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Revista Brasileira de Hematologia e Hemoterapia

Print version ISSN 1516-8484

Rev. Bras. Hematol. Hemoter. vol.33 no.6 São Paulo Dec. 2011 



Bone marrow cytomorphological changes in patients co-infected with visceral leishmaniasis and human immunodeficiency virus



Alana Jocelina Montenegro de CastroI; Romelia Pinheiro GonçalvesII; Maria Helena da Silva PitombeiraIII

IPathology Department, Universidade Federal do Ceará - UFC, Fortaleza, CE, Brazil
IIDepartment of Clinical Analysis and Toxicology, Universidade Federal do Ceará - UFC, Fortaleza, CE, Brazil
IIIDepartment of Clinical Medicine, Universidade Federal do Ceará - UFC, Fortaleza, CE, Brazil

Corresponding author




Visceral leishmaniasis (VL) is a severe systemic infectious disease.(1) It has been recognized as an opportunistic disease in patients infected with human immunodeficiency virus (HIV).(2,3) The analysis of the bone marrow of patients co-infected with VL and HIV showed dysplasia of erythroid, granulocytic and megakaryocytic lineages (Figure 1), besides the presence of plasmacytosis, cytoplasmic bodies, hemophagocytosis, granuloma and intracellular and extracellular leishmania amastigotes (Figure 2). These findings are found in the analysis of bone marrow of patients co-infected with HIV and VL; knowledge of these findings may be useful for the diagnosis and prognosis of patients.

Keywords: HIV infections; Bone marrow examination; Leishmaniasis, visceral; AIDS-related opportunistic infections







1. Jawhar NM. Visceral Leishmaniasis with an Unusual Presentation in an HIV positive patient. Sultan Qaboos Univ Med J. 2011;11(2):269-72.         [ Links ]

2. Daher EF, Fonseca PP, Gerhard ES, Leitão TM, Silva Júnior GB. Clinical and epidemiological features of visceral leishmaniasis and HIV co-infection in fifteen patients from Brazil. J Parasitol. 2009;95(3):652-5        [ Links ]

3. Alexandrino-de-Oliveira P, Santos-Oliveira JR, Dorval ME, Da-Costa FC, Pereira GR, da Cunha RV, et al. HIV/AIDS-associated visceral leishmaniasis in patients from an endemic area in Central-west Brazil. Mem Inst Oswaldo Cruz. 2010;105(5):692-7.         [ Links ]



Corresponding author:
Romelia Pinheiro Gonçalves
Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Ceará - UFC
Rua Capitão Francisco Pedro 1210
Rodolfo Teófilo
60430-370 - Fortaleza, CE, Brazil

Submitted: 10/18/2011
Accepted: 10/21/2011
Conflict-of-interest disclosure: The authors declare no competing financial interest or

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