyzanowski RF, Ferreira MCG. Avaliação de periódicos científicos e técnicos brasileiros [Criteria for merit evaluation of Brazilian current periodicals]. Ci Inf. 1998;27(2):165-75.         [ Links ]

6. Yoshida WB. O fator de impacto do Jornal Vascular Brasileiro [The impact factor of Jornal Vascular Brasileiro]. J Vasc Bras. 2008;7(3):187-8.         [ Links ]

7. Rassi Júnior A. Análise econômica dos Stents coronarianos farmacológicos no Brasil: para todos ou para poucos pacientes? [Economic analysis of drug-eluting coronary stents in Brazil: a choice for all or just for a few patients?] Arq Bras Cardiol. 2007;88(4):376-7.         [ Links ]

8. Atik E. Caso 6/2007: criança de dez anos com estenose pulmonar valvar discreta [Case 6/2007: a ten-year-old child with mild pulmonary valve stenosis]. Arq Bras Cardiol. 2007;89(5):341-2.         [ Links ]

9. Atik E. Caso 3/2007: lactente de três meses com criss-cross heart, discordância atrioventricular e dupla via de saída de ventrículo direito, sem estenose pulmonar [Case 3/2007: a three-month-old male infant with criss-cross heart, atrioventricular discordance, and double-outlet right ventricle, without pulmonary stenosis]. Arq Bras Cardiol. 2007;88(6):693-5.         [ Links ]

10. Ronderos RE, Morcerf F, Boskis M, et al. Diretriz e recomendações para o uso da Ecocardiografia Contrastada: Fórum Latino-Americano de Ecocardiografia com Contraste. Arq Bras Cardiol. 2007;88(supl. 2):1-12.         [ Links ]

11. Abello M, González-Zuelgaray J, Daglio ME, Lopez C, Garraza S, Szyszko A. Padrão circadiano dos episódios de taquicardia ventricular em portadores de cardiopatia chagásica [Circadian pattern of ventricular tachycardia episodes in patients with chagas heart disease]. Arq Bras Cardiol. 2007;88(2):240-2.         [ Links ]

12. Moreira MM, Terzi RGG, Vieira RW, et al. Variáveis capnográficas pré e pós-tromboendarterectomias pulmonares [Pre and post-pulmonary thromboendarterectomies campnographic variables]. Rev Bras Cir Cardiovasc. 2007;22(4):509-12.         [ Links ]

13. Croti UA, Braile DM, Hassem Sobrinho S, Marchi CH. Caso 8/2007: conexão anômala parcial de veias pulmonares em átrio direito com ausência de comunicação interatrial [Case 8/2007: partial anomalous pulmonary venous connection into the right atrium with absence of interatrial communication]. Rev Bras Cir Cardiovasc. 2007;22(4):513-4.         [ Links ]

14. Milani R, Brofman PR, Souza JAM, et al. Revascularização do miocárdio sem circulação extracorpórea em pacientes submetidos à hemodiálise [OPCAB in patients on hemodialysis]. Rev Bras Cir Cardiovasc. 2007;22(1):104-10.         [ Links ]

15. Cavalcante MA, Bombig MTN, Luna Filho B, Carvalho ACC, Paola AAV, Póvoa R. Qualidade de vida de pacientes hipertensos em tratamento ambulatorial [Quality of life of hypertensive patients treated at an outpatient clinic]. Arq Bras Cardiol. 2007;89(4):245-50.         [ Links ]

16. De Biase SG, Fernandes SFC, Gianini RJ, Duarte JLG. Dieta vegetariana e níveis de colesterol e triglicérides [Vegetarian diet and cholesterol and triglycerides levels]. Arq Bras Cardiol. 2007;88(1):35-9.         [ Links ]

17. Costa JSD, Barcellos FC, Sclowitz ML, et al. Prevalência de hipertensão arterial em adultos e fatores associados: um estudo de base populacional urbana em Pelotas, Rio Grande do Sul, Brasil [Hypertension prevalence and its associated risk factors in adults: a population-based study in Pelotas]. Arq Bras Cardiol. 2007;88(1):59-65.         [ Links ]

18. Piovesan F, Veronese FJV, Santos AF, et al. Avaliação dos níveis séricos de homocisteína em transplantados renais com e sem hipercolesterolemia [Serum homocysteine levels in renal transplant recipients with and without hypercholesterolemia]. Arq Bras Cardiol. 2007;89(3):170-5.         [ Links ]

19. Miana LA, Lima DS, Whitaker JF, Passos PHC, Loures JBL, Miana AA. Resultados imediatos da artéria torácica interna direita e artéria radial como segundo enxerto arterial em revascularização do miocárdio [Immediate results of right internal thoracic artery and radial artery as the second arterial graft in myocardial revascularization]. Rev Bras Cir Cardiovasc. 2007;22(1):60-7.         [ Links ]

20. Gaiotto FA, Puig LB, Mady C, et al. Substituição da valva mitral com tração dos músculos papilares em pacientes com miocardiopatia dilatada [Mitral valve replacement with chordae tendineae preservation, traction and fixation in end-stage dilated cardiomyopathy]. Rev Bras Cir Cardiovasc. 2007;22(1):68-74.         [ Links ]

21. Vieira MLC, Sproesser AJ. V Diretrizes Brasileiras de Hipertensão Arterial. Arq Bras Cardiol. 2007;89(3):e24-e79.         [ Links ]

22. Sociedade Brasileira de Cardiologia. Diretrizes (IIª Edição, 2007) da Sociedade Brasileira de Cardiologia sobre angina instável e infarto agudo do miocárdio sem supradesnível do segmento ST. Arq Bras Cardiol. 2007;89(4):e89-e131.         [ Links ]

23. Sociedade Brasileira de Cirurgia Cardiovascular. Diretrizes para o tratamento cirúrgico das doenças da aorta da Sociedade Brasileira de Cirurgia Cardiovascular [Guidelines for surgery of aortic diseases from Brazilian Society of Cardiovascular Surgery]. Rev Bras Cir Cardiovasc. 2007;22(2):137-59.         [ Links ]

24. Sociedade Brasileira de Cardiologia. Sociedade Brasileira de Arritmias Cardíacas. Departamento de Estimulação Cardíaca Artificial. Diretrizes Brasileiras de Dispositivos Cardíacos Eletrônicos Implantáveis (DCEI). Arq Bras Cardiol. 2007;89(6):210-38.         [ Links ]

25. Felício JS, Pacheco JT, Ferreira SR, et al. Reprodutibilidade da medida ambulatorial da pressão arterial em pacientes hipertensos com diabete melito tipo 2 [Reproducibility of ambulatory blood pressure monitoring in hypertensive patients with type 2 diabetes mellitus]. Arq Bras Cardiol. 2007;88(2):206-11.         [ Links ]

26. Leite FS, Santos LM, Bonafé WW, et al. Influência da circulação extracorpórea sobre as concentrações plasmáticas de atenolol [Influence of cardiopulmonary bypass on the plasma concentrations of atenolol]. Arq Bras Cardiol. 2007;88(6):637-42.         [ Links ]

27. Teno LAC, Costa R, Martinelli Filho M, Castilho FCT, Ruiz I. Mudança do modo VVI para DDD ("upgrade") na troca eletiva do gerador de pulsos: análise comparativa clínico-funcional [Upgrading from VVI to DDD pacing Mode during elective replacement of pulse generator: a comparative clinical-functional analysis]. Arq Bras Cardiol. 2007;88(2):128-33.         [ Links ]

28. Pugliese R, Zanella MT, Blay SL, Plavinik F, Andrade MA, Galvão R. Eficácia de uma intervenção psicológica no estilo de vida para redução do risco coronariano [Efficacy of lifestyle change psychological intervention in coronary risk reduction]. Arq Bras Cardiol. 2007;89(4):225-30.         [ Links ]

29. Rocha EA, Gondim TP, Abreu S, et al. Ressincronização ventricular: comparando os marcapassos biventriculares com os marcapassos bifocais de ventrículo direito [Ventricular resynchronization: comparing biventricular and bifocal right ventricular pacemakers]. Arq Bras Cardiol. 2007;88(6):674-82.         [ Links ]

30. Barcellos CS, Wender OCB, Azambuja PC. Glicose insulina e potássio (GIK) na revascularização do miocárdio de pacientes diabéticos: ensaio clínico randomizado [Clinical and hemodynamic outcome following coronary artery bypass surgery in diabetic patients using glucose-insulin-potassium (GIK) solution: a randomized clinical trial]. Rev Bras Cir Cardiovasc. 2007;22(3):275-84.         [ Links ]

31. Milani R, Brofman PRS, Souza JAM, et al. Análise dos resultados imediatos de estudo comparativo entre anastomose mecânica aorto-safena versus convencional [Analysis of the immediate outcomes of a comparative randomized study between aorto-saphenous mechanical anastomosis versus conventional anastomosis]. Rev Bras Cir Cardiovasc. 2007;22(3):310-6.         [ Links ]

32. Avila Neto V, Costa R, Silva KR, et al. Efeitos da estimulação temporária atrial direita na prevenção da fibrilação atrial no pós-operatório de revascularização do miocárdio com circulação extracorpórea [Effect of temporary right atrial pacing in prevention of atrial fibrillation after coronary artery bypass graft surgery]. Rev Bras Cir Cardiovasc. 2007;22(3):332-40.         [ Links ]

33. Nascimento JS, Modolo NSP, Silva RCR, Santos KP, Carvalho HG. Efeitos sedativos e cardiovasculares do midazolam e do diazepam, associados ou não a clonidina, em pacientes submetidos a estudos hemodinâmicos por suspeita de doença arterial coronariana [Sedative and cardiovascular effects of midazolam and diazepam alone or combined with clonidine in patients undergoing hemodynamic studies for suspected coronary artery disease]. Arq Bras Cardiol. 2007;89(6):403-8.         [ Links ]

34. Menezes Júnior AS, Martinelli Filho M, Menezes CCS, Costa R, Ramires JAF. Efeitos da associação da estimulação atrial dinâmica em duplo sítio atrial com atenolol na prevenção da fibrilação atrial recorrente [Effects of the association of dual-site dynamic atrial overdrive and atenolol in preventing recurrent atrial fibrillation]. Arq Bras Cardiol. 2007;88(1):1-7.         [ Links ]

35. Esporcatte R, Rey HCV, Rangel FOD, et al. Valor preditivo da mieloperoxidase na identificação de pacientes de alto risco admitidos por dor torácica aguda [Predictive value of myeloperoxidase to identify high risk patients admitted to the hospital with acute chest pain]. Arq Bras Cardiol. 2007;89(6):377-84.         [ Links ]

36. Teixeira RCMA, Molina MCB, Zandonade E, Mill JG. Risco cardiovascular em vegetarianos e onívoros: um estudo comparativo [Cardiovascular risk in vegetarians and omnivores: a comparative study]. Arq Bras Cardiol. 2007;89(4):237-44.         [ Links ]

37. Makdisse M, Ramos LR, Moreira F, et al. Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periférica [A risk score for predicting peripheral arterial disease in individuals 75 years or older]. Arq Bras Cardiol. 2007;88(6):630-6.         [ Links ]

38. Azevedo JC, Félix RCM, Corrêa PL, et al. Prognóstico em médio prazo da cintilografia de perfusão miocárdica de estresse na unidade de dor torácica [Medium term prognostic value of stress myocardial perfusion scintigraphy in a chest pain unit]. Arq Bras Cardiol. 2007;88(5):602-10.         [ Links ]

39. Villacorta H, Masetto AC, Mesquita ET. Proteína C-reativa: marcador inflamatório com valor prognóstico em pacientes com insuficiência cardíaca descompensada [C-reactive protein: an inflammatory marker with prognostic value in patients with decompensated heart failure]. Arq Bras Cardiol. 2007;88(5):585-9.         [ Links ]

40. Cardoso CO, Rossi Filho RI, Machado PR, François LMG, Horowitz ESK, Sarmento-Leite R. Efetividade da prótese de Amplatzer® para fechamento percutâneo do defeito do septo interatrial tipo Ostium Secundum [Effectiveness of the Amplatzer® device for transcatheter closure of an ostium secundum atrial septal defect]. Arq Bras Cardiol. 2007; 88(4):384-9.         [ Links ]

41. Silva JP, Fonseca L, Baumgratz JF, et al. Síndrome da hipoplasia do coração esquerdo: a influência da estratégia cirúrgica nos resultados [Hypoplastic left heart syndrome: the influence of surgical strategy on outcomes]. Arq Bras Cardiol. 2007;88(3):354-60.         [ Links ]

42. Rosa EM, Sant'anna JRM, Oppermann LP, Castro I. Prognóstico da esclerose valvar aórtica na mortalidade cardíaca de pacientes atendidos no instituto de cardiologia do Rio Grande do Sul [Prognosis of aortic valve sclerosis in cardiovascular mortality of patients seen at the cardiology institute of Rio Grande do Sul]. Arq Bras Cardiol. 2007;88(2):234-9.         [ Links ]

43. Carvalho T, Curi ALH, Andrade DF, Singer JM, Benetti M, Mansur AJ. Reabilitação cardiovascular de portadores de cardiopatia isquêmica submetidos a tratamento clínico, angioplastia coronariana transluminal percutânea e revascularização cirúrgica do miocárdio [Cardiovascular rehabilitation of patients with ischemic heart disease undergoing medical treatment, percutaneous transluminal coronary angioplasty, and coronary artery bypass grafting]. Arq Bras Cardiol. 2007;88(1):72-8.         [ Links ]

44. Silva JP, Fonseca L, Baumgratz JF, et al. Síndrome do coração esquerdo hipoplásico: estratégia cirúrgica e comparação de resultados com técnicas de Norwood x Sano [Hypoplastic left heart syndrome: the report of a surgical strategy and comparative results of Norwood x Norwood-Sano approach]. Rev Bras Cir Cardiovasc. 2007;22(2):160-8.         [ Links ]

45. Kochi AC, Martins AS, Balbi AL, et al. Fatores de risco pré-operatórios para o desenvolvimento de Insuficiência Renal Aguda em cirurgia cardíaca [Preoperative risk factors for the development of Acute Renal Failure in cardiac surgery]. Rev Bras Cir Cardiovasc. 2007;22(1):33-40.         [ Links ]

46. Araújo F, Yamada AT, Markus MRP, Antelmi I, Latorre MRDO, Mansur AJ. Aumento do índice de massa corporal em relação a variáveis clínicas e laboratoriais quanto ao sexo em indivíduos sem evidências de cardiopatia [Gender-related associations of increased body mass index with clinical and laboratory variables in individuals with no evidence of heart disease]. Arq Bras Cardiol. 2007;88(6):624-9.         [ Links ]

47. Areosa CMN, Almeida DR, Carvalho AC, Paola AAV. Avaliação de fatores prognósticos da insuficiência cardíaca em pacientes encaminhados para avaliação de transplante cardíaco [Evaluation of heart failure prognostic factors in patients referred for heart transplantation]. Arq Bras Cardiol. 2007;88(6):667-73.         [ Links ]

48. Vieira VP, De Biase N, Peccin MS, Atallah AN. The research questions and methodological adequacy of clinical studies of the voice and larynx published in Brazilian and international journals. J Eval Clin Pract. 2009;15(3):473-7.         [ Links ]



Address for correspondence:
Cristiane Rufino Macedo
Centro Cochrane do Brasil
Rua Pedro de Toledo, 598
Vila Clementino — São Paulo (SP) — Brazil
CEP 04039-001
Tel/Fax. (+55 11) 5575-2970/5579-0469

Date of first submission: April 14, 2010
Last received: April 15, 2010
Accepted: April 29, 2010
Sources of funding: Capes bursary
Conflict of interest: None



Brazilian Cochrane Center, São Paulo, Brazil.

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License