A Proteína S100B e o exercício físico

Protein S100B and physical exercise

ARTIGO DE REVISÃO

A Proteína S100B e o exercício físico

Protein S100B and physical exercise

Cíntia Mussi Alvim Stocchero^I; Alexandre Pastoris Muller^II; Álvaro Reischak de Oliveira^I; Luis Valmor Portela^II

^IUniversidade Federal do Rio Grande do Sul. Escola de Educação Física. Porto Alegre, RS, Brasil.

^IIUniversidade Federal do Rio Grande do Sul. Departamento de Bioquímica. Porto Alegre, RS, Brasil.

^{Correspondencia para}

RESUMO

A proteína S100B cerebral tem sido utilizada como um marcador periférico de injúrias do sistema nervoso central (SNC). Entretanto, estudos recentes demonstraram que a S100B também aumenta após o exercício físico, embora o significado desse aumento ainda não esteja bem claro. Apesar de ser liberada, principalmente, por astrócitos, no sistema nervoso central, fontes de produção extracerebral de S100B durante o exercício podem estar implicadas no aumento sérico desta proteína. No entanto, exercícios que implicam impacto ao cérebro como o boxe, por exemplo, o aumento é claramente associado à lesão cerebral. Assim, trabalhos propõem que o aumento da S100B após o exercício estaria relacionado à secreção ativa por adipócitos e músculos lesados. Uma vez que a liberação da S100B pelo músculo lesado seja confirmada experimentalmente, o uso desta proteína poderia ser aprofundado, principalmente, no treinamento esportivo. Atualmente, estamos desenvolvendo protocolos na direção de avaliar o potencial valor da S100B como indicador de lesão do músculo esquelético. Portanto, o objetivo da presente revisão é apresentar o atual estado de conhecimento sobre a relação entre a proteína S100B e o exercício físico, discutindo os possíveis mecanismos envolvidos e propondo novas abordagens.

Palavras-chave: Sistema Nervoso Central; Proteína S100B; Exercício físico; Lesão muscular.

ABSTRACT

Protein S100B has been used as a peripheral biochemical marker of brain injury and/or activity. However, recent studies have demonstrated that this protein is also increased in serum after physical exercise, although the interpretation of this finding remains controversial. Although predominantly released by astrocytes in the central nervous system, extracerebral sources of protein S100B have been suggested to contribute to the increase in serum levels of this protein. However, in the case of exercises that have an impact on the brain such as boxing, elevated levels are clearly associated with brain damage. More recently, some studies have proposed that protein S100B might be released by activated adipocytes and by damaged muscle cells. If confirmed experimentally, protein S100B might be potentially useful in sports training. We are currently investigating the potential role of serum protein S100B as an indicator of muscle damage. Therefore, the objective of this review was to discuss the current knowledge about the relationship between physical exercise and serum protein S100B and its possible leakage from muscle cells injured by exercise.

Keywords: Central nervous system; Protein S100B; Physical exercise; Muscle damage.

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Recebido em 11/09/08

Revisado em 20/11/08

Aprovado em 06/02/09

• 1. Daussin FN, Zoll J, Dufour SP, Ponsot E, Lonsdorfer-Wolf E, Doutreleau S, et al. Effect of interval versus continuous training on cardiorespiratory and mitochondrial functions: relationship to aerobic performance improvements in sedentary subjects. Am J Physiol Regul Integr Comp Physiol 2008;295(1):R264-R272.
• 2. Rogers CJ, Colbert LH, Greiner JW, Perkins SN, Hursting SD. Physical activity and cancer prevention: pathways and targets for intervention. Sports Med 2008;38(4):271-296.
• 3. Cotman CW, Berchtold NC. Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci 2002;25(6):295-301.
• 4. Coffey VG, Hawley JA. The molecular bases of training adaptation. Sports Med 2007;37(9):737-763.
• 5. Huonker M, Halle M, Keul J. Structural and functional adaptations of the cardiovascular system by training. Int J Sports Med 1996;17 Suppl 3:S164-S172.
• 6. Donato R. S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. Int J Biochem Cell Biol 2001;33(7):637-668.
• 7. Nishiyama H, Knopfel T, Endo S, Itohara S. Glial protein S100B modulates long-term neuronal synaptic plasticity. Proc Natl Acad Sci U S A 2002;99(6):4037-4042.
• 8. Tramontina F, Conte S, Goncalves D, Gottfried C, Portela LV, Vinade L, et al. Developmental changes in S100B content in brain tissue, cerebrospinal fluid, and astrocyte cultures of rats. Cell Mol Neurobiol 2002;22(3):373-378.
• 9. Portela LV, Tort AB, Schaf DV, Ribeiro L, Nora DB, Walz R, et al. The serum S100B concentration is age dependent. Clin Chem 2002;48(6 Pt 1):950-952.
• 10. Portela LV, Brenol JC, Walz R, Bianchin M, Tort AB, Canabarro UP, et al. Serum S100B levels in patients with lupus erythematosus: preliminary observation. Clin Diagn Lab Immunol 2002;9(1):164-146.
• 11. Nylen K, Ost M, Csajbok LZ, Nilsson I, Hall C, Blennow K, et al. Serum levels of S100B, S100A1B and S100BB are all related to outcome after severe traumatic brain injury. Acta Neurochir (Wien) 2008;150(3):221-227; discussion 227.
• 12. Petzold A, Michel P, Stock M, Schluep M. Glial and axonal body fluid biomarkers are related to infarct volume, severity, and outcome. J Stroke Cerebrovasc Dis 2008;17(4):196-203.
• 13. Walz R, Portela LV, Tort AB, Neto EC, Fernandes LN, Goncalves CA, et al. Serum S100B levels in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis. Neurology 2000;54(10):2021-2022.
• 14. Portela LV, Tort AB, Walz R, Bianchin M, Trevisol-Bittencourt PC, Wille PR, et al. Interictal serum S100B levels in chronic neurocysticercosis and idiopathic epilepsy. Acta Neurol Scand 2003;108(6):424-7.
• 15. Schaf DV, Tort AB, Fricke D, Schestatsky P, Portela LV, Souza DO, et al. S100B and NSE serum levels in patients with Parkinson's disease. Parkinsonism Relat Disord 2005;11(1):39-43.
• 16. Lara DR, Gama CS, Belmonte-de-Abreu P, Portela LV, Goncalves CA, Fonseca M, et al. Increased serum S100B protein in schizophrenia: a study in medication-free patients. J Psychiatr Res 2001;35(1):11-14.
• 17. Machado-Vieira R, Lara DR, Portela LV, Goncalves CA, Soares JC, Kapczinski F, et al. Elevated serum S100B protein in drug-free bipolar patients during first manic episode: a pilot study. Eur Neuropsychopharmacol 2002;12(3):269-272.
• 18. Otto M, Holthusen S, Bahn E, Sohnchen N, Wiltfang J, Geese R, et al. Boxing and running lead to a rise in serum levels of S-100B protein. Int J Sports Med 2000;21(8):551-555.
• 19. Stalnacke BM, Tegner Y, Sojka P. Playing soccer increases serum concentrations of the biochemical markers of brain damage S-100B and neuron-specific enolase in elite players: a pilot study. Brain Inj 2004;18(9):899-909.
• 20. Stalnacke BM, Tegner Y, Sojka P. Playing ice hockey and basketball increases serum levels of S-100B in elite players: a pilot study. Clin J Sport Med 2003;13(5):292-302.
• 21. Dietrich MO, Tort AB, Schaf DV, Farina M, Goncalves CA, Souza DO, et al. Increase in serum S100B protein level after a swimming race. Can J Appl Physiol 2003;28(5):710-716.
• 22. Schulpis KH, Moukas M, Parthimos T, Tsakiris T, Parthimos N, Tsakiris S. The effect of alpha-Tocopherol supplementation on training-induced elevation of S100B protein in sera of basketball players. Clin Biochem 2007;40(12):900-906.
• 23. Hasselblatt M, Mooren FC, von Ahsen N, Keyvani K, Fromme A, Schwarze-Eicker K, et al. Serum S100beta increases in marathon runners reflect extracranial release rather than glial damage. Neurology 2004;62(9):1634-1636.
• 24. Cheuvront SN, Chinevere TD, Ely BR, Kenefick RW, Goodman DA, McClung JP, et al. Serum S-100beta Response to Exercise-Heat Strain before and after Acclimation. Med Sci Sports Exerc 2008;40(8):1477-1482.
• 25. Netto CB, Conte S, Leite MC, Pires C, Martins TL, Vidal P, et al. Serum S100B protein is increased in fasting rats. Arch Med Res 2006;37(5):683-686.
• 26. Scaccianoce S, Del Bianco P, Pannitteri G, Passarelli F. Relationship between stress and circulating levels of S100B protein. Brain Res 2004;1004(1-2):208-211.
• 27. Woertgen C, Rothoerl RD, Sauer K, Brawanski A. Does bungee jumping release S-100B protein? J Clin Neurosci 2002;9(1):51-52.
• 28. Dietrich M, O., Souza DO, Portela LV. Serum S100B protein: what does it mean during exercise? Clin J Sport Med 2004;14(6):368; author reply 368-369.
• 29. Van de Kar LD, Rittenhouse PA, Li Q, Levy AD. Serotonergic regulation of renin and prolactin secretion. Behav Brain Res 1996;73(1-2):203-208.
• 30. Struder HK, Weicker H. Physiology and pathophysiology of the serotonergic system and its implications on mental and physical performance. Part I. Int J Sports Med 2001;22(7):467-481.
• 31. Azmitia EC. Neuronal instability: implications for Rett's syndrome. Brain Dev 2001;23 Suppl 1:S1-S10.
• 32. Blomstrand E, Perrett D, Parry-Billings M, Newsholme EA. Effect of sustained exercise on plasma amino acid concentrations and on 5-hydroxytryptamine metabolism in six different brain regions in the rat. Acta Physiol Scand 1989;136(3):473-481.
• 33. Chaouloff F. Effects of acute physical exercise on central serotonergic systems. Med Sci Sports Exerc 1997;29(1):58-62.
• 34. Berchtold NC, Chinn G, Chou M, Kesslak JP, Cotman CW. Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus. Neuroscience 2005;133(3):853-861.
• 35. Cotman CW, Berchtold NC, Christie LA. Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci 2007;30(9):464-472.
• 36. Dietrich Mde O, Souza DO, Portela LV. Serum S100B protein: what does it mean during exercise? Clin J Sport Med 2004;14(6):368; author reply 368-369.
• 37. Mazzini GS, Schaf DV, Oliveira AR, Goncalves CA, Bello-Klein A, Bordignon S, et al. The ischemic rat heart releases S100B. Life Sci 2005;77(8):882-889.
• 38. Snyder-Ramos SA, Gruhlke T, Bauer H, Bauer M, Luntz AP, Motsch J, et al. Cerebral and extracerebral release of protein S100B in cardiac surgical patients. Anaesthesia 2004;59(4):344-349.
• 39. Suzuki F, Kato K, Nakajima T. Regulation of nervous system-specific S-100 protein and enolase levels in adipose tissue by catecholamines. J Neurochem 1984;42(1):130-134.
• 40. Balnave CD, Thompson MW. Effect of training on eccentric exercise-induced muscle damage. J Appl Physiol 1993;75(4):1545-1551.
• 41. Nosaka K, Clarkson PM. Muscle damage following repeated bouts of high force eccentric exercise. Med Sci Sports Exerc 1995;27(9):1263-1269.

Datas de Publicação

• Publicação nesta coleção
  06 Fev 2013
• Data do Fascículo
  Fev 2010

Histórico

• Recebido
  11 Set 2008
• Aceito
  06 Fev 2009
• Revisado
  20 Nov 2008