Abstract
Visceral leishmaniasis (VL) is a severe systemic infectious disease.(1) It has been recognized as an opportunistic disease in patients infected with human immunodeficiency virus (HIV).(2,3) The analysis of the bone marrow of patients co-infected with VL and HIV showed dysplasia of erythroid, granulocytic and megakaryocytic lineages (Figure 1), besides the presence of plasmacytosis, cytoplasmic bodies, hemophagocytosis, granuloma and intracellular and extracellular leishmania amastigotes (Figure 2). These findings are found in the analysis of bone marrow of patients co-infected with HIV and VL; knowledge of these findings may be useful for the diagnosis and prognosis of patients.
HIV infections; Bone marrow examination; Leishmaniasis, visceral; AIDS-related opportunistic infections
IMAGES IN CLINICAL HEMATOLOGY
Bone marrow cytomorphological changes in patients co-infected with visceral leishmaniasis and human immunodeficiency virus
Alana Jocelina Montenegro de CastroI; Romelia Pinheiro GonçalvesII; Maria Helena da Silva PitombeiraIII
IPathology Department, Universidade Federal do Ceará - UFC, Fortaleza, CE, Brazil
IIDepartment of Clinical Analysis and Toxicology, Universidade Federal do Ceará - UFC, Fortaleza, CE, Brazil
IIIDepartment of Clinical Medicine, Universidade Federal do Ceará - UFC, Fortaleza, CE, Brazil
Corresponding author Corresponding author: Romelia Pinheiro Gonçalves Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Ceará - UFC Rua Capitão Francisco Pedro 1210 Rodolfo Teófilo 60430-370 - Fortaleza, CE, Brazil romelia.pinheiro@pq.cnpq.br
ABSTRACT
Visceral leishmaniasis (VL) is a severe systemic infectious disease.(1) It has been recognized as an opportunistic disease in patients infected with human immunodeficiency virus (HIV).(2,3) The analysis of the bone marrow of patients co-infected with VL and HIV showed dysplasia of erythroid, granulocytic and megakaryocytic lineages (Figure 1), besides the presence of plasmacytosis, cytoplasmic bodies, hemophagocytosis, granuloma and intracellular and extracellular leishmania amastigotes (Figure 2). These findings are found in the analysis of bone marrow of patients co-infected with HIV and VL; knowledge of these findings may be useful for the diagnosis and prognosis of patients.
Keywords: HIV infections; Bone marrow examination; Leishmaniasis, visceral; AIDS-related opportunistic infections
Submitted: 10/18/2011
Accepted: 10/21/2011
Conflict-of-interest disclosure: The authors declare no competing financial interest
- 1. Jawhar NM. Visceral Leishmaniasis with an Unusual Presentation in an HIV positive patient. Sultan Qaboos Univ Med J. 2011;11(2):269-72.
- 2. Daher EF, Fonseca PP, Gerhard ES, Leitão TM, Silva Júnior GB. Clinical and epidemiological features of visceral leishmaniasis and HIV co-infection in fifteen patients from Brazil. J Parasitol. 2009;95(3):652-5
- 3. Alexandrino-de-Oliveira P, Santos-Oliveira JR, Dorval ME, Da-Costa FC, Pereira GR, da Cunha RV, et al. HIV/AIDS-associated visceral leishmaniasis in patients from an endemic area in Central-west Brazil. Mem Inst Oswaldo Cruz. 2010;105(5):692-7.
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Publication Dates
-
Publication in this collection
12 Mar 2012 -
Date of issue
Dec 2011
History
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Received
18 Oct 2011 -
Accepted
21 Oct 2011