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Brazilian Journal of Otorhinolaryngology

Print version ISSN 1808-8694

Braz. j. otorhinolaryngol. (Impr.) vol.76 no.1 São Paulo Jan./Feb. 2010

http://dx.doi.org/10.1590/S1808-86942010000100024 

CASE REPORT

 

Post-stapedotomy granulomatous reaction

 

 

Fernando Kaoru YonamineI; Danilo Kanashiro SegallaII; Marcos Luiz AntunesIII

IMedical resident in Otorhinolaryngology, Otorhinolaryngology and Head & Neck Surgery Department, Sao Paulo Federal University, Paulista Medical School (EPM). Diadema State Hospital, Otorhinolaryngology and Head & Neck Surgery Department, Sao Paulo Federal University, EPM
IIMedical resident. Diadema State Hospital, Otorhinolaryngology and Head & Neck Surgery Department, Sao Paulo Federal University, EPM
IIIDoctorate in Otorhinolaryngology, Sao Paulo Federal University, EPM. Coordinator of the Otorrinolaringology Unit of the Diadema State Hospital. Diadema State Hospital, Otorhinolaryngology and Head & Neck Surgery Department, Sao Paulo Federal University, EPM

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Keywords: stapedectomy, granuloma, vertigo.


 

 

INTRODUCTION

Since the advent of stapedotomy and its use in the treatment of otosclerosis, a few complications have been reported in the literature. Among them, the granulomatous reaction, described by Harris and Weiss in 1962,1 is rare. It is an excessive inflammation that forms granulation tissue around the prosthesis and the oval windows.2

Although the etiology is uncertain, several authors believe that the main cause is a foreign body reaction to the material used in filling the oval windows.3

The post-stapedotomy incidence is 0.07% and the post-stapedectomy incidence is 0.1%; it generally manifests after surgery as sensorineural dysacusis and vertigo. It may be confirmed by exploratory tympanotomy to visualize granulation tissue around the prosthesis and the oval window in a symptomatic patient.3

 

CASE REPORT

A white female patient aged 35 years complained of progressive bilateral hypoacusis during the last seven years, worse to the right. There was no significant history of disease. Her mother had bilateral hearing loss of unknown cause. There were no findings on the physical and otorhinolaryngological examination. Audiometry showed mild mixed hearing loss with a 5-10 dB gap at low frequencies and 30 dB SRT to the left, and moderate to severe mixed loss with a 20-35 dB gap and 80 dB SRT to the right (Fig. 1A); the speech recognition index and tympanometry were within normal limits, and the stapedian reflexes were absent. The patient underwent stapedotomy and placement of a Teflon prosthesis in the right ear; the oval window was filled with 1 ml of blood; no complications ensued. Post-operatively, the patient presented intense vertigo and the hearing loss remained. Vertigo diminished partially and hearing improved after treatment with an antivertiginous drug and corticosteroids (Fig. 1B). Two months of medication resulted only in partially regression of vertigo; but hearing worsened significantly. Computed tomography of the temporal bones revealed apparently well located soft tissue density material in the oval window and around the prosthesis (Fig. 1D). A revision of the stapedotomy was carried out, which showed granulation tissue in the oval window. The prosthesis was removed with the granuloma. One month later the patient had improved partially from the vertigo, but hearing was worse. Audiometry showed profound sensorineural hearing loss to the right, with 95 dB SRT (Fig. 1C).

 


 

DISCUSSION

The disease should be suspected in patients presenting postoperative vertigo and persistent sensorineural dysacusia within six months of surgery.2 The differential diagnosis is made with perilymphatic fistula and stapedotomy long prosthesis. High resolution computed tomography may be used, since this method makes it possible to identify these conditions.4

A foreign body reaction has been suggested as the hypothesis, although autoimmune reactions, infection and local inflammation have not been discarded.1 The most common filling materials in stapedotomy that have been associated with granuloma are blood and gelfoam; in stapedectomy, these materials are fat and gelfoam.3 They are used to fill in the oval window and to decrease the risk of a perilymphatic fistula. An animal experimental model showed that gelfoam placed in the open oval window niche caused injury to the basilar membrane on histology.5

Surgical treatment may be exploratory tympanotomy with removal of the granuloma and the prosthesis; a second prosthesis may be placed, or the granuloma may be removed only. Clinical therapy is done with corticosteroids and antibiotics.3

Even though there are no published papers specifically on the treatment of granulomas, several authors, based on their experience, have obtained better results by combining corticosteroids and early revision with removal of the granuloma and placement of a new prosthesis.3,6

 

FINAL COMMENTS

Granulomatous reaction following stapedotomy/stapedectomy is rare, rather annoying for patients, and frustrating for surgeons. Unfortunately, there are not predictive patterns for its occurrence. We should be ready to deal with this situation, notwithstanding its rarity.

 

REFERENCES

1. Harris I, Weiss L. Granulomatous complications of the oval window fat grafts. Laryngoscope. 1962;72:870-85.         [ Links ]

2. Fenton JE, Turner J, Shirazi A, Fagan PA. Post-stapedectomy reparative granuloma: a misnomer. J Laryngol Otol. 1996;110(2):185-8.         [ Links ]

3. Seicshnaydre MA, Sismanis A, Hughes GB. Update of reparative granuloma: survey of the American Otological Society and the American Neurotology Society. Am J Otol. 1994;15(2):155-60.         [ Links ]

4. Mann WJ, Amedee RG, Fuerst G, Tabb HG. Hearing loss as a complication of stapes surgery. Otolaryngol Head Neck Surg. 1996;115(4):324-8.         [ Links ]

5. Bellucci RJ, Wolff D. Tissue reaction following reconstruction of the oval window in experimental animals. Ann Otol Rhinol Laryngol. 1960;69:517-39.         [ Links ]

6. Tange RA, Schimanski G, van Lange JW, Grolman W, Zuur LC. Reparative granuloma seen in cases of gold piston implantation after stapes surgery for otosclerosis. Auris Nasus Larynx. 2002; 29(1):7-10.         [ Links ]

 

 

Send correspondence to:
Danilo Kanashiro Segalla
Av. Dr. Altino Arantes 648 Ap. 71
São Paulo-SP 04042-003
E-mail: danilosegalla@yahoo.com.br

Paper submitted to the BJORL-SGP (Publishing Management System - Brazilian Journal of Otorhinolaryngology) on July 29, 2007; and accepted on September 11, 2007. cod. 4690

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