We read the publication on “Zika virus infection followed by a first episode of psychosis” with great interest.11. Corrêa-Oliveira GE, do Amaral JL, da Fonseca BA, Del-Ben CM. Zika virus infection followed by a first episode of psychosis: another flavivirus leading to pure psychiatric symptomatology. Rev Bras Psiquiatr. 2017;39:381-2. Corrêa-Oliveira et al. noted that “to the best of our knowledge, this is the first report in which psychiatric symptoms were the only complication of acute ZIKV infection”11. Corrêa-Oliveira GE, do Amaral JL, da Fonseca BA, Del-Ben CM. Zika virus infection followed by a first episode of psychosis: another flavivirus leading to pure psychiatric symptomatology. Rev Bras Psiquiatr. 2017;39:381-2. and concluded that “Neuroimmune mechanisms leading to psychosis during acute CNS stress is an open and prolific field for research.”11. Corrêa-Oliveira GE, do Amaral JL, da Fonseca BA, Del-Ben CM. Zika virus infection followed by a first episode of psychosis: another flavivirus leading to pure psychiatric symptomatology. Rev Bras Psiquiatr. 2017;39:381-2. In fact, a wide clinical spectrum of Zika virus infection has been reported, and psychological problems are possible.22. Joob B, Yasser F. Phenotypic spectrum of congenital Zika syndrome: a comment on the usefulness of case report. Case Study Case Rep. 2017;7:29-30.,33. Pinheiro TJ, Guimarães LF, Silva MT, Soares CN. Neurological manifestations of Chikungunya and Zika infections. Arq Neuropsiquiatr. 2016;74:937-43. Neuropsychiatric problems as the only clinical presentation in acute Zika virus disease is not a new finding. At least, psychotic features in acute Zika virus infection have already been observed in cases in which meningoencephalitis was later proved.44. Schwartzmann PV, Ramalho LN, Neder L, Vilar FC, Ayub-Ferreira SM, Romeiro MF, et al. Zika virus meningoencephalitis in an immunocompromised patient. Mayo Clin Proc. 2017;92:460-6. In the Zika virus infection with meningoencephalitis, spatial delusions with visual and kinesthetic hallucinations are observable.55. Carteaux G, Maquart M, Bedet A, Contou D, Brugières P, Fourati S, et al. Zika virus associated with meningoencephalitis. N Engl J Med. 2016;374:1595-6.
References
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1Corrêa-Oliveira GE, do Amaral JL, da Fonseca BA, Del-Ben CM. Zika virus infection followed by a first episode of psychosis: another flavivirus leading to pure psychiatric symptomatology. Rev Bras Psiquiatr. 2017;39:381-2.
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2Joob B, Yasser F. Phenotypic spectrum of congenital Zika syndrome: a comment on the usefulness of case report. Case Study Case Rep. 2017;7:29-30.
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3Pinheiro TJ, Guimarães LF, Silva MT, Soares CN. Neurological manifestations of Chikungunya and Zika infections. Arq Neuropsiquiatr. 2016;74:937-43.
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4Schwartzmann PV, Ramalho LN, Neder L, Vilar FC, Ayub-Ferreira SM, Romeiro MF, et al. Zika virus meningoencephalitis in an immunocompromised patient. Mayo Clin Proc. 2017;92:460-6.
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5Carteaux G, Maquart M, Bedet A, Contou D, Brugières P, Fourati S, et al. Zika virus associated with meningoencephalitis. N Engl J Med. 2016;374:1595-6.
Publication Dates
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Publication in this collection
Jan-Mar 2018
History
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Received
27 June 2017 -
Accepted
29 July 2017
