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Coluna/Columna

Print version ISSN 1808-1851

Coluna/Columna vol.12 no.4 São Paulo Oct./Dec. 2013

http://dx.doi.org/10.1590/S1808-18512013000400013 

ORIGINAL ARTICLE ARTIGO ORIGINAL ARTÍCULO ORIGINAL

 

Misplacement of lumbar pedicular screws that produce postoperative mechanical radiculalgia with normal intraoperative neurophysiological stimulation: the value of neurophysiological stimulation at the pedicular mid-track

 

Mal posicionamento de parafusos pediculares lombares que produzem radiculalgia mecânica pós-operatória com estimulação neurofisiológica intraoperatória normal: o valor da estimulação neurofisiológica no trajeto do parafuso

 

 

Vicente García GonzálezI; Jesús Burgos FloresI; Teresa Del OlmoII; Carlos Barrios PitarqueIII; Eduardo Hevia SierraIV; Luis Miguel Antón RodrigálvarezV; Gema De Blas BeorleguiVI

IOrthopedic Surgery, Hospital Mancha-Centro, Alcázar de San Juan, C. Real, Spain
IIOrthopedic surgery, Hospital de Tudela, Tudela, Navarra, Spain
IIIOrthopedic Surgery, Universidad Católica de Valencia, Valencia, Valencia, Spain
IVSpine Unit, Hospital La Fraternity, Madrid, Madrid, Spain
VOrthopedic Surgery, Hospital Ramón y Cajal, Madrid, Madrid, Spain
VIDepartment of Neurophysiology, Hospital Ramón y Cajal, Madrid, Madrid, Spain

Correspondence

 

 


ABSTRACT

OBJECTIVE: To carry out a neurophysical evaluation that can identify these cases during surgery, and that prevents misplacement of pedicular screws.
METHODS: A total of 6739 screws were placed in 293 patients submitted to scoliosis correction via the posterior route with pedicular screws using the freehand technique. Of this total, eight patients (2.7%), with a mean age of 24 years, developed postoperative radiculopathy. Lumbar CT scans showed 10 misplaced lumbar screws (2L1-3L2-4L3-1L4), with minimal protrusion of the lower part of the screw. EMG thresholds of the screw and track were evaluated.
RESULTS: In the initial surgery, no anomalies were detected on palpation of the screw track or in the radioscopic control; neither were any neurophysiological alterations detected in the neurophysiological stimulation with t-EMG. All the patients had radicular pain in the standing and seated positions, which disappeared when lying on the bed. The screws were surgically removed at an average of 37 days after surgery (range: 4-182). In this surgical procedure, the neurophysiological monitoring was repeated, again showing normal thresholds (>11mA). After screw removal, stimulation of the probe within the track showed very low thresholds (range: 3.9-10.7 mA) at mid pedicular track. After a mean follow-up time of 4.4 years (Range: 2.6-6.8), five patients reported occasional radicular discomfort, and had minimal motor deficit in the affected limb.
CONCLUSIONS: A type of misplacement of lumbar pedicle screws is presented that produces radicular pain in the standing and seated positions, and that may not be detected by conventional monitoring. Neurophysiological stimulation of the mid pedicular track, after removal of the screw, produces low stimulation thresholds. Systematic stimulation of the track prior to insertion of the lumbar pedicular screw is recommended.

Keywords: Radiculopathy; Spine; Bone screws.


RESUMO

OBJETIVO: Avaliar a exploração neurofisiológica que identifica esses casos no intraoperatório e que evite o mal posicionamento de parafusos pediculares.
MÉTODOS: Em 293 pacientes submetidos à intervenção para escoliose por via posterior com parafusos pediculares e técnica "free hand", foram implantados 6.739 parafusos. Do total, oito pacientes (2,7%) com média de idade de 24 anos, tiveram dor radicular lombar no pós-operatório. Na TC depois da cirurgia, foram encontrados 10 parafusos lombares (2L1-3L2-4L3-1L4) com proeminência mínima na parte inferior do pedículo. Foram avaliados os limiares EMG do parafuso e do trajeto.
RESULTADOS: Na cirurgia inicial, não foram detectadas anomalias à palpação do trajeto nem no controle radioscópico; também não se verificaram alterações neurofisiológicas na estimulação neurofisiológica com t-EMG. Todos os pacientes tiveram dor radicular em posição ortostática e sentada, que passava com o repouso na cama. Os parafusos foram retirados cirurgicamente aos 37 dias, em média (R:4-182). Nesta cirurgia repetiu-se a monitoração neurofisiológica, que voltou a mostrar valores normais (> 11mA). Depois da retirada dos parafusos, realizou-se estimulação do trajeto que mostrou, na parte média, limiares inferiores aos valores normais (3,9-10,7mA). Depois de acompanhamento médio de 4,4 anos (R:2,6-6.8), cinco pacientes relatavam incômodos radiculares ocasionais e um tinha déficit motor mínimo no membro afetado.
CONCLUSÕES: Apresenta-se um tipo de mal posicionamento de parafuso pedicular lombar que produz radiculalgia em posição ortostática e sentada, que não é detectado pela monitoração convencional. A estimulação neurofisiológica do trajeto na zona média, depois da retirada do parafuso, produziu limiares baixos de estimulação. Recomenda-se a estimulação sistemática do trajeto antes da inserção do parafuso pedicular lombar.

Descritores: Radiculopatia; Coluna vertebral; Parafusos ósseos.


 

 

INTRODUCTION

Surgical treatment is an accepted method for correcting and preventing the progression of deformity of the thoracolumbar spine. However, the possibility of radiculomedullary neurological complication during surgery is a major cause of concern for surgeons.

Neurological complications can occur at the moment of insertion of the screws or sublaminar wires/hooks, in the process of neural release or bending of the spine, or at the moment of reduction of the deformity.

The occurrence of pedicle screw misplacement in surgery for deformity of the thoracolumbar spine ranges from 6% to 30%,1 usually without any neurological consequences.

In larger case series, an incidence of radicular complications during surgical treatment of spinal deformity of between 0.41% and 2.24% has been reported, despite the existence of correct neurophysiological monitoring and other controls.2

The rate of radicular complications caused by misplacement of pedicle screws that escaped detection by conventional neurophysiological and imaging systems is reported to be 3.38%.3

A mean intracanal deviation of 2 mm is considered acceptable in placement of the pedicle screw, at least in the thoracic region.1.4

Multiple intraoperative controls are recommended, such as the technique of pedicle insertion and intraoperative freehand palpation, neurophysiological control with somatosensory evoked potentials (SSEP) and motor evoked potentials (PEM) and monitoring of screws (t-EMG), and finally, intraoperative radioscopic control5 in patients undergoing surgery for deformity of the thoracolumbar spine.

In relation to the pedicle screw stimulus-evoked thresholds (t-EMG) introduced by Calancie et al.6 in 1991, there is some discrepancy between authors when it comes to determining the pathological values that suggest perforation of the medial cortex of the lumbar pedicle and close contact with the nerve root. Glassmann et al.7 suggest lower thresholds of 10 mA as highly suggestive of cortical perforation. Toleikis et al.8 suggest a threshold of <5 mA, and Raynor et al.5 present a stimulus-evoked threshold of 8 mA as unacceptable, due to the possibility of medial perforation of the lumbar pedicle.

According to the scientific evidence and our surgical experience, there are a number of patients with postoperative radicular complications that go undetected despite multiple controls.

The objective of this work is to analyze a group of patients with postoperative pain and/or motor deficit of the lower limbs following surgical correction of spinal deformity, whose symptoms occur exclusively when in the standing and/or seated positions, seeking to improve the neurophysiological detection of misplaced lumbar screws that go undetected in the usual intraoperative controls (freehand pedicle insertion technique, t-EMG and intraoperative imaging control).

 

METHODS

We studied 294 patients who underwent surgery for spinal deformity of multiple etiologies between 2004 and 2010, in three hospitals. All the surgical operations were performed by a primary surgeon with wide experience in surgical correction of deformities, assisted by several orthopedic surgeons with experience in spinal surgery, who were actively involved in the insertion of the pedicle screws, particularly on the right side of the patient.

A surgical technique by the posterior approach was used, essentially only with screws.

A total of 6,765 pedicle screws were inserted in these patients: 1,550 lumbar, 5,088 thoracic, and 127 iliac screws.

The screws were inserted freehand in most cases. All patients underwent intraoperative neurophysiological monitoring with potentials (SSEP and MEP) and monitoring of the screws (t-EMG). All patients underwent an intraoperative imaging exam at the end of the surgery, to confirm the correct positioning of the screws.

The neurophysiological study was carried out with a specific intraoperative monitoring Keypoint machine (Alpine Skovlunde-Denmark). The pedicles were stimulated with a pedicle screw Probe (Viasys Healthcare, Madison WI), used as a cathode that sits on the screw head, and a monopolar needle of 12 mm in length (Neuroline Subdermal, Ambu), which was inserted into the paraspinal musculature, acting as an anode.

A constant stimulus current was applied with a frequency of 1 Hz and duration of 0.1 ms, with intensity increasing from 0.2 mA to 50 mA until a repeatable compound action potential was obtained in the muscle of the corresponding myotome. The responses were recorded using filters at between 20Hz and 5 KHz, with amplifier sensitivity 50 µV per division and 10 ms of stimulation pulse. A pair of stainless steel monopolar needle recording electrodes, 12 mm in length (Neuroline Subdermal, Ambu), were inserted into the muscles of the corresponding myotomes.

The acceptable thresholds, according to the recommendations of Glassman et al.,7 were threshold >15 mA: 98% confidence for the intrapedicular position of the screw. Threshold 10-15 mA: 87% confidence for the intrapedicular position of the screw. Threshold <10 mA: perforation of the cortex in 90% of cases. In the screws with thresholds below 15 mA, the track was reviewed in all cases and the screw was definitively inserted, according to the palpation assessment, particularly if the threshold was between 10-15 mA and it was considered a fundamental screw.

Statistical analysis was performed using the software program SPSS v 1800 (IBM Corp, Armonk, NY) and the chi-square test of independence for the study of the association between "surgeon's experience" and "outcome of the implant".

Of the 294 patients who underwent surgery, 8 (2.7%) patients with a mean age of 24 years (11-39) developed postoperative radicular pain/motor deficit. An axial computed tomography (CT) was requested in these patients, which showed that 10 (0.67%) malpositioned lumbar screws (2L1-3L2-4L3-1L4), all of them with minimal prominence in the lower region of the pedicle. (Figure 1) The malpositioned screws were removed, and the EMG thresholds of the screw and pedicle track were assessed during the surgery.

 

 

Patients with malpositioned screws presented the following diagnoses: 1 congenital heart disease, 1 infantile cerebral palsy, 1 Marfan syndrome, 3 adolescent idiopathic scoliosis, 1 adult scoliosis, and 1 Scheuermann's disease. (Table 1)

 

RESULTS

The eight patients with postoperative radiculopathy presented palpation of the track, t-EMG and intraoperative radioscopy without pathological changes during the first surgery. Postoperative CT showed, in all cases (10 screws) misplacement of the lumbar screw, with invasion <2 mm in the lower region of the pedicle. The screws were removed without replacement at 37 days, on average (4-182).

Prior to removal of the screw, a new stimulation was performed on the malpositioned screw, which once again showed normal values (>11 mA). After withdrawal of the screw, stimulation of the pedicle track was performed, showing very low values in its mid portion (3.9 -10.7 mA) and normal values (>11 mA) at the bottom of the pedicular track (Figures 2 and 3).

 

 

 

 

After a mean follow-up of 4.4 years (2-6.8 years), two patients reported moderate pain in the affected root, one reported mild motor deficit of the quadriceps (L3D), one patient had paresthesia, and four patients were asymptomatic.

The malpositioned screws mainly occurred on the right side of the patient (9/1), a fact that presents a statistically significant relationship, with p<0.05 (chi-square).

 

DISCUSSION

All the patients presented pain in the standing/seated position in the metamere of the affected root, which disappeared when lying down. All the cases had low levels of track stimulation (t-EMG) in the mid-pedicle region after removal of the screw, which suggests greater sensitivity to detect an abnormal positioning of the lumbar pedicle screw, compared with direct stimulation of the screw.

We believe that the presence of symptoms mainly in the standing/seated positions is related to the decreased height of the disc that occurs in both positions, while the presence of rigid instrumentation in the vertebra adjacent to the disc is a drawback for attributing the pathogenesis of the symptoms to the decreased disc height. However the discs retain some mobility in spite of the posterior instrumentation.

Most malpositioned screws are on the right side of the patient, which coincides with the position in which the less experienced surgeon stands. Statistical analysis shows a causal relationship between the surgeon's experience and the likelihood of misplacement of the pedicle screw for a level of significance α of 5%, but not for a significance α level of 1%.

 

CONCLUSIONS

Neurophysiological stimulation of the mid track of the pedicle screw in the lumbar region showed low thresholds (<11 mA) in all cases.

In patients who underwent surgery for vertebral deformity, track stimulation can detect misplacement of lumbar screws that go unnoticed in the normal controls.

We recommend systematic stimulation of the lumbar pedicular track in patients undergoing surgery for vertebral deformity.

There is a statistically significant relationship between the surgeon's experience and lumbar pedicle screw misplacement.

 

REFERENCES

1. Upendra BN, Meena D, Chowdhury B, Ahmad A, Jayaswal A. Outcome-based classification for assessment of thoracic pedicular screw placement. Spine (Phila Pa 1976). 2008;33(4):384-90.         [ Links ]

2. Hamilton DK, Smith JS, Sansur CA, Glassman SD, Ames CP, Berven SH, et al. Rates of new neurological deficit associated with spine surgery based on 108,419 procedures: a report of the scoliosis research society morbidity and mortality committee. Spine (Phila Pa 1976). 2011;36(15):1218-28.         [ Links ]

3. Alemo S, Sayadipour A. Role of intraoperative neurophysiologic monitoring in lumbosacral spine fusion and instrumentation: a retrospective study. World Neurosurg. 2010;73(1):72-6;         [ Links ]

4. Polly DW Jr, Potter BK, Kuklo T, Young S, Johnson C, Klemme WR. Volumetric spinal canal intrusion: a comparison between thoracic pedicle screws and thoracic hooks. Spine (Phila Pa 1976). 2004;29(1):63-9.         [ Links ]

5. Raynor BL, Lenke LG, Bridwell KH, Taylor BA, Padberg AM. Correlation between low triggered electromyographic thresholds and lumbar pedicle screw malposition: analysis of 4857 screws. Spine (Phila Pa 1976). 2007;32(24):2673-8.         [ Links ]

6. Calancie B, Lebwohl N, Madsen P, Klose KJ. Intraoperative evoked EMG monitoring in an animal model. A new technique for evaluating pedicle screw placement. Spine (Phila Pa 1976). 1992;17(10):1229-35.         [ Links ]

7. Glassman SD, Dimar JR, Puno RM, Johnson JR, Shields CB, Linden RD. A prospective analysis of intraoperative electromyographic monitoring of pedicle screw placement with computed tomographic scan confirmation. Spine (Phila Pa 1976). 1995;20(12):1375-9.         [ Links ]

8. Toleikis JR, Skelly JP, Carlvin AO, Toleikis SC, Bernard TN, Burkus JK, et al. The usefulness of electrical stimulation for assessing pedicle screw placements. J Spinal Disord. 2000;13(4):283-9.         [ Links ]

 

 

Correspondence:
Avenida Constitucion s/n, 13600 Alcazar de San Juan.
Ciudad Real. Spain.

Received on 10/17/2013, accepted on 11/14/2013.

 

 

Study conducted at the Hospital Mancha-Centro, Alcázar de San Juan, C. Real, Spain.
All authors declare no potential conflict of interest concerning this article.

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