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Brazilian Journal of Psychiatry

Print version ISSN 1516-4446On-line version ISSN 1809-452X

Rev. Bras. Psiquiatr. vol.40 no.1 São Paulo Jan./Mar. 2018 


Zika virus infection and psychosis

Beuy Joob1 

Viroj Wiwanitkit2 

1Medical Academic Center, Bangkok, Thailand

2Joseph Ayo Babalola University, Ilara-Mokin, Nigeria

We read the publication on “Zika virus infection followed by a first episode of psychosis” with great interest.1 Corrêa-Oliveira et al. noted that “to the best of our knowledge, this is the first report in which psychiatric symptoms were the only complication of acute ZIKV infection”1 and concluded that “Neuroimmune mechanisms leading to psychosis during acute CNS stress is an open and prolific field for research.”1 In fact, a wide clinical spectrum of Zika virus infection has been reported, and psychological problems are possible.2,3 Neuropsychiatric problems as the only clinical presentation in acute Zika virus disease is not a new finding. At least, psychotic features in acute Zika virus infection have already been observed in cases in which meningoencephalitis was later proved.4 In the Zika virus infection with meningoencephalitis, spatial delusions with visual and kinesthetic hallucinations are observable.5


1. Corrêa-Oliveira GE, do Amaral JL, da Fonseca BA, Del-Ben CM. Zika virus infection followed by a first episode of psychosis: another flavivirus leading to pure psychiatric symptomatology. Rev Bras Psiquiatr. 2017;39:381-2. [ Links ]

2. Joob B, Yasser F. Phenotypic spectrum of congenital Zika syndrome: a comment on the usefulness of case report. Case Study Case Rep. 2017;7:29-30. [ Links ]

3. Pinheiro TJ, Guimarães LF, Silva MT, Soares CN. Neurological manifestations of Chikungunya and Zika infections. Arq Neuropsiquiatr. 2016;74:937-43. [ Links ]

4. Schwartzmann PV, Ramalho LN, Neder L, Vilar FC, Ayub-Ferreira SM, Romeiro MF, et al. Zika virus meningoencephalitis in an immunocompromised patient. Mayo Clin Proc. 2017;92:460-6. [ Links ]

5. Carteaux G, Maquart M, Bedet A, Contou D, Brugières P, Fourati S, et al. Zika virus associated with meningoencephalitis. N Engl J Med. 2016;374:1595-6. [ Links ]

Received: June 27, 2017; Accepted: July 29, 2017

Disclosure The authors report no conflicts of interest.

Creative Commons License This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.