Left ventricular noncompaction highlighted by three-dimensional and speckle tracking echocardiography

Left ventricular noncompaction (LVNC) is a relatively new and heterogeneous cardiomyopathy, first reported by Chin et al. in 1990.(¹) It is characterized by prominent ventricular trabeculations, intratrabecular recesses and a bi-layered myocardium, composed of compacted and noncompacted layers.(¹,²) Left ventricular noncompaction may be an isolated finding or associated to other cardiomyopathies, metabolic disorders and congenital heart diseases.(²) It is believed to result from failure of ventricular compaction in the embryogenic phase, with increasing evidence of a genetic component.(²)

Since its first description, much has been learned about this disease, but there are some limitations for its diagnosis. Cardiac magnetic resonance imaging is considered the gold standard for diagnosis of LVNC, but echocardiography remains the first line imaging modality due to its availability and cost-effectiveness.

We report a case of an asymptomatic 21-year-old male, with no personal or family history of cardiomyopathy. Two-dimensional echocardiography (2D echo) showed increased left ventricular trabeculation in the apical segments of lateral and anterior walls, and a noncompacted myocardium/compacted + noncompacted myocardium ratio of 0.33, compatible with LVNC, according to Chin´s criteria.(¹) 3D echo provided more detailed left ventricle morphology analysis and 3D echo color Doppler demonstrated ventricular flow within the intraventricular recesses. Strain analysis by speckle tracking echocardiography (STE) evidenced global longitudinal strain = -17% (normal values <-18%), probably related to an incipient systolic dysfunction not shown by evaluation of left ventricular ejection fraction in 2D echo (Figure 1).

Figure 1
Images from conventional, three-dimensional and speckle tracking echocardiography. 2D echo and 3D echo, respectively, on apical 4-chamber view (A, B and C) and transversal view (D, E and F) depicting left ventricular noncompaction (red arrows). 3D echo on apical 4-chamber and transversal view of the same patient (C and F). 3D and triplanar views of the left ventricle (G, H and I). 2D (J) and 3D color Doppler (K to O) showing blood flow within the left ventricle recesses. Strain analysis with global longitudinal strain slightly decreased = -17% (P and Q)

This case illustrates echocardiographic modalities for LVNC diagnosis. 3D echo and STE are technologies that may play an incremental role in evaluation of LVNC but need further investigation and validation.(³)

REFERENCES

• ¹
  Chin TK, Perloff JK, Williams RG, Jue K, Mohrmann R. Isolated noncompaction of left ventricular myocardium. A study of eight cases. Circulation. 1990;82(2):507-13.
• ²
  Mavrogeni SI, Markousis-Mavrogenis G, Vartela V, Manolopoulou D, Abate E et al. The pivotal role of cardiovascular imaging in the identification and risk stratification of non-compaction cardiomyopathy patients. Heart Fail Rev. 2020;25(6):1007-15. Review.
• ³
  Hotta VT, Martinelli LM, Fernandes F, Moises VA, Vieira ML, Mady C. P697 left ventricular non compaction highlighted by three-dimensional and speckle tracking echocardiography [Poster Session i394]. Eur Heart J Cardiovasc Imaging. 2020;21(Supp 1):jez319.371.

Publication Dates

• Publication in this collection
  15 Aug 2022
• Date of issue
  2022

History

• Received
  17 June 2021
• Accepted
  6 Jan 2022