versión impresa ISSN 1516-8913
Braz. arch. biol. technol. vol.55 no.1 Curitiba enero/feb. 2012
HUMAN AND ANIMAL HEALTH
Nelson de Souza PintoI; Milena de Oliveira Bravo MonteiroII; Dulciane Nunes PaivaIII; Sebastião David Santos-FilhoI,*; Sotiris MisssailidisIV; Diane ThompsonV; Pedro Marín CabezueloV,VII; Mario Bernardo-FilhoI,VIII
IDepartamento de Biofísica e Biometria; Instituto de Biologia Roberto Alcantara Gomes; Universidade do Estado do Rio de Janeiro; Rio de Janeiro - RJ - Brasil
IIClínica de Fisioterapia e Biomedicina; Rio de Janeiro - RJ - Brasil
IIIUniversidade Santa Cruz do Sul; Santa Cruz do Sul -RS - Brasil
IVThe Open University; UK
VThe Queen's Medical Center; Cancer Center Program Medical Director, Women's Health Center; Honolulu - HI - USA
VILaboratory of Physiology; European University Miguel de Cervantes; Valladolid - Spain
VIIResearch Center on Physical Disability, ASPAYM; Castilla y León -Spain
VIIICoordenadoria de Pesquisa, Instituto Nacional do Câncer; Rio de Janeiro - RJ -Brasil
Among nonpharmacological strategy to manage fibromyalgia, exercise (aerobic) has shown efficacy. Whole-body vibration (WBV) exercise has been proposed as a potential clinical intervention. WBV would induce increase in growth hormone (GH). An impairment of the hypothalamic-pituitary-GH-Insulin Growth Factor-1(IGF-1) axis has been implicated in the pathophysiology of fibromyalgia. This article aims to review the studies on exploring the relationship between WBV and fibromyalgia. Literature searches were performed in the PubMed database on 04/03/2010 using terms related to "pain", "whole body vibration" and "fibromyalgia". An important number of publications were identified with the term "pain" and in comparison, only a small number of articles were found related to "fibromyalgia". Three publications found with "whole body vibration" and fibromyalgia were analyzed.There are reports describing increase in serum IGF-1 following exposure to WBV in elderly patients. However, one randomized fibromyalgia trial revealed no changes in serum IGF-1 levels in women undergoing WBV. Due to the paucity of available, effective therapies for fibromyalgia, further studies that explore the relationship between the neuroendocrine system, fibromyalgia and WBV are merited.
Key words: Fibromyalgia; Whole body vibration, PubMed
Fibromyalgia is a clinical condition characterized mainly by the chronic widespread musculoskeletal pain and localized tenderness (Gusi et al. 2010). The multiple symptoms related with this condition include fatigue, anxiety, sleep disturbances, and depressive episodes (Goldenberg et al. 2004; Claw 2009). Common medical disorders associated with fibromyalgia are chronic fatigue syndrome, irritable bowel syndrome, irritable bladder syndrome, or interstitial cystitis, temporomandibular disorder (Claw 2009) and impaired balance (Gusi et al. 2010), as well as obesity (Mengshoel and Haugen 2001) and migraine headaches (Thompson et al 2003). While extremely complex, the pathophysiology of fibromyalgia is thought to be related to disregulation of the hypothalamic-pituitary axis and thus has the potential to affect a myriad of physical and emotional symptoms.
Fibromyalgia patients are prone to the utilization of all types of medical interventions throughout their lifetime. They show more symptoms and comorbid or associated conditions than the patients with other rheumatic conditions. These symptoms are linked to service utilization and, to a lesser extent, functional disability and global disease severity (Wolfe et al. 1997). Thompson et al. (2003) reported that fibromyalgia questionnaires, along with commonalities of age, gender, menopause status, sleep disturbances, and mood symptoms, may aid in the diagnosis. Mengshoel and Haugen (2001) studied the obesity as a possible comorbid factor. Body mass indexes were recorded in 211 women with fibromyalgia in a rheumatology clinic. Results revealed that over 60% of the women were overweight and over half were classified as obese (Mengshoel and Haugen 2001).
Women are more likely than men to have chronic pain due to clinical disorders, but the sex-based difference is much more apparent in clinical settings compared with the population-based samples (Claw 2009; Thompson et al. 2003). The prevalence of fibromyalgia has been considered for many years to be approximately 2 to 3%. Estimation from the United States suggests that fibromyalgia affects about 5% of all women, and it is the third most common rheumatic disorder after low back pain and osteoarthritis (Lawrence et al. 2008; Spaeth 2009).
The management of fibromyalgia is based on a symptomatic treatment involving various professionals and pharmacological and nonpharmacological strategies. Among all the non-pharmacological treatments, aerobic exercises (walking, strengthening and flexibility) have shown the strongest evidence of efficacy (Goldenberg et al. 2004), although several other procedures (cognitive behavioral therapy, patient education, hypnotherapy and balneotherapy) have been used successfully (Claw 2009). In addition, Panton et al. 2009 have reported that, although research on the effects of resistance training in the women with fibromyalgia is limited, some studies have shown improvements in strength, decreases in total myalgic score, and decreases in the impact of fibromyalgia. A problem with the resistance training studies is the poor adherence rates. In consequence, it would be important to develop strategies to keep the fibromyalgia patients in this exercise program. It is suggested that research is needed to find a way to enhance the adherence to this exercises (Panton et al. 2009).
Whole-body vibration is a modality of exercise in an oscillating platform that has been proposed as clinical intervention in the treatment of several disorders, including fibromyalgia. This kind of exercise improves the strength of the muscle (Bosco et al. 1999; Cardinale and Lim 2003; Cochrane and Stannard 2005; Delecluse et al. 2005; deRuite et al. 2003; Torvinen et al. 2002; Roelants et al. 2004; Verschueren et al. 2004), bone density (Verschueren et al. 2004; Iwamoto et al. 2005), cardiovascular parameters (Mester et al. 2006), body balance (Torvinen et al. 2002; Cardinale and Wakeling 2005). Moreover, the health-related quality of life is increased and the fall risk is decreased (Santos-Filho et al. 2010).
In the therapy involving whole body vibration, normally, the subject stands on an oscillating platform that generates sinusoidal vertical vibrations with frequency and amplitude that are selected and controlled by a trained professional. The time of the subject in the platform working, the time of the subject in the platform resting, the number of sets in a session and the number of sessions are determined following the clinical disorder to be treated, as well as the physical conditions of the subject (Cardinale and Wakeling 2005; Santos-Filho et al. 2010). Marin et al. (2009) have studied the neuromuscular activity during whole-body vibration of different amplitudes in relation to footwear. The effects of the whole body vibration are probably related to direct and indirect actions (Santos-Filho et al. 2010). The indirect effects have been hypothesized to be associated with the neuroendocrine system (Prisby et al. 2008). Whole body mechanical vibration on the muscle performance would be due to the activation of a tonic excitatory effect, the tonic vibration reflex (Torniven et al. 2002). Some authors have described that repeated muscle contractions might exert endocrine and/or metabolic effects (Di Loreto et al. 2004).
The therapeutic effect of exercise has been linked to the growth hormone (GH) regulation (Nindl and Pierce 2010). These findings have lead to the exploration of unique exercise therapies for the fibromyalgia patients based on the hypothesis that hormone regulation is a key factor in symptom control (Abeles et al. 2007; Bennett et al. 1997).
For example, impairment in the hypothalamic- pituitary-GH-IGF-1 axis might manifest as a reduction in serum IGF-1 levels (Bennett et al. 1997; Bagge et al. 1998, Leal-Cerro et al. 1999, Paiva et al. 2002) which in turn has been related to sleep disturbances, poor muscle performance, fatigue, and muscle pain. Moreover, fibromyalgia patients that have underwent GH therapy showed improvements in symptoms and daily functioning in women with fibromyalgia (Bennett et al. 1998). However, it is important to consider that the high cost of this therapy prevents a wide use.
Exercises in oscillating platforms would induce increases in growth hormone (GH) (Cardinale et al. 2006; Bosco et al. 2000; Kvorning et al. 2006; Gosselink et al. 2004). The effects on GH have been attributed to a muscle afferent-pituitary axis (Cardinale et al. 2006; Gosselinnk et al. 2004; McCall et al. 2000). GH is synthesized and secreted in a pulsating manner by the anterior pituitary gland. Serum insulin-like growth factor-1 (IGF-1) is secreted by the liver in response to GH release (Florini et al. 1985). Studies vary regarding the effectives of WBV on the serum hormone levels in non-fibromyalgia-patients following whole body vibration (Di Loreto et al. 2004; Cardinale et al. 2006). However, a study by Cardinale et al. (2006) demonstrated a significant increase in serum IGF-1 following a single exposure to whole body vibration in elderly patients. The vibration produced in oscillating platforms is a low cost physiologic strategy (Winchester et al. 2010) that may be beneficial for the management of the symptoms of fibromyalgia.
PubMed is a databank that comprises more than 19 million citations for biomedical articles from MEDLINE and life science journals. These citations may include links to full-text articles from PubMed Central or publisher web sites. Moreover, these citations have been used as tool to obtain various scientific information (Santos-Filho et al. 2008; Santos-Filho et al. 2010; Winchester et al. 2010).
To our knowledge no previous reviews have been published involving whole body vibration and fibromyalgia. The aim of this work was to present a review on the use of the whole body vibration in patients with fibromyalgia.
MATERIALS AND METHODS
The papers were searched in the PubMed (http://www.ncbi.nlm.nih.gov/PubMed/) on April 3rd 2010. The search was performed using the terms (i) pain, (2) "whole body vibration" and pain, (iii) "whole body vibration exercises" and pain, (iv) fibromyalgia, (v) pain and fibromyalgia, (vi) "whole body vibration", (vii) "whole body vibration exercises", (viii) "whole body vibration exercises" and fibromyalgia and (ix) "whole body vibration" and fibromyalgia.
The number of publications (NP) was determined. A percentage between the NP in fibromyalgia and pain was calculated. The NP in fibromyalgia was divided by the NP in pain.
The value was multiplied by 100. The publications involving effects of the whole body vibration in workers were excluded. The selected papers concerning to the use of whole body vibration and fibromyalgia were critically reviewed and were considered to be relevant.
Table 1 lists the number of publications involving pain and fibromyalgia and the whole body vibration. An important number of publications were identified with the term "pain" and, in comparison, only a small number of publications were found with "fibromyalgia". However, 58.48% of the papers about fibromyalgia are found with the association of the terms pain and fibromyalgia.
A limited number of publications was found with the association between fibromyalgia and whole body vibration. Furthermore, one of them involves workers/employees and was not considered in this study.
The three publications found with "whole body vibration" and fibromyalgia were analyzed in Table 2 and 3. The information in Table 2 describes the device of the oscillating platform, the subjects (number, sex and age), the frequency and the amplitude used in the oscillating platforms. Table 2 contains information about the conditions of protocols used in the treated, control groups and the clinical findings.
The American College of Rheumatology, in 1990 defines fibromyalgia as the presence of chronic widespread pain and allodynia (pain responses to normally non-painful stimuli) to pressure in more than 11 of 18 specified sites or tender points (Wolfe et al. 1990). As expected, the association of pain in the patients with fibromyalgia is strong (see Table 1). Although several others symptoms are associated with the fibromyalgia, 58.47% of the total publications in fibromyalgia involve also pain. This showed the interest in these studies and the relevance of the pain and the pain control in the fibromyalgia, as indicated in Table 1.
Although the use of the oscillating platforms is very inexpensive, there are only a limited number of studies involving fibromyalgia and whole body vibration exercises (Table 1). In consequence, high costs should not be a barrier to future studies.
The clinical findings involving whole body vibration exercises in the management of the fibromyalgia (Gusi et al. 2010), or in the understanding of the mechanism involved in this disease can be seen in the Table 2 and Table 3. The studies revealed the findings with the women and they were similar to the well documented gender differences in fibromyalgia patients, and confirmed that women were disproportionately affected (Thompson et al. 2003).
Little has been addressed on the clinical effect of the whole body vibration exercises in the management of women with fibromyalgia (Gusi et al. 2010). Although the devices of the platforms, the frequencies and amplitudes used were different in the studies reported, positive effects of the whole body vibration exercises in the treatment of the symptoms of the fibromyalgia have been reported. The findings described by Gusi et al. (2010) were obtained from a randomized controlled trial and it was observed that the dynamic balance of the women of the group that had received whole body vibration therapy was improved by 36%, as compared to the baseline, whereas that of the control group (not received the whole body vibration therapy) was unchanged. Although the design of the procedures and of the controls, the results of (Gusi et al. 2010) were in agreement. Moreover, they support whole body vibration as a promising therapy for fibromyalgia.
Studies have postulated that an impairment of the hypothalamic-pituitary-GH-IGF-1 axis could be one among the several mechanisms implicated in the pathophysiology of fibromyalgia (Abeles et al. 2007; Bennett et al. 1997) and as a consequence of this impairment, a reduction in serum IGF-1 levels would be observed (Bennett et al. 1997; Bagge et al. 1998, Leal-Cerro et al. 1999; Paiva et al. 2002).
Cardinale et al. (2006) have demonstrated a significant increase in the serum IGF-1 following a single exposure to whole body vibration in elderly patients. However, a randomized trial with the women with fibromyalgia, showed no change in serum IGF-1 levels in these women undergoing whole body vibration exercise in comparison with a control group that had performed the same protocol without vibratory stimulus. Although, the parameters used in both the works were similar, the protocol used as well as the individual characteristics of the patients could be responsible for the different findings concerning the plasma concentration of IGF-1.
In conclusion, there are a limited number of studies on fibromyalgia and whole body vibration. Only one study presented positive finding which was related to a randomized controlled trial involving whole body vibration and fibromyalgia. One another work showed no change in serum IGF-1 levels in the women with fibromyalgia undergoing whole-body vibration exercise, although whole body vibration exercise increased the serum IGF-1 in healthy individuals.
Due to the negative clinical characteristics of the fibromyalgia and the effectiveness of the whole body vibration exercises in the improvement of the musculoskeletal disorders, it is relevant to pursue additional studies in whole body vibration as a therapeutic option for the fibromyalgia patients. Furthermore, further studies are relevant to try to fully understand and characterize the effect of whole body vibration on fibromyalgia and the chemical changes to the body related to these effects.
We are grateful to Mr. Carlos Brown Scavarda (B.A., University of Michigan) for the English language revision. This work was supported by CNPq, FAPERJ, UERJ and INCa.
Abeles AM, Pillinger MH, Solitar BM, Abeles M. Narrative review: The pathophysiology of fibromyalgia. Ann Intern Med. 2007;146:726-34. [ Links ]
Bagge E, Bengtsson BA, Carlsson L, Carlsson J. Low growth hormone secretion in patients with fibromyalgia: A preliminary report on 10 patients and 10 controls. J Rheumatol. 1998;25:145-8. [ Links ]
Bennett RM, Clark SC, Walczyk J. A randomized, doubleblind, placebo-controlled study of growth hormone in the treatment of fibromyalgia. Am J Med. 1998;104:227-31. [ Links ]
Bennett RM, Cook DM, Clark SR. Hypothalamic- pituitary-insulin-like growth factor-1 axis dysfunction in patients with fibromyalgia. J Rheumatol. 1997;24:1384-9. [ Links ]
Bosco C, Colli R, Introini E, Cardinale M, Tsarpela O, Madella A. Adaptive responses of human skeletal muscle to vibration exposure. Clin Physiol. 1999;19:183-7. [ Links ]
Bosco C, Iacovelli M, Tsarpela O. Hormonal responses to whole-body vibration in men. Eur J Appl Physiol. 2000;81:449-54. [ Links ]
Cardinale M, Leiper J, Erskine J. The acute effects of different whole body vibration amplitudes on the endocrine system of young healthy men: A preliminary study. Clin Physiol Funct Imaging. 2006;26:380-4. [ Links ]
Cardinale M, Lim J. Electromyography activity of vastus lateralis muscle during whole-body vibrations of different frequencies. J Strength Cond Res. 2003;17:621-4. [ Links ]
Cardinale M, Wakeling J. Whole body vibration exercises: are vibrations good for you? British J Sports Med. 2005;39:585-9 [ Links ]
Claw DJ. Fibromyalgia: and overview. Am J Med. 2009;122:S3-S13. [ Links ]
Cochrane DJ, Stannard SR. Acute whole body vibrationtraining increases vertical jump and flexibility performance in elite female field hockey players. Br J Sports Med. 2005;39:860-5. [ Links ]
Delecluse C, Roelants M, Diels R, Koninckx E, Verschueren S. Effects of whole body vibration training on muscle strength and sprint performance in sprinttrained athletes. Int J Sports Med. 2005;26:662-8. [ Links ]
deRuiter CJ, vanRaak SM, Schilperoort JV, Hollander AP, deHaa nA. The effects of 11 weeks whole body vibrationtraining on jump height, contractile properties and activation of human knee extensors. Eur J Appl Physiol. 2003;90:595-600. [ Links ]
Di Loreto C, Ranchelli A, Lucidi P. Effects of wholebody vibration exercise on the endocrine system of healthy men. J Endocrinol Invest. 2004;27:323-7. [ Links ]
Florini JR, Prinz PN, Vitiello MV, Hintz RL. Somatomedin-C levels in healthy young and old men: Relationship to peak and 24-hour integrated levels of growth hormone. J Gerontol. 1985; 40:2-7. [ Links ]
Goldenberg DL, Burckhardt CS, Crofford L. Management of fibromyalgia syndrome. JAMA. 2004;292:2388-95. [ Links ]
Gosselink KL, Roy RR, Zhong H. Vibration-induced activation of muscle afferents modulates bioassayable growth hormone release. J Appl Physiol. 2004;96:2097-102. [ Links ]
Gusi N, Parraca JA, Olivares PR, Leal A, Adsuar JC. The vibratory exercises improves the dynamic balance in fibromyalgia: a randomized controlled trial. Arthrits Care Res. 2010, in press [ Links ]
Iwamoto J, Takeda T, Sato Y, Uzawa M. Effect of whole-body vibration exercise on lumbar bone mineral density, bone turnover, and chronic back pain in postmenopausal osteoporotic women treated with alendronate. Aging Clin Exp Res. 2005;17:157-63. [ Links ]
Kvorning T, Bagger M, Caserotti P, Madsen K. Effects of vibration and resistance training on neuromuscular and hormonal measures. Eur J Appl Physiol. 2006;96:615-25. [ Links ]
Lawrence RC, Felson DT, Helmick CG, Arnold LM, Choi H, Deyo RA et al. National Arthritis Work Group: Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum. 2008;58:26-35. [ Links ]
Leal-Cerro A, Povedano J, Astorga R. The growth hormone (GH)-releasing hormone-GH-insulin-like growth factor-1 axis in patients with fibromyalgia syndrome. J Clin Endocrin Metabol. 1999;84:3378-81. [ Links ]
McCall GE, Grindeland RE, Roy RR, Edgerton VR. Muscle afferent activity modulates bioassayable growth hormone in human plasma. J Appl Physiol. 2000;89:1137-41 [ Links ]
Mengshoel AM, Haugen M. Health status in fibromyalgia-a followup study. J Rheumatol. 2001;28:2085-9. [ Links ]
Mester J, Kleinöder H, Yue Z. Vibration training: benefits and risks. J Biomech. 2006;39:1056-65. [ Links ]
Nindl B, Pierce J. Insulin-like growth factor I as a biomarker of health, fitness, and training status. Med Sci Sports Exerc. 2010;42:39-49 [ Links ]
Paiva ES, Deodhar A, Jones KD, Bennett RM. Impaired growth hormone secretion in fibromyalgia patients. Arthritis Rheum. 2002;46:1344-50. [ Links ]
Panton LB, Figueroa A, Kingsley JD, Hornbuckle L, Wilson J, St John N et al. Effects of resistance training and chiropractic treatment in women with fibromyalgia. J Altern Complement Med. 2009; 15:321-8. [ Links ]
Prisby R, Lafage-Proust M, Malaval L, Belli A, Vico L. Effects of whole body vibration on the skeleton and other organ systems in man and animal models: what we know and what we need to know. Ageing Res Rev. 2008;7:319-29. [ Links ]
Roelants M, Delecluse C, Goris M, Verschueren S. Effects of 24 weks of whole body vibrationtraining on body composition and muscle strength in untrained females. Int J Sport Med. 2004;25:1-5 [ Links ]
Santos-Filho SD, Meyer PF, Ronzio OA, Bonelli L, Fonseca AS, Bernardo-Filho M. Whole body vibration exercise: what do you know about the scientific interest? FIEP Bull. 2010;80:875-8 [ Links ]
Santos-Filho SD, Missaidilis S, Fonseca AS, Bernardo-Filho M. Prostate cancer, treatment modalities and complications: an evaluation of the scientific literature. Braz Arch Biol Technol. 2008;51:51-6 [ Links ]
Spaeth M. Epidemiology, costs, and the economic burden of fibromyalgia. Arthritis Res Ther. 2009;11(3):117. [ Links ]
Thompson D, Lettich L, Takeshita J. Fibromyalgia: an overview. Curr Psychiatry Rep. 2003;5:211-7. [ Links ]
Torniven S, Kannus P, Sievanen H. Effect of vibration exposure on muscular performance and body balance. Randomized cross-over study. Clin Physiol Func Imaging. 2002;22:145-52 [ Links ]
Torvinen S, Kannus P, Sievanen H, Jarvinen TA, Pasanen M, Kontulainen S. Effect of four-month vertical whole body vibrationon performance and balance. Med Sci Sports Exerc. 2002;34:1523-8. [ Links ]
Torvinen S, Sievanen H, Jarvinen TA, Pasanen M, Kontulainen S, Kannus P. Effect of 4-min vertical whole body vibration on muscle performance and body balance: a randomized cross-over study. Int J Sports Med. 2002;23:374-9. [ Links ]
Verschueren SM, Roelants M, Delecluse C, Swinnen S, Vanderschueren D, Boonen SJ. Effect of 6-month whole body vibrationtraining on hip density,muscle strength, and postural control in postmenopausal women: a randomized controlled pilot study. Bone Miner Res. 2004;19:352-9. [ Links ]
Winchester D, Wymer D, Shifrin R, Kraft S, Hill J. Responsible use of computed tomography in the evaluation of coronary artery disease and chest pain. Mayo Clin Proc. 2010;85(4):358-64. [ Links ]
Wolfe F, Anderson J, Harkness D, Bennett RM, Caro XJ, Goldenberg DL et al. A prospective, longitudinal, multicenter study of service utilization and costs in fibromyalgia. Arthrits Rheum. 1997;40:1560-70. [ Links ]
Wolfe F, Smythe H, Yunus M, Bennett R, Bonbardier C, Goldenberg D et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia, Arthritis.Rheum. 1990;33:160-72. [ Links ]
Received: December 21, 2010; Revised: January 20, 2011; Accepted: July 22, 2011