Renal arteriovenous fistula after renal biopsy: a case report and literature review

Abstract

Acquired renal arteriovenous fistulas (AVF) are rare conditions in which an anomalous connection arises between the arterial and venous systems. Renal AVFs can be classified into three main groups: idiopathic, congenital, and acquired, the last of which are the most common. Incidence has been increasing, due to the growing number of renal biopsies. Although the renal biopsy procedure is relatively safe nowadays, one possible complication is formation of an AVF in the renal vascular territory. Treatment of renal AVF is widely discussed in the literature and a variety of treatment methods can be employed. We report a case of arteriovenous fistula after renal biopsy that was successfully treated with endovascular coil embolization.

Keywords:
arteriovenous fistula; therapeutic embolization; needle biopsy; coil embolization; post-biopsy hematuria; renal Doppler

Resumo

Fístulas arteriovenosas (FAVs) renais adquiridas são raras, correspondendo a uma conexão anômala entre o sistema arterial e o sistema venoso. As FAVs renais se dividem em três grandes grupos: idiopáticas, congênitas e adquiridas, sendo as últimas as mais comuns. Atualmente, têm incidência aumentada em decorrência do crescente número de biópsias renais. Apesar de, atualmente, o procedimento de biópsia renal ser relativamente seguro, ele carrega como complicação a formação de FAV no território vascular renal. O tratamento de FAV renal é amplamente discutido na literatura e diversas modalidades terapêuticas podem ser aplicadas. Apresentamos um caso de FAV pós-biópsia renal que foi submetida a tratamento endovascular com sucesso mediante embolização com molas.

Palavras-chave:
fístula arteriovenosa; embolização terapêutica; biópsia por agulha; embolização com molas; hematúria pós-biópsia; Doppler renal

INTRODUCTION

An arteriovenous fistula (AVF) is an anomalous connection between the arterial and venous systems. ¹ The first report of an intrarenal AVF was published by Varela in 1928. ² The overall prevalence of all types of renal AVF is less than 0.04%, according to estimates by Cho and Stanley. ³

Three types of renal AVF are described: congenital, accounting for 14 to 27% of these abnormalities ⁴ ; idiopathic, accounting for 4.8% ⁵ ; and acquired, accounting for 70 to 80%. ^4-6 Acquired and idiopathic renal AVF typically involve large arteriovenous communications. The lower venous vascular resistance of the communication is responsible for reduced blood flow through the renal parenchyma, with renal ischemia and consequent activation of the renin-angiotensin system, causing hypertension and kidney failure. Additionally, the ‘vascular steal’ phenomenon caused by the AVF increases venous return and predisposes patients to high-output heart failure. ^7-9

The elevated incidence of the acquired form of renal AVF has been attributed to the growing number of renal biopsies. However, the condition can also be caused by trauma, inflammation, surgery, tumors, or atherosclerosis. ^1,7,10-13 In the majority of cases, the patient does not exhibit symptoms, but there may be hematuria and even hemodynamic changes or loss of renal function in more extreme cases. ¹

Generally, AVFs do not require any intervention whatsoever, because spontaneous closure occurs within 3 months of the biopsy in 95.4% of cases. ¹ In cases of major hematuria causing hemodynamic instability, surgical repair is needed. In the past, open surgery was the standard treatment for this condition. However, with the advent of endovascular treatments, high success rates and lower morbidity and mortality can be achieved. Endovascular embolization is now the first line of treatment for AVF cases. Surgery and embolization are successful in 85% of cases. ^14,15

CASE DESCRIPTION

A 28-year-old patient, with no comorbidities, was admitted to hospital with acute renal failure. A hemolytic-uremic syndrome was suspected and a left renal biopsy was performed via a translumbar puncture. After the procedure, the patient exhibited intense hematuria for 48 hours and became hemodynamically instable, with hemoglobin 5.8 g/% (12.6 g/% at admission) and she required blood transfusion.

Ultrasound examination of the abdomen and urinary tract was conducted, revealing a large vesical clot. The patient then underwent renal arteriography, which showed rapid filling of the renal venous system, characteristic of a renal AVF ( Figure 1 ). Coil embolization was performed (three units of 3 × 10 mm, controlled-release, three-dimensional coils: Trufill DCS Orbit Complex) ( Figure 2 ). Control angiography showed that the fistula had closed, with normal pelvic renal contrast behavior, and slow venous flow ( Figure 3 ). The hematuria resolved soon after the procedure, and the patient recovered with no further intercurrent conditions and no additional blood transfusions. She remained in the intensive care unit for observation only and was discharged from the critical care department 24 hours later. Her renal function remained unchanged throughout her hospital stay.

Figure 1
Renal arteriography showing the rapid filling of the renal venous system characteristic of arteriovenous fistulas.

Figure 2
Coil embolization (three units of 3 × 10 mm, three-dimensional, controlled-release coils: Trufill DCS Orbit Complex).

Figure 3
Control angiography showing treatment of the arteriovenous fistula.

DISCUSSION

Renal biopsy is a very useful tool for diagnosis, to determine prognosis, and to guide treatment. Although it is considered safe, since it is an invasive procedure, it is not free from complications, one of which is AVF. These are rare, with incidence rates of 3 to 5% in native kidneys and 10 to 16% in transplanted kidneys, but AVFs can be avoided or their incidence reduced to less than 0.1% if biopsy is conducted with real-time ultrasound guidance and automatic needles. ^1,16,17 The procedure is considered a success if, in addition to acquiring sufficient material for diagnostic biopsy, it causes less adverse outcomes for the patient. ¹⁸

An arteriovenous fistula is an anomalous communications between the arterial and venous systems. There are three types of renal AVF: congenital, idiopathic, and acquired. Acquired AVFs are caused by trauma, inflammation, surgery, tumors, atherosclerosis, or percutaneous biopsy and account for 70 to 80% of arteriovenous abnormalities. ^1,12,17 Of these, the most common are AVFs associated with percutaneous renal biopsy, those caused by traumas, and those secondary to percutaneous renal surgery. ¹³ An idiopathic AVF is one that is acquired at some point during life, but has no definite etiologic factor. ⁴

Clinical diagnosis of an AVF can be difficult. Signs and symptoms include microscopic and macroscopic hematuria, arterial hypertension refractory to medical treatment, flank pain, and audible sounds in the renal arteries caused by turbulent blood flow. ^19,20 The objective of treatment of fistulae and renal arteriovenous malformations is to eradicate the symptoms and hemodynamic effects (arterial hypertension and heart failure), with maximum preservation of functioning renal parenchyma. ^12,17,21

Less aggressive treatment options include blood transfusions. Invasive options that may be necessary in refractory cases and those with major hematuria or hemodynamic instability ⁶ include cystoscopy, angiography with subsequent embolization with gel-foam or coils (with a success rate of around 85% in patients with acquired fistulae), and surgical nephrectomy. ¹⁴

Described initially in 1973, to deal with AVF associated with biopsy, ²² treatment with percutaneous angiography and embolization is the most effective method and is considered the first-line treatment for these fistulas, achieving success in 70 to 100% of cases. ^15,19,23 It is a widely adopted treatment option that can be used as definitive treatment or in an attempt to reduce fistula throughput, and is a less invasive surgical procedure. ^12,17,21 The many different embolization agents employed include steel coils, as used in the case described here, balloons, autologous blood clots, absorbable gelatin foam, cyanoacrylate, plastic polymers, and absolute alcohol. ²⁴

Controlled-release coils offer certain advantages in relation to other methods. Embolization only takes place in the target vessel and, because they offer controlled release, they can be placed exactly where intended. Once they are correctly positioned, they are released. They are also associated with minimal renal ischemia, since they do not close the distal microcirculation and it is possible to precisely occlude only the point at which the artery communicates with the vein. Therefore, this type of material was used in the procedure described here because it offers controlled release without distal occlusion of the vessel, which avoids provoking renal ischemia, occluding the fistula with greater precision.

Embolization can be performed via an intra-arterial access or using a combined approach via arterial and venous routes simultaneously. ²³ Although small, there is a risk of complications, such as closure of nearby vessels or intact proximal vessels, resulting in notable loss of renal parenchyma, pulmonary embolism, and others. ^15,25

It can therefore be concluded that endovascular intervention for coil embolization is indicated for treatment of the majority of renal AVFs because it is a less invasive method that achieves a high rate of success.

• How to cite: Belczak SQ, Pedroso GD, Atihe LF, et al. Renal arteriovenous fistula after renal biopsy: a case report and literature review‏. J Vasc Bras. 2019;18:e20180112. https://doi.org/10.1590/1677-5449.011218
• Financial support: None.
• The study was carried out at Instituto de Aprimoramento e Pesquisa em Angiorradiologia e Cirurgia Endovascular (IAPACE), São Paulo, SP, Brazil.

REFERÊNCIAS

• ¹
  Sosa-Barrios RH, Burguera V, Rodriguez-Mendiola N, et al. Arteriovenous fistulae after renal biopsy: diagnosis and outcomes using Doppler ultrasound assessment. BMC Nephrol. 2017;18(1):365. http://dx.doi.org/10.1186/s12882-017-0786-0. PMid:29262805.
  » http://dx.doi.org/10.1186/s12882-017-0786-0
• ²
  Rezende LS, Ortiz MR, de Paula SC, Gemelli JJ, Linhares A, Carvalho JGR. Relato de caso: fístula arteriovenosa renal idiopática como causa de hipertensão renovascular e insuficiência cardíaca. J Bras Nefrol. 2002;24(2):110-4.
• ³
  Cho KJ, Stanley JC. Non-neoplastic congenital and acquired renal arteriovenous malformations and fistulas. Radiology. 1978;129(2):333-43. http://dx.doi.org/10.1148/129.2.333. PMid:704845.
  » http://dx.doi.org/10.1148/129.2.333
• ⁴
  Maldonado JE, Sheps SG, Bernatz PE, Deweerd JH, Harrison EG Jr. Renal arteriovenous fistula: a reversible cause of hypertension and heart failure. Am J Med. 1964;37(4):499-513. http://dx.doi.org/10.1016/0002-9343(64)90064-6. PMid:14215839.
  » http://dx.doi.org/10.1016/0002-9343(64)90064-6
• ⁵
  Imray TJ, Cohen AJ, Hahn L. Renal arteriovenous fistula associated with fibromuscular dysplasia. Urology. 1984;23(4):378-80. http://dx.doi.org/10.1016/0090-4295(84)90146-8. PMid:6710713.
  » http://dx.doi.org/10.1016/0090-4295(84)90146-8
• ⁶
  Crotty KL, Orihuela E, Warren MM. Recent advances in the diagnosis and treatment of renal arteriovenous malformations and fistulas. J Urol. 1993;150(5 Pt 1):1355-9. http://dx.doi.org/10.1016/S0022-5347(17)35778-6. PMid:8411399.
  » http://dx.doi.org/10.1016/S0022-5347(17)35778-6
• ⁷
  Rezende LS, Ortiz MR, Paula SC, Gemelli JJ, Linhares A, de Carvalho JG. Idiopathic renal arteriovenous fistula causing renovascular hypertension and cardiac failure. Braz J Nephrol. 2002;24(2):110-4.
• ⁸
  Bates MC, Almehmi A. High-output congestive heart failure successfully treated with transcatheter coil embolization of a large renal arteriovenous fistula. Catheter Cardiovasc Interv. 2004;63(3):373-6. http://dx.doi.org/10.1002/ccd.20181. PMid:15505842.
  » http://dx.doi.org/10.1002/ccd.20181
• ⁹
  Abassi ZA, Winaver J, Hoffman A. Large A-V fistula: pathophysiological consequences and therapeutic perspectives. Curr Vasc Pharmacol. 2003;1(3):347-54. http://dx.doi.org/10.2174/1570161033476619. PMid:15320481.
  » http://dx.doi.org/10.2174/1570161033476619
• ¹⁰
  Fogazzi GB, Moriggi M, Fontanella U. Spontaneous renal arteriovenous fistula as a cause of haematuria. Nephrol Dial Transplant. 1997;12(2):350-6. http://dx.doi.org/10.1093/ndt/12.2.350. PMid:9132662.
  » http://dx.doi.org/10.1093/ndt/12.2.350
• ¹¹
  Osawa T, Watarai Y, Morita K, Kakizaki H, Nonomura K. Surgery for giant high-flow renal arteriovenous fistula: experience in one institution. BJU Int. 2006;97(4):794-8. http://dx.doi.org/10.1111/j.1464-410X.2006.06108.x. PMid:16536776.
  » http://dx.doi.org/10.1111/j.1464-410X.2006.06108.x
• ¹²
  Gopi P, Vasudevan S, Kumar A, et al. Secondary hematuria from traumatic renal artery pseudo aneurysm with arteriovenous fistula treated by successful stenting. Kerala Med J. 2017;10(1):44-8.
• ¹³
  Sezer R, Uslu N, Akdur A, Haberal M. Biopsy-related renal allograft arteriovenous fistulas: a series of 5 cases. Transplant. 2018;102:S522. http://dx.doi.org/10.1097/01.tp.0000543359.62730.30.
  » http://dx.doi.org/10.1097/01.tp.0000543359.62730.30
• ¹⁴
  McAlhany JC Jr, Black HC Jr, Hanback LD Jr, Yarbrough DR 3rd. Renal arteriovenous fistula as a cause of hypertension. Am J Surg. 1971;122(1):117-20. http://dx.doi.org/10.1016/0002-9610(71)90363-1. PMid:5091842.
  » http://dx.doi.org/10.1016/0002-9610(71)90363-1
• ¹⁵
  Zhang Z, Yang M, Song L, Tong X, Zou Y. Endovascular treatment of renal artery aneurysms and renal arteriovenous fistulas. J Vasc Surg. 2013;57(3):765-70. http://dx.doi.org/10.1016/j.jvs.2012.09.042. PMid:23312837.
  » http://dx.doi.org/10.1016/j.jvs.2012.09.042
• ¹⁶
  Merkus JW, Zeebregts CJ, Hoitsma AJ, van Asten WN, Koene RA, Skotnicki SH. High incidence of arteriovenous fistula after biopsy of kidney allografts. Br J Surg. 1993;80(3):310-2. http://dx.doi.org/10.1002/bjs.1800800313. PMid:8472136.
  » http://dx.doi.org/10.1002/bjs.1800800313
• ¹⁷
  Kuklik E, Sojka M, Karska K, Szajner M. Endovascular treatment of renal arteriovenous fistula with N-Butyl Cyanoacrylate (NBCA). Pol J Radiol. 2017;82:304-6. http://dx.doi.org/10.12659/PJR.900106. PMid:28656066.
  » http://dx.doi.org/10.12659/PJR.900106
• ¹⁸
  Whittier WL, Korbet SM. Timing of complications in percutaneous renal biopsy. J Am Soc Nephrol. 2004;15(1):142-7. http://dx.doi.org/10.1097/01.ASN.0000102472.37947.14. PMid:14694166.
  » http://dx.doi.org/10.1097/01.ASN.0000102472.37947.14
• ¹⁹
  Saliou C, Raynaud A, Blanc F, Azencot M, Fabiani JN. Idiopathic renal arteriovenous fistula: treatment with embolization. Ann Vasc Surg. 1998;12(1):75-7. http://dx.doi.org/10.1007/s100169900119. PMid:9452001.
  » http://dx.doi.org/10.1007/s100169900119
• ²⁰
  Grocela JA, Dretler SP. Intracorporeal lithotripsy. Instrumentation and development. Urol Clin North Am. 1997;24(1):13-23. http://dx.doi.org/10.1016/S0094-0143(05)70351-7. PMid:9048849.
  » http://dx.doi.org/10.1016/S0094-0143(05)70351-7
• ²¹
  Ozyer U, Harman A, Soy EHA, Aytekin C, Boyvat F, Haberal M. Endovascular management of arterial complications following renal transplant biopsy. Transplant. 2018;102:S632. http://dx.doi.org/10.1097/01.tp.0000543542.40272.a5.
  » http://dx.doi.org/10.1097/01.tp.0000543542.40272.a5
• ²²
  Benson DA, Stockinger ZT, McSwain NE Jr. Embolization of an acute renal arteriovenous fistula following a stab wound: case report and review of the literature. Am Surg. 2005;71(1):62-5. PMid:15757060.
• ²³
  Aston W, Whiting R, Bultitude M, Challacombe B, Glass J, Dasgupta P. Pseudoaneurysm formation after flexible ureterorenoscopy and electrohydraulic lithotripsy. Int J Clin Pract. 2004;58(3):310-1. http://dx.doi.org/10.1111/j.1368-5031.2004.00046.x. PMid:15117102.
  » http://dx.doi.org/10.1111/j.1368-5031.2004.00046.x
• ²⁴
  Schwartz MJ, Smith EB, Trost DW, Vaughan ED Jr. Renal artery embolization: clinical indications and experience from over 100 cases. BJU Int. 2007;99(4):881-6. http://dx.doi.org/10.1111/j.1464-410X.2006.06653.x. PMid:17166242.
  » http://dx.doi.org/10.1111/j.1464-410X.2006.06653.x
• ²⁵
  Güneyli S, Gök M, Bozkaya H, et al. Endovascular management of iatrogenic renal arterial lesions and clinical outcomes. Diagn Interv Radiol. 2015;21(3):229-34. http://dx.doi.org/10.5152/dir.2014.14286. PMid:25835080.
  » http://dx.doi.org/10.5152/dir.2014.14286

Publication Dates

• Publication in this collection
  04 Apr 2019
• Date of issue
  2019

History

• Received
  10 Oct 2018
• Accepted
  01 Feb 2019