Abstract
Dementia with Parkinson's disease represents a controversial issue in the complex group of alpha-synucleinopathies. The author acknowledges the concept of a "continuum" between Parkinson disease's (PD), Lewy body dementia (LBD), and dementia in Parkinson's disease (PDD). However, the practicing neurologist needs to identify the phenotypic signs of each dementia. The treatment and prognosis are different in spite of the overlaps between them. The main aim of this review was to characterize the clinical diagnoses of dementia associated with Parkinson's disease (PDD). Secondarily, the review discussed some epidemiological and neuropsychological issues. Selection of articles was not systematic and reflects the author's opinion, where the main text selected was the recommendations from the Movement Disorder Society Task Force for PDD diagnosis. The Pub Med, OVID, and Proquest data bases were used for the search.
Key words:
dementia with Parkinson's disease; Parkinson's disease; cognitive impairment; Alzheimer's disease; Lewy body dementia; mild cognitive impairment.
Resumo
Demência com doença de Parkinson constitui um assunto controverso no complexo grupo das alfa-sinucleinopatias. O autor admite o conceito de um "continuum" entre doença de Parkinson (DP), demência com corpos de Lewy (DCL) e demência na doença de Parkinson (DDP). Todavia, neurologistas necessitam identificar os sinais fenotípicos de cada uma. O tratamento e prognóstico são diferentes, apesar das sobreposições entre elas. O primeiro objetivo desta revisão foi o de caracterizar o diagnóstico clínico de demência associada à DP. Secundariamente, a revisão discute alguns aspectos epidemiológicos e neuropsicológicos. A seleção dos artigos não foi sistemática e reflete a opinião do autor, escolhendo como texto principal as recomendações da Força Tarefa da Sociedade de Transtornos do Movimento para diagnóstico de DDP. Foram utilizados as bases de dados do Pub Med, OVID e Proquest como bases de dados.
Palavras-chave:
demência na doença de Parkinson; doença de Parkinson; comprometimento cognitivo; doença de Alzheimer; demência com corpos de Lewy; comprometimento cognitivo leve.
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Full text available only in PDF format.
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Publication Dates
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Publication in this collection
Oct-Dec 2008
History
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Received
01 Aug 2008 -
Accepted
20 Oct 2008