Investigation of Fracture in an Interface Crack Between Bone Cement and Stainless Steel

Abstract

Interface strength is considered as one of the most influential factors in the long-term durability of the replaced joint in cemented total hip replacement. Several researchers have suggested that the damage initiation in a replaced joint is a mechanical phenomenon primarily taking place in the vicinity of cement-prosthesis interface. In this study, the fracture behavior of a crack at the interface of cement-prosthesis was investigated both experimentally and theoretically under static loading conditions. The finite element method, and then the maximum tangential stress (MTS) and the generalized MTS (GMTS) criteria were used for theoretical study of interface fracture. Some experiments were also carried out to investigate the effect of cement mixing methods (hand mixing and vacuum mixing) on crack growth pattern. The results showed that the vacuum-mixed cement led to self-similar crack growth along the cement-prosthesis interface, while the crack kinked into the cement in the samples prepared by hand-mixed cement. Then some experiments were performed to verify the theoretical results obtained for mixed mode fracture angles in the samples prepared by hand-mixed cement. The sandwich Brazilian disk model was used in both finite element and experimental approaches to simulate the cement-prosthesis interface. The experimental results were found to be in good agreement with those predicted by the GMTS criterion.

Keywords:
Fracture mechanics; finite element stress analysis; mechanical properties of adhesives; bone cement

1 INTRODUCTION

In the early 1960s, Sir John Charnley introduced a new method, using acrylic bone cement (PolyMethylMethAcrylate, PMMA), to fill the space between the prosthetic stem and bone, which has been a brilliant practice for hip joint replacement (Ohashi, 2000). In a replaced joint, multiple biological and mechanical factors may cause the joint damage, while the preliminary defects after surgery are suggested to be mainly mechanical (Tong et al., 2007). Researchers have considered different mechanical factors that might directly influence the prosthesis failure initiation including the cement strength (Knets et al., 2007), the strength of bone-cement interface (Mann et al., 2001), the strength of cement-prosthesis interface (Ohashi, 2000), the thickness of cement mantle (Wang and Agrawal, 2000), the elastic modulus incompatibility at the cement interface and the cement porosity (Dunne and Orr, 2001). There are some evidence indicating the separation of prosthesis from cement in samples used for more than four years, even when the bone-cement interface survives (Ohashi, 2000). These factors demonstrate the significance of investigating the cement-prosthesis connection. In this study, the sandwich Brazilian disk model shown in Figure 1 has been used to analyze the cement-prosthesis separation process. The Brazilian disk sample is a widely used model providing the loading mode conditions from mode I to mode II as a function of loading angle φ. The sandwich Brazilian disk sample can be employed to reflect the loading nature at the cement-prosthesis interface due to the fact that the prosthesis, in a general case, is subjected to a combination of compression and shear, which the Brazilian disk is capable of creating (Tong et al., 2007; Yuuki et al., 1994).

Figure 1:
Geometry and loading conditions of a sandwich Brazilian disk.

As shown in Figure 1, in the present study the prosthesis and the bone cement are indicated by material numbers 1 and 2 respectively and a central crack of length 2a is embedded in the interface between the two materials. By this configuration, under the compression load P, various combinations of mode I and mode II can be provided in different loading angles φ by rotating the disk. Finite element analysis was conducted to compute the stress intensity factors and the T-stress. Porosity, leading to accelerated micro-crack formations, weakens the bone cement. Therefore, the mixing method for raw materials can play a key role in the bone cement quality. The effects of hand-mixing and vacuum-mixing of bone cement on the bond strength of cement-prosthesis connection was also investigated experimentally. Subsequently, to verify the fracture angles predicted from finite element analysis, a number of experiments were carried out for loading angles φ ranging from 7.5° to 60°.

2 STRESS FIELD NEART THE CRACK TIP AT THE INTERFACE OF TWO MATERIALS

Figure 2 shows a crack of length 2a in the interface of two materials with the elastic constants E ₁, υ ₁ for the material 1 and E ₂, υ ₂ for the material 2. (x, y) and (r, θ) are the Cartesian and polar coordinate systems, respectively.

Figure 2:
The area nearby the interface of two materials.

The elastic stresses for material 1 have been given in (Ravichandran and Ramesh, 2005) in terms of stress intensity factors K _I and K _II. If the first non-singular term of stress, often called the T-Stress, is also taken into account, the elastic stresses can be written in the polar coordinates as:

The bi-material constant ∈ in these equations can be expressed in terms of the elastic constants of materials 1 and 2 as (Ravichandran and Ramesh, 2005):

where μ ₁ and μ ₂ are shear moduli and k is expressed as:

While equations (1-3) present the stress field for material 1, similar equations can be obtained for material 2 by converting e ^-∈π to e ^+∈π and e ^+∈π to e ^-∈π. Moreover, the T-stress in material 2 can be found by replacing D ₁ by D ₂ as followed:

If the crack parameters K_I, K_II and T-stress are determined, the stress field in the vicinity of crack tip can be identified.

3 FINITE ELEMENT ANALYSIS

In this study, the finite element approach was employed to obtain the elastic stresses for a crack embedded between two dissimilar materials in a sandwich Brazilian disk and then, to calculate the stress intensity factors and the T-stress. Isoparametric 8-node plane strain elements were used for finite element simulation (see Figure 3).

Figure 3:
The mesh pattern for the simulated sandwich Brazilian disk.

Figure 4 illustrates the dimensions of sandwich Brazilian disk used for finite element modeling and also later for the experiments. The material properties considered for the bone cement and the stainless steel are given in Table 1. Figure 4also shows the loading and boundary conditions of the disk specimen. Finite element modeling was performed for different loading angles of φ = 7.5º, 15º, 20º, 30º, 40º, 50º, and 60º.

Figure 4:
Dimensions of the sandwich Brazilian disk specimen.

Table 1:
The elastic constants of bone cement and stainless steel.

Materials	E(GPa)	ν
Stainless Steel (316L)	193	0.3
Bonte Cement (CEMEX RX)	2.4	0.3

After obtaining the near-crack tip stresses from the finite element analysis a numerical technique called the Finite Element Over-Deterministic Method (FEODM) were employed to calculate SIFs and the T-stress (Ayatollahi and Nejati, 2011). This method is based on the exploiting a large number of data to find a small number of unknowns. Accordingly, applying the stress equations (1-3) to numerous numbers of nodes in the vicinity of the crack tip, the three unknowns K_I, K_II and T are obtained by solving a system of linear equations. More details about FEODM can be found in (Ayatollahi and Nejati, 2011).

The stress intensity factors K_I, K_II and the T-stress calculated for the interface crack were then normalized according to Equation (7):

where P, R, B, and T ^* are the applied load, the disk radius, the disk thickness, the normalized SIFs, and the normalized T-stress, respectively. Table 2shows the numerical values of , and T ^* for different loading angles φ. It should be noted that finite element analyses were performed only for loading angles for which the value of K_I is positive i.e. there is crack opening. It was found that for loading angles equal and larger than 60^o the mode I stress intensity factor is negative, thus the results presented in Table 2 are only confined to loading angles less than 60^o.

Table 2:
Finite element results for

4 FRACTURE ANALYSIS

Having calculated the stress intensity factors and the T-stress and their corresponding normalized values, the angle of fracture initiation in bone cement can be estimated by applying appropriate criteria. In this section, two fracture criteria are employed for estimating the angle of fracture initiation in the sandwich Brazilian disk specimen for different loading angles φ.

As shown in Figure 5, an interface crack may extend according to different possible paths under combined mode I/II loading (Chandra Kishen and Darunkumar Singh, 2001):

1. a. Crack may grow along the interface (case A).

2. b. Crack may branch off into each of the two materials (cases B and C).

3. c. Crack may both grow along the interface and branch off to each of the two materials, simultaneously (cases D and E).

Figure 5:
The possible cases of crack extension for an interface crack under mixed mode loading.

According to (Chandra Kishen and Darunkumar Singh, 2001), a crack often branches off into a material outside the interface, if the interface connection is strong enough and the crack plane is exposed to shear stresses as well.

Maximum tangential stress (MTS) (Erdogan and Sih, 1963) and generalized maximum tangential stress (GMTS) (Smith et al., 2001) criteria have been developed in order to investigate brittle fracture in linear elastic materials under combined tensile and shear loading. According to these criteria, the crack will grow through a direction in which the tangential stress reaches its maximum. In the MTS criterion, only the singular term of stress (i.e. the term corresponding to K_I and KII) is considered. While in GMTS, in addition to K_I and K_II , the non-singular term T is taken into account in the equation of tangential stress in the vicinity of the crack tip. To calculate the fracture angle, SIFs and T-stress should be substituted into equation (2) and then, equation (8) should be solved to find the angle of maximum tangential stress.

It is assumed that the strength of the cement-prosthesis joint is high enough such that the crack kinks out of the interface within the weaker material (i.e. the bone cement) according to case C in Figure 5. This is in agreement with the experimental observations, as described later. Therefore, the angle of maximum tangential stress around the crack tip was extracted just within the bone cement. Table 3 shows the fracture initiation angles calculated according to the MTS and GMTS criteria, i.e. θ_MTS and θ_MTS .

Table 3:
Fracture initiation angles predicted using the MTS and GMTS criteria.

Loading angle (deg)	θMTS (deg)	θGMTS (deg)
7.5	36.41	58.92
15	43.82	62.93
20	47.91	65.22
30	54.89	70.38
40	60.60	75.54
50	65.21	80.69

One should note that for an interface crack, the values of T-stress above and below the interface are not the same (Jian-Jun and Yi-Heng, 2000). Consequently, the normalized T-stresses presented in Table 2 are related to the bone cement material in the sandwich Brazilian disk specimen.

Table 3 reveals that the fracture angles obtained from the MTS criterion is significantly different from those calculated from the GMTS criterion. This finding highlights the important role of T-stress in the fracture behavior of stainless steel-bone cement interface cracks. In the following, the credibility of the theoretical results will be investigated via experimental studies.

5 EXPERIMENTS

A number of experiments were conducted to verify the results obtained for the fracture angles using the MTS and GMTS criteria. The experiments were performed on the sandwich Brazilian disk. In the first stage, some experiments were carried out to study the influence of cement mixing method upon the test results. Cement vacuum mixing is utilized as a widely acceptable technique to make the cement homogenous, to decrease porosity, and to increase the cement strength. This method can improve the cement properties by extracting the MMA vapor resulting from polymerization in PMMA combination step, evacuating the cement from air and averting bubble formation inside the sample. However, the effect of vacuum mixing on the adhesion between the bone cement and the prosthesis is not clear. When two materials are brought in contact, the proper adhesion between them is very important and it is necessary to use appropriate ways to attain the highest bond strength. Therefore, the quality of the interface is significantly influenced by the properties of the adhesive and the substrate (Baldan, 2012). As a result, the fracture tests were first performed on the sandwich Brazilian disk specimens, its adhesive prepared by several mixing methods in order to find the suitable option for the subsequent experiments. The most appropriate method to mix the cement regarding the strength investigation at the cement-prosthesis interface is the one which provides a complete connection between the cement and the prosthesis so that the crack, under loading, kinks and enters the cement. Consequently, such a connection endures a higher fracture load.

5.1 Materials and sample preparation

Bone cement was purchased from Cemex RX Company (Tecres, Verona, Italy). To mix bone cement, three different methods including hand mixing, vacuum after hand mixing (using vacuum chamber) and simultaneous vacuum and mixing (or vacuum mixing) were utilized. More details on these mixing methods are given below.

5.1.1 Hand Mixing (HM)

After blending with the corresponding monomer (according to the instruction), the bone cement was mixed in a container with the frequency of 1 Hz for one minute and then, through a syringe was injected into the space between the two half-disks held inside a fixture.

5.1.2 Vacuum after Hand Mixing (VAHM)

In this method, a vacuum chamber with the pressure of 140 Mbar was employed (Dunne and Orr, 2001). First, the cement powder and the liquid component were mixed by hand in a container. Then, the mixture was exposed to the vacuum conditions for about 10 seconds and finally was injected in the space described earlier. However the mixture cannot be kept inside the vacuum chamber for a longer time otherwise it hardens and its viscosity increases. One should note that, in this method, it is not possible to decrease the amount of vapors resulting from the polymerization procedure at the early moments since the mixture is mixed outside the vacuum machine.

5.1.3 Vacuum Mixing (VM)

Vacuum mixing was carried out by employing a mixing machine manufactured for this purpose. Having investigated the commercial VM machines, a similar one with less capacity was made by glass (see Figure 6). The sample in this method was prepared according to the instructions given for commercial VM machines such that the cement powder and the liquid component were blended in 0.7bar vacuum for 15 seconds. Then, after mixing for 30 seconds, the mixture was left at the same situation for 15 seconds (Mau et al., 2004).

Figure 6:
The utilized vacuum mixing machine.

After preparation, the bone cement was injected through a syringe into the space between the two metal half-disks.

The half-disks were produced from stainless steel (316L) and the necessary surface preparation was performed on the straight edge of each half-disk. The preparation procedure consists of these steps: the half-disk edges were first degreased with soap and hot water, and then were polished by using a 120 grit emery paper, and the surfaces were finally degreased again with acetone. The crack was created by sticking a 50 µm thick (Tong et al., 2007and Yuuki et al., 1994) and 5 mm wide scotch tape to the center of one of the half-disks. In this way, an artificial separation between bone cement and one of the metallic half-disks was created in order to play the role of a crack.

5.2 Experiment procedure

Twenty four hours after connecting the two half-disks, the sandwich samples were subjected to compression by a universal machine with a loading rate of 1mm/min as depicted in Figure 4. To assess the impact of production method upon the crack growth pattern, the samples prepared by different methods of cement mixing were initially tested at the arbitrary loading angle of 20°. According to the finite element results, the values of and are almost equal for this loading angle and neither of the loading modes is dominant. The experiments, for this loading angle, were repeated for at least 5 samples.

5.3 Experimental results

It was observed that for almost all samples prepared by the hand-mixed cement, the crack kinked from its left side tip and entered the cement. Accordingly in this case, the fracture angle is measurable. In contrast, for vacuum mixed cements the crack in all samples grew at the interface of cement and prosthesis, indicating the poor connection at the interface. The fracture loads obtained for the samples prepared by the two vacuum mixing methods can be compared with those of the samples prepared by hand mixing. Further details will be presented in the following section.

5.3.1 Fracture load analysis

The experimental results showed that for all samples prepared by vacuum mixing method, fracture occurred at the cement-prosthesis interface and the crack did not kink into the cement. Figure 7 displays a fractured sample prepared by vacuum-mixed cement and also the crack growth at the interface.

Figure 7:
The crack extension at the interface of cement and disk.

Regardless of the path along which the crack grows, one can obtain an estimation of the sample strength in each case by comparing the fracture load for different mixing methods. Figure 8 shows the fracture loads obtained for the samples containing the cements prepared by hand and vacuum mixing methods. The average fracture loads have also been given in Table 4. It is seen that the fracture load in samples prepared by vacuum-mixed cement is notably lower load than that of the samples prepared by hand-mixed cement. Therefore, the bond strength of the prosthesis and cement connection prepared by hand mixing is higher than that prepared by vacuum mixing. Meanwhile, within the vacuum mixed cements, the bond strength in the VAHM method is higher than in the VM method. One can suggest that although in the VM method, the cement strength itself is very good, its bonding method to the stainless steel prosthesis should be improved in order to achieve the bond strength desired for clinical applications.

Figure 8:
The fracture load variation for the samples prepared by hand mixing (HM), vacuum after hand mixing (VAHM) and vacuum mixing (VM) at the loading angle of 20°.

Table 4:
Average fracture loads obtained for samples prepared by different cement mixing methods.

Mixing method	Average fracture load (N)
HM	5384.95
VAHM	4245.28
VM	2851.23

5.3.2 Fracture angle analysis

The experimental results obtained for different methods of cement mixing at the sample loading angle of 20° recommend the use of hand-mixed cements due to its better bond strength with the prosthesis. Hence, additional experiments were conducted at loading angles of 7.5°, 15°, 20°, 30°, 40°, 50° and 60°, similar to finite element analyses but only on samples containing hand-mixed cements. The angles of fracture initiation were determined from the experimental results for different loading angles.

Figure 9displays a fractured sample and also the direction considered for measuring the crack kinking angle. As described earlier, for all samples containing hand-mixed cement, the interface crack kinked into the cement.

Figure 9:
The angle of crack kinking into cement at loading angle of 15°.

Table 5shows the crack kinking angles versus the loading angles. Since 4 or 5 tests were performed for each loading angle, the illustrated kinking angles are the averages of the measured values. It is worth mentioning that at the loading angle of 60°, no crack extension was observed. This can be due to the fact that none of the crack tips are under local tension at this loading angle.

Table 5:
The average kinking angles versus the loading angles, obtained from samples prepared by hand-mixed cement.

Loading angle (deg)	Average kinking angle (deg)
7.5	60.43
15	62
20	65.5
30	69.1
40	72.28

The experimental results obtained for the fracture angles together with the theoretical results predicted by the MTS and GMTS criteria are depicted in Figure 10. Very good agreement can be seen between the experimental results and theoretical values of fracture angles predicted by the GMTS criterion. It is worth noting that the predicted and measured fracture angles in Tables 3 and 5 are all positive. This is because the sign of is negative in the test specimens, as shown in Table 2(more details can be found in Smith et al. (2001)).

Figure 10:
Theoretical and experimental results obtained for the fracture angle in the samples prepared by hand-mixed cement.

As described earlier, the main difference between the MTS and GMTS criteria is the inclusion of T-stress in the GMTS criterion. Figure 10 reveals that the T-stress has a significant role in improving the estimates of fracture angles in the sandwich Brazilian disk samples. Figure 11 shows the fracture loads obtained from the experiments performed for each loading angle together with a linear line fitted to the test data using the least square method. According to this figure, as the loading angle (and hence mode II deformation) increases, the fracture load also enhances.

Figure 11:
The fracture loads versus loading angles in the samples prepared by hand-mixed cement.

6 DISCUSSION

To simulate the effect of a pre-existing crack on the bond strength of the cement-prosthesis connection in hip joint arthroplasty, a series of finite element analyses were conducted using sandwich Brazilian disk model. The stress intensity factors and the T-stress were calculated employing the "finite element over-deterministic" method. The results showed that increasing the loading angle, results in lowering K_I and raising K_II until the angle of 58.5° at which K_II is almost zero and the specimen is subjected to pure mode II. The maximum tangential stress (MTS) and the generalized maximum tangential stress (GMTS) criteria were utilized to compute the angle of crack growth for several loading angles ranging from 7.5° to 60° and to study the effect of T-stress on the angle of crack kinking. To verify the theoretical estimates and also to determine the influence of vacuum in cement mixing on the experimental results, a few experiments were carried out on an interface crack between the stainless steel and the bone cement. First, some experiments were conducted in order to study the influence of the cement mixing method on the bond strength of the cement-prosthesis connection. As a factor accelerating micro-crack formation, porosity weakens the bone cement. Therefore, the way of mixing raw materials can play a decisive role in the quality of bone cement. According to the previous studies, the tensile and tribological properties of bone cement are considerably improved by vacuum mixing. For instance, Karimzadeh and Ayatollahi (2012) made use of the nano-indentation and nano-scratch testing and compared the properties of the bond cements prepared by two methods of hand mixing and vacuum mixing. The materials and the protocol used in (Karimzadeh and Ayatollahi, 2012) were the same as those introduced in the present study. Their results revealed that the elastic modulus and mode I fracture toughness for the cement samples mixed in vacuum were higher than those of the samples mixed by hand, due to a decline in the porosity volume of the samples prepared in vacuum (Karimzadeh and Ayatollahi, 2012). However, the influence of the cement mixing method on the bond strength of cement-prosthesis connection has not been contemplated in the past.

To investigate the effect of the cement mixing method on the strength of cement-prosthesis connection, for the first series of tests the cement was mixed by hand, but for the second series the cement was mixed by two different methods, one by utilizing a vacuum box and the other one by using a machine similar to the conventional VM machines. The experimental results were then compared to each other and also to those of hand mixing method. The results obtained from the tests on the vacuum-mixed cement samples indicated that the crack extended self-similarly along the interface between the bone cement and the steel. As a result, those samples fractured under a remarkably lower load than the hand-mixed cement samples. This issue indicates that although vacuum mixing improves the cement properties (lower porosity and higher strength), it has an adverse effect on the cement tendency to stick to stainless steel. Therefore, it would be very useful to find improved methods for bonding the vacuum-mixed cements to stainless steel in order to achieve superior mechanical properties both in the cement itself and in its connection to the prosthesis. The cracks in all hand-mixed cement samples kinked into the cement indicating a strong interface bonding which is likely due to lower viscosity of the hand-mixed cement.

The fracture load was higher in the hand-mixed cement cases because higher energy was required for the extension of interface crack within the bone cement.

In the next stage, to validate the theoretical results obtained for fracture angles, a number of experiments were conducted at different loading angles on samples prepared by hand-mixed cement. It was observed that in almost all samples the crack kinked from its left hand side tip and entered the cement. The fracture angles were then measured and compared with those calculated by the MTS and GMTS criteria. The good agreement found between the results of GMTS criterion and the experiments indicates that the T-stress can be of a significant effect in interface cracks kinking into a brittle material. Indeed, by considering the T-stress in equation (2), a more precise model for the mathematical equation of stress is achieved in the vicinity of the crack which makes the GMTS criterion more accurate than the MTS criterion.

Since the strength of cement alone, the bond strength of bone-cement connection and the bond strength of cement-prosthesis are among the significant factors involved in a successful hip arthroplasty, improved material preparation methods can increase the efficiency of surgery. In the present study the bond strength was investigated for the cement-prosthesis connection under static loading. However, further studied should be performed to assess the fatigue and impact behavior of such connections in order to achieve a more comprehensive conclusion on suitable methods for connecting the cement to a steel prosthesis.

7 CONCLUSIONS

• • In almost all the sandwich Brazilian disk samples prepared by hand-mixed cement the crack kinked from the interface into the bone cement. The fracture loads in these samples were higher than those prepared by vacuum-mixed cements.

• • For the samples prepared by hand-mixed cement, the crack kinking angles were measured from the experiments and compared to those predicted by the MTS and GMTS criteria.

• • The kinking angles obtained from the GMTS criterion were in good agreement with those of experimental results. Hence, the T-stress can play an important role in mixed mode fracture in interface cracks.

• • Appropriate methods should be found to improve the bond strength between the vacuum-mixed cement and the stainless steel.

References

• Ayatollahi, M.R., Nejati, M., (2011). Determination of NSIFs and coefficients of higher order terms for sharp notches using finite element method. International Journal of Mechanical Sciences 53: 164-177.
• Baldan, A., (2012). Adhesion phenomena in bonded joints. Int J Adhes Adhes 38: 95-116.
• Chandra Kishen, J.M., Darunkumar Singh, K., (2001). Stress intensity factors based fracture criteria for kinking and branching of interface crack: applications to dams. Engineering fracture mechanics 68: 201-219.
• Dunne, N.J., Orr, J.F., (2001). Influence of mixing techniques on the physical properties of acrylic bone cement. Biomaterials 22: 1819-1826.
• Erdogan, F., Sih, G.C., (1963). On the crack extension in plates under plane loading and transverse shear. Transactions of the ASME, Journal of Basic Engineering 85: 519-527.
• Jian-Jun, H., Yi-Heng, C., (2000). T-effect for the interaction problem of an interface macrocrack with a near-tip microvoid. International Journal of Fracture 102: 205-222.
• Karimzadeh, A., Ayatollahi, M.R., (2012). Investigation of mechanical and tribological properties of bone cement by nano-indentation and nano-scratch experiments. Polymer Testing 31: 828-833.
• Knets, I., Krilova, V., Cimdins, R., Berzina, L., Vitins, V., (2007). Stiffness and strength of composite acrylic bone cements. The Journal of Achievements in Materials and Manufacturing Engineering 20: 135-138.
• Mann, K.A., Mocarski, R., Damron, L.A., Allen, M.J., Ayers, D.C., (2001). Mixed-mode failure response of the cement-bone interface. Journal of Orthopedic Research 19: 1153-1161.
• Mau, H., Schelling, K., Heisel, C., Wang, J.S., Breusch, S.J., (2004). Comparison of various vacuum mixing systems and bone cements as regards reliability, porosity and bending strength. Acta Orthop Scand 75: 160-172.
• Ohashi, K.L., (2000). Debonding of metal-PMMA interfaces in load bearing prosthetics. MSc thesis of Department of Mechanical Engineering, Stanford University.
• Ravichandran, M., Ramesh, K., (2005). Evaluation of stress field parameters for an interface crack in a bimaterial by digital photoelasticity. The Journal of Strain Analysis for Engineering Design January 40: 327-343.
• Smith, D.J., Ayatollahi, M.R., Pavier, M.J., (2001). The role of T-stress in brittle fracture for linear elastic materials under mixed mode loading. Fatigue and Fracture of Engineering Materials and Structures 24: 137-150.
• Tong, J., Wong, K.Y., Lupton, C., (2007). Determination of interfacial fracture toughness of bone-cement interface usi sandwich Brazilian disks. Engineering Fracture Mechanics 74: 1904-1916.
• Wang, X., Agrawal, C.M., (2000). A Mixed Mode Fracture Toughness Test of Bone-Biomaterial Interfaces. Journal of Biomedical Materials Research 53: 664-672.
• Yuuki, R., Liu, J.Q., Xu, J.Q., Ohira, T., Ono, T., (1994). Mixed mode fracture criteria for an interface crack. Engineering Fracture Mechanics 47: 367-377.

Publication Dates

• Publication in this collection
  Mar 2015

History

• Received
  22 Dec 2013
• Reviewed
  09 Aug 2014
• Accepted
  21 Oct 2014