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Dementia & Neuropsychologia

Print version ISSN 1980-5764

Dement. neuropsychol. vol.3 no.3 São Paulo July/Sept. 2009

https://doi.org/10.1590/S1980-57642009DN30300006 

Views & Reviews

Does prevention for Alzheimer's disease exist?

A prevenção da doença de Alzheimer existe?

Sonia Maria Dozzi Brucki1 

1MD, PhD, Neurologist from the Cognitive and Behavioral Neurology Group (University of São Paulo); Psychobiology Department (Federal University of São Paulo); Hospital Santa Marcelina, São Paulo, SP, Brazil.


Abstract

The prevention of Alzheimer's disease is a growing public health concern amidst an ageing population. Meanwhile, there is no effective or curative treatment available where prevention could greatly reduce health costs. This review was based on reports of potential preventive factors, including modifiable lifestyle factors, as well as preventive pharmacological strategies. Although the present review was not systematic, the reports selected from PubMed using "Alzheimer's disease" and "prevention" as key-words, allow us to affirm that pursuing a healthy lifestyle; physical, cognitive, leisure activities; good social engagement; a high consumption of fish, low consumption of dietary fat and moderate consumption of wine, and control of vascular risk factors appear to be potential factors for delaying dementia.

Key words: Alzheimer's disease; prevention; physical exercise; statins; cholinesterase inhibitors; nutrition.

Resumo

A prevenção da doença de Alzheimer é um problema de saúde pública, enquanto a população está envelhecendo. Por enquanto, não há tratamento efetivo ou curativo e prevenção poderia evitar grandes custos financeiros. Esta revisão foi baseada em estudos sobre potenciais fatores preventivos, incluindo fatores modificáveis de estilo de vida, bem como estratégias farmacológicas preventivas. Embora esta revisão não seja sistemática, estudos selecionados do PubMed, com palavras-chave "Alzheimer's disease" e " prevention", permitem afirmar que ter um estilo de vida saudável, atividades físicas, cognitivas e de lazer; bom engajamento social; aumento no consumo de peixes, redução no consumo de gorduras consumo meoderado de vinho; controle dos fatores de risco vasculares parecem ter vantagens potenciais em retardar a demência.

Palavras-chave: doença de Alzheimer; prevenção; exercício físico; estatinas; inibidores de colinesterases; nutrição.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

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Received: July 08, 2009; Accepted: August 12, 2009

Sonia Maria Dozzi Brucki - Rua Rio Grande 180/61 - 04018-000 São Paulo SP - Brazil. E-mail: sbrucki@uol.com.br

Disclosure: The authors report no conflicts of interest.

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