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Print version ISSN 1517-8692
On-line version ISSN 1806-9940
Rev Bras Med Esporte vol.10 no.5 Niterói Sept./Oct. 2004
Physical rehabilitation in heart transplantation*
Rehabilitación física en transplante de corazón
Guilherme Veiga Guimarães; Veridiana Moraes d'Avila; Paulo Roberto Chizzola; Fernando Bacal; Noedir Stolf; Edimar Alcides Bocchi
After heart transplantation patients improve their quality of life. However, they frequently have clinical problems in the post operative period, as physical deconditioning, muscular atrophy, weakness and lower maximal aerobic capacity, in part due to the inactivity in the preoperative period and to factors as the difference in donor/receptor body surface, heart denervation, among others. Regular physical activity plays an important role in heart transplanted patients follow-up and should be recommended as soon as possible, may be in predischarge phase, going on after discharge, which could help patients to have a satisfactory life-style, similar to what they had before the disease, returning to active and productive life.
Key words: Heart transplantation. Rehabilitation. Physical activity. Exercise.
Luego de la transplantación cardiaca, los pacientes mejoran su calidad de vida. No obstante, presentan problemas pos-operatorios, como descondicionamiento físico, atrofia y debilidad muscular y menor capacidad aerobia máxima, que derivan parcialmente de la inactividad pre-operatoria y de factores como diferencia de superficie corpórea del donador / receptor, denervación cardiaca, entre otros. La actividad física regular tiene papel importante en la terapéutica de los transplantados, debiendo iniciarse precozmente, si posible aun en la fase hospitalaria, manteniéndose después del alta hospitalaria, para que los pacientes puedan volver a un estilo normal de vida que se acerque al cual tenían antes de la enfermedad, con una convivencia social satisfactoria y una vida activa y productiva.
Palabras-clave: Transplante de corazón. Rehabilitación. Actividad física. Ejercicio.
The heart transplantation is the last therapy for patients with final-stage heart failure, resulting in hemodynamic normalization in rest and during exercise, improving tissue perfusion and the neurohormonal harmful effects that follow heart failure(1).
After heart transplantation, patients present physical exercise intolerance due to disturbance on hemodynamic performance as result of cardiac, neurohormonal, vascular, muscle-skeletal and pulmonary abnormalities. This could be partially explained by the pre-transplant heart failure, the surgical act itself, the in-hospital period, the use of immunosuppressive agents, the number of rejection events and the transplantation time(2,3).
Physical activity has demonstrated to be of great relevance in the post-transplantation rehabilitation, improving the exercise capacity, thus facilitating the return to regular daily activities after long pre- and post-transplantation deconditioning period, also reducing some frequent complications such as: hypertension, obesity, body alteration, libido reduction, osteoporosis, anxiety, depression, euphoria and lower physical capacity(3).
PHYSIOLOGICAL RESPONSE OF THE TRANSPLANTED HEART
Among the surgical techniques for heart transplantation, the most employed are the standard and the bicaval. The standard technique involves the neural cut at the atrioventricular connection level, thus preserving more parasympathetic than sympathetic fibers. The bicaval technique involves the full removal of the cardiac junction, the upper and lower vena cava, resulting in complete heart denervation(4,5).
Thus, the stimulus required for the beginning of the nervous fibers reinnervation process presents higher probability to occur when the neural cut occurs in full. This may explain why the standard surgical technique shows evidences of regeneration only of sympathetic fibers, while the bicaval technique shows reinnervation evidences of both the sympathetic and parasympathetic fibers(5), fact that may have clinical relevance, once the complete reinnervation increases the control of the blood pressure due to the higher reflex in the heart rate change, leading to a better adaptation during physical exercise.
The post-transplantation rest heart rate is high when compared to healthy individuals of same gender and age. However, a progressive delay both to reach maximal heart rate and to its reduction in the recovery period is observed during the exercise. In heart rate variability analysis, where the measurement of the maximal and minimal spectral bands in the variability indicates parasympathetic and sympathetic activation, respectively, a decline on the maximal variability at the exercise initial phase was observed, what probably would be indicating parasympathetic reinnervation in transplanted individuals through the bicaval technique, what was not observed through the standard technique(6).
The peak oxygen intake presents reduced value in transplanted individuals, what may be related to the surgical technique employed, among other factors such as: systolic and diastolic dysfunction, muscular atrophy, metabolic abnormalities as result of the heart failure (that remain after transplant), use of medicine that reduce the exercise capacity and sympathetic stimulation as result of the use of immunosuppressive agents. However, the regular physical activity may improve the oxygen intake(7).
The systemic effects of nitric oxide influence from the denervated sinus node and the modifications of the cardiac wall tension up to the serum catecholamine concentration. In transplanted individuals, the nitric oxide improves the heart rate regulation through the sinus node stimulation, through the reflex response to vasodilatation and through the neuromodulation influences on the autonomic heart control(8,9).
The ciclosporine associated to hypertension may be partly mediated through the sodium retention and the body plasma volume(10). Both are described as stimulators of the atrial natriuretic peptides (ANP) secretion for the protection against the blood pressure elevation. Thus, it has been demonstrated that the ANP is increased after heart transplantation. However, no difference in the ANP level between the bicaval and standard techniques was observed(2).
The type B natriuretic peptide (BNP) also presents elevated plasmatic concentration. It deals about a natural antagonist of the renin-angiotensin-aldosterone system and its secretion is sensible to the plasma volume expansion and to the ventricular wall distension. The findings of higher BNP levels in patients submitted to standard surgical technique if compared to patients submitted to bicaval technique may be a result of the increase on the right ventricle post-load, presenting higher transpulmonary gradient and the incidence of the mitral incompetence, what may contribute to the increase in the pulmonary capillary pressure, without leading to ventricular dysfunction(2).
The reduction in the blood compliance observed in transplanted individuals might be a reflex of the hypertension induced by ciclosporine by means of a decline in the peripheral vasodilatation or alterations in the vascular mechanisms. Furthermore, the higher sympathetic activity in the blood vessels outlet may lead to an increase in the tonus of the arteries smooth musculature with consequent increase in the vessels stiffness.
The cardiac output in rest and in the beginning of the exercise in denervated heart is basically mediated through the increase in the pre-load, in other words, increase in the final diastolic volume and increase in the systolic volume through Frank-Starling mechanism. However, during progressive exercise, the inadequate increase in the heart rate through the release of the surrounding catecholamines leads to the increase in the cardiac output, however, not sufficient for maximal exercise(11,12).
In studies where the standard and bicaval techniques are compared, the cardiac output presented similar values between groups in the first six months and higher after one year with the standard technique. Besides, the standard technique also presented lower values of pulmonary resistance and higher values of right atrium pressure in the same period(4). However, no alterations in the performance between techniques during the exercise were observed.
Studies are controversial with regard to the rest ejection fraction of the left ventricle after heart transplantation when presenting similarity in relation to the reference value. However, there is an agreement that the ejection fraction of the left ventricle increases along the exercise in the same proportion as for a healthy individual(13,14).
PHYSICAL REHABILITATION OF THE TRANSPLANTED HEART
The regular physical activity has played important role in the improvement of quality of life both in healthy individuals and in people suffering from heart disease, either in the primary phase or in the second phase of the heart disease (figure 1).
Post-heart transplantation patients present improvement in the quality of life. However, they frequently present physical deconditioning, muscular atrophy, muscle weakness and lower aerobic capacity as result in part of the pre-surgical inactivity and factors as the difference in the donor/receptor body surface and heart denervation(15). The immunosuppressive therapy that aids receptor to tolerate the donor's heart limits the physical capacity such as the rejection episodes or symptoms that suggested the reduction in the cardiocirculatory performance(16).
Regular physical activity plays important post-transplantation role and should be recommended as soon as possible for the reestablishment of the physical capacity, enabling transplanted individuals to take over their daily and recreative activities(17).
During the in-hospital phase, we initiate the physical conditioning program in the Heart failure and transplantation Unit-InCor-HCFMUSP as soon as the hemodynamic reestablishment and the weaning from post-transplant intravenous drugs occur. The physical rehabilitation program used in this phase is the one proposed by the University of Stanford, which consists of aerobic exercises in cycle-ergometer or walking with progressive increase on duration and intensity with monitoring of the heart rate, blood pressure and subjective fatigue (Borg Scale (figure 2) from slightly tiring and tiring)(18). Besides the proposed program, we also initiate training of articular mobility, flexibility and resistance of the large muscular groups(19). At the discharge phase, we orient patients to walk on the plane level for a period of 40 to 60 minutes in speed of 80 to 100 meters/minute, 4 to 5 times a week in home regimen. Six months after discharge the hemodynamically stable patients perform cardiopulmonary exercise test for cardiopulmonary evaluation, being later allowed to regular physical conditioning programs, with ventilatory thresholds being used for the physical activity prescription.
The physical training adequate intensity for transplanted individuals is not yet well established. However, some methods for the prescription of physical activity have been suggested such as the maximal heart rate percentile, the peak oxygen intake and the ventilatory thresholds(15,16). Regardless the post-transplantation physical activity prescription method, patients have obtained beneficial results (table 1).
Studies have demonstrated that the regular physical activity may revert or diminish the physiological alterations in transplanted patients(15,16). Transplanted individuals submitted to cardiac rehabilitation programs in exercise sessions of four times a week with moderate intensity present improvement in the aerobic capacity between 20 and 50%. The possible mechanisms for this improvement are the increase in the peripheral metabolism, especially through the better oxygen extraction and hemodynamic changes including the increase in the heart rate, the cardiac output(20), the endothelial function(16) and the reduction in the neurohormonal activity(21). Besides, the respiratory efficiency is also improved during exercise(15).
Physical activity with resistance exercises has been used in the post-transplant period to increase muscular mass and bone density(22,23). This activity is particularly important because a loss of free fat and bone mass occurs in this group of patients as result of the heart failure and the use of post-transplant medicine. Thus, it was demonstrated in transplanted patients submitted to resistance-exercise training that the bone density was reestablished at the pre-transplant level while in the control group the bone density decreased in 6%(22).
Home physical training programs with aerobic and resistance exercises have been proposed for transplanted patients(15). However, an increase of 49% of the O2 peak was observed in supervised training against 18% in home exercises as well as a higher exercise tolerance and lower ventilatory response after 6 months of training.
However, the effect of physical activity and post-transplant arteriosclerosis as secondary prevention that theoretically could delay or prevent the coronary arterial disease is not yet elucidated. Just as physical activity and immunologic system in transplanted patients, it is known that in healthy individuals the moderate intensity exercise may increase the resistance to infection by activating the release of immunostimulative factors such as growth hormone, prolactin and cytokines. Paradoxically, the intense exercise may reduce this beneficial effect by elevating immunosuppressive factors such as glucocorticoids and opioids(24).
Thus, the treatment of post-heart transplantation patients must include a physical activity program. Just as the clinical therapeutics deals about maintaining the function of organs, the physical activity further favors physiological adaptations resulting in improvements on quality of life.
POST-HEART TRANSPLANTATION REHABILITATION AND PHYSICAL CONDITIONING HANDBOOK
Class I Conditions in which there are evidences and/or agreement that some procedure is effective or useful:
1) early physical
2) aerobic physical activity;
3) resistance-exercise physical activity;
4) supervised physical activity program;
5) exercise test, preferably cardiopulmonary exercise test.
Class II Condition in which there are conflicting evidences and/or divergence of opinion with regard to the usefulness and effectiveness of some procedure or treatment:
a) Evidence or opinion that favors the utilization of the treatment:
1) non-supervised physical activity program;
2) physical activity in heated swimming pool;
3) recreative activities.
b) Evidence of less established opinion:
1) participation in competitive games without supervision;
2) high-intensity sporadic physical activity.
Class III Condition in which there are evidences and/or agreement that the procedure/treatment is not useful and in some cases, it may even be harmful:
2) light or severe rejection episodes;
3) infection process;
4) clinical, orthopedic or neurological limitation that disables physical activity.
All the authors declared there is not any potential conflict of interests regarding this article.
1. Zoll J, N'Guessan B, Ribera F, Lampert E, Fortin D, Veksler V, et al. Preserved response of mitochondrial function to short-term endurance training in skeletal muscle of heart transplant recipients. J Am Coll Cardiol 2003;42:126-32. [ Links ]
2. El Gamel A, Yonan NA, Keevil B, Warbuton R, Kakadellis J, Woodcock A, et al. Significance of raised natriuretic peptides after bicaval and standard cardiac transplantation. Ann Thorac Surg 1997;63:1095-100. [ Links ]
3. Marconi C, Marzorati M. Exercise after heart transplantation. Eur J Appl Physiol 2003;90:250-9. [ Links ]
4. Grande AM, Rinaldi M, D'Armini AM, Campana C, Traversi E, Pederzolli C, et al. Orthotopic heart transplantation: standard versus bicaval technique. Am J Cardiol 2000;85:1329-33. [ Links ]
5. Bernardi L, Valenti C, Wdowczyck-Szulc J, Frey AW, Rinaldi M, Spadacini G, et al. Influence of type on surgery on the occurrence of parasympathetic reinnervation after cardiac transplantation. Circulation 1998;97:1368-74. [ Links ]
6. Yoshitatsu M, Ohtake S, Sawa Y, Fukushima N, Nishimura M, Sakakida S, et al. Assessment of autonomic reinnervation of cardiac grafts by analysis of heart variability transplantation. Proceedings 2000;32:2383-5. [ Links ]
7. Kavanagh T, Mertens DJ, Shephard RJ, Beyene J, Kennedy J, Campbell R, et al. Long-term cardiorespiratory results of exercise training following cardiac transplantation. Am J Cardiol 2003;91:190-4. [ Links ]
8. Chowdhary S, Harrington D, Bonser RS, Coote JH, Townend JN. Chronotropic effects of nitric oxide in the denervated human heart. J Physiol 2002;541:645-51. [ Links ]
9. Salles AF, Oliveira Fº JA. Adaptações ao exercício pós-transplante cardíaco. Arq Bras Cardiol 2000;75:79-84. [ Links ]
10. Schwietzer GK, Hartmann A, Kober G, Jungmann E, Stratmann D, Kaltenbach M, et al. Chronic angiotensin-converting enzyme inhibition may improve sodium excretion in cardiac transplant hypertension. Transplantation 1995;59:999-1004. [ Links ]
11. Beckers F, Ramaekers D, Van Cleemput J, Droogne W, Vanhaecke J, Van de Werf F, et al. Association between restoration of autonomic modulation in the native sinus node of hemodynamic improvement after cardiac transplantation. Transplantation 2002;73:1614-20. [ Links ]
12. Squires R. Exercise training after cardiac transplantation. Med Sci Sports Exerc 1991; 23:686-94. [ Links ]
13. Uberfuhr P, Frey AW, Fuchs A, Paniara C, Roskamm H, Schwaiger M, et al. Signs of vagal reinnervation 4 years after transplantation in spectra of heart rate variability. Eur J Cardiothorac Surg 1997;12:907-12. [ Links ]
14. Kao AC, Van Trigt P 3rd, Shaeffer-McCall GS, Shaw JP, Kuzil BB, Page RD, et al. Heart failure/cardiac transplantation/artificial heart disease: central transplant and peripheral limitations to upright exercise in untrained cardiac transplant recipients. Circulation 1994;89:2605-15. [ Links ]
15. Kobashigawa JA, Leaf DA, Lee N, Gleeson MP, Liu H, Hamilton MA, et al. A controlled trial of exercise rehabilitation after heart transplantation. N Engl J Med 1999;340:272-7. [ Links ]
16. Schmidt A, Pleiner J, Bayerle-Eder M, Wiesinger GF, Rodler S, Quittan M, et al. Regular physical exercise improves endothelial function in heart transplant recipients. Clin Transplant 2002;16:137-43. [ Links ]
17. Ferraz AS, Arakaki H. Atividade física e qualidade de vida após transplante cardíaco. Rev Soc Cardiol Est São Paulo 1995;4:272-7. [ Links ]
18. Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc 1982;14:377-8. [ Links ]
19. Guimarães GV, Bacal F, Bocchi EA. Reabilitação e condicionamento físico após transplante cardíaco. Rev Bras Med Esporte 1999;5:144-6. [ Links ]
20. Kavanagh T, Yacoub MH, Mertens DJ, Kennedy J, Campbell RB, Sawyer P, et al. Cardiorespiratory responses to exercise training after orthotopic cardiac transplantation. Circulation 1988;77:311-7. [ Links ]
21. Geny B, Richard R, Mettauer B, Lonsdorfer J, Piquard F. Cardiac natriuretic peptides during exercise and training after heart transplantation. Cardiovasc Res 2001;51:521-8. [ Links ]
22. Braith RW, Magyari PM, Fulton MN, Aranda J, Walker T, Hill JA. Resistance exercise training restores bone mineral density in heart transplant recipients. J Am Coll Cardiol 1996;28:1471-7. [ Links ]
23. Oliver D, Pflugfelder PW, McCartney N, McKelvie RS, Suskin N, Kostuk WJ. Acute cardiovascular responses to leg-press resistance exercise in heart transplant recipients. Int J Cardiol 2001;81:61-74. [ Links ]
24. Mackinnon LT. Current challenges and future expectations in exercise immunology: back to the future. Med Sci Sports Exerc 1994;2:191-4. [ Links ]
Guilherme Veiga Guimarães
Rua Dr. Baeta Neves, 98
05444-050 São Paulo, SP
Received in 21/2/04. 2nd version received in 21/5/04. Approved in 4/7/04.
* Heart Institute-HC/FMUSP São Paulo and Sportive Practice Center University of São Paulo.